CA1203531A - 1-SUBSTITUANT N-(8.alpha.-ERGOLINYL)-N',N'-DIETHYLUREES; METHODE DE PREPARATION - Google Patents

1-SUBSTITUANT N-(8.alpha.-ERGOLINYL)-N',N'-DIETHYLUREES; METHODE DE PREPARATION

Info

Publication number
CA1203531A
CA1203531A CA000423264A CA423264A CA1203531A CA 1203531 A CA1203531 A CA 1203531A CA 000423264 A CA000423264 A CA 000423264A CA 423264 A CA423264 A CA 423264A CA 1203531 A CA1203531 A CA 1203531A
Authority
CA
Canada
Prior art keywords
ergolinyl
alpha
diethylurea
methyl
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000423264A
Other languages
English (en)
Inventor
Jiri Krepelka
Antonin Cerny
Karel Rezabek
Miroslav Seda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
Original Assignee
Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spofa Spojene Podniky Pro Zdravotnickou Vyrobu filed Critical Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
Application granted granted Critical
Publication of CA1203531A publication Critical patent/CA1203531A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000423264A 1982-03-12 1983-03-10 1-SUBSTITUANT N-(8.alpha.-ERGOLINYL)-N',N'-DIETHYLUREES; METHODE DE PREPARATION Expired CA1203531A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CSPV1734-82 1982-03-12
CS821734A CS231214B1 (en) 1982-03-12 1982-03-12 Processing method of 1-substituted n+l8alpha-ergoline+p-n,diethyl urea

Publications (1)

Publication Number Publication Date
CA1203531A true CA1203531A (fr) 1986-04-22

Family

ID=5352449

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000423264A Expired CA1203531A (fr) 1982-03-12 1983-03-10 1-SUBSTITUANT N-(8.alpha.-ERGOLINYL)-N',N'-DIETHYLUREES; METHODE DE PREPARATION

Country Status (15)

Country Link
JP (1) JPS58180484A (fr)
AT (1) AT383349B (fr)
AU (1) AU555961B2 (fr)
BE (1) BE896122A (fr)
CA (1) CA1203531A (fr)
CH (1) CH652125A5 (fr)
CS (1) CS231214B1 (fr)
DE (1) DE3308719A1 (fr)
DK (1) DK84683A (fr)
FI (1) FI830754A7 (fr)
FR (1) FR2523131B1 (fr)
GB (1) GB2116548B (fr)
IT (1) IT1161209B (fr)
NL (1) NL8300829A (fr)
SE (1) SE452321B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3309493A1 (de) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
EP0208417A3 (fr) * 1985-06-12 1989-09-06 SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu Utilisation de dérivés de 1-(8alpha-ergolinyl)-3,3-diéthylurée pour le traitement de l'endométrite
DE3522894A1 (de) * 1985-06-24 1987-01-02 Schering Ag Verwendung von tergurid als geriatrikum
FR2584720B1 (fr) * 1985-07-11 1987-10-02 Rhone Poulenc Sante Procede de preparation de derives n-methyles de l'ergoline
DE3620293A1 (de) * 1986-06-16 1987-12-17 Schering Ag 1-und/oder 2-substituierte ergolinderivate
DE3623503A1 (de) * 1986-07-09 1988-01-21 Schering Ag 1-aryl-ergolinyl-harnstoffderivate, verfahren zu deren herstellung sowie die verwendung dieser verbindungen als arzneimittel
DE10212564B4 (de) * 2002-03-12 2007-04-19 Neurobiotec Gmbh 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne
EP2637644A1 (fr) * 2010-11-11 2013-09-18 Sinoxa Pharma UG Lisuride, terguride et leurs dérivés pour une utilisation dans la prophylaxie et/ou la thérapie de modifications fibreuses
BR112017015510A2 (pt) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc composto de fórmula estrutural (i), método de tratamento e/ou prevenção, método de agonização do receptor d2 em um indivíduo, método de antagonização do receptor d3 em um indivíduo, método de agonização do receptor 5-ht1d em um indivíduo, método de agonização do receptor 5-ht1a em um indivíduo, método de agonização seletiva do receptor 5-ht1d em vez do receptor 5-ht1b em um indivíduo, método de agonização seletiva do re-ceptor 5-ht2c em vez do receptor 5-ht2a ou 5-ht2b em um indivíduo, método de agonização do receptor 5-ht2c em um indivíduo, método de fornecimento de atividade antagonista funcional no receptor 5-ht2b ou receptor 5-ht7, e, método de fornecimento de atividade antagonista funcional nos receptores adrenérgicos em um indivíduo
CN113149982A (zh) 2015-01-20 2021-07-23 Xoc制药股份有限公司 麦角灵化合物及其用途
JP2020522504A (ja) 2017-06-01 2020-07-30 エックスオーシー ファーマシューティカルズ インコーポレイテッドＸｏｃ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ 多環式化合物およびそれらの用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH344731A (de) * 1956-05-18 1960-02-29 Sandoz Ag Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe
AT231082B (de) * 1960-10-12 1964-01-10 Sandoz Ag Verfahren zur Herstellung von neuen Harnstoff-Derivaten
DE3063869D1 (en) * 1979-06-13 1983-07-28 Schering Ag (ergolin-yl)-n', n'-diethyl urea derivatives, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
SE8301257D0 (sv) 1983-03-08
FI830754L (fi) 1983-09-13
AU1216783A (en) 1983-09-15
FR2523131A1 (fr) 1983-09-16
CH652125A5 (de) 1985-10-31
DK84683A (da) 1983-09-13
SE452321B (sv) 1987-11-23
GB8305735D0 (en) 1983-04-07
DE3308719A1 (de) 1983-09-22
ATA72783A (de) 1986-11-15
SE8301257L (sv) 1983-09-13
IT8319935A0 (it) 1983-03-07
BE896122A (fr) 1983-07-01
FI830754A0 (fi) 1983-03-07
CS231214B1 (en) 1984-10-15
IT1161209B (it) 1987-03-18
FR2523131B1 (fr) 1987-08-28
FI830754A7 (fi) 1983-09-13
GB2116548B (en) 1985-03-20
AT383349B (de) 1987-06-25
GB2116548A (en) 1983-09-28
NL8300829A (nl) 1983-10-03
DK84683D0 (da) 1983-02-24
AU555961B2 (en) 1986-10-16
JPS58180484A (ja) 1983-10-21

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Legal Events

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