CA1185183A - Castration chimique - Google Patents

Castration chimique

Info

Publication number: CA1185183A
Authority: CA; Canada
Prior art keywords: composition; chemical castration; castration; testes; aqueous solution
Prior art date: 1979-04-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000413080A

Other languages

English (en)

Inventor

Charles M. Stagg

Ronald L. Tribble

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Philips Roxane Inc

Original Assignee

Philips Roxane Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-04-13

Filing date

1982-10-08

Publication date

1985-04-09

1982-10-08 Application filed by Philips Roxane Inc filed Critical Philips Roxane Inc

1985-04-09 Application granted granted Critical

1985-04-09 Publication of CA1185183A publication Critical patent/CA1185183A/fr

Status Expired legal-status Critical Current

Links

239000000126 substance Substances 0.000 title claims abstract description 15
238000012360 testing method Methods 0.000 claims abstract description 16
210000001550 testis Anatomy 0.000 claims abstract description 15
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims abstract description 5
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 4
150000008064 anhydrides Chemical class 0.000 claims abstract description 3
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 30
244000309464 bull Species 0.000 claims description 15
239000004310 lactic acid Substances 0.000 claims description 15
235000014655 lactic acid Nutrition 0.000 claims description 15
241000124008 Mammalia Species 0.000 claims description 7
239000000203 mixture Substances 0.000 claims description 7
239000007864 aqueous solution Substances 0.000 claims description 6
239000002253 acid Substances 0.000 claims description 3
150000002763 monocarboxylic acids Chemical class 0.000 claims 1
238000000034 method Methods 0.000 abstract description 23
241001465754 Metazoa Species 0.000 abstract description 6
210000004392 genitalia Anatomy 0.000 abstract description 2
150000002762 monocarboxylic acid derivatives Chemical class 0.000 abstract description 2
241000282472 Canis lupus familiaris Species 0.000 description 8
239000000243 solution Substances 0.000 description 8
230000037396 body weight Effects 0.000 description 5
244000309466 calf Species 0.000 description 5
239000003795 chemical substances by application Substances 0.000 description 5
238000002347 injection Methods 0.000 description 5
239000007924 injection Substances 0.000 description 5
239000003153 chemical reaction reagent Substances 0.000 description 4
238000005303 weighing Methods 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
210000000918 epididymis Anatomy 0.000 description 3
201000010063 epididymitis Diseases 0.000 description 3
210000000582 semen Anatomy 0.000 description 3
206010003694 Atrophy Diseases 0.000 description 2
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Natural products OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
230000037444 atrophy Effects 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
230000000694 effects Effects 0.000 description 2
230000002349 favourable effect Effects 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
230000021595 spermatogenesis Effects 0.000 description 2
238000004659 sterilization and disinfection Methods 0.000 description 2
230000000451 tissue damage Effects 0.000 description 2
231100000827 tissue damage Toxicity 0.000 description 2
HFVMEOPYDLEHBR-UHFFFAOYSA-N (2-fluorophenyl)-phenylmethanol Chemical compound C=1C=CC=C(F)C=1C(O)C1=CC=CC=C1 HFVMEOPYDLEHBR-UHFFFAOYSA-N 0.000 description 1
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
HMUNWXXNJPVALC-UHFFFAOYSA-N 1-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C(CN1CC2=C(CC1)NN=N2)=O HMUNWXXNJPVALC-UHFFFAOYSA-N 0.000 description 1
NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
LDXJRKWFNNFDSA-UHFFFAOYSA-N 2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound C1CN(CC2=NNN=C21)CC(=O)N3CCN(CC3)C4=CN=C(N=C4)NCC5=CC(=CC=C5)OC(F)(F)F LDXJRKWFNNFDSA-UHFFFAOYSA-N 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
241000283707 Capra Species 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
206010024870 Loss of libido Diseases 0.000 description 1
101100494762 Mus musculus Nedd9 gene Proteins 0.000 description 1
241001494479 Pecora Species 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
241000282887 Suidae Species 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
206010043376 Tetanus Diseases 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
239000003098 androgen Substances 0.000 description 1
229940030486 androgens Drugs 0.000 description 1
229960003473 androstanolone Drugs 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000003433 contraceptive agent Substances 0.000 description 1
229940124558 contraceptive agent Drugs 0.000 description 1
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000003993 interaction Effects 0.000 description 1
210000002570 interstitial cell Anatomy 0.000 description 1
JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
230000001338 necrotic effect Effects 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
210000003899 penis Anatomy 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
230000001850 reproductive effect Effects 0.000 description 1
230000002784 sclerotic effect Effects 0.000 description 1
210000002863 seminiferous tubule Anatomy 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
230000028016 temperature homeostasis Effects 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
230000036269 ulceration Effects 0.000 description 1
230000002792 vascular Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA000413080A 1979-04-13 1982-10-08 Castration chimique Expired CA1185183A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US2963779A	1979-04-13	1979-04-13

