CA1216232A - Produit et methode pour vaincre le ronflement du dormeur - Google Patents

Produit et methode pour vaincre le ronflement du dormeur

Info

Publication number: CA1216232A
Authority: CA; Canada
Prior art keywords: composition; composition according; group; surface active; active substance
Prior art date: 1983-05-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000429349A

Other languages

English (en)

Inventor

Dietrich Reichert

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-31

Filing date

1983-05-31

Publication date

1987-01-06

1983-05-31 Application filed by Individual filed Critical Individual

1983-05-31 Priority to CA000429349A priority Critical patent/CA1216232A/fr

1987-01-06 Application granted granted Critical

1987-01-06 Publication of CA1216232A publication Critical patent/CA1216232A/fr

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 83
206010041235 Snoring Diseases 0.000 title claims abstract description 22
238000000034 method Methods 0.000 title abstract description 8
210000004400 mucous membrane Anatomy 0.000 claims abstract description 51
239000000126 substance Substances 0.000 claims abstract description 29
239000004094 surface-active agent Substances 0.000 claims abstract description 24
235000002639 sodium chloride Nutrition 0.000 claims abstract description 19
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 18
239000011780 sodium chloride Substances 0.000 claims abstract description 13
239000003755 preservative agent Substances 0.000 claims abstract description 12
239000000243 solution Substances 0.000 claims abstract description 11
239000000654 additive Substances 0.000 claims abstract description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 31
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 31
210000003800 pharynx Anatomy 0.000 claims description 18
150000002148 esters Chemical class 0.000 claims description 14
235000019441 ethanol Nutrition 0.000 claims description 13
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 12
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 12
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims description 12
239000000645 desinfectant Substances 0.000 claims description 12
235000011187 glycerol Nutrition 0.000 claims description 11
239000003795 chemical substances by application Substances 0.000 claims description 10
SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 9
229960000686 benzalkonium chloride Drugs 0.000 claims description 9
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 9
229940101267 panthenol Drugs 0.000 claims description 9
235000020957 pantothenol Nutrition 0.000 claims description 9
239000011619 pantothenol Substances 0.000 claims description 9
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 7
229920000053 polysorbate 80 Polymers 0.000 claims description 7
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 6
229940090248 4-hydroxybenzoic acid Drugs 0.000 claims description 6
239000005711 Benzoic acid Substances 0.000 claims description 6
102000004157 Hydrolases Human genes 0.000 claims description 6
108090000604 Hydrolases Proteins 0.000 claims description 6
102000035195 Peptidases Human genes 0.000 claims description 6
108091005804 Peptidases Proteins 0.000 claims description 6
239000004365 Protease Substances 0.000 claims description 6
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 6
229930003427 Vitamin E Natural products 0.000 claims description 6
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 6
235000010233 benzoic acid Nutrition 0.000 claims description 6
229960004926 chlorobutanol Drugs 0.000 claims description 6
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 6
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 6
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 6
150000003839 salts Chemical class 0.000 claims description 6
235000010199 sorbic acid Nutrition 0.000 claims description 6
239000004334 sorbic acid Substances 0.000 claims description 6
229940075582 sorbic acid Drugs 0.000 claims description 6
235000019155 vitamin A Nutrition 0.000 claims description 6
239000011719 vitamin A Substances 0.000 claims description 6
235000019165 vitamin E Nutrition 0.000 claims description 6
229940046009 vitamin E Drugs 0.000 claims description 6
239000011709 vitamin E Substances 0.000 claims description 6
229940045997 vitamin a Drugs 0.000 claims description 6
-1 fatty acid esters Chemical class 0.000 claims description 5
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
229920001214 Polysorbate 60 Polymers 0.000 claims description 3
CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 claims description 3
235000014113 dietary fatty acids Nutrition 0.000 claims description 3
239000000194 fatty acid Substances 0.000 claims description 3
229930195729 fatty acid Natural products 0.000 claims description 3
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 2
QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims 5
102000004882 Lipase Human genes 0.000 claims 5
108090001060 Lipase Proteins 0.000 claims 5
239000004367 Lipase Substances 0.000 claims 5
229960004365 benzoic acid Drugs 0.000 claims 5
235000019421 lipase Nutrition 0.000 claims 5
229960005323 phenoxyethanol Drugs 0.000 claims 5
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
235000010445 lecithin Nutrition 0.000 claims 2
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims 2
235000010356 sorbitol Nutrition 0.000 claims 2
239000000600 sorbitol Substances 0.000 claims 2
229960001716 benzalkonium Drugs 0.000 claims 1
239000013543 active substance Substances 0.000 description 9
230000000694 effects Effects 0.000 description 8
150000001875 compounds Chemical class 0.000 description 6
210000003097 mucus Anatomy 0.000 description 6
230000015572 biosynthetic process Effects 0.000 description 4
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
238000001035 drying Methods 0.000 description 3
229940117927 ethylene oxide Drugs 0.000 description 3
239000010642 eucalyptus oil Substances 0.000 description 3
210000004379 membrane Anatomy 0.000 description 3
239000012528 membrane Substances 0.000 description 3
GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
241000282414 Homo sapiens Species 0.000 description 2
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
239000004902 Softening Agent Substances 0.000 description 2
DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 2
239000003708 ampul Substances 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
230000000844 anti-bacterial effect Effects 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
229940044949 eucalyptus oil Drugs 0.000 description 2
150000002191 fatty alcohols Chemical class 0.000 description 2
230000001408 fungistatic effect Effects 0.000 description 2
230000007794 irritation Effects 0.000 description 2
230000000813 microbial effect Effects 0.000 description 2
229920000136 polysorbate Polymers 0.000 description 2
229940068968 polysorbate 80 Drugs 0.000 description 2
230000029058 respiratory gaseous exchange Effects 0.000 description 2
150000005846 sugar alcohols Polymers 0.000 description 2
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 1
JVSWJIKNEAIKJW-UHFFFAOYSA-N 2-Methylheptane Chemical compound CCCCCC(C)C JVSWJIKNEAIKJW-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
241001006782 Amage Species 0.000 description 1
GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
DUFKCOQISQKSAV-UHFFFAOYSA-N Polypropylene glycol (m w 1,200-3,000) Chemical compound CC(O)COC(C)CO DUFKCOQISQKSAV-UHFFFAOYSA-N 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
230000002411 adverse Effects 0.000 description 1
229940008126 aerosol Drugs 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
150000001409 amidines Chemical group 0.000 description 1
150000001412 amines Chemical group 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
230000001387 anti-histamine Effects 0.000 description 1
229940125715 antihistaminic agent Drugs 0.000 description 1
239000000739 antihistaminic agent Substances 0.000 description 1
229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
229940064004 antiseptic throat preparations Drugs 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
210000004081 cilia Anatomy 0.000 description 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
230000007423 decrease Effects 0.000 description 1
229940079919 digestives enzyme preparation Drugs 0.000 description 1
GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
238000009472 formulation Methods 0.000 description 1
238000009499 grossing Methods 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000011835 investigation Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000033001 locomotion Effects 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
YAHRDLICUYEDAU-UHFFFAOYSA-N methylhexaneamine Chemical compound CCC(C)CC(C)N YAHRDLICUYEDAU-UHFFFAOYSA-N 0.000 description 1
229950000752 methylhexaneamine Drugs 0.000 description 1
230000001473 noxious effect Effects 0.000 description 1
125000006353 oxyethylene group Chemical group 0.000 description 1
229940055726 pantothenic acid Drugs 0.000 description 1
235000019161 pantothenic acid Nutrition 0.000 description 1
239000011713 pantothenic acid Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
229950008882 polysorbate Drugs 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
230000001172 regenerating effect Effects 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
VSRBKQFNFZQRBM-UHFFFAOYSA-N tuaminoheptane Chemical compound CCCCCC(C)N VSRBKQFNFZQRBM-UHFFFAOYSA-N 0.000 description 1
230000002227 vasoactive effect Effects 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1

