CA1248700A - Antagonistes de la gnrh - Google Patents

Antagonistes de la gnrh

Info

Publication number: CA1248700A
Authority: CA; Canada
Prior art keywords: trp; group; peptide; tyr; des
Prior art date: 1982-12-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000442638A

Other languages

English (en)

Inventor

Wylie W. Vale, Jr.

Jean E.F. Rivier

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Salk Institute for Biological Studies

Original Assignee

Salk Institute for Biological Studies

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-12-06

Filing date

1983-12-06

Publication date

1989-01-10

1983-12-06 Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies

1989-01-10 Application granted granted Critical

1989-01-10 Publication of CA1248700A publication Critical patent/CA1248700A/fr

Status Expired legal-status Critical Current

Links

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GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 description 1
108010004977 Vasopressins Proteins 0.000 description 1
102000002852 Vasopressins Human genes 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
229940022663 acetate Drugs 0.000 description 1
125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 1
125000005076 adamantyloxycarbonyl group Chemical group C12(CC3CC(CC(C1)C3)C2)OC(=O)* 0.000 description 1
229940072056 alginate Drugs 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
150000003973 alkyl amines Chemical class 0.000 description 1
ZGUNAGUHMKGQNY-UHFFFAOYSA-N alpha-phenylglycine Chemical compound OC(=O)C(N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
125000003368 amide group Chemical group 0.000 description 1
238000007098 aminolysis reaction Methods 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
150000003931 anilides Chemical group 0.000 description 1
125000000748 anthracen-2-yl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C([H])=C([*])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
229940072107 ascorbate Drugs 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
229910052788 barium Inorganic materials 0.000 description 1
DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
229940050390 benzoate Drugs 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
230000008827 biological function Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
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210000003169 central nervous system Anatomy 0.000 description 1
JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
229960004630 chlorambucil Drugs 0.000 description 1
125000002668 chloroacetyl group Chemical group ClCC(=O)* 0.000 description 1
229940001468 citrate Drugs 0.000 description 1
150000004696 coordination complex Chemical class 0.000 description 1
125000000753 cycloalkyl group Chemical group 0.000 description 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
WVIIMZNLDWSIRH-UHFFFAOYSA-N cyclohexylcyclohexane Chemical group C1CCCCC1C1CCCCC1 WVIIMZNLDWSIRH-UHFFFAOYSA-N 0.000 description 1
230000006378 damage Effects 0.000 description 1
125000003963 dichloro group Chemical group Cl* 0.000 description 1
125000006286 dichlorobenzyl group Chemical group 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000010828 elution Methods 0.000 description 1
125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
230000035558 fertility Effects 0.000 description 1
229940050411 fumarate Drugs 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
210000002816 gill Anatomy 0.000 description 1
229940050410 gluconate Drugs 0.000 description 1
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
210000002149 gonad Anatomy 0.000 description 1
XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
238000007327 hydrogenolysis reaction Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
229960000310 isoleucine Drugs 0.000 description 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
239000004571 lime Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229940049920 malate Drugs 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
210000004997 mammalian reproductive system Anatomy 0.000 description 1
230000035800 maturation Effects 0.000 description 1
238000006140 methanolysis reaction Methods 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
UBLQIESZTDNNAO-UHFFFAOYSA-N n,n-diethylethanamine;phosphoric acid Chemical compound [O-]P([O-])([O-])=O.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC UBLQIESZTDNNAO-UHFFFAOYSA-N 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
SHDMMLFAFLZUEV-UHFFFAOYSA-N n-methyl-1,1-diphenylmethanamine Chemical compound C=1C=CC=CC=1C(NC)C1=CC=CC=C1 SHDMMLFAFLZUEV-UHFFFAOYSA-N 0.000 description 1
210000000653 nervous system Anatomy 0.000 description 1
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
229960003104 ornithine Drugs 0.000 description 1
210000001672 ovary Anatomy 0.000 description 1
230000016087 ovulation Effects 0.000 description 1
229940039748 oxalate Drugs 0.000 description 1
XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 1
229960001723 oxytocin Drugs 0.000 description 1
238000004810 partition chromatography Methods 0.000 description 1
NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 description 1
125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
125000001557 phthalyl group Chemical group C(=O)(O)C1=C(C(=O)*)C=CC=C1 0.000 description 1
230000001817 pituitary effect Effects 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
229920005990 polystyrene resin Polymers 0.000 description 1
229940077150 progesterone and estrogen Drugs 0.000 description 1
125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
239000002516 radical scavenger Substances 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000003746 solid phase reaction Methods 0.000 description 1
239000002904 solvent Substances 0.000 description 1
210000003594 spinal ganglia Anatomy 0.000 description 1
125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
229940086735 succinate Drugs 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical compound C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
229960003726 vasopressin Drugs 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

CA000442638A 1982-12-06 1983-12-06 Antagonistes de la gnrh Expired CA1248700A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/447,091 US4410514A (en)	1982-12-06	1982-12-06	GnRH Agonists
US447,091		1982-12-06

Publications (1)

Publication Number	Publication Date
CA1248700A true CA1248700A (fr)	1989-01-10

Family

ID=23774968

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000442638A Expired CA1248700A (fr)	1982-12-06	1983-12-06	Antagonistes de la gnrh

Country Status (8)

