CA1198675A - Compositions anti-acides - Google Patents

Compositions anti-acides

Info

Publication number: CA1198675A
Authority: CA; Canada
Prior art keywords: compound; magnesium; aluminum; process according; alkali
Prior art date: 1981-11-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000415688A

Other languages

English (en)

Inventor

John D. Buehler

Joseph R. Luber

Wayne M. Grim

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Rorer International Holdings Inc

Original Assignee

Rorer International Holdings Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-11-23

Filing date

1982-11-16

Publication date

1985-12-31

1982-11-16 Application filed by Rorer International Holdings Inc filed Critical Rorer International Holdings Inc

1985-12-31 Application granted granted Critical

1985-12-31 Publication of CA1198675A publication Critical patent/CA1198675A/fr

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 26
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 title abstract description 24
229940069428 antacid Drugs 0.000 title abstract description 24
239000003159 antacid agent Substances 0.000 title abstract description 24
230000001458 anti-acid effect Effects 0.000 title abstract description 22
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
238000000034 method Methods 0.000 claims description 13
150000001875 compounds Chemical class 0.000 claims description 9
239000003513 alkali Substances 0.000 claims description 8
229910052782 aluminium Inorganic materials 0.000 claims description 8
239000011777 magnesium Substances 0.000 claims description 8
101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 claims description 7
229910019142 PO4 Inorganic materials 0.000 claims description 7
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 7
229910052749 magnesium Inorganic materials 0.000 claims description 7
239000000126 substance Substances 0.000 claims description 7
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 6
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 6
-1 aluminum compound Chemical class 0.000 claims description 6
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 6
239000010452 phosphate Substances 0.000 claims description 6
239000002585 base Substances 0.000 claims description 5
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 5
239000000347 magnesium hydroxide Substances 0.000 claims description 5
229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 5
239000011541 reaction mixture Substances 0.000 claims description 5
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 4
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 4
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 4
VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 4
229910021529 ammonia Inorganic materials 0.000 claims description 3
238000003756 stirring Methods 0.000 claims description 3
BNGXYYYYKUGPPF-UHFFFAOYSA-M (3-methylphenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].CC1=CC=CC(C[P+](C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 BNGXYYYYKUGPPF-UHFFFAOYSA-M 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims description 2
238000001816 cooling Methods 0.000 claims description 2
150000004820 halides Chemical class 0.000 claims description 2
239000000395 magnesium oxide Substances 0.000 claims description 2
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 2
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 2
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 2
125000005270 trialkylamine group Chemical group 0.000 claims description 2
150000002681 magnesium compounds Chemical class 0.000 claims 3
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
239000007787 solid Substances 0.000 claims 2
125000000217 alkyl group Chemical group 0.000 claims 1
238000001035 drying Methods 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
239000004480 active ingredient Substances 0.000 abstract description 3
229910020038 Mg6Al2 Inorganic materials 0.000 abstract 1
229920002472 Starch Polymers 0.000 description 10
239000008107 starch Substances 0.000 description 10
235000019698 starch Nutrition 0.000 description 10
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
239000000725 suspension Substances 0.000 description 7
239000003826 tablet Substances 0.000 description 7
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
230000002496 gastric effect Effects 0.000 description 6
239000000843 powder Substances 0.000 description 6
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 5
239000008187 granular material Substances 0.000 description 5
229960001138 acetylsalicylic acid Drugs 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
230000000694 effects Effects 0.000 description 4
238000009472 formulation Methods 0.000 description 4
239000004615 ingredient Substances 0.000 description 4
235000019359 magnesium stearate Nutrition 0.000 description 4
238000002156 mixing Methods 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
159000000000 sodium salts Chemical class 0.000 description 4
239000005715 Fructose Substances 0.000 description 3
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 3
229930091371 Fructose Natural products 0.000 description 3
206010020601 Hyperchlorhydria Diseases 0.000 description 3
102000057297 Pepsin A Human genes 0.000 description 3
108090000284 Pepsin A Proteins 0.000 description 3
GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 description 3
229960001545 hydrotalcite Drugs 0.000 description 3
229910001701 hydrotalcite Inorganic materials 0.000 description 3
230000003472 neutralizing effect Effects 0.000 description 3
229940111202 pepsin Drugs 0.000 description 3
238000010992 reflux Methods 0.000 description 3
239000007858 starting material Substances 0.000 description 3
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
238000009835 boiling Methods 0.000 description 2
HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
239000000796 flavoring agent Substances 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
210000004211 gastric acid Anatomy 0.000 description 2
210000004051 gastric juice Anatomy 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
WGYKZJWCGVVSQN-UHFFFAOYSA-N mono-n-propyl amine Natural products CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 2
QUSNBJAOOMFDIB-UHFFFAOYSA-N monoethyl amine Natural products CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
125000001477 organic nitrogen group Chemical group 0.000 description 2
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
229940081974 saccharin Drugs 0.000 description 2
235000019204 saccharin Nutrition 0.000 description 2
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
206010053155 Epigastric discomfort Diseases 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
208000008469 Peptic Ulcer Diseases 0.000 description 1
235000018734 Sambucus australis Nutrition 0.000 description 1
244000180577 Sambucus australis Species 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
238000002441 X-ray diffraction Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000009858 acid secretion Effects 0.000 description 1
230000032683 aging Effects 0.000 description 1
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
150000004645 aluminates Chemical class 0.000 description 1
SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
UJOHNXQDVUADCG-UHFFFAOYSA-L aluminum;magnesium;carbonate Chemical compound [Mg+2].[Al+3].[O-]C([O-])=O UJOHNXQDVUADCG-UHFFFAOYSA-L 0.000 description 1
DOEVMNBDNQNWEJ-UHFFFAOYSA-K aluminum;magnesium;phosphate Chemical compound [Mg+2].[Al+3].[O-]P([O-])([O-])=O DOEVMNBDNQNWEJ-UHFFFAOYSA-K 0.000 description 1
229940011037 anethole Drugs 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
210000000941 bile Anatomy 0.000 description 1
239000000872 buffer Substances 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
230000029087 digestion Effects 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
RBNPZEHAODHBPZ-UHFFFAOYSA-M dihydroxyaluminium Chemical compound O.O.NCC(=O)O[Al] RBNPZEHAODHBPZ-UHFFFAOYSA-M 0.000 description 1
MCWXGJITAZMZEV-UHFFFAOYSA-N dimethoate Chemical compound CNC(=O)CSP(=S)(OC)OC MCWXGJITAZMZEV-UHFFFAOYSA-N 0.000 description 1
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
235000019797 dipotassium phosphate Nutrition 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
201000006549 dyspepsia Diseases 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
239000007942 layered tablet Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
BAVYZALUXZFZLV-UHFFFAOYSA-N mono-methylamine Natural products NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
239000002994 raw material Substances 0.000 description 1
230000028327 secretion Effects 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
PESXGULMKCKJCC-UHFFFAOYSA-M sodium;4-methoxycarbonylphenolate Chemical compound [Na+].COC(=O)C1=CC=C([O-])C=C1 PESXGULMKCKJCC-UHFFFAOYSA-M 0.000 description 1
IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical compound [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
238000010998 test method Methods 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
210000002438 upper gastrointestinal tract Anatomy 0.000 description 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA000415688A 1981-11-23 1982-11-16 Compositions anti-acides Expired CA1198675A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32382681A	1981-11-23	1981-11-23
US323,826		1981-11-23