Landscapes

Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA000429349A 1983-05-31 1983-05-31 Produit et methode pour vaincre le ronflement du dormeur Expired CA1216232A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000429349A CA1216232A (fr)	1983-05-31	1983-05-31	Produit et methode pour vaincre le ronflement du dormeur

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000429349A CA1216232A (fr)	1983-05-31	1983-05-31	Produit et methode pour vaincre le ronflement du dormeur

Publications (1)

Publication Number	Publication Date
CA1216232A true CA1216232A (fr)	1987-01-06

Family

ID=4125370

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000429349A Expired CA1216232A (fr)	1983-05-31	1983-05-31	Produit et methode pour vaincre le ronflement du dormeur

Country Status (1)

Country	Link
CA (1)	CA1216232A (fr)

1983
- 1983-05-31 CA CA000429349A patent/CA1216232A/fr not_active Expired

Legal Events

Date	Code	Title	Description
2004-01-06	MKEX	Expiry

Publication	Publication Date	Title
US4556557A (en)	1985-12-03	Method and composition for combating snoring, and the use of surface active substances for the preparation of said composition
US5897858A (en)	1999-04-27	Nasal spray compositions exhibiting increased retention in the nasal cavity
US6673835B1 (en)	2004-01-06	Method and composition for delivering zinc to the nasal membrane
CN103096908B (zh)	2017-03-15	喷鼻剂
DE3874798T2 (de)	1993-04-15	Therapeutisches proteinagens in form von aerosol.
US4876283A (en)	1989-10-24	Antisnoring agent
NO891379D0 (no)	1989-03-31	Anestetisk hudfuktingspreparat og fremgangsmaate for fremstilling derav.
CA2039055A1 (fr)	1991-09-28	Traitement de la sinusite
DE69429964D1 (de)	2002-04-04	Feste, therapeutische oder hygienische, mucoadhäsive Zusammensetzung zur Verabreichung durch Auftragen auf der Mund-schleimhaut oder der Nasen-schleimhaut
CA1223210A (fr)	1987-06-23	Agent contre le ronflement
WO2004024122A1 (fr)	2004-03-25	Composition et procede d'hydratation du tissu nasal
US4892877A (en)	1990-01-09	Antitussive liquid compositions containing phenol
DE3601923A1 (de)	1987-07-30	Nasal applizierbares arzneimittel, verfahren zu seiner herstellung und seine verwendung
CA1216232A (fr)	1987-01-06	Produit et methode pour vaincre le ronflement du dormeur
DE3610997A1 (de)	1987-10-15	Ambroxol-nasenspray
US5925625A (en)	1999-07-20	Pharmaceutical composition for the intranasal administration of hydroxocobalamin
KR900701278A (ko)	1990-12-01	바이러스 감염 치료용 담즙산
JPH0253728A (ja)	1990-02-22	いびき防止剤
JPH10130148A (ja)	1998-05-19	ネブライザー用組成物
JP2004075571A (ja)	2004-03-11	点鼻剤およびその製造方法
EP0666078A2 (fr)	1995-08-09	Compositions pulvérisables pour l'administration par voie nasale
DE4226217A1 (de)	1994-02-10	Verwendung von Zubereitungen zur Bekämpfung der trockenen Nase und Mittel hierfür
DE3917109A1 (de)	1990-12-06	Mittel zur bekaempfung des schnarchens