CA1208580A - Isolation of pancreatin - Google Patents

Isolation of pancreatin

Info

Publication number: CA1208580A
Authority: CA; Canada
Prior art keywords: pancreatin; isopropyl alcohol; autolysis; concentration; carried out
Prior art date: 1982-12-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000444332A

Other languages

English (en)

French (fr)

Inventor

Hans Schultze

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nordmark Werke GmbH

Original Assignee

Nordmark Werke GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-12-30

Filing date

1983-12-28

Publication date

1986-07-29

1982-12-30 Priority claimed from DE19823248588 external-priority patent/DE3248588A1/de

1982-12-30 Priority claimed from DE19823248587 external-priority patent/DE3248587A1/de

1983-12-28 Application filed by Nordmark Werke GmbH filed Critical Nordmark Werke GmbH

1986-07-29 Application granted granted Critical

1986-07-29 Publication of CA1208580A publication Critical patent/CA1208580A/en

Status Expired legal-status Critical Current

Links

108010019160 Pancreatin Proteins 0.000 title claims abstract description 42
229940055695 pancreatin Drugs 0.000 title claims abstract description 41
238000002955 isolation Methods 0.000 title abstract description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 120
208000035404 Autolysis Diseases 0.000 claims abstract description 31
206010057248 Cell death Diseases 0.000 claims abstract description 27
230000028043 self proteolysis Effects 0.000 claims abstract description 27
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 18
239000000835 fiber Substances 0.000 claims abstract description 13
239000000725 suspension Substances 0.000 claims abstract description 12
238000001035 drying Methods 0.000 claims abstract description 10
239000000243 solution Substances 0.000 claims abstract description 10
238000003756 stirring Methods 0.000 claims abstract description 9
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 6
238000001556 precipitation Methods 0.000 claims abstract description 5
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 3
238000000034 method Methods 0.000 claims description 38
230000008569 process Effects 0.000 claims description 31
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
239000002244 precipitate Substances 0.000 claims description 10
238000004062 sedimentation Methods 0.000 claims description 9
239000006228 supernatant Substances 0.000 claims description 7
239000013049 sediment Substances 0.000 claims description 6
210000004923 pancreatic tissue Anatomy 0.000 claims description 4
210000001519 tissue Anatomy 0.000 claims description 4
239000012137 tryptone Substances 0.000 claims description 4
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 3
-1 alkali metal bicarbonate Chemical class 0.000 claims description 3
239000007864 aqueous solution Substances 0.000 claims description 3
229910001424 calcium ion Inorganic materials 0.000 claims description 3
239000000470 constituent Substances 0.000 claims description 3
230000005484 gravity Effects 0.000 claims description 3
229910052783 alkali metal Inorganic materials 0.000 claims description 2
210000002808 connective tissue Anatomy 0.000 claims description 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
238000000967 suction filtration Methods 0.000 claims description 2
229960004592 isopropanol Drugs 0.000 abstract description 33
238000002360 preparation method Methods 0.000 abstract description 6
239000002002 slurry Substances 0.000 abstract description 4
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 abstract 1
238000001914 filtration Methods 0.000 abstract 1
230000001376 precipitating effect Effects 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 description 29
108090000790 Enzymes Proteins 0.000 description 29
229940088598 enzyme Drugs 0.000 description 29
235000019441 ethanol Nutrition 0.000 description 16
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
108091005804 Peptidases Proteins 0.000 description 13
239000004365 Protease Substances 0.000 description 13
230000000694 effects Effects 0.000 description 12
210000000496 pancreas Anatomy 0.000 description 12
108090001060 Lipase Proteins 0.000 description 11
102000004882 Lipase Human genes 0.000 description 11
239000004367 Lipase Substances 0.000 description 11
102000035195 Peptidases Human genes 0.000 description 11
235000019421 lipase Nutrition 0.000 description 11
239000004382 Amylase Substances 0.000 description 10
102000013142 Amylases Human genes 0.000 description 10
108010065511 Amylases Proteins 0.000 description 10
235000019418 amylase Nutrition 0.000 description 10
MCWXGJITAZMZEV-UHFFFAOYSA-N dimethoate Chemical group CNC(=O)CSP(=S)(OC)OC MCWXGJITAZMZEV-UHFFFAOYSA-N 0.000 description 10
229940040461 lipase Drugs 0.000 description 10
239000000203 mixture Substances 0.000 description 8
239000003925 fat Substances 0.000 description 6
239000002904 solvent Substances 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 5
