CA1139668A - Preparation ophtalmique et mode d'emploi - Google Patents

Preparation ophtalmique et mode d'emploi

Info

Publication number: CA1139668A
Authority: CA; Canada
Prior art keywords: glaucoma; composition; colchicine; temporarily; vinblastine
Prior art date: 1978-05-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000327076A

Other languages

English (en)

Inventor

Kenneth E. Eakins

Parimal Bhattacherjee

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nelson Research and Development Co

Original Assignee

Nelson Research and Development Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-05-08

Filing date

1979-05-07

Publication date

1983-01-18

1978-05-08 Priority claimed from US05/903,586 external-priority patent/US4188394A/en

1978-05-10 Priority claimed from US05/904,586 external-priority patent/US4190673A/en

1979-05-07 Application filed by Nelson Research and Development Co filed Critical Nelson Research and Development Co

1983-01-18 Application granted granted Critical

1983-01-18 Publication of CA1139668A publication Critical patent/CA1139668A/fr

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract 8
238000000034 method Methods 0.000 title abstract description 10
IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 claims abstract description 24
229960001338 colchicine Drugs 0.000 claims abstract description 12
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims abstract description 10
229960003048 vinblastine Drugs 0.000 claims abstract description 10
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims abstract description 10
230000004410 intraocular pressure Effects 0.000 claims abstract description 9
229930013930 alkaloid Natural products 0.000 claims abstract description 3
150000003797 alkaloid derivatives Chemical class 0.000 claims abstract description 3
230000001225 therapeutic effect Effects 0.000 claims abstract 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
239000007864 aqueous solution Substances 0.000 claims description 3
239000003755 preservative agent Substances 0.000 claims description 2
239000011780 sodium chloride Substances 0.000 claims description 2
239000003381 stabilizer Substances 0.000 claims description 2
230000000699 topical effect Effects 0.000 claims description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
239000000463 material Substances 0.000 claims 1
230000002335 preservative effect Effects 0.000 claims 1
208000010412 Glaucoma Diseases 0.000 abstract description 14
239000003814 drug Substances 0.000 abstract description 5
229940079593 drug Drugs 0.000 abstract description 4
230000003547 miosis Effects 0.000 abstract description 3
QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 abstract description 2
239000003937 drug carrier Substances 0.000 abstract description 2
230000001771 impaired effect Effects 0.000 abstract description 2
210000001747 pupil Anatomy 0.000 abstract description 2
UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
208000024891 symptom Diseases 0.000 abstract 2
229930182837 (R)-adrenaline Natural products 0.000 abstract 1
QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 abstract 1
238000011443 conventional therapy Methods 0.000 abstract 1
229960005139 epinephrine Drugs 0.000 abstract 1
229960001416 pilocarpine Drugs 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
239000010452 phosphate Substances 0.000 description 3
229920000642 polymer Polymers 0.000 description 3
-1 e.g. Substances 0.000 description 2
230000007794 irritation Effects 0.000 description 2
235000019271 petrolatum Nutrition 0.000 description 2
FJNCXZZQNBKEJT-UHFFFAOYSA-N 8beta-hydroxymarrubiin Natural products O1C(=O)C2(C)CCCC3(C)C2C1CC(C)(O)C3(O)CCC=1C=COC=1 FJNCXZZQNBKEJT-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
241000189665 Colchicum autumnale Species 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
201000005569 Gout Diseases 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
241000985284 Leuciscus idus Species 0.000 description 1
239000004264 Petrolatum Substances 0.000 description 1
206010037660 Pyrexia Diseases 0.000 description 1
206010057430 Retinal injury Diseases 0.000 description 1
DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
241000863480 Vinca Species 0.000 description 1
239000008365 aqueous carrier Substances 0.000 description 1
239000013011 aqueous formulation Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 1
229960004926 chlorobutanol Drugs 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000012050 conventional carrier Substances 0.000 description 1
210000004087 cornea Anatomy 0.000 description 1
239000006071 cream Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
239000006196 drop Substances 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
239000003889 eye drop Substances 0.000 description 1
229940012356 eye drops Drugs 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000002674 ointment Substances 0.000 description 1
239000003883 ointment base Substances 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
230000001179 pupillary effect Effects 0.000 description 1
229940070891 pyridium Drugs 0.000 description 1
229940001607 sodium bisulfite Drugs 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA000327076A 1978-05-08 1979-05-07 Preparation ophtalmique et mode d'emploi Expired CA1139668A (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US903,586		1978-05-08
US05/903,586 US4188394A (en)	1978-05-08	1978-05-08	Ophthalmic composition and method of use
US05/904,586 US4190673A (en)	1978-05-10	1978-05-10	Colchicine ophthalmic composition and method of use
US904,586		1986-09-08

Publications (1)

