CA1179675A - Derives du 7-oxo-1-azabicyclo ¬3,2,0| heptene-2- - Google Patents

Derives du 7-oxo-1-azabicyclo ¬3,2,0| heptene-2-

Info

Publication number
CA1179675A
CA1179675A CA000393840A CA393840A CA1179675A CA 1179675 A CA1179675 A CA 1179675A CA 000393840 A CA000393840 A CA 000393840A CA 393840 A CA393840 A CA 393840A CA 1179675 A CA1179675 A CA 1179675A
Authority
CA
Canada
Prior art keywords
alkyl
group
methyl
hydrogen
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000393840A
Other languages
English (en)
Inventor
Erwin Gotschi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH62081A external-priority patent/CH646171A5/de
Priority claimed from CH7802/81A external-priority patent/CH651564A5/de
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of CA1179675A publication Critical patent/CA1179675A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000393840A 1981-01-30 1982-01-08 Derives du 7-oxo-1-azabicyclo ¬3,2,0| heptene-2- Expired CA1179675A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH62081A CH646171A5 (en) 1981-01-30 1981-01-30 Bicyclic compounds
CH620/81 1981-01-30
CH7802/81A CH651564A5 (en) 1981-12-07 1981-12-07 7-Oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives
CH7802/81 1981-12-07

Publications (1)

Publication Number Publication Date
CA1179675A true CA1179675A (fr) 1984-12-18

Family

ID=25685143

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000393840A Expired CA1179675A (fr) 1981-01-30 1982-01-08 Derives du 7-oxo-1-azabicyclo ¬3,2,0| heptene-2-

Country Status (15)

Country Link
AT (1) AT377762B (fr)
AU (1) AU7979882A (fr)
CA (1) CA1179675A (fr)
DE (1) DE3201957A1 (fr)
DK (1) DK32082A (fr)
FR (1) FR2499081B1 (fr)
GB (1) GB2092147B (fr)
IE (1) IE52421B1 (fr)
IL (1) IL64859A (fr)
IT (1) IT1153416B (fr)
LU (1) LU83906A1 (fr)
NL (1) NL8200217A (fr)
NZ (1) NZ199487A (fr)
PH (1) PH19227A (fr)
SE (1) SE8200515L (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729993A (en) * 1984-12-13 1988-03-08 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
US4680292A (en) * 1984-12-13 1987-07-14 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
US4725594A (en) * 1984-12-13 1988-02-16 Merck & Co., Inc. Carbapenems having an internally or externally alkylated mono- or bicyclic 2-quaternary heteroarylalxyl heteromethyl substituent
GB8607921D0 (en) * 1986-04-01 1986-05-08 Fujisawa Pharmaceutical Co 3,4-disubstituted-2-azetidinone derivatives
ZA912279B (en) * 1990-04-09 1992-02-26 Hoffmann La Roche Carbapenem compounds
US5068232A (en) * 1990-04-10 1991-11-26 American Cyanamid Company Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them
US5607928A (en) * 1994-08-05 1997-03-04 Zeneca Limited Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives
EP2127650B1 (fr) * 2004-06-10 2018-12-05 FOB Synthesis, Inc. Bactéricides au carbapenem à activité gram-négative et procédés d'élaboration correspondants
US20110118462A1 (en) * 2009-11-18 2011-05-19 Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical Factory N-heterocyclic substituent-containing antibiotic, preparation and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
DE2811514A1 (de) * 1977-03-19 1978-09-21 Beecham Group Ltd Ester der 7-oxo-1-azabicyclo eckige klammer auf 3.2.0 eckige klammer zu hept- 2-en-2-carbonsaeure und deren derivate, verfahren zur herstellung dieser verbindungen und diese verbindungen enthaltende pharmazeutische zubereitungen
DE2918938A1 (de) * 1978-05-11 1979-11-15 Ladd Vorrichtung und verfahren zur herstellung von falten in naehbarem material
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
JPS56122379A (en) * 1980-03-03 1981-09-25 Sankyo Co Ltd 1-carba-2-penem-3-carboxylic acid derivative

Also Published As

Publication number Publication date
ATA34082A (de) 1984-09-15
PH19227A (en) 1986-02-12
FR2499081B1 (fr) 1985-07-26
IL64859A (en) 1985-06-30
DE3201957A1 (de) 1982-09-09
AT377762B (de) 1985-04-25
DK32082A (da) 1982-07-31
SE8200515L (sv) 1982-07-31
IT1153416B (it) 1987-01-14
LU83906A1 (de) 1983-09-02
IT8219187A0 (it) 1982-01-19
FR2499081A1 (fr) 1982-08-06
NZ199487A (en) 1986-02-21
GB2092147B (en) 1984-12-05
IE820197L (en) 1982-07-30
AU7979882A (en) 1982-09-23
IE52421B1 (en) 1987-10-28
GB2092147A (en) 1982-08-11
NL8200217A (nl) 1982-08-16

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Legal Events

Date Code Title Description
MKEC Expiry (correction)
MKEX Expiry