CA1138778A - Compose utilise pour prevenir et inhiber la carie dentaire - Google Patents

Compose utilise pour prevenir et inhiber la carie dentaire

Info

Publication number: CA1138778A
Authority: CA; Canada
Prior art keywords: dental; composition; dental composition; caries; dioxotetrafluoromolybdate
Prior art date: 1979-05-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000328352A

Other languages

English (en)

Inventor

Hiroji Yamamoto

Hirohisa Okuda

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Toyo Seiyaku Kasei Co Ltd

Original Assignee

Toyo Seiyaku Kasei Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-05-25

Filing date

1979-05-25

Publication date

1983-01-04

1979-05-25 Application filed by Toyo Seiyaku Kasei Co Ltd filed Critical Toyo Seiyaku Kasei Co Ltd

1979-05-25 Priority to CA000328352A priority Critical patent/CA1138778A/fr

1983-01-04 Application granted granted Critical

1983-01-04 Publication of CA1138778A publication Critical patent/CA1138778A/fr

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 73
208000002925 dental caries Diseases 0.000 title claims abstract description 36
230000002401 inhibitory effect Effects 0.000 title claims abstract description 17
239000002253 acid Substances 0.000 claims abstract description 13
-1 molybdate compound Chemical class 0.000 claims abstract description 12
ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims abstract description 10
229910052750 molybdenum Inorganic materials 0.000 claims abstract description 9
239000011733 molybdenum Substances 0.000 claims abstract description 9
239000003085 diluting agent Substances 0.000 claims abstract description 4
239000003937 drug carrier Substances 0.000 claims abstract description 4
239000007788 liquid Substances 0.000 claims description 11
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 10
229910052708 sodium Inorganic materials 0.000 claims description 10
239000011734 sodium Substances 0.000 claims description 10
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 8
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 5
229910052700 potassium Inorganic materials 0.000 claims description 5
239000011591 potassium Substances 0.000 claims description 5
229910052783 alkali metal Inorganic materials 0.000 claims description 3
150000001875 compounds Chemical class 0.000 claims 1
210000001519 tissue Anatomy 0.000 abstract description 17
108091005804 Peptidases Proteins 0.000 abstract description 15
239000004365 Protease Substances 0.000 abstract description 15
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract description 15
230000029087 digestion Effects 0.000 abstract description 15
230000000694 effects Effects 0.000 abstract description 11
210000004872 soft tissue Anatomy 0.000 abstract description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
239000008367 deionised water Substances 0.000 description 20
229910021641 deionized water Inorganic materials 0.000 description 20
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 16
239000004615 ingredient Substances 0.000 description 12
241000700159 Rattus Species 0.000 description 11
239000000243 solution Substances 0.000 description 11
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
230000005764 inhibitory process Effects 0.000 description 9
150000004673 fluoride salts Chemical class 0.000 description 8
239000000843 powder Substances 0.000 description 8
239000011775 sodium fluoride Substances 0.000 description 8
235000013024 sodium fluoride Nutrition 0.000 description 8
238000012360 testing method Methods 0.000 description 7
238000011282 treatment Methods 0.000 description 7
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
239000011575 calcium Substances 0.000 description 6
229910052791 calcium Inorganic materials 0.000 description 6
239000003814 drug Substances 0.000 description 6
210000004268 dentin Anatomy 0.000 description 5
MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical class [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 5
FDEIWTXVNPKYDL-UHFFFAOYSA-N sodium molybdate dihydrate Chemical compound O.O.[Na+].[Na+].[O-][Mo]([O-])(=O)=O FDEIWTXVNPKYDL-UHFFFAOYSA-N 0.000 description 5
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
238000000034 method Methods 0.000 description 4
102000008186 Collagen Human genes 0.000 description 3
108010035532 Collagen Proteins 0.000 description 3
230000015556 catabolic process Effects 0.000 description 3
229920001436 collagen Polymers 0.000 description 3
238000006731 degradation reaction Methods 0.000 description 3
210000003298 dental enamel Anatomy 0.000 description 3
210000003074 dental pulp Anatomy 0.000 description 3
238000004090 dissolution Methods 0.000 description 3
210000003296 saliva Anatomy 0.000 description 3
229920001817 Agar Polymers 0.000 description 2
102000029816 Collagenase Human genes 0.000 description 2
108060005980 Collagenase Proteins 0.000 description 2
239000008272 agar Substances 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
230000001013 cariogenic effect Effects 0.000 description 2
229960002424 collagenase Drugs 0.000 description 2
230000037213 diet Effects 0.000 description 2
235000005911 diet Nutrition 0.000 description 2
LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
150000004682 monohydrates Chemical class 0.000 description 2
TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 2
235000018102 proteins Nutrition 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 description 2
230000001988 toxicity Effects 0.000 description 2
231100000419 toxicity Toxicity 0.000 description 2
239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
235000019743 Choline chloride Nutrition 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
229910020435 K2MoO4 Inorganic materials 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
229910013812 M2MoO4 Inorganic materials 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
229910017974 NH40H Inorganic materials 0.000 description 1
229910004619 Na2MoO4 Inorganic materials 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
241000194019 Streptococcus mutans Species 0.000 description 1
HEAFLBOWLRRIHV-UHFFFAOYSA-N [Na].[P] Chemical compound [Na].[P] HEAFLBOWLRRIHV-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
APUPEJJSWDHEBO-UHFFFAOYSA-P ammonium molybdate Chemical compound [NH4+].[NH4+].[O-][Mo]([O-])(=O)=O APUPEJJSWDHEBO-UHFFFAOYSA-P 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 description 1
229960003178 choline chloride Drugs 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
229940116333 ethyl lactate Drugs 0.000 description 1
210000004195 gingiva Anatomy 0.000 description 1
229910052588 hydroxylapatite Inorganic materials 0.000 description 1
238000001802 infusion Methods 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
229960003511 macrogol Drugs 0.000 description 1
238000002156 mixing Methods 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
231100000957 no side effect Toxicity 0.000 description 1
238000010422 painting Methods 0.000 description 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
150000004686 pentahydrates Chemical class 0.000 description 1
DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000011684 sodium molybdate Substances 0.000 description 1
235000015393 sodium molybdate Nutrition 0.000 description 1
238000013222 sprague-dawley male rat Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
229960002799 stannous fluoride Drugs 0.000 description 1
239000000725 suspension Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
238000010792 warming Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1
230000004584 weight gain Effects 0.000 description 1
235000019786 weight gain Nutrition 0.000 description 1
235000008939 whole milk Nutrition 0.000 description 1

