CA1218948A - Purification of monoclonal antibodies - Google Patents

Purification of monoclonal antibodies

Info

Publication number
CA1218948A
CA1218948A CA000479140A CA479140A CA1218948A CA 1218948 A CA1218948 A CA 1218948A CA 000479140 A CA000479140 A CA 000479140A CA 479140 A CA479140 A CA 479140A CA 1218948 A CA1218948 A CA 1218948A
Authority
CA
Canada
Prior art keywords
monoclonal antibody
sample
silica gel
ascites fluid
mouse ascites
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000479140A
Other languages
English (en)
French (fr)
Inventor
Michael Flashner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avantor Performance Materials LLC
Original Assignee
JT Baker Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JT Baker Chemical Co filed Critical JT Baker Chemical Co
Application granted granted Critical
Publication of CA1218948A publication Critical patent/CA1218948A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/806—Drug, bio-affecting and body treating compositions involving IgM
    • Y10S424/807—Monoclonal
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM
    • Y10S530/864—Monoclonal

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CA000479140A 1984-05-23 1985-04-15 Purification of monoclonal antibodies Expired CA1218948A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/613,248 US4604235A (en) 1984-05-23 1984-05-23 Purification of monoclonal antibodies
US613,248 1984-05-23

Publications (1)

Publication Number Publication Date
CA1218948A true CA1218948A (en) 1987-03-10

Family

ID=24456492

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000479140A Expired CA1218948A (en) 1984-05-23 1985-04-15 Purification of monoclonal antibodies

Country Status (11)

Country Link
US (1) US4604235A (2)
EP (1) EP0162462B1 (2)
JP (1) JPS60260593A (2)
KR (1) KR870001434B1 (2)
AT (1) ATE48615T1 (2)
AU (1) AU576713B2 (2)
CA (1) CA1218948A (2)
DE (1) DE3574709D1 (2)
IL (1) IL75006A (2)
NZ (1) NZ211813A (2)
ZA (1) ZA852803B (2)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2571745B1 (fr) * 1984-10-17 1988-10-28 Trest Juzhvodoprovod Anticorrosif pour proteger la surface interne d'une canalisation contre la corrosion, procede d'obtention de cet anticorrosif et procede de protection de la surface interne d'une canalisation contre la corrosion utilisant cet anticorrosif
US4606825A (en) * 1985-04-22 1986-08-19 J. T. Baker Chemical Company Purification of immunoglobulin G
JPS6419024A (en) * 1987-07-15 1989-01-23 Tosoh Corp Separation of immunoglobulin g subclass
JPH01503808A (ja) * 1987-07-16 1989-12-21 イー・アイ・デユポン・ド・ネモアース・アンド・コンパニー（インコーポレイテツド） 固定化された凝集剤を用いるアフイニテイ分離
US5157113A (en) * 1987-08-10 1992-10-20 Miles Inc. Removal of nucleic acids from monoclonal antibody preparations
DE3875852T2 (de) * 1987-08-10 1993-03-18 Miles Inc Gereinigtes igm.
IL90281A (en) * 1988-06-06 1994-10-07 Miles Inc Preparations containing MGI antibodies
DE3825429C2 (de) * 1988-07-27 1994-02-10 Biotest Pharma Gmbh Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt
US5126250A (en) * 1988-09-28 1992-06-30 Eli Lilly And Company Method for the reduction of heterogeneity of monoclonal antibodies
US5759864A (en) * 1995-06-23 1998-06-02 Cedars Sinai Medical Center Methods for reducing background binding in antibody preparations
JP4728140B2 (ja) * 2005-02-21 2011-07-20 国立大学法人九州大学 タンパク質の固定化方法
KR100795945B1 (ko) * 2005-08-24 2008-01-21 가부시키가이샤 엔.티.티.도코모 송신 전력 제어 방법 및 무선 네트워크 제어국
US8580935B2 (en) 2007-02-26 2013-11-12 Alltech Associates, Inc. Ultra-fast chromatography

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196265A (en) * 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
CA1142466A (en) * 1979-01-09 1983-03-08 National Research Development Corporation Cell lines
US4381295A (en) * 1979-04-26 1983-04-26 Ortho Pharmaceutical Corporation Monoclonal antibody to human helper T cells and methods of preparing same
US4271145A (en) * 1979-10-22 1981-06-02 The Massachusetts General Hospital Process for producing antibodies to hepatitis virus and cell lines therefor
US4361550A (en) * 1979-12-04 1982-11-30 Ortho Pharmaceutical Corporation Complement-fixing monoclonal antibody to human suppressor T cells and methods of preparing same
US4423147A (en) * 1980-04-11 1983-12-27 Secher David S Monoclonal antibody to interferon-α
US4427653A (en) * 1981-01-26 1984-01-24 President And Fellows Of Harvard College Method of making monoclonal antibodies
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
JPS5929622A (ja) * 1982-08-10 1984-02-16 Meiji Seika Kaisha Ltd モノクロ−ナル抗体、その製造法およびその用途
US4469630A (en) * 1983-11-25 1984-09-04 J. T. Baker Chemical Co. Purification of monoclonal antibodies

Also Published As

Publication number Publication date
AU576713B2 (en) 1988-09-01
IL75006A (en) 1989-09-28
EP0162462A2 (en) 1985-11-27
JPH0144315B2 (2) 1989-09-27
DE3574709D1 (de) 1990-01-18
NZ211813A (en) 1988-08-30
ATE48615T1 (de) 1989-12-15
KR850008099A (ko) 1985-12-13
IL75006A0 (en) 1985-08-30
ZA852803B (en) 1986-02-26
US4604235A (en) 1986-08-05
AU4144685A (en) 1985-11-28
JPS60260593A (ja) 1985-12-23
KR870001434B1 (ko) 1987-08-06
EP0162462A3 (en) 1987-05-13
EP0162462B1 (en) 1989-12-13

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Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 20050415