Publications (1)

Publication Number	Publication Date
CA1185183A true CA1185183A (fr)	1985-04-09

Family

ID=21850077

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000413080A Expired CA1185183A (fr)	1979-04-13	1982-10-08	Castration chimique

Country Status (6)

Country	Link
JP (1)	JPS5933217A (fr)
AU (1)	AU556482B2 (fr)
CA (1)	CA1185183A (fr)
DE (1)	DE3229234C2 (fr)
FR (1)	FR2531858B1 (fr)
GB (1)	GB2126478B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101686692B (zh) *	2007-04-18	2013-02-06	菲海姆技术公司	通过减少公猪的异味来改善肉质的方法
KR101360830B1 (ko) *	2013-11-21	2014-02-11	(주)나비바이오텍	젖산을 함유한 동물의 난소 기능 불활 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1089361A (fr) *	1976-01-23	1980-11-11	Mostafa S. Fahim	Produit sterilisant injectable aux animaux males pour controler de facon selective la fonction des testicules
CA1189789A (fr) *	1979-03-02	1985-07-02	Gursaran P. Talwar	Procede de sterilisation des mammiferes

1982
- 1982-08-05 DE DE19823229234 patent/DE3229234C2/de not_active Expired
- 1982-08-13 JP JP14159182A patent/JPS5933217A/ja active Pending
- 1982-08-19 FR FR8214338A patent/FR2531858B1/fr not_active Expired
- 1982-09-06 GB GB08225296A patent/GB2126478B/en not_active Expired
- 1982-09-06 AU AU88051/82A patent/AU556482B2/en not_active Ceased
- 1982-10-08 CA CA000413080A patent/CA1185183A/fr not_active Expired

Also Published As

Publication number	Publication date
AU556482B2 (en)	1986-11-06
AU8805182A (en)	1984-03-15
GB2126478A (en)	1984-03-28
JPS5933217A (ja)	1984-02-23
DE3229234C2 (de)	1986-06-19
FR2531858B1 (fr)	1988-11-10
FR2531858A1 (fr)	1984-02-24
GB2126478B (en)	1986-06-18
DE3229234A1 (de)	1984-02-09

Legal Events

Date	Code	Title	Description
2002-04-10	MKEC	Expiry (correction)
2002-10-08	MKEX	Expiry

Publication	Publication Date	Title
Olson et al.	1993	New developments in small animal population control
US4520014A (en)	1985-05-28	Treatment of diarrhoea
CN110882215A (zh)	2020-03-17	安全广谱型聚维酮碘制剂及其制备方法与应用
CA1185183A (fr)	1985-04-09	Castration chimique
Kopcha et al.	1989	Experimental uses of flunixin meglumine and phenylbutazone in food-producing animals
Lawson et al.	1972	The ERA strain of rabies vaccine
Andriole	1970	Water, acidosis, and experimental pyelonephritis
US4339438A (en)	1982-07-13	Injectable male animal sterilant for selectively controlling the function of testes
US4156427A (en)	1979-05-29	Injectable male animal sterilant for selectively controlling the function of testes
Matschke	1977	Microencapsulated diethylstilbestrol as an oral contraceptive in white-tailed deer
Horta et al.	1986	Possibility of reducing the luteolytic dose of cloprostenol in cyclic dairy cows
Howey et al.	1983	Evaluation of clinical and luteolytic effects of a novel prostaglandin analogue in normal and problem mares
US4356189A (en)	1982-10-26	Chemical castration
Lubicz-Nawrocki et al.	1974	The onset and duration of infertility in hamsters treated with α-chlorohydrin
IE54150B1 (en)	1989-07-05	Method of castration and contraception
CA1189789A (fr)	1985-07-02	Procede de sterilisation des mammiferes
Yelich et al.	2012	Synchronization response: Bos taurus vs. Bos indicus cattle
EP0059057A1 (fr)	1982-09-01	Traitement de la diarrhée
US4191746A (en)	1980-03-04	Sterilization process for mammals
Botha	1964	Berenil: efficacy against Babesia canis and comparison with phenamidine
RU2062068C1 (ru)	1996-06-20	Среда для разбавления и хранения спермы хряков
RU2113847C1 (ru)	1998-06-27	Способ лечения эндометритов у коров
JPH06192102A (ja)	1994-07-12	アルトレノゲストの新規な用途
RU2010573C1 (ru)	1994-04-15	Способ лечения коров при задержании последа
US3336190A (en)	1967-08-15	Method of protecting the offspring of a herd of breeding swine from turbinate atrophy