CA1223209A - Comprimes en forme de capsule - Google Patents

Comprimes en forme de capsule

Info

Publication number: CA1223209A
Authority: CA; Canada
Prior art keywords: article; tablet; manufacture according; film forming; pharmaceutically active
Prior art date: 1983-04-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000451433A

Other languages

English (en)

Inventor

Thomas M. Tencza

Mahesh Patell

F. Henry Merkle

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Co

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-07

Filing date

1984-04-06

Publication date

1987-06-23

1984-04-06 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1987-06-23 Application granted granted Critical

1987-06-23 Publication of CA1223209A publication Critical patent/CA1223209A/fr

Status Expired legal-status Critical Current

Links

239000002775 capsule Substances 0.000 title claims abstract description 43
238000000576 coating method Methods 0.000 claims abstract description 30
239000011248 coating agent Substances 0.000 claims abstract description 29
229920000642 polymer Polymers 0.000 claims abstract description 20
239000004480 active ingredient Substances 0.000 claims abstract description 17
239000007903 gelatin capsule Substances 0.000 claims abstract description 11
239000002552 dosage form Substances 0.000 claims abstract description 8
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 28
239000000203 mixture Substances 0.000 claims description 28
238000004519 manufacturing process Methods 0.000 claims description 23
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 18
229960001138 acetylsalicylic acid Drugs 0.000 claims description 14
229960005489 paracetamol Drugs 0.000 claims description 14
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 9
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 8
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 8
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 7
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 7
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 5
229920000609 methyl cellulose Polymers 0.000 claims description 5
239000001923 methylcellulose Substances 0.000 claims description 5
235000010981 methylcellulose Nutrition 0.000 claims description 5
229960002900 methylcellulose Drugs 0.000 claims description 5
239000001856 Ethyl cellulose Substances 0.000 claims description 4
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims description 4
229960001948 caffeine Drugs 0.000 claims description 4
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims description 4
229920001249 ethyl cellulose Polymers 0.000 claims description 4
235000019325 ethyl cellulose Nutrition 0.000 claims description 4
229960004667 ethyl cellulose Drugs 0.000 claims description 3
DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 claims description 3
229960000395 phenylpropanolamine Drugs 0.000 claims description 3
239000011782 vitamin Substances 0.000 claims description 3
229940088594 vitamin Drugs 0.000 claims description 3
229930003231 vitamin Natural products 0.000 claims description 3
235000013343 vitamin Nutrition 0.000 claims description 3
MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 claims description 2
SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical compound NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 claims description 2
229920002301 cellulose acetate Polymers 0.000 claims description 2
229960001985 dextromethorphan Drugs 0.000 claims description 2
229960000581 salicylamide Drugs 0.000 claims description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 claims 2
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
229940046978 chlorpheniramine maleate Drugs 0.000 claims 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
JXYWFNAQESKDNC-BTJKTKAUSA-N (z)-4-hydroxy-4-oxobut-2-enoate;2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl-dimethylazanium Chemical compound OC(=O)\C=C/C(O)=O.C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 JXYWFNAQESKDNC-BTJKTKAUSA-N 0.000 claims 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
230000000202 analgesic effect Effects 0.000 claims 1
239000006172 buffering agent Substances 0.000 claims 1
DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 claims 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
229960001802 phenylephrine Drugs 0.000 claims 1
SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims 1
229940018203 pyrilamine maleate Drugs 0.000 claims 1
150000003722 vitamin derivatives Chemical class 0.000 claims 1
239000003826 tablet Substances 0.000 description 82
239000007888 film coating Substances 0.000 description 15
238000009501 film coating Methods 0.000 description 15
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
238000000034 method Methods 0.000 description 12
239000004615 ingredient Substances 0.000 description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
238000005469 granulation Methods 0.000 description 8
230000003179 granulation Effects 0.000 description 8
239000000843 powder Substances 0.000 description 8
239000008187 granular material Substances 0.000 description 6
239000002904 solvent Substances 0.000 description 6
239000007921 spray Substances 0.000 description 6
238000001035 drying Methods 0.000 description 5
