CA1172590A - Steroides derives du pregnane substitues en 17, procede de production et utilisation - Google Patents

Steroides derives du pregnane substitues en 17, procede de production et utilisation

Info

Publication number: CA1172590A
Authority: CA; Canada
Prior art keywords: dione; gms; pregnene; hydroxy; mixture
Prior art date: 1978-01-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000417837A

Other languages

English (en)

Inventor

Joachim-Friedrich Kapp

Hans Wendt

Klaus Annen

Henry Laurent

Rudolf Wiechert

Ernst Schottle

Alfred Weber

Mario Kennecke

Helmut Dahl

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Schering AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-01-25

Filing date

1982-12-15

Publication date

1984-08-14

1978-01-25 Priority claimed from DE19782803661 external-priority patent/DE2803661A1/de

1978-12-21 Priority claimed from DE2855456A external-priority patent/DE2855456C2/de

1979-01-24 Priority claimed from CA000320177A external-priority patent/CA1144538A/fr

1982-12-15 Application filed by Schering AG filed Critical Schering AG

1982-12-15 Priority to CA000417837A priority Critical patent/CA1172590A/fr

1984-08-14 Application granted granted Critical

1984-08-14 Publication of CA1172590A publication Critical patent/CA1172590A/fr

Status Expired legal-status Critical Current

Links

238000004519 manufacturing process Methods 0.000 title claims abstract description 16
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125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000002674 ointment Substances 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
101150066242 outO gene Proteins 0.000 description 1
150000003891 oxalate salts Chemical class 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
DUCKXCGALKOSJF-UHFFFAOYSA-N pentanoyl pentanoate Chemical compound CCCCC(=O)OC(=O)CCCC DUCKXCGALKOSJF-UHFFFAOYSA-N 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
150000003014 phosphoric acid esters Chemical class 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
235000011056 potassium acetate Nutrition 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
239000000843 powder Substances 0.000 description 1
229960005205 prednisolone Drugs 0.000 description 1
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
239000013558 reference substance Substances 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
201000004700 rosacea Diseases 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229910052711 selenium Inorganic materials 0.000 description 1
239000011669 selenium Substances 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
229910001923 silver oxide Inorganic materials 0.000 description 1
208000017520 skin disease Diseases 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
235000009518 sodium iodide Nutrition 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
RBWSWDPRDBEWCR-RKJRWTFHSA-N sodium;(2r)-2-[(2r)-3,4-dihydroxy-5-oxo-2h-furan-2-yl]-2-hydroxyethanolate Chemical compound [Na+].[O-]C[C@@H](O)[C@H]1OC(=O)C(O)=C1O RBWSWDPRDBEWCR-RKJRWTFHSA-N 0.000 description 1
CMXPERZAMAQXSF-UHFFFAOYSA-M sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate;1,8-dihydroxyanthracene-9,10-dione Chemical compound [Na+].O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O.CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC CMXPERZAMAQXSF-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
KXCAEQNNTZANTK-UHFFFAOYSA-N stannane Chemical class [SnH4] KXCAEQNNTZANTK-UHFFFAOYSA-N 0.000 description 1
210000000434 stratum corneum Anatomy 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 1
239000003826 tablet Substances 0.000 description 1
150000003892 tartrate salts Chemical class 0.000 description 1
VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 1
125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
125000001382 thioacetal group Chemical group 0.000 description 1
DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 1
229960005294 triamcinolone Drugs 0.000 description 1
GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
PIILXFBHQILWPS-UHFFFAOYSA-N tributyltin Chemical compound CCCC[Sn](CCCC)CCCC PIILXFBHQILWPS-UHFFFAOYSA-N 0.000 description 1
CPRPKIMXLHBUGA-UHFFFAOYSA-N triethyltin Chemical compound CC[Sn](CC)CC CPRPKIMXLHBUGA-UHFFFAOYSA-N 0.000 description 1
125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 description 1
ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical group C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
229940102001 zinc bromide Drugs 0.000 description 1

Landscapes

Steroid Compounds (AREA)

CA000417837A 1978-01-25 1982-12-15 Steroides derives du pregnane substitues en 17, procede de production et utilisation Expired CA1172590A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000417837A CA1172590A (fr)	1978-01-25	1982-12-15	Steroides derives du pregnane substitues en 17, procede de production et utilisation

