CA1175422A - Preparation de 5-0-mycaminosyl-tylonolide - Google Patents

Preparation de 5-0-mycaminosyl-tylonolide

Info

Publication number: CA1175422A
Authority: CA; Canada
Prior art keywords: dmt; dihydro; omt; demycinosyltylosin; tylosin
Prior art date: 1980-06-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000436136A

Other languages

English (en)

Inventor

Gene M. Wild

Richard H. Baltz

Eugene T. Seno

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-06-12

Filing date

1983-09-06

Publication date

1984-10-02

1980-06-12 Priority claimed from US06/156,854 external-priority patent/US4321361A/en

1983-09-06 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1983-09-06 Priority to CA000436136A priority Critical patent/CA1175422A/fr

1984-10-02 Application granted granted Critical

1984-10-02 Publication of CA1175422A publication Critical patent/CA1175422A/fr

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 28
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WGUJDBLMJBJUQU-VKRLOHBMSA-N 5-O-mycaminosyltylonolide Chemical compound O=CC[C@H]1C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@H](CO)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@H](O)[C@@H](C)O1 WGUJDBLMJBJUQU-VKRLOHBMSA-N 0.000 claims abstract description 20
ZVOOGERIHVAODX-QWWGUZMMSA-N 2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4r,5r,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-d Chemical compound O=CC[C@H]1C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@H](CO)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1 ZVOOGERIHVAODX-QWWGUZMMSA-N 0.000 claims abstract description 10
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231100000331 toxic Toxicity 0.000 description 1
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230000001988 toxicity Effects 0.000 description 1
238000000825 ultraviolet detection Methods 0.000 description 1
230000009105 vegetative growth Effects 0.000 description 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)

CA000436136A 1980-06-12 1983-09-06 Preparation de 5-0-mycaminosyl-tylonolide Expired CA1175422A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000436136A CA1175422A (fr)	1980-06-12	1983-09-06	Preparation de 5-0-mycaminosyl-tylonolide

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US06/156,854 US4321361A (en)	1980-06-12	1980-06-12	Demycinosyltylosin and process for its production
US156,854		1980-06-12
US06/156,855 US4321362A (en)	1980-06-12	1980-06-12	De(mycinosyloxy)tylosin and process for its production
CA000379320A CA1172189A (fr)	1980-06-12	1981-06-09	De(mycinosyloxy)tylosine et methode de preparation
CA000436136A CA1175422A (fr)	1980-06-12	1983-09-06	Preparation de 5-0-mycaminosyl-tylonolide

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000379320A Division CA1172189A (fr)	1980-06-12	1981-06-09	De(mycinosyloxy)tylosine et methode de preparation

Publications (1)

Publication Number	Publication Date
CA1175422A true CA1175422A (fr)	1984-10-02

Family

ID=27426310

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000436136A Expired CA1175422A (fr)	1980-06-12	1983-09-06	Preparation de 5-0-mycaminosyl-tylonolide

Country Status (1)

Country	Link
CA (1)	CA1175422A (fr)

1983
- 1983-09-06 CA CA000436136A patent/CA1175422A/fr not_active Expired

Legal Events

Date	Code	Title	Description
2001-10-02	MKEX	Expiry

Publication	Publication Date	Title
EP0042250B1 (fr)	1984-03-07	Antibiotiques macrolidiques
US4559301A (en)	1985-12-17	Process for preparing macrocin derivatives
EP0052005B1 (fr)	1985-01-30	Antibiotiques du type macrolide
CA1225053A (fr)	1987-08-04	Methodes et composes pour le traitement des infections a protozoaires a l'aide d'un nouvel antibiotique
EP0042694B1 (fr)	1984-03-07	Antibiotiques macrolidiques
US4385116A (en)	1983-05-24	Demethylmacrocin and process for its production
CA1171009A (fr)	1984-07-17	Methode de preparation d'un macrolide
EP0098732B1 (fr)	1986-02-26	Dérivés de de(mycinosyloxy)tylosine
EP0045157B1 (fr)	1984-04-18	Antibiotiques macrolides, leur préparation et compositions vétérinaires les contenant
US4419447A (en)	1983-12-06	Fermentation process for producing demycinosyltylosin
US4486584A (en)	1984-12-04	Demethylmacrocin compounds and derivatives thereof
US4537957A (en)	1985-08-27	Process for the production of mycaminosyltylonolide
US4334019A (en)	1982-06-08	Process for producing de(mycinosyloxy)tylosin
US4792522A (en)	1988-12-20	Rigolettone antitumor complex
US4419508A (en)	1983-12-06	20-Dihydro-20-deoxy-23-demycinosyltylosin and process for its production
CA1175423A (fr)	1984-10-02	Preparation de 23-desoxy-5-0-mycaminosyltylonolide
US4656258A (en)	1987-04-07	Macrocin derivatives
EP0045205B1 (fr)	1984-10-03	Macrolides