Landscapes

Cosmetics (AREA)

CA000328352A 1979-05-25 1979-05-25 Compose utilise pour prevenir et inhiber la carie dentaire Expired CA1138778A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000328352A CA1138778A (fr)	1979-05-25	1979-05-25	Compose utilise pour prevenir et inhiber la carie dentaire

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000328352A CA1138778A (fr)	1979-05-25	1979-05-25	Compose utilise pour prevenir et inhiber la carie dentaire

Publications (1)

Publication Number	Publication Date
CA1138778A true CA1138778A (fr)	1983-01-04

Family

ID=4114288

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000328352A Expired CA1138778A (fr)	1979-05-25	1979-05-25	Compose utilise pour prevenir et inhiber la carie dentaire

Country Status (1)

Country	Link
CA (1)	CA1138778A (fr)

1979
- 1979-05-25 CA CA000328352A patent/CA1138778A/fr not_active Expired

Legal Events

Date	Code	Title	Description
2000-01-04	MKEX	Expiry

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GB2141340A (en)	1984-12-19	Dental composition
CA1138778A (fr)	1983-01-04	Compose utilise pour prevenir et inhiber la carie dentaire
JPH07165544A (ja)	1995-06-27	口腔用組成物
US4252788A (en)	1981-02-24	Dental composition for preventing and inhibiting dental caries
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JP6960382B2 (ja)	2021-11-05	練歯磨組成物
GB2048666A (en)	1980-12-17	Dental compositions containing molybdate compounds
JPH0314512A (ja)	1991-01-23	歯垢付着抑制口腔用組成物
JPS62230712A (ja)	1987-10-09	抗齲蝕剤
JPS6147810B2 (fr)	1986-10-21
WO2022220044A1 (fr)	2022-10-20	Composition pour cavité buccale
EP0086290B1 (fr)	1986-01-29	Compositions d'hygiène dentaire et leur production
HK40090032A (zh)	2023-10-27	口腔用组合物
JPS5835486B2 (ja)	1983-08-03	う蝕の予防および進行抑制用組成物