Publications (1)

Publication Number	Publication Date
CA1198675A true CA1198675A (fr)	1985-12-31

Family

ID=23260894

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000415688A Expired CA1198675A (fr)	1981-11-23	1982-11-16	Compositions anti-acides

Country Status (1)

Country	Link
CA (1)	CA1198675A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5362457A (en) *	1992-08-13	1994-11-08	Aluminum Company Of America	Direct synthesis of anion substituted hydrotalcite

1982
- 1982-11-16 CA CA000415688A patent/CA1198675A/fr not_active Expired

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5362457A (en) *	1992-08-13	1994-11-08	Aluminum Company Of America	Direct synthesis of anion substituted hydrotalcite
US5484583A (en) *	1992-08-13	1996-01-16	Aluminum Company Of America	Filler material containing an anion substituted hydrotalcite

Legal Events

Date	Code	Title	Description
2002-12-31	MKEX	Expiry

Publication	Publication Date	Title
US4560545A (en)	1985-12-24	Basic aluminum magnesium carbonate
CA1040532A (fr)	1978-10-17	Procede de preparation de produits pharmaceutiques solides contenant du bismuth
EP2194972B1 (fr)	2017-03-08	Composés métalliques mélangés utilisés en tant qu'antiacides
JP2907299B2 (ja)	1999-06-21	胃酸を結合する薬学的製剤
US2848366A (en)	1958-08-19	Non-hydrated ferrous fumarate and hematinic composition thereof
US4482542A (en)	1984-11-13	Antacid material based on magnesium aluminium hydroxide and the preparation thereof
US3361769A (en)	1968-01-02	Bi-metallic salts of gluconic, glucuronic, or galacturonic acid
CA1198675A (fr)	1985-12-31	Compositions anti-acides
US4225614A (en)	1980-09-30	Method of treatment for mucocutaneous herpes simplex infections
CA1198674A (fr)	1985-12-31	Compositions anti-acides
US3239416A (en)	1966-03-08	Aluminum hydroxide-metal hydroxide antacid and process of making the same
US4465838A (en)	1984-08-14	Oxaprozin calcium salt
US3215601A (en)	1965-11-02	Antacid composition and method of making same
US3712948A (en)	1973-01-23	Antiperspirant action by bimetallic salts of gluconic,glucuronic and galacturonic acids
US4443433A (en)	1984-04-17	Antacid material based on magnesium aluminum hydroxide and preparation thereof
US3499963A (en)	1970-03-10	Codried aluminum hydroxide-aluminum chelate antacid
US3245876A (en)	1966-04-12	Antacid compositions containing high concentrations of magnesium hydroxide and process of making the same
FI79945C (fi)	1990-04-10	Foerfarande foer framstaellning av nya modifierade leror.
US4931289A (en)	1990-06-05	Oral phosphate ion adsorbent
US3401015A (en)	1968-09-10	Magnesium silicate and process for making same
US3491135A (en)	1970-01-20	Pamoates of (3-cyclohexyl-3-hydroxy-3-phenylpropyl) triethylammonium having unobjectionable flavors
EP0715520B1 (fr)	2000-06-28	Utilisatioin d'une suspension a base de gel de sucralphate comme antiacide
WO1999035088A1 (fr)	1999-07-15	Carbonate basique de magnesium et d'aluminium, son procede de fabrication et son utilisation comme composition pharmaceutique destinee au traitement de l'acidite gastrique
US2940898A (en)	1960-06-14	Aluminum salt antacid compositions and method of using same
AU578106B2 (en)	1988-10-13	High-density antacid powders