108010013369 Enteropeptidase Proteins 0.000 description 4
102100029727 Enteropeptidase Human genes 0.000 description 4
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
108090000631 Trypsin Proteins 0.000 description 4
102000004142 Trypsin Human genes 0.000 description 4
239000012588 trypsin Substances 0.000 description 4
239000010014 Mentat Substances 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
244000052616 bacterial pathogen Species 0.000 description 3
235000014571 nuts Nutrition 0.000 description 3
239000012071 phase Substances 0.000 description 3
239000000047 product Substances 0.000 description 3
239000000758 substrate Substances 0.000 description 3
NJXWZWXCHBNOOG-UHFFFAOYSA-N 3,3-diphenylpropyl(1-phenylethyl)azanium;chloride Chemical compound [Cl-].C=1C=CC=CC=1C(C)[NH2+]CCC(C=1C=CC=CC=1)C1=CC=CC=C1 NJXWZWXCHBNOOG-UHFFFAOYSA-N 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
241000511343 Chondrostoma nasus Species 0.000 description 2
241000518994 Conta Species 0.000 description 2
101150038444 Ment gene Proteins 0.000 description 2
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
230000004913 activation Effects 0.000 description 2
159000000007 calcium salts Chemical class 0.000 description 2
239000005018 casein Substances 0.000 description 2
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
235000021240 caseins Nutrition 0.000 description 2
238000004821 distillation Methods 0.000 description 2
238000004108 freeze drying Methods 0.000 description 2
239000011521 glass Substances 0.000 description 2
239000000463 material Substances 0.000 description 2
235000018102 proteins Nutrition 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
239000002994 raw material Substances 0.000 description 2
238000007873 sieving Methods 0.000 description 2
235000017557 sodium bicarbonate Nutrition 0.000 description 2
229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
239000003826 tablet Substances 0.000 description 2
GRYSXUXXBDSYRT-WOUKDFQISA-N (2r,3r,4r,5r)-2-(hydroxymethyl)-4-methoxy-5-[6-(methylamino)purin-9-yl]oxolan-3-ol Chemical compound C1=NC=2C(NC)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1OC GRYSXUXXBDSYRT-WOUKDFQISA-N 0.000 description 1
FWEOQOXTVHGIFQ-UHFFFAOYSA-N 8-anilinonaphthalene-1-sulfonic acid Chemical compound C=12C(S(=O)(=O)O)=CC=CC2=CC=CC=1NC1=CC=CC=C1 FWEOQOXTVHGIFQ-UHFFFAOYSA-N 0.000 description 1
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
102000010911 Enzyme Precursors Human genes 0.000 description 1
108010062466 Enzyme Precursors Proteins 0.000 description 1
101000768061 Escherichia phage P1 Antirepressor protein 1 Proteins 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
241000022563 Rema Species 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229960004494 calcium gluconate Drugs 0.000 description 1
239000004227 calcium gluconate Substances 0.000 description 1
235000013927 calcium gluconate Nutrition 0.000 description 1
NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 1
229940077731 carbohydrate nutrients Drugs 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
GPUADMRJQVPIAS-QCVDVZFFSA-M cerivastatin sodium Chemical compound [Na+].COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 GPUADMRJQVPIAS-QCVDVZFFSA-M 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
230000000332 continued effect Effects 0.000 description 1
230000008602 contraction Effects 0.000 description 1
238000001816 cooling Methods 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
230000029087 digestion Effects 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
210000001198 duodenum Anatomy 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000012065 filter cake Substances 0.000 description 1
239000006260 foam Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229940050410 gluconate Drugs 0.000 description 1
150000005826 halohydrocarbons Chemical class 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
239000011261 inert gas Substances 0.000 description 1
235000019626 lipase activity Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
239000012452 mother liquor Substances 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000002245 particle Substances 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
238000005086 pumping Methods 0.000 description 1
239000000344 soap Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000010414 supernatant solution Substances 0.000 description 1
125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/94—Pancreatin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA000444332A 1982-12-30 1983-12-28 Isolation of pancreatin Expired CA1208580A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DEP3248587.5		1982-12-30
DE19823248588 DE3248588A1 (de)	1982-12-30	1982-12-30	Verfahren zur gewinnung von pankreatin von hohem schuettgewicht
DEP3248588.3		1982-12-30
DE19823248587 DE3248587A1 (de)	1982-12-30	1982-12-30	Verfahren zur gewinnung von pankreatin