Publication Number	Publication Date
CA1139668A true CA1139668A (fr)	1983-01-18

Family

ID=27129366

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000327076A Expired CA1139668A (fr)	1978-05-08	1979-05-07	Preparation ophtalmique et mode d'emploi

Country Status (7)

Country	Link
AU (1)	AU527129B2 (fr)
CA (1)	CA1139668A (fr)
DE (1)	DE2918264A1 (fr)
FR (1)	FR2425243A1 (fr)
GB (1)	GB2020180B (fr)
IE (1)	IE48222B1 (fr)
IT (1)	IT1113376B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1170152B (it) *	1982-07-19	1987-06-03	Lilly Co Eli	Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi
GB8710780D0 (en) *	1987-05-07	1987-06-10	Scras	Opthalmological application of eicosapentaenoic acid
IL83086A (en) *	1987-07-06	1991-03-10	Teva Pharma	Stable,injectable solutions of vincristine salts
US4918165A (en) *	1987-07-16	1990-04-17	Ophthalmic Research Corporation	Mitotic inhibitor and method for preventing posterior lens capsule opacification after extracapsular extraction
FR2623089B1 (fr) *	1987-11-13	1990-04-27	Pf Medicament	Composition pharmaceutique pour l'administration parenterale de navelbine

1979
- 1979-04-25 GB GB7914444A patent/GB2020180B/en not_active Expired
- 1979-05-03 AU AU46651/79A patent/AU527129B2/en not_active Ceased
- 1979-05-07 CA CA000327076A patent/CA1139668A/fr not_active Expired
- 1979-05-07 FR FR7911494A patent/FR2425243A1/fr active Granted
- 1979-05-07 DE DE19792918264 patent/DE2918264A1/de not_active Ceased
- 1979-05-08 IT IT22443/79A patent/IT1113376B/it active
- 1979-08-08 IE IE908/79A patent/IE48222B1/en unknown

Also Published As

Publication number	Publication date
AU4665179A (en)	1979-11-15
IT7922443A0 (it)	1979-05-08
DE2918264A1 (de)	1979-11-15
IT1113376B (it)	1986-01-20
IE48222B1 (en)	1984-10-31
AU527129B2 (en)	1983-02-17
GB2020180B (en)	1982-08-25
FR2425243B1 (fr)	1984-07-20
GB2020180A (en)	1979-11-14
IE790908L (en)	1979-11-08
FR2425243A1 (fr)	1979-12-07

Legal Events

Date	Code	Title	Description
2000-01-18	MKEX	Expiry

Publication	Publication Date	Title
KR950013754B1 (ko)	1995-11-15	안과용 비스테로이드계 소염제제
CN102548548B (zh)	2017-09-01	用于医学和兽医学的眼科药物组合物
US5610184A (en)	1997-03-11	Method for sustained and extended corneal analgesia
US5414011A (en)	1995-05-09	Preservative system for ophthalmic formulations
CA2507375C (fr)	2009-11-24	Utilisation du rimexolone dans le traitement de l'oeil sec
NL192821C (nl)	1998-03-04	Oftalmische oplossing.
US4127674A (en)	1978-11-28	Method of treatment for glaucoma
JPS62178514A (ja)	1987-08-05	眼局所投与用眼圧降下剤
US5961987A (en)	1999-10-05	Ocular protein stimulants
US5314909A (en)	1994-05-24	Use of non-steroidal antiiflammatory agents in macular degeneration
GB2110532A (en)	1983-06-22	Bendazac compositions for treatment of cataract
AU616748B2 (en)	1991-11-07	Ophthalmic solution for intraocular pressure adjustment
US4626530A (en)	1986-12-02	Treatment of eye inflammation with biphenamine
US4197301A (en)	1980-04-08	Topical ophthalmic use of Prazosin
US4853375A (en)	1989-08-01	Method of lowering intraocular (eye) pressure
CA1139668A (fr)	1983-01-18	Preparation ophtalmique et mode d'emploi
US5270050A (en)	1993-12-14	Paracetamol-based pharmaceutical composition
US20010021723A1 (en)	2001-09-13	Histochrome and its therapeutic use in ophthalmology
US4190673A (en)	1980-02-26	Colchicine ophthalmic composition and method of use
Quickert	1967	A fluorescein-anesthetic solution for applanation tonometry
US4459292A (en)	1984-07-10	Therapeutic compositions for the treatment of accommodation problems of the eye and method of using inosine monophosphate
GB2100599A (en)	1983-01-06	Pharmaceutical preparation for treating glaucoma and ocular hypertension
RU2633054C1 (ru)	2017-10-11	Фармацевтическая композиция в виде геля для лечения блефаритов
US4188394A (en)	1980-02-12	Ophthalmic composition and method of use
WO1987007141A1 (fr)	1987-12-03	Methode de traitement du glaucome