CA1248537A - Tetralines 2-amino substituees et procede de synthese - Google Patents

Tetralines 2-amino substituees et procede de synthese

Info

Publication number: CA1248537A
Authority: CA; Canada
Prior art keywords: compound; formula; group; pharmaceutically acceptable; pyridyl
Prior art date: 1984-05-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000454789A

Other languages

English (en)

Inventor

Alan S. Horn

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nelson Research and Development Co

Original Assignee

Nelson Research and Development Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-22

Filing date

1984-05-22

Publication date

1989-01-10

1984-05-22 Application filed by Nelson Research and Development Co filed Critical Nelson Research and Development Co

1984-05-22 Priority to CA000454789A priority Critical patent/CA1248537A/fr

1989-01-10 Application granted granted Critical

1989-01-10 Publication of CA1248537A publication Critical patent/CA1248537A/fr

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 34
230000008569 process Effects 0.000 title claims abstract description 17
230000015572 biosynthetic process Effects 0.000 title abstract description 5
238000003786 synthesis reaction Methods 0.000 title abstract description 4
LCGFVWKNXLRFIF-UHFFFAOYSA-N 1,2,3,4-tetrahydronaphthalen-2-amine Chemical class C1=CC=C2CC(N)CCC2=C1 LCGFVWKNXLRFIF-UHFFFAOYSA-N 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims abstract description 55
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 13
125000000217 alkyl group Chemical group 0.000 claims abstract description 8
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims abstract description 7
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims abstract description 7
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 7
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239000000203 mixture Substances 0.000 claims description 26
150000003839 salts Chemical class 0.000 claims description 17
-1 n-propylaminotetralin compound Chemical class 0.000 claims description 13
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239000004480 active ingredient Substances 0.000 claims description 9
150000003512 tertiary amines Chemical class 0.000 claims description 9
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239000011976 maleic acid Substances 0.000 description 1
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QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
230000020477 pH reduction Effects 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
150000007519 polyprotic acids Polymers 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000004044 response Effects 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910001467 sodium calcium phosphate Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
239000008096 xylene Substances 0.000 description 1

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Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA000454789A 1984-05-22 1984-05-22 Tetralines 2-amino substituees et procede de synthese Expired CA1248537A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000454789A CA1248537A (fr)	1984-05-22	1984-05-22	Tetralines 2-amino substituees et procede de synthese

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000454789A CA1248537A (fr)	1984-05-22	1984-05-22	Tetralines 2-amino substituees et procede de synthese

Publications (1)

Publication Number	Publication Date
CA1248537A true CA1248537A (fr)	1989-01-10

Family

ID=4127907

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000454789A Expired CA1248537A (fr)	1984-05-22	1984-05-22	Tetralines 2-amino substituees et procede de synthese

Country Status (1)

Country	Link
CA (1)	CA1248537A (fr)

1984
- 1984-05-22 CA CA000454789A patent/CA1248537A/fr not_active Expired

Legal Events

Date	Code	Title	Description
2006-01-10	MKEX	Expiry

Publication	Publication Date	Title
US4564628A (en)	1986-01-14	Substituted 2-aminotetralins
EP0168505B1 (fr)	1989-08-09	2-Aminotétralines substituées et procédé de synthèse
DK172103B1 (da)	1997-10-27	Hidtil ukendte 3,3-difenylpropylaminer, farmaceutiske præparater indeholdende disse, deres anvendelse til fremstilling af et anticholinergt lægemiddel samt fremgangsmåde til deres fremstilling
JP2002518385A (ja)	2002-06-25	フェノキシプロパノールアミン類、それらの製法及びそれらを含有する医薬組成物
US6172099B1 (en)	2001-01-09	Tricyclic compounds having saturated rings and medicinal compositions containing the same
CA2222658A1 (fr)	1991-06-30	Intermediaires pour la preparation de nouvelles phenylethanolaminomethyltetralines
US5070106A (en)	1991-12-03	Compounds active on the cardiovascular system
PL173659B1 (pl)	1998-04-30	Sposób wytwarzania nowych pochodnych piperydyny
HU185975B (en)	1985-04-28	Process forproducing new, benzoaxazolinone derivatives substituted with an aminoalkohol- or aminoketone chain at the 6 position and pharmaceutically acceptable salts thereof
IE59651B1 (en)	1994-03-09	Fused benzazepines
CA2601126A1 (fr)	2006-10-05	Derives substitues d'aminoalkyl- et amidoalkyl-benzopyran
CA1248537A (fr)	1989-01-10	Tetralines 2-amino substituees et procede de synthese
EP0699198B1 (fr)	1999-06-30	Derives de paroxetine a substitution n-benzoylmethyle
US6696489B1 (en)	2004-02-24	2-Methylpropionic acid derivatives and medicinal compositions containing the same
US20030096811A1 (en)	2003-05-22	Aminomethyl-phenyl-cyclohexanone derivatives
GB2123410A (en)	1984-02-01	New derivatives of 1,2,3,4-tetrahydronaphthalene, process for their preparation and associated pharmaceutical compositions
JPH058196B2 (fr)	1993-02-01
WO1998043964A1 (fr)	1998-10-08	Derives de 2-[(3-substitue)-5-isoxazolylmethylamino]alkanamide
IE57491B1 (en)	1993-03-10	Substituted 2-aminotetralins and processes for synthesis
IE902313A1 (en)	1991-01-16	2-amino-1,2,3,4-tetrahydronaphthalene derivatives with¹cardiovascular activity, process for their preparation and¹pharmaceutical compositions containing them
JP2003522814A (ja)	2003-07-29	アミノアルコール誘導体
EP2963028B1 (fr)	2018-08-01	Dérivés de pipérazine et leur utilisation pharmaceutique
WO1990004583A1 (fr)	1990-05-03	Antagonistes de recepteurs de muscarine
JP2772650B2 (ja)	1998-07-02	新規化合物およびその医薬的用途
FR2833010A1 (fr)	2003-06-06	Propanolaminomethyltetralines, leur preparation et compositions pharmaceutiques les contenant