Publications (1)

Publication Number	Publication Date
CA1208580A true CA1208580A (en)	1986-07-29

Family

ID=25807022

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000444332A Expired CA1208580A (en)	1982-12-30	1983-12-28	Isolation of pancreatin

Country Status (15)

Country	Link
US (1)	US4623624A (de)
EP (1)	EP0115023B1 (de)
AR (1)	AR232000A1 (de)
BR (1)	BR8307280A (de)
CA (1)	CA1208580A (de)
DD (1)	DD212981A5 (de)
DE (1)	DE3377506D1 (de)
DK (1)	DK173599B1 (de)
ES (1)	ES8407516A1 (de)
HU (1)	HU196435B (de)
MD (1)	MD411C2 (de)
PL (1)	PL141118B1 (de)
SU (1)	SU1644712A3 (de)
UA (1)	UA5996A1 (de)
YU (1)	YU45584B (de)

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US6632429B1 (en)	1999-12-17	2003-10-14	Joan M. Fallon	Methods for treating pervasive development disorders
KR100367659B1 (ko) *	2000-05-08	2003-01-14	주식회사 바이넥스	선택적 안정화제의 첨가에 따른 자가분해(autolysis)를 통한 고역가 판크레아틴의 제조방법
US20070053895A1 (en)	2000-08-14	2007-03-08	Fallon Joan M	Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
IT1319655B1 (it)	2000-11-15	2003-10-23	Eurand Int	Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
US8030002B2 (en)	2000-11-16	2011-10-04	Curemark Llc	Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
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AU2004260961B2 (en) *	2003-07-29	2010-05-20	Abbott Laboratories Gmbh	Analytical method for pancreatin and comparable compositions
ES2314646T3 (es) *	2004-03-22	2009-03-16	Solvay Pharmaceuticals Gmbh	Composiciones farmaceuticas por via de productos que contienen lipasa , en particular de pancreatina, que contienen tensioactivos.
US7153504B2 (en) *	2004-07-30	2006-12-26	Can Technologies, Inc.	Stabilized pancreas product
CN101184780B (zh)	2005-05-05	2012-10-03	森馨香料公司	β-葡聚糖和甘露聚糖的制备
HUE031042T2 (en)	2005-07-29	2017-06-28	Abbott Laboratories Gmbh	Methods for producing pancreatin powder with low viral content
US11266607B2 (en) *	2005-08-15	2022-03-08	AbbVie Pharmaceuticals GmbH	Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) *	2005-08-15	2015-12-01	Abbott Products Gmbh	Delayed release pancreatin compositions
US20080058282A1 (en)	2005-08-30	2008-03-06	Fallon Joan M	Use of lactulose in the treatment of autism
TW200745337A (en) *	2006-02-24	2007-12-16	Aminotech As	Modified process
US10072256B2 (en) *	2006-05-22	2018-09-11	Abbott Products Gmbh	Process for separating and determining the viral load in a pancreatin sample
AU2008218595B2 (en)	2007-02-20	2012-05-24	Allergan Therapeutics LLC	Stable digestive enzyme compositions
US20090130063A1 (en) *	2007-11-15	2009-05-21	Solvay Pharmaceuticals Gmbh	Process for separating and determining the viral load in a pancreatin sample
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US8658163B2 (en)	2008-03-13	2014-02-25	Curemark Llc	Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en)	2008-04-18	2011-12-27	Curemark Llc	Method for the treatment of the symptoms of drug and alcohol addiction
US9320780B2 (en)	2008-06-26	2016-04-26	Curemark Llc	Methods and compositions for the treatment of symptoms of Williams Syndrome
ES2732453T3 (es)	2008-07-01	2019-11-22	Curemark Llc	Métodos y composiciones para el tratamiento de síntomas de trastornos neurológicos y de salud mental
