CA1162331A - Source de vapeur d'ions pour la spectrometrie de masse de liquides - Google Patents
Source de vapeur d'ions pour la spectrometrie de masse de liquidesInfo
- Publication number
- CA1162331A CA1162331A CA000378268A CA378268A CA1162331A CA 1162331 A CA1162331 A CA 1162331A CA 000378268 A CA000378268 A CA 000378268A CA 378268 A CA378268 A CA 378268A CA 1162331 A CA1162331 A CA 1162331A
- Authority
- CA
- Canada
- Prior art keywords
- vaporizer
- ion
- vapor
- nozzle assembly
- ion vapor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 61
- 238000004949 mass spectrometry Methods 0.000 title abstract description 7
- 239000002245 particle Substances 0.000 claims abstract description 63
- 238000009834 vaporization Methods 0.000 claims abstract description 48
- 238000000034 method Methods 0.000 claims abstract description 26
- 239000000443 aerosol Substances 0.000 claims abstract description 15
- 239000006200 vaporizer Substances 0.000 claims description 75
- 239000000523 sample Substances 0.000 claims description 58
- 230000008016 vaporization Effects 0.000 claims description 42
- 238000010438 heat treatment Methods 0.000 claims description 37
- 239000007921 spray Substances 0.000 claims description 34
- 238000012546 transfer Methods 0.000 claims description 15
- 238000000451 chemical ionisation Methods 0.000 claims description 13
- 238000004458 analytical method Methods 0.000 claims description 8
- 238000005192 partition Methods 0.000 claims description 8
- 238000010894 electron beam technology Methods 0.000 claims description 7
- 238000007599 discharging Methods 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000002798 polar solvent Substances 0.000 claims description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052802 copper Inorganic materials 0.000 claims description 3
- 239000010949 copper Substances 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims 4
- 229910052751 metal Inorganic materials 0.000 claims 4
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- 239000006193 liquid solution Substances 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 230000003116 impacting effect Effects 0.000 abstract description 2
- 150000002500 ions Chemical class 0.000 description 73
- 150000001875 compounds Chemical class 0.000 description 31
- 239000002904 solvent Substances 0.000 description 27
- 238000001819 mass spectrum Methods 0.000 description 14
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 10
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 9
- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 description 8
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 8
- 229950006790 adenosine phosphate Drugs 0.000 description 8
- 238000001228 spectrum Methods 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- 238000010884 ion-beam technique Methods 0.000 description 6
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 5
- 235000019253 formic acid Nutrition 0.000 description 5
- 238000003795 desorption Methods 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 150000001793 charged compounds Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007792 gaseous phase Substances 0.000 description 2
- 239000012454 non-polar solvent Substances 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000002311 subsequent effect Effects 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15276780A | 1980-05-23 | 1980-05-23 | |
| US152,767 | 1980-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1162331A true CA1162331A (fr) | 1984-02-14 |
Family
ID=22544349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000378268A Expired CA1162331A (fr) | 1980-05-23 | 1981-05-25 | Source de vapeur d'ions pour la spectrometrie de masse de liquides |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0052140A1 (fr) |
| CA (1) | CA1162331A (fr) |
| WO (1) | WO1981003394A1 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6044A (ja) * | 1983-06-16 | 1985-01-05 | Hitachi Ltd | 二次イオン化質量分析装置 |
| GB2146170B (en) * | 1983-08-18 | 1988-08-10 | Jeol Ltd | Ion source for mass spectrometer or the like |
| US4861989A (en) * | 1983-08-30 | 1989-08-29 | Research Corporation Technologies, Inc. | Ion vapor source for mass spectrometry of liquids |
| US4730111A (en) * | 1983-08-30 | 1988-03-08 | Research Corporation | Ion vapor source for mass spectrometry of liquids |
| US4814612A (en) * | 1983-08-30 | 1989-03-21 | Research Corporation | Method and means for vaporizing liquids for detection or analysis |
| GB8404683D0 (en) * | 1984-02-22 | 1984-03-28 | Vg Instr Group | Mass spectrometers |
| GB2240176B (en) * | 1987-03-06 | 1991-12-04 | Extrel Corp | Introduction of effluent into mass spectrometers and other gas-phase or particle detectors |
| US5896199A (en) * | 1996-07-26 | 1999-04-20 | Litton Systems, Inc. | High efficiency magnetic shield for a fiber optic gyroscope |
| EP1669738A3 (fr) * | 1996-10-09 | 2007-12-12 | Symyx Technologies, Inc. | Spectroscopie infrarouge et formation d'images de bibliothèques |
| US6864091B1 (en) | 2000-08-31 | 2005-03-08 | Symyx Technologies, Inc. | Sampling probe |
| CN113447603B (zh) * | 2020-03-27 | 2025-01-03 | 云南省烟草质量监督检测站 | 一种温度可调节的离子色谱仪 |
| CN115097057B (zh) * | 2022-06-02 | 2023-07-21 | 浙江大学 | 基于热辅助中性双喷雾快速蒸发的可直接分析含盐样品的液质联用检测方法 |
| CN118330010B (zh) * | 2024-06-17 | 2024-08-30 | 成都艾立本科技有限公司 | 多路液相进样的质谱分析方法及多路液相进样系统及用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2621296A (en) * | 1944-09-02 | 1952-12-09 | Robert W Thompson | Ion source |
| US3336475A (en) * | 1964-02-05 | 1967-08-15 | Electro Optical Systems Inc | Device for forming negative ions from iodine gas and a lanthanum boride contact ionizer surface |
| JPS5291494A (en) * | 1976-01-28 | 1977-08-01 | Hitachi Ltd | Mass spectrometer |
| US4055987A (en) * | 1976-03-04 | 1977-11-01 | Finnigan Corporation | Liquid chromatograph/mass spectrometer interface |
| US4160161A (en) * | 1978-05-30 | 1979-07-03 | Phillips Petroleum Company | Liquid chromatograph/mass spectrometer interface |
-
1981
- 1981-05-22 WO PCT/US1981/000693 patent/WO1981003394A1/fr not_active Ceased
- 1981-05-22 EP EP19810901659 patent/EP0052140A1/fr not_active Withdrawn
- 1981-05-25 CA CA000378268A patent/CA1162331A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0052140A1 (fr) | 1982-05-26 |
| WO1981003394A1 (fr) | 1981-11-26 |
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| Lemière | Interfaces for lc-ms |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 20010214 |