CA1197242A - Derives de l'acide pyrimido¬1,2-a|pyrrolo ¬2,1-c|¬1,4|benzodiazepine-3-carboxylique - Google Patents

Derives de l'acide pyrimido¬1,2-a|pyrrolo ¬2,1-c|¬1,4|benzodiazepine-3-carboxylique

Info

Publication number
CA1197242A
CA1197242A CA000422672A CA422672A CA1197242A CA 1197242 A CA1197242 A CA 1197242A CA 000422672 A CA000422672 A CA 000422672A CA 422672 A CA422672 A CA 422672A CA 1197242 A CA1197242 A CA 1197242A
Authority
CA
Canada
Prior art keywords
compound
pyrrolo
pyrimido
carboxylic acid
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000422672A
Other languages
English (en)
Inventor
Jean A. Gauthier
Andre A. Asselin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Canada Inc
Original Assignee
Ayerst Mckenna and Harrison Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ayerst Mckenna and Harrison Inc filed Critical Ayerst Mckenna and Harrison Inc
Priority to CA000422672A priority Critical patent/CA1197242A/fr
Application granted granted Critical
Publication of CA1197242A publication Critical patent/CA1197242A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000422672A 1983-03-02 1983-03-02 Derives de l'acide pyrimido¬1,2-a|pyrrolo ¬2,1-c|¬1,4|benzodiazepine-3-carboxylique Expired CA1197242A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000422672A CA1197242A (fr) 1983-03-02 1983-03-02 Derives de l'acide pyrimido¬1,2-a|pyrrolo ¬2,1-c|¬1,4|benzodiazepine-3-carboxylique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA000422672A CA1197242A (fr) 1983-03-02 1983-03-02 Derives de l'acide pyrimido¬1,2-a|pyrrolo ¬2,1-c|¬1,4|benzodiazepine-3-carboxylique

Publications (1)

Publication Number Publication Date
CA1197242A true CA1197242A (fr) 1985-11-26

Family

ID=4124689

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000422672A Expired CA1197242A (fr) 1983-03-02 1983-03-02 Derives de l'acide pyrimido¬1,2-a|pyrrolo ¬2,1-c|¬1,4|benzodiazepine-3-carboxylique

Country Status (1)

Country Link
CA (1) CA1197242A (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105793263A (zh) * 2013-12-05 2016-07-20 豪夫迈·罗氏有限公司 反式-8-氯-5-甲基-1-[4-(吡啶-2-基氧基)-环己基]-5,6-二氢-4h-2,3,5,10b-四氮杂-苯并[e]薁及其晶型的合成
WO2018195163A1 (fr) * 2017-04-18 2018-10-25 Gemphire Therapeutics Inc. Gemcabène, sels pharmaceutiquement acceptables de celui-ci, compositions de celui-ci et procédés d'utilisation de celui-ci
US10227285B2 (en) 2014-11-14 2019-03-12 Gemphire Therapeutics Inc. Processes and intermediates for preparing alpha,omega-dicarboxylic acid-terminated dialkane ethers

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105793263A (zh) * 2013-12-05 2016-07-20 豪夫迈·罗氏有限公司 反式-8-氯-5-甲基-1-[4-(吡啶-2-基氧基)-环己基]-5,6-二氢-4h-2,3,5,10b-四氮杂-苯并[e]薁及其晶型的合成
US10246460B2 (en) 2013-12-05 2019-04-02 Hoffmann-La Roche Inc. Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[E]azulene and crytalline forms thereof
CN105793263B (zh) * 2013-12-05 2019-08-23 豪夫迈·罗氏有限公司 一种苯并[e]薁化合物及其晶型的合成
AU2019201183B2 (en) * 2013-12-05 2021-03-04 F. Hoffmann-La Roche Ag Synthesis of trans-8-chloro-5-methyl-1 -[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene and crytalline forms thereof
US12459947B2 (en) 2013-12-05 2025-11-04 Hoffmann-La Roche Inc. Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[e]azulene and crystalline forms thereof
US10227285B2 (en) 2014-11-14 2019-03-12 Gemphire Therapeutics Inc. Processes and intermediates for preparing alpha,omega-dicarboxylic acid-terminated dialkane ethers
WO2018195163A1 (fr) * 2017-04-18 2018-10-25 Gemphire Therapeutics Inc. Gemcabène, sels pharmaceutiquement acceptables de celui-ci, compositions de celui-ci et procédés d'utilisation de celui-ci
CN110996928A (zh) * 2017-04-18 2020-04-10 燿石治疗公司 吉卡宾、其药学上可接受的盐、其组合物和其使用方法
US12503422B2 (en) 2017-04-18 2025-12-23 Neurobo Pharmaceuticals, Inc. Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor

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Legal Events

Date Code Title Description
MKEC Expiry (correction)
MKEX Expiry