CA1164344A - Procede de preparation de facteurs antihemophiliques hautement purifies - Google Patents
Procede de preparation de facteurs antihemophiliques hautement purifiesInfo
- Publication number
- CA1164344A CA1164344A CA000387782A CA387782A CA1164344A CA 1164344 A CA1164344 A CA 1164344A CA 000387782 A CA000387782 A CA 000387782A CA 387782 A CA387782 A CA 387782A CA 1164344 A CA1164344 A CA 1164344A
- Authority
- CA
- Canada
- Prior art keywords
- antihemophilic factor
- factor
- per
- antihemophilic
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102100026735 Coagulation factor VIII Human genes 0.000 title claims abstract description 65
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 title claims abstract description 65
- 238000000034 method Methods 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title claims description 10
- 239000000203 mixture Substances 0.000 claims abstract description 17
- 239000000243 solution Substances 0.000 claims description 21
- 102000004169 proteins and genes Human genes 0.000 claims description 19
- 108090000623 proteins and genes Proteins 0.000 claims description 19
- 230000000694 effects Effects 0.000 claims description 18
- 210000002381 plasma Anatomy 0.000 claims description 10
- 108010054218 Factor VIII Proteins 0.000 claims description 7
- 102000001690 Factor VIII Human genes 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 102000008946 Fibrinogen Human genes 0.000 claims description 5
- 108010049003 Fibrinogen Proteins 0.000 claims description 5
- 229940012952 fibrinogen Drugs 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 5
- 230000000890 antigenic effect Effects 0.000 claims description 4
- 229960000301 factor viii Drugs 0.000 claims description 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 230000001376 precipitating effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 238000000746 purification Methods 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 238000005194 fractionation Methods 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 102000016359 Fibronectins Human genes 0.000 description 2
- 108010067306 Fibronectins Proteins 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 230000020477 pH reduction Effects 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 108010088842 Fibrinolysin Proteins 0.000 description 1
- 101000882917 Penaeus paulensis Hemolymph clottable protein Proteins 0.000 description 1
- 102000013566 Plasminogen Human genes 0.000 description 1
- 108010051456 Plasminogen Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 229910001679 gibbsite Inorganic materials 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000002311 subsequent effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000387782A CA1164344A (fr) | 1981-10-13 | 1981-10-13 | Procede de preparation de facteurs antihemophiliques hautement purifies |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000387782A CA1164344A (fr) | 1981-10-13 | 1981-10-13 | Procede de preparation de facteurs antihemophiliques hautement purifies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1164344A true CA1164344A (fr) | 1984-03-27 |
Family
ID=4121150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000387782A Expired CA1164344A (fr) | 1981-10-13 | 1981-10-13 | Procede de preparation de facteurs antihemophiliques hautement purifies |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA1164344A (fr) |
-
1981
- 1981-10-13 CA CA000387782A patent/CA1164344A/fr not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 20010327 |