US10776453B2 (en)	2008-08-04	2020-09-15	Galenagen, Llc	Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
EP2165717A1 (de) *	2008-08-27	2010-03-24	Nordmark Arzneimittel GmbH & Co.KG	Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte
US20100092447A1 (en)	2008-10-03	2010-04-15	Fallon Joan M	Methods and compositions for the treatment of symptoms of prion diseases
JP2012514604A (ja)	2009-01-06	2012-06-28	キュレロンリミテッドライアビリティカンパニー	大腸菌（Ｅ．ｃｏｌｉ）による経口感染の治療または予防のための組成物および方法
CA3050530A1 (en)	2009-01-06	2010-07-15	Galenagen, Llc	Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus on surfaces
US9056050B2 (en)	2009-04-13	2015-06-16	Curemark Llc	Enzyme delivery systems and methods of preparation and use
US9511125B2 (en)	2009-10-21	2016-12-06	Curemark Llc	Methods and compositions for the treatment of influenza
UA111726C2 (uk)	2010-10-01	2016-06-10	Апталіс Фарма Лімітед	Препарат панкреліпази низької сили з кишковорозчинним покриттям
MX362974B (es)	2011-04-21	2019-02-28	Curemark Llc	Compuestos para el tratamiento de alteraciones neuropsiquiatricas.
MX351014B (es)	2011-08-08	2017-09-28	Aptalis Pharma Ltd	Metodo para la prueba de disolucion de composiciones solidas que contienen enzimas digestivas.
US10350278B2 (en)	2012-05-30	2019-07-16	Curemark, Llc	Methods of treating Celiac disease
US10184121B2 (en)	2013-06-28	2019-01-22	Allergan Pharmaceuticals International Limited	Methods for removing viral contaminants from pancreatic extracts
US20160152968A1 (en) *	2013-07-22	2016-06-02	Aptalis Pharma Ltd.	High potency pancreatin pharmaceutical compositions
US20160108389A1 (en) *	2013-07-22	2016-04-21	Aptalis Pharma Ltd.	High potency pancreatin pharmaceutical compositions
CN106163544A (zh)	2013-08-09	2016-11-23	阿勒根制药国际有限公司	适于经肠施用的消化酶组合物
CN106659773A (zh) *	2013-11-05	2017-05-10	阿勒根制药国际有限公司	高效的胰酶药物组合物
MX391630B (es)	2014-11-05	2025-03-19	Abbott Laboratories Gmbh	Procesos para la producción de composiciones con perfil de seguridad mejorado teniendo actividad lipasa y composiciones adecuadas para medicamentos
ES2970869T3 (es)	2016-03-28	2024-05-31	Abbott Laboratories Gmbh	Composiciones enzimáticas con contaminación vírica y microbiana reducida
US11278603B2 (en)	2016-03-28	2022-03-22	Abbvie Inc.	Enzyme compositions with reduced viral and microbial contamination
AU2018250823A1 (en)	2017-04-10	2019-10-17	Curemark, Llc	Compositions for treating addiction
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GB928654A (en) *	1960-10-25	1963-06-12	Philips Nv	Improvements in or relating to the production of pancreatin
GB1328202A (en)	1969-06-17	1973-08-30	Union International Co Ltd	Manufacture of pancreatin
DE2106706B2 (de) *	1971-02-12	1973-05-10	Wilson Pharmaceutical & Chemical Corp., Chicago, 111. (V.St.A.)	Verfahren zur herstellung von pankreatin als trockenes pulver mit hoher proteolytischer, amylolytischer und lipolytischer aktivitaet
DE2620289C2 (de) *	1976-05-07	1982-05-19	A. Nattermann & Cie GmbH, 5000 Köln	Herstellung eines lipasereichen Enzympräparates
US4088539A (en)	1976-05-07	1978-05-09	A. Nattermann & Cie Gmbh	Process of manufacturing enzyme preparation rich in lipase

