CA1231052A - Vehicule utilisable dans les preparations medicinales - Google Patents

Vehicule utilisable dans les preparations medicinales

Info

Publication number: CA1231052A
Authority: CA; Canada
Prior art keywords: base formulation; weight; present; base; consisting essentially
Prior art date: 1984-07-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000460030A

Other languages

English (en)

Inventor

Subhan Lakhani

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Taro Pharmaceuticals Inc

Original Assignee

Taro Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-30

Filing date

1984-07-30

Publication date

1988-01-05

1984-07-30 Application filed by Taro Pharmaceuticals Inc filed Critical Taro Pharmaceuticals Inc

1984-07-30 Priority to CA000460030A priority Critical patent/CA1231052A/fr

1988-01-05 Application granted granted Critical

1988-01-05 Publication of CA1231052A publication Critical patent/CA1231052A/fr

Status Expired legal-status Critical Current

Links

238000002360 preparation method Methods 0.000 title abstract description 5
239000000203 mixture Substances 0.000 claims description 96
238000009472 formulation Methods 0.000 claims description 86
PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 42
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 31
235000011187 glycerol Nutrition 0.000 claims description 18
239000004014 plasticizer Substances 0.000 claims description 16
239000007822 coupling agent Substances 0.000 claims description 15
230000002378 acidificating effect Effects 0.000 claims description 14
150000002191 fatty alcohols Chemical class 0.000 claims description 14
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 14
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
ZWVMLYRJXORSEP-UHFFFAOYSA-N 1,2,6-Hexanetriol Chemical compound OCCCCC(O)CO ZWVMLYRJXORSEP-UHFFFAOYSA-N 0.000 claims description 10
239000002202 Polyethylene glycol Substances 0.000 claims description 6
125000004432 carbon atom Chemical group C* 0.000 claims description 6
229920001223 polyethylene glycol Polymers 0.000 claims description 6
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
239000000600 sorbitol Substances 0.000 claims description 5
229920006395 saturated elastomer Polymers 0.000 claims description 3
NJTGANWAUPEOAX-UHFFFAOYSA-N molport-023-220-454 Chemical compound OCC(O)CO.OCC(O)CO NJTGANWAUPEOAX-UHFFFAOYSA-N 0.000 claims 4
150000003431 steroids Chemical class 0.000 abstract description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
239000003814 drug Substances 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 5
239000002674 ointment Substances 0.000 description 5
229940093429 polyethylene glycol 6000 Drugs 0.000 description 5
239000002253 acid Substances 0.000 description 4
239000006071 cream Substances 0.000 description 4
229940079593 drug Drugs 0.000 description 3
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 3
208000002193 Pain Diseases 0.000 description 2
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 2
239000002904 solvent Substances 0.000 description 2
229960005294 triamcinolone Drugs 0.000 description 2
241000228245 Aspergillus niger Species 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
241000588722 Escherichia Species 0.000 description 1
WJOHZNCJWYWUJD-IUGZLZTKSA-N Fluocinonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)C)[C@@]2(C)C[C@@H]1O WJOHZNCJWYWUJD-IUGZLZTKSA-N 0.000 description 1
235000017858 Laurus nobilis Nutrition 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
239000004264 Petrolatum Substances 0.000 description 1
241000589517 Pseudomonas aeruginosa Species 0.000 description 1
241000191940 Staphylococcus Species 0.000 description 1
235000005212 Terminalia tomentosa Nutrition 0.000 description 1
244000125380 Terminalia tomentosa Species 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 description 1
229960000541 cetyl alcohol Drugs 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000000470 constituent Substances 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
230000000694 effects Effects 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
229940043075 fluocinolone Drugs 0.000 description 1
FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 1
229960000785 fluocinonide Drugs 0.000 description 1
239000008309 hydrophilic cream Substances 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000006210 lotion Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
230000035515 penetration Effects 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
238000000926 separation method Methods 0.000 description 1
230000036556 skin irritation Effects 0.000 description 1
229940100611 topical cream Drugs 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)

CA000460030A 1984-07-30 1984-07-30 Vehicule utilisable dans les preparations medicinales Expired CA1231052A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000460030A CA1231052A (fr)	1984-07-30	1984-07-30	Vehicule utilisable dans les preparations medicinales

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000460030A CA1231052A (fr)	1984-07-30	1984-07-30	Vehicule utilisable dans les preparations medicinales

Publications (1)

Publication Number	Publication Date
CA1231052A true CA1231052A (fr)	1988-01-05

Family

ID=4128428

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000460030A Expired CA1231052A (fr)	1984-07-30	1984-07-30	Vehicule utilisable dans les preparations medicinales

Country Status (1)

Country	Link
CA (1)	CA1231052A (fr)

1984
- 1984-07-30 CA CA000460030A patent/CA1231052A/fr not_active Expired

Legal Events

Date	Code	Title	Description
2005-01-05	MKEX	Expiry

Publication	Publication Date	Title
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