239000000463 material Substances 0.000 description 5
239000002480 mineral oil Substances 0.000 description 5
235000010446 mineral oil Nutrition 0.000 description 5
WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 4
241000282320 Panthera leo Species 0.000 description 4
229920002472 Starch Polymers 0.000 description 4
239000008107 starch Substances 0.000 description 4
235000019698 starch Nutrition 0.000 description 4
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
244000147568 Laurus nobilis Species 0.000 description 3
235000017858 Laurus nobilis Nutrition 0.000 description 3
235000005212 Terminalia tomentosa Nutrition 0.000 description 3
240000008042 Zea mays Species 0.000 description 3
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
235000002017 Zea mays subsp mays Nutrition 0.000 description 3
238000007906 compression Methods 0.000 description 3
235000005822 corn Nutrition 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000003814 drug Substances 0.000 description 3
-1 gastric protestants Substances 0.000 description 3
239000011734 sodium Substances 0.000 description 3
229910052708 sodium Inorganic materials 0.000 description 3
239000000725 suspension Substances 0.000 description 3
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
239000003125 aqueous solvent Substances 0.000 description 2
239000000872 buffer Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
239000008199 coating composition Substances 0.000 description 2
230000006835 compression Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
239000000820 nonprescription drug Substances 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
229940127557 pharmaceutical product Drugs 0.000 description 2
239000004014 plasticizer Substances 0.000 description 2
238000005498 polishing Methods 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000007787 solid Substances 0.000 description 2
229920002261 Corn starch Polymers 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
229920003134 Eudragit® polymer Polymers 0.000 description 1
208000010201 Exanthema Diseases 0.000 description 1
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
241000985630 Lota lota Species 0.000 description 1
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
WUGQZFFCHPXWKQ-UHFFFAOYSA-N Propanolamine Chemical compound NCCCO WUGQZFFCHPXWKQ-UHFFFAOYSA-N 0.000 description 1
229910000831 Steel Inorganic materials 0.000 description 1
NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000011149 active material Substances 0.000 description 1
239000008186 active pharmaceutical agent Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
229940035676 analgesics Drugs 0.000 description 1
230000000954 anitussive effect Effects 0.000 description 1
229940069428 antacid Drugs 0.000 description 1
239000003159 antacid agent Substances 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000002921 anti-spasmodic effect Effects 0.000 description 1
239000003173 antianemic agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000002518 antifoaming agent Substances 0.000 description 1
229940125715 antihistaminic agent Drugs 0.000 description 1
239000000739 antihistaminic agent Substances 0.000 description 1
239000003434 antitussive agent Substances 0.000 description 1
229940124584 antitussives Drugs 0.000 description 1
239000002830 appetite depressant Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229940124630 bronchodilator Drugs 0.000 description 1
239000000168 bronchodilator agent Substances 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000004203 carnauba wax Substances 0.000 description 1
235000013869 carnauba wax Nutrition 0.000 description 1
239000004359 castor oil Substances 0.000 description 1
235000019438 castor oil Nutrition 0.000 description 1
SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 description 1
229960003291 chlorphenamine Drugs 0.000 description 1
239000000812 cholinergic antagonist Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
238000005056 compaction Methods 0.000 description 1
239000007891 compressed tablet Substances 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
239000000850 decongestant Substances 0.000 description 1
229940124581 decongestants Drugs 0.000 description 1
238000007907 direct compression Methods 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
238000007908 dry granulation Methods 0.000 description 1
239000000428 dust Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
201000005884 exanthem Diseases 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000007941 film coated tablet Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
239000012530 fluid Substances 0.000 description 1
239000006260 foam Substances 0.000 description 1
238000005187 foaming Methods 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
239000003979 granulating agent Substances 0.000 description 1
239000008141 laxative Substances 0.000 description 1
229940125722 laxative agent Drugs 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 description 1
229960000582 mepyramine Drugs 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000012254 powdered material Substances 0.000 description 1
206010037844 rash Diseases 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000010959 steel Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1