1983
- 1983-12-20 DE DE8383112809T patent/DE3377506D1/de not_active Expired
- 1983-12-20 EP EP83112809A patent/EP0115023B1/de not_active Expired
- 1983-12-23 US US06/565,220 patent/US4623624A/en not_active Expired - Lifetime
- 1983-12-28 CA CA000444332A patent/CA1208580A/en not_active Expired
- 1983-12-28 YU YU252483A patent/YU45584B/sh unknown
- 1983-12-28 AR AR295280A patent/AR232000A1/es active
- 1983-12-28 PL PL1983245381A patent/PL141118B1/pl unknown
- 1983-12-29 DD DD83258863A patent/DD212981A5/de not_active IP Right Cessation
- 1983-12-29 SU SU833682185A patent/SU1644712A3/ru active
- 1983-12-29 BR BR8307280A patent/BR8307280A/pt not_active IP Right Cessation
- 1983-12-29 HU HU834516A patent/HU196435B/hu not_active IP Right Cessation
- 1983-12-29 UA UA3682185A patent/UA5996A1/uk unknown
- 1983-12-29 ES ES528537A patent/ES8407516A1/es not_active Expired
- 1983-12-29 DK DK198306055A patent/DK173599B1/da not_active IP Right Cessation
1994
- 1994-12-29 MD MD95-0074A patent/MD411C2/ro unknown

Also Published As

Publication number	Publication date
DE3377506D1 (en)	1988-09-01
YU45584B (sh)	1992-07-20
ES528537A0 (es)	1984-09-16
PL245381A1 (en)	1984-10-22
DK605583A (da)	1984-07-01
DK605583D0 (da)	1983-12-29
DK173599B1 (da)	2001-04-23
EP0115023A2 (de)	1984-08-08
EP0115023A3 (en)	1986-04-09
HU196435B (en)	1988-11-28
AR232000A1 (es)	1985-04-30
PL141118B1 (en)	1987-06-30
UA5996A1 (uk)	1994-12-29
MD411C2 (ro)	1996-06-30
US4623624A (en)	1986-11-18
BR8307280A (pt)	1984-08-07
ES8407516A1 (es)	1984-09-16
DD212981A5 (de)	1984-08-29
EP0115023B1 (de)	1988-07-27
YU252483A (en)	1986-10-31
SU1644712A3 (ru)	1991-04-23

Legal Events

Date	Code	Title	Description
2003-12-28	MKEX	Expiry

Publication	Publication Date	Title
US4623624A (en)	1986-11-18	Isolation of pancreatin
US3223594A (en)	1965-12-14	Method of producing pancreatin
DE69429167T2 (de)	2002-07-04	Eine stabilisierte phenylalanin-ammonia-lyase
US4016039A (en)	1977-04-05	Process for the recovery of proteins from aqueous solutions of proteins
EP0758380A1 (de)	1997-02-19	Verfahren zur trennung milchgerinnender enzyme, und stabile labzusammensetzungen
KR870001071B1 (ko)	1987-05-27	고 결정성 나트륨 세포페라존의 제조방법
CN110183550A (zh)	2019-08-30	一种精品肝素钠的制备工艺
US2958632A (en)	1960-11-01	Process for recovery of highly active, stable, substantially sterile, soluble, proteolytic, enzyme composition from commercial crude papain
US2922749A (en)	1960-01-26	Enzymes
US3284316A (en)	1966-11-08	Stable papain derivative
US2847350A (en)	1958-08-12	Preparation of highly active thromboplastin
US3168448A (en)	1965-02-02	Process of preparing a lipolytic enzyme composition
US2950227A (en)	1960-08-23	Ferments of the papain type and process of making same
US3660237A (en)	1972-05-02	Process for obtaining kallekrein from pancreas or submandibularis glands of pigs
CZ293310B6 (cs)	2004-03-17	Způsob izolace imunostimulačního glukanu z hlívy ústřičné
US2926122A (en)	1960-02-23	Method of preparing glucose oxidase
RU1794080C (ru)	1993-02-07	Способ выделени крахмала из суспензии процессовой воды, полученной при производстве крахмала из муки зерна
CN119524019B (zh)	2025-05-16	一种胎盘脂多糖制剂及其制备方法
US2406840A (en)	1946-09-03	Method of preparing pectase
US3260654A (en)	1966-07-12	Method for the preparation of a pancreas extract having a high proteolytic activity
US2779706A (en)	1957-01-29	Insulin extraction
US2921000A (en)	1960-01-12	Thromboplastin
FI75169C (fi)	1988-05-09	Foerfarande foer framstaellning av kristallint natriumcefoperazon.
US3075886A (en)	1963-01-29	Purification of enzymes
EP0049576A2 (de)	1982-04-14	Verfahren zum Sterilisieren und Waschen immobilisierter Lactase