CA1210697A - Poudres de vitamines liposolubles non agglomerees, a densite elevee et ecoulement facile - Google Patents

Poudres de vitamines liposolubles non agglomerees, a densite elevee et ecoulement facile

Info

Publication number: CA1210697A
Authority: CA; Canada
Prior art keywords: vitamin; fat; soluble; powders; soluble vitamin
Prior art date: 1983-05-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000453177A

Other languages

English (en)

Inventor

Douglass N. Schmidt

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

BASF Corp

Original Assignee

BASF Wyandotte Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-02

Filing date

1984-04-30

Publication date

1986-09-02

1984-04-30 Application filed by BASF Wyandotte Corp filed Critical BASF Wyandotte Corp

1986-09-02 Application granted granted Critical

1986-09-02 Publication of CA1210697A publication Critical patent/CA1210697A/fr

Status Expired legal-status Critical Current

Links

229940088594 vitamin Drugs 0.000 title claims abstract description 46
229930003231 vitamin Natural products 0.000 title claims abstract description 46
235000013343 vitamin Nutrition 0.000 title claims abstract description 46
239000011782 vitamin Substances 0.000 title claims abstract description 46
150000003722 vitamin derivatives Chemical class 0.000 title claims abstract description 41
239000000843 powder Substances 0.000 title abstract description 53
239000002245 particle Substances 0.000 claims abstract description 17
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims abstract description 10
229910052710 silicon Inorganic materials 0.000 claims abstract description 10
239000010703 silicon Substances 0.000 claims abstract description 10
239000011236 particulate material Substances 0.000 claims abstract description 6
238000009826 distribution Methods 0.000 claims abstract description 5
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 64
235000019165 vitamin E Nutrition 0.000 claims description 33
239000011709 vitamin E Substances 0.000 claims description 33
229930003427 Vitamin E Natural products 0.000 claims description 31
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 31
229940046009 vitamin E Drugs 0.000 claims description 31
238000000034 method Methods 0.000 claims description 29
239000000463 material Substances 0.000 claims description 17
239000000203 mixture Substances 0.000 claims description 8
ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 7
239000007788 liquid Substances 0.000 claims description 7
229940042585 tocopherol acetate Drugs 0.000 claims description 7
238000002156 mixing Methods 0.000 claims description 6
ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 5
150000002148 esters Chemical class 0.000 claims description 5
235000015097 nutrients Nutrition 0.000 claims description 4
235000019155 vitamin A Nutrition 0.000 claims description 4
239000011719 vitamin A Substances 0.000 claims description 4
235000019166 vitamin D Nutrition 0.000 claims description 3
239000011710 vitamin D Substances 0.000 claims description 3
229910021486 amorphous silicon dioxide Inorganic materials 0.000 claims 2
235000019168 vitamin K Nutrition 0.000 claims 2
239000011712 vitamin K Substances 0.000 claims 2
239000000306 component Substances 0.000 claims 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 16
239000003463 adsorbent Substances 0.000 description 15
230000000717 retained effect Effects 0.000 description 10
238000002360 preparation method Methods 0.000 description 9
235000012239 silicon dioxide Nutrition 0.000 description 9
239000000377 silicon dioxide Substances 0.000 description 7
239000011732 tocopherol Substances 0.000 description 7
239000003921 oil Substances 0.000 description 6
235000019198 oils Nutrition 0.000 description 6
229930003799 tocopherol Natural products 0.000 description 6
230000000694 effects Effects 0.000 description 5
238000001179 sorption measurement Methods 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
230000000052 comparative effect Effects 0.000 description 4
235000005911 diet Nutrition 0.000 description 4
230000037213 diet Effects 0.000 description 4
238000001694 spray drying Methods 0.000 description 4
235000019149 tocopherols Nutrition 0.000 description 4
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 4
QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 4
238000007907 direct compression Methods 0.000 description 3
238000011156 evaluation Methods 0.000 description 3
238000010079 rubber tapping Methods 0.000 description 3
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 2
239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
238000005054 agglomeration Methods 0.000 description 2
230000002776 aggregation Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000003995 emulsifying agent Substances 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
230000000704 physical effect Effects 0.000 description 2
229910052711 selenium Inorganic materials 0.000 description 2
239000011669 selenium Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000010998 test method Methods 0.000 description 2
229960001295 tocopherol Drugs 0.000 description 2
235000010384 tocopherol Nutrition 0.000 description 2
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
BUCORZSTKDOEKQ-UHFFFAOYSA-N 7-chloro-4-hydroxy-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-imine Chemical compound C=12C=C(Cl)C=CC2=NC(=NC)CN(O)C=1C1=CC=CC=C1 BUCORZSTKDOEKQ-UHFFFAOYSA-N 0.000 description 1
241000711313 Athesis Species 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
235000019739 Dicalciumphosphate Nutrition 0.000 description 1
240000007594 Oryza sativa Species 0.000 description 1
235000007164 Oryza sativa Nutrition 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
239000002156 adsorbate Substances 0.000 description 1
238000013019 agitation Methods 0.000 description 1
229910052910 alkali metal silicate Inorganic materials 0.000 description 1
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
229940087168 alpha tocopherol Drugs 0.000 description 1
150000008064 anhydrides Chemical class 0.000 description 1
239000002585 base Substances 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000011575 calcium Substances 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
239000000378 calcium silicate Substances 0.000 description 1
229910052918 calcium silicate Inorganic materials 0.000 description 1
OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
239000002775 capsule Substances 0.000 description 1
238000005336 cracking Methods 0.000 description 1
238000013461 design Methods 0.000 description 1
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
229940038472 dicalcium phosphate Drugs 0.000 description 1
229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000010419 fine particle Substances 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
238000003475 lamination Methods 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000002844 melting Methods 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
238000005029 sieve analysis Methods 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000012360 testing method Methods 0.000 description 1
229960000984 tocofersolan Drugs 0.000 description 1
150000003611 tocopherol derivatives Chemical class 0.000 description 1
239000011882 ultra-fine particle Substances 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
239000010497 wheat germ oil Substances 0.000 description 1
235000004835 α-tocopherol Nutrition 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CA000453177A 1983-05-02 1984-04-30 Poudres de vitamines liposolubles non agglomerees, a densite elevee et ecoulement facile Expired CA1210697A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US49097683A	1983-05-02	1983-05-02
US490,976		1983-05-02