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
DE19782803661 DE2803661A1 (de)	1978-01-25	1978-01-25	Neue in 17-position substituierte 11beta-hydroxysteroide der pregnanreihe, ihre herstellung und verwendung
DEP2803661.5		1978-01-25
DEP2855456.6		1978-12-19
DE2855456A DE2855456C2 (de)	1977-12-22	1978-12-21	Regelvorrichtung für die Leerlaufdrehzahl von Brennkraftmaschinen
CA000320177A CA1144538A (fr)	1978-01-25	1979-01-24	Steroides de la serie des pregnanes substitues en position 17, fabrication et utilisation
CA000417837A CA1172590A (fr)	1978-01-25	1982-12-15	Steroides derives du pregnane substitues en 17, procede de production et utilisation

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000320177A Division CA1144538A (fr)	1978-01-25	1979-01-24	Steroides de la serie des pregnanes substitues en position 17, fabrication et utilisation

Publications (1)

Publication Number	Publication Date
CA1172590A true CA1172590A (fr)	1984-08-14

Family

ID=27426125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000417837A Expired CA1172590A (fr)	1978-01-25	1982-12-15	Steroides derives du pregnane substitues en 17, procede de production et utilisation

Country Status (1)

Country	Link
CA (1)	CA1172590A (fr)

1982
- 1982-12-15 CA CA000417837A patent/CA1172590A/fr not_active Expired

Legal Events

Date	Code	Title	Description
2001-08-14	MKEX	Expiry

Publication	Publication Date	Title
RU2532902C1 (ru)	2014-11-20	Способ получения 11бета, 17альфа, 21-тригидрокси-16альфа-метил-9альфа-фторпрегна-1,4-диен-3,20-диона (дексаметазона) из фитостерина
US4587236A (en)	1986-05-06	Novel 6α-methylprednisolone derivatives, their preparation, and their use
US4026921A (en)	1977-05-31	D-homosteroids
EP0072546B1 (fr)	1985-10-09	Dérivés d'hydrocortisone, leur préparation et leur utilisation
CA1159822A (fr)	1984-01-03	Steroides halogenes
US4912098A (en)	1990-03-27	Antiinflammatory 6 alpha-methylhydrocortisones
US4196203A (en)	1980-04-01	Novel corticoids
EP0003341B1 (fr)	1984-06-27	Prégnanes substitués en positions 11 et 17, leur préparation et leur utilisation pour la préparation de compositions pharmaceutiques
US4012510A (en)	1977-03-15	Novel methylene steroids
EP0941361B1 (fr)	2001-11-28	Procede de preparation de composes steroides
JP4016070B2 (ja)	2007-12-05	（１１β，１６β）―２１―（アセチルオキシ）―１１―ヒドロキシ―２’―メチル―５’Ｈ―プレグナ―１，４―ジエノ［１７，１６―Ｄ］オキサゾール―３，２０―ジオンの製造
CA1144538A (fr)	1983-04-12	Steroides de la serie des pregnanes substitues en position 17, fabrication et utilisation
US4088537A (en)	1978-05-09	Δ1 Dehydrogenation of corticoids without side chain degradation by Septomyxa
EP0000609B1 (fr)	1981-09-23	19-Nor pregnahexaènes, procédé pour leur préparation et compositions pharmaceutiques les contenant
JPS6361000B2 (fr)	1988-11-28
US3822253A (en)	1974-07-02	Process for the preparation of delta4-3,20-diketo-6,6-difluoro-11beta,16alpha,17alpha,21-tetrahydroxypregnene 16,17-ketals
US2979517A (en)	1961-04-11	12alpha-fluoro-16alpha-hydroxy pregnenes
DE2753839A1 (de)	1979-05-31	Neue kortikoide
JPS60994B2 (ja)	1985-01-11	プレグナン系化合物の１７α―エステル類の製造法
DE2855465A1 (de)	1980-07-10	Neue kortikoide, verfahren zu ihrer herstellung, ihre verwendung und diese kortikoide enthaltende pharmazeutische praeparate
JPH0120876B2 (fr)	1989-04-18