CA1154677A - Creme contenant un corticosteroide - Google Patents

Creme contenant un corticosteroide

Info

Publication number: CA1154677A
Authority: CA; Canada
Prior art keywords: parts; cream according; fatty acids; cream; fatty acid
Prior art date: 1981-06-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000379538A

Other languages

English (en)

Inventor

Henning Sattler

Georg A. Ulex

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Beiersdorf AG

Original Assignee

Beiersdorf AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-06-11

Filing date

1981-06-11

Publication date

1983-10-04

1981-06-11 Application filed by Beiersdorf AG filed Critical Beiersdorf AG

1981-06-11 Priority to CA000379538A priority Critical patent/CA1154677A/fr

1983-10-04 Application granted granted Critical

1983-10-04 Publication of CA1154677A publication Critical patent/CA1154677A/fr

Status Expired legal-status Critical Current

Links

239000006071 cream Substances 0.000 title claims abstract description 31
239000003246 corticosteroid Substances 0.000 title claims abstract description 15
235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 43
229930195729 fatty acid Natural products 0.000 claims abstract description 43
239000000194 fatty acid Substances 0.000 claims abstract description 43
150000004665 fatty acids Chemical class 0.000 claims abstract description 30
239000000203 mixture Substances 0.000 claims abstract description 29
GAKMQHDJQHZUTJ-ULHLPKEOSA-N fluocortolone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@@H](C)[C@H](C(=O)CO)[C@@]2(C)C[C@@H]1O GAKMQHDJQHZUTJ-ULHLPKEOSA-N 0.000 claims abstract description 22
229960003973 fluocortolone Drugs 0.000 claims abstract description 22
-1 fatty acid sorbitan esters Chemical class 0.000 claims abstract description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
235000013871 bee wax Nutrition 0.000 claims abstract description 8
239000012166 beeswax Substances 0.000 claims abstract description 8
229940057995 liquid paraffin Drugs 0.000 claims abstract description 8
235000019271 petrolatum Nutrition 0.000 claims abstract description 7
125000004432 carbon atom Chemical group C* 0.000 claims description 12
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 6
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 6
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 6
239000005642 Oleic acid Substances 0.000 claims description 6
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 6
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 6
239000012188 paraffin wax Substances 0.000 claims description 6
229920006395 saturated elastomer Polymers 0.000 claims description 6
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 5
239000000839 emulsion Substances 0.000 claims description 5
238000000034 method Methods 0.000 claims description 5
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 5
150000002763 monocarboxylic acids Chemical class 0.000 claims description 4
238000002360 preparation method Methods 0.000 claims description 4
235000003441 saturated fatty acids Nutrition 0.000 claims description 4
150000004671 saturated fatty acids Chemical class 0.000 claims description 4
235000021122 unsaturated fatty acids Nutrition 0.000 claims description 4
150000004670 unsaturated fatty acids Chemical class 0.000 claims description 4
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 3
150000002148 esters Chemical class 0.000 claims description 3
125000005456 glyceride group Chemical group 0.000 claims description 3
238000003756 stirring Methods 0.000 claims description 3
235000021355 Stearic acid Nutrition 0.000 claims description 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
239000008117 stearic acid Substances 0.000 claims description 2
238000010438 heat treatment Methods 0.000 claims 2
239000005639 Lauric acid Substances 0.000 claims 1
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims 1
238000001816 cooling Methods 0.000 claims 1
230000001804 emulsifying effect Effects 0.000 claims 1
235000015110 jellies Nutrition 0.000 claims 1
239000008274 jelly Substances 0.000 claims 1
238000002156 mixing Methods 0.000 claims 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract description 2
239000002260 anti-inflammatory agent Substances 0.000 abstract description 2
230000000699 topical effect Effects 0.000 abstract description 2
239000003871 white petrolatum Substances 0.000 description 8
210000003491 skin Anatomy 0.000 description 7
239000003925 fat Substances 0.000 description 5
235000021313 oleic acid Nutrition 0.000 description 5
230000001225 therapeutic effect Effects 0.000 description 5
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
239000004480 active ingredient Substances 0.000 description 4
VBICKXHEKHSIBG-UHFFFAOYSA-N beta-monoglyceryl stearate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
229960001334 corticosteroids Drugs 0.000 description 4
210000002268 wool Anatomy 0.000 description 4
230000002009 allergenic effect Effects 0.000 description 3
230000000694 effects Effects 0.000 description 3
150000002334 glycols Chemical class 0.000 description 3
239000000463 material Substances 0.000 description 3
150000003431 steroids Chemical class 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
206010061218 Inflammation Diseases 0.000 description 2
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
206010040880 Skin irritation Diseases 0.000 description 2
206010047139 Vasoconstriction Diseases 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
230000004888 barrier function Effects 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
230000004054 inflammatory process Effects 0.000 description 2
239000002674 ointment Substances 0.000 description 2
230000036961 partial effect Effects 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
230000036556 skin irritation Effects 0.000 description 2
231100000475 skin irritation Toxicity 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
230000025033 vasoconstriction Effects 0.000 description 2
LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
239000004166 Lanolin Substances 0.000 description 1
239000004264 Petrolatum Substances 0.000 description 1
LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 description 1
230000037374 absorbed through the skin Effects 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000011835 investigation Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000003883 ointment base Substances 0.000 description 1
150000002889 oleic acids Chemical class 0.000 description 1
230000035515 penetration Effects 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
208000017520 skin disease Diseases 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
210000000434 stratum corneum Anatomy 0.000 description 1
230000003639 vasoconstrictive effect Effects 0.000 description 1
239000007762 w/o emulsion Substances 0.000 description 1

Landscapes

Medicinal Preparation (AREA)

CA000379538A 1981-06-11 1981-06-11 Creme contenant un corticosteroide Expired CA1154677A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000379538A CA1154677A (fr)	1981-06-11	1981-06-11	Creme contenant un corticosteroide

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000379538A CA1154677A (fr)	1981-06-11	1981-06-11	Creme contenant un corticosteroide

Publications (1)

Publication Number	Publication Date
CA1154677A true CA1154677A (fr)	1983-10-04

Family

ID=4120211

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000379538A Expired CA1154677A (fr)	1981-06-11	1981-06-11	Creme contenant un corticosteroide

Country Status (1)

Country	Link
CA (1)	CA1154677A (fr)

1981
- 1981-06-11 CA CA000379538A patent/CA1154677A/fr not_active Expired

Legal Events

Date	Code	Title	Description
2000-10-04	MKEX	Expiry

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CA1336762C (fr)	1995-08-22	Methode et composition pour le traitement et la prevention de l'assechement dermique
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EP1660029A2 (fr)	2006-05-31	Compositions contenant des agents actifs topiques et du pentylene glycol
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