CA1179338A - Methode de preparation de l'acide n(4-((2, 4-diamino-6-pteridinyl)-methyl)methylamino) benzoyl)'glutamique - Google Patents

Methode de preparation de l'acide n(4-((2, 4-diamino-6-pteridinyl)-methyl)methylamino) benzoyl)'glutamique

Info

Publication number
CA1179338A
CA1179338A CA000385665A CA385665A CA1179338A CA 1179338 A CA1179338 A CA 1179338A CA 000385665 A CA000385665 A CA 000385665A CA 385665 A CA385665 A CA 385665A CA 1179338 A CA1179338 A CA 1179338A
Authority
CA
Canada
Prior art keywords
benzoyl
glutamic acid
methylamino
methyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000385665A
Other languages
English (en)
Inventor
Karol Alster
Jens K. Jensen
Bjorn Svendsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Farmos Yhtyma Oy
Original Assignee
Farmos Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmos Yhtyma Oy filed Critical Farmos Yhtyma Oy
Application granted granted Critical
Publication of CA1179338A publication Critical patent/CA1179338A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA000385665A 1980-09-12 1981-09-11 Methode de preparation de l'acide n(4-((2, 4-diamino-6-pteridinyl)-methyl)methylamino) benzoyl)'glutamique Expired CA1179338A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK3903/80 1980-09-12
DK390380 1980-09-12

Publications (1)

Publication Number Publication Date
CA1179338A true CA1179338A (fr) 1984-12-11

Family

ID=8128060

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000385665A Expired CA1179338A (fr) 1980-09-12 1981-09-11 Methode de preparation de l'acide n(4-((2, 4-diamino-6-pteridinyl)-methyl)methylamino) benzoyl)'glutamique

Country Status (5)

Country Link
EP (1) EP0048001B1 (fr)
AT (1) ATE10845T1 (fr)
CA (1) CA1179338A (fr)
DE (1) DE3167839D1 (fr)
FI (1) FI812773A7 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3009486A1 (de) * 1980-03-12 1981-09-17 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 1,1-dichlor-alkenen
US5140104A (en) * 1982-03-09 1992-08-18 Cytogen Corporation Amine derivatives of folic acid analogs
US4781200A (en) * 1985-10-04 1988-11-01 Baker Donald A Ambulatory non-invasive automatic fetal monitoring system

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4057548A (en) * 1975-11-11 1977-11-08 Jacek Wiecko Process for preparing methotrexate or an N-substituted derivative thereof and/or a di (lower) alkyl ester thereof and precursor therefor

Also Published As

Publication number Publication date
FI812773L (fi) 1982-03-13
DE3167839D1 (en) 1985-01-31
EP0048001A1 (fr) 1982-03-24
FI812773A7 (fi) 1982-03-13
EP0048001B1 (fr) 1984-12-19
ATE10845T1 (de) 1985-01-15

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Legal Events

Date Code Title Description
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