Publications (1)

Publication Number	Publication Date
CA1210697A true CA1210697A (fr)	1986-09-02

Family

ID=23950309

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000453177A Expired CA1210697A (fr)	1983-05-02	1984-04-30	Poudres de vitamines liposolubles non agglomerees, a densite elevee et ecoulement facile

Country Status (1)

Country	Link
CA (1)	CA1210697A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN117243943A (zh) *	2023-09-26	2023-12-19	山西振东五和堂制药有限公司	一种维生素e粉及其制备方法和应用

1984
- 1984-04-30 CA CA000453177A patent/CA1210697A/fr not_active Expired

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN117243943A (zh) *	2023-09-26	2023-12-19	山西振东五和堂制药有限公司	一种维生素e粉及其制备方法和应用

Legal Events

Date	Code	Title	Description
2004-04-30	MKEX	Expiry

Publication	Publication Date	Title
US4603143A (en)	1986-07-29	Free-flowing, high density, fat soluble vitamin powders with improved stability
EP0229652B1 (fr)	1991-10-30	Tocophérol stabilisé sous forme de particules sèches à libre écoulement
US5179122A (en)	1993-01-12	Nutritional supplement containing vitamin e
US4486435A (en)	1984-12-04	Spray-dried vitamin powders using hydrophobic silica
US5635214A (en)	1997-06-03	Sorbent precipitated silica particulates
KR100222503B1 (ko)	1999-10-01	사료용 비타민 c피복제제, 그 제조방법 및 용도
EP1044687B1 (fr)	2008-09-03	Poudres contenant des trocotrienols et comprimes prepares par moulage par compression de ces poudres
US6303167B1 (en)	2001-10-16	Method of producing vitamin powders
US4976977A (en)	1990-12-11	Pelleting agent having energy value
Tao et al.	1976	Evidence for a lack of an effect of dietary fluoride level on reproduction in mice
EP1272059B1 (fr)	2005-12-07	Procede pour la production de suspensions huileuses de vitamines solubles dans l'eau
US2937091A (en)	1960-05-17	Stabilized fat-soluble vitamin and method of making same
US4820532A (en)	1989-04-11	Preparation of a low-dust free-flowing choline chloride powder
Reddy et al.	1965	Iron and copper utilization in rabbits as affected by diet and germfree status
EP1358805A1 (fr)	2003-11-05	Fourrage supplémentaire
US5064829A (en)	1991-11-12	Composition of a b vitamin and mannitol and a method for production
CA1210697A (fr)	1986-09-02	Poudres de vitamines liposolubles non agglomerees, a densite elevee et ecoulement facile
JP2004503493A (ja)	2004-02-05	イソトレチノインの生物学的有効投与形態
MD3264915T2 (ro)	2021-08-31	Formulare de produse alimentare care cuprind pământ decolorant epuizat de la tratarea uleiului comestibil
US6248374B1 (en)	2001-06-19	Stabilized food additive
AU2018387680B2 (en)	2024-08-08	Storage stable mixtures
JP3051093B2 (ja)	2000-06-12	製剤
US2855306A (en)	1958-10-07	Fat-soluble vitamin composition
SA518400019B1 (ar)	2022-12-11	مركبات وطرق لزيادة امتصاص الحديد في الثدييات
JP2914637B2 (ja)	1999-07-05	油脂組成物の調製方法

CA1210697A - Poudres de vitamines liposolubles non agglomerees, a densite elevee et ecoulement facile - Google Patents

Info

Links

Landscapes

Applications Claiming Priority (2)

Publications (1)

Family

ID=23950309

Family Applications (1)

Country Status (1)

Cited By (1)

Cited By (1)

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