Landscapes

Medicinal Preparation (AREA)

CA000451433A 1983-04-07 1984-04-06 Comprimes en forme de capsule Expired CA1223209A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US48305183A	1983-04-07	1983-04-07
US483,051		1983-04-07

Publications (1)

Publication Number	Publication Date
CA1223209A true CA1223209A (fr)	1987-06-23

Family

ID=23918450

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000451433A Expired CA1223209A (fr)	1983-04-07	1984-04-06	Comprimes en forme de capsule

Country Status (1)

Country	Link
CA (1)	CA1223209A (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5089270A (en) *	1990-05-15	1992-02-18	L. Perrigo Company	Capsule-shaped tablet
US5198227A (en) *	1990-01-22	1993-03-30	Mcneil-Ppc, Inc.	Dual subcoated simulated capsule medicament
US5213738A (en) *	1990-05-15	1993-05-25	L. Perrigo Company	Method for making a capsule-shaped tablet
US5658589A (en) *	1989-04-28	1997-08-19	Mcneil-Ppc, Inc.	Subcoated simulated capsule-like medicament

1984
- 1984-04-06 CA CA000451433A patent/CA1223209A/fr not_active Expired

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5658589A (en) *	1989-04-28	1997-08-19	Mcneil-Ppc, Inc.	Subcoated simulated capsule-like medicament
US5770225A (en) *	1989-04-28	1998-06-23	Mcneil-Ppc, Inc.	Process of preparing a subcoated simulated capsule-like medicament
US5916592A (en) *	1989-04-28	1999-06-29	Mcneil-Ppc, Inc.	Subcoated simulated capsule-like medicament
US6120801A (en) *	1989-04-28	2000-09-19	Mcneil-Ppc, Inc.	Subcoated simulated capsule-like medicament
US6214380B1 (en)	1989-04-28	2001-04-10	Mcneil-Ppc, Inc.	Subcoated simulated capsule-like medicament
US6326026B1 (en)	1989-04-28	2001-12-04	Mcneil-Ppc, Inc.	Subcoated simulated capsule-like medicament
US7087242B2 (en)	1989-04-28	2006-08-08	Mcneil-Ppc, Inc.	Subcoated simulated capsule-like medicament
US5198227A (en) *	1990-01-22	1993-03-30	Mcneil-Ppc, Inc.	Dual subcoated simulated capsule medicament
US5296233A (en) *	1990-01-22	1994-03-22	Mcneil-Ppc, Inc.	Dual subcoated simulated capsule-like medicament
US5089270A (en) *	1990-05-15	1992-02-18	L. Perrigo Company	Capsule-shaped tablet
US5213738A (en) *	1990-05-15	1993-05-25	L. Perrigo Company	Method for making a capsule-shaped tablet

Legal Events

Date	Code	Title	Description
2004-06-23	MKEX	Expiry

Publication	Publication Date	Title
US4851230A (en)	1989-07-25	Capsule shaped tablets
AU700949B2 (en)	1999-01-14	New beads for controlled release and a pharmaceutical preparation containing the same
US6126969A (en)	2000-10-03	Immediate release/sustained release compressed tablets
US4684516A (en)	1987-08-04	Sustained release tablets and method of making same
AU704524B2 (en)	1999-04-29	Controlled-release formulations coated with aqueous dispersions of ethylcellulose
CA1247009A (fr)	1988-12-20	Forme posologique a unites multiples a enrobage diffusible dans l'eau
US3074852A (en)	1963-01-22	Pharmaceuticals with delayed release
US5009897A (en)	1991-04-23	Pharmaceutical granules and tablets made therefrom
US5126145A (en)	1992-06-30	Controlled release tablet containing water soluble medicament
US4900557A (en)	1990-02-13	Pellet formulation
CA1209474A (fr)	1986-08-12	Capsule d'analgesique
US5186943A (en)	1993-02-16	Compressed-molded preparations
US20030215504A1 (en)	2003-11-20	Directly compressible acetaminophen compositions
US3148124A (en)	1964-09-08	Method of preparing sustained release pharmaceutical tablets
WO2008140459A1 (fr)	2008-11-20	Forme solide
MXPA97001465A (en)	1998-04-01	Formulation of acetaminofeno, liberacion sosten
MXPA03009588A (es)	2004-12-06	Un recubrimiento novedoso para una composicion farmaceutica de liberacion sostenida.
DK158562B (da)	1990-06-11	Diffusionsovertrukket polydepotpraeparat og fremgangsmaade til fremstilling deraf
CN101969930A (zh)	2011-02-09	防滥用控制释放制剂
US4025613A (en)	1977-05-24	Timed-release aspirin
CA2328154A1 (fr)	1999-10-28	Comprimes a liberation prolongee a unites multiples
CA2435714C (fr)	2011-02-22	Comprimes de fenofibrate
CA2101697C (fr)	2004-02-10	Comprime de chlorure de potassium a relargage controle
MXPA06010775A (es)	2006-12-15	Formulaciones de tableta recubierta y metodo.
IE63242B1 (en)	1995-04-05	Pharmaceutical granules and tablets made therefrom