Country	Link
US (1)	US4410514A (fr)
EP (1)	EP0131007B1 (fr)
JP (1)	JPS60500057A (fr)
CA (1)	CA1248700A (fr)
DE (1)	DE3381822D1 (fr)
IL (1)	IL70388A (fr)
PH (1)	PH19343A (fr)
WO (1)	WO1984002341A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU185535B (en) *	1982-05-25	1985-02-28	Mta Koezponti Hivatala	Process for preparing new gonadoliberin derivatives
US4410514A (en) *	1982-12-06	1983-10-18	The Salk Institute For Biological Studies	GnRH Agonists
HU187503B (en) *	1983-03-29	1986-01-28	Magyar Tudomanyos Akademia,Hu	Process for preparing gonadoliberine derivatives containing beta-aspartyl group
FR2551088B1 (fr) *	1983-08-29	1985-12-06	Pasteur Institut
GB8327966D0 (en) *	1983-10-19	1983-11-23	Nyegaard & Co As	Chemical compounds
US4530920A (en) *	1983-11-07	1985-07-23	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist
HU189394B (en) *	1983-12-23	1986-06-30	Koezponti Valto- Es Hitelbank Rt Innovacios Alap,Hu	Method for producing spermatozoa suitable for fertilization from mature fishes
IT1178775B (it) *	1983-12-23	1987-09-16	Konzponti Valto Es Hitelbank R	Derivati della gonadoliberina e procedimento per la loro preparazione
US4632979A (en) *	1984-06-18	1986-12-30	Tulane Educational Fund	Therapeutic LHRH analogs
HU193093B (en) *	1985-04-16	1987-08-28	Innofinance	Process for stimulating sexual activity of birds and domestic mammalians and process for producing spermatocytes for their propagation
HU193607B (en) *	1985-07-18	1987-11-30	Innofinance Altalanos Innovaci	Process for production of sexual products applyable for natural or artificial insemination for mammates
HU194280B (en) *	1985-10-22	1988-01-28	Richter Gedeon Vegyeszet	Process for producing new gonadoliberin analogues of high effectivity and pharmaceutical compositions containing them
US4705778A (en) *	1985-10-22	1987-11-10	Sri International	Orally active LHRH analogs
HU199694B (en) *	1988-05-10	1990-03-28	Innofinance Altalanos Innovaci	Process for producing citostatic pharmaceutical compositions containing gonadoliberin derivatives
IL87982A0 (en) *	1988-10-10	1989-03-31	Israel Oceanographic & Limnolo	Compositions and methods for manipulating ovulation and spawning in fish
US5166192A (en) *	1989-05-09	1992-11-24	Mathias John R	Treatment of motility disorders with a GnRH analog
US5068221A (en) *	1989-05-09	1991-11-26	Mathias John R	Treatment of motility disorders with a gnrh analog
CA2029018A1 (fr) *	1989-11-01	1991-05-02	Robert P. Millar	Analogues de l'hormone liberant de la gonadotrophine
US5434136A (en) *	1990-12-14	1995-07-18	Mathias; John R.	Treatment of motility disorders with a GNRH analog
GB9100468D0 (en) *	1991-01-09	1991-02-20	Proteus Molecular Design	Improvements in and relating to hormones
US5760000A (en) *	1994-05-13	1998-06-02	University Technologies International,Inc.	Inhibition of liver cancer by the use of GnRH and GnRH analogs
US5643877A (en)	1994-12-05	1997-07-01	University Of Maryland Biotechnology Institute	Compounds comprising gonadotropin releasing hormone (GnRH) and methods for controlling reproduction in fish
US6635739B2 (en) *	1999-10-15	2003-10-21	Theresa Siler-Khodr	Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
US6323179B1 (en) *	1999-10-15	2001-11-27	Theresa Siler-Khodr	Chicken GNRH analogs and uses thereof in regulation of fertility and pregnancy
WO2003016331A2 (fr) *	2001-08-17	2003-02-27	Siler-Khodr Theresa M	Analogues de gnrh non-mammaliens et leurs utilisations dans la regulation de la fertilite et de la gestation
US20050282745A1 (en) *	2001-08-28	2005-12-22	Siler-Khodr Theresa M	Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
US20040152639A1 (en) *	2001-08-28	2004-08-05	Siler-Khodr Theresa M.	Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
US6949365B2 (en) *	2002-06-12	2005-09-27	University Of New Hampshire	Polynucleotides encoding lamprey GnRH-III
US20050054576A1 (en) *	2003-08-12	2005-03-10	Siler-Khodr Theresa M.	Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
US7194978B2 (en) *	2003-08-22	2007-03-27	University Of Maryland Biotechnology Institute	Inducing sterility in fish by disrupting the development of the GnRH system

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7505590A (nl) *	1974-05-18	1975-11-20	Hoechst Ag	Werkwijze voor het bereiden van peptiden met lh-rh/fsh-rh-werking.
GB1532211A (en) *	1974-10-25	1978-11-15	Wellcome Found	Lh-rh peptide analogues
DE2649114A1 (de) *	1975-10-29	1977-05-12	Parke Davis & Co	Octapeptide
NL7611963A (nl) *	1975-10-29	1977-05-03	Parke Davis & Co	Werkwijze voor het bereiden van nieuwe nonapep- tiden.
DE2617646C2 (de) *	1976-04-22	1986-07-31	Hoechst Ag, 6230 Frankfurt	Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
US4244946A (en) *	1979-06-11	1981-01-13	The Salk Institute For Biological Studies	Water-soluble peptides affecting gonadal function
US4410514A (en) *	1982-12-06	1983-10-18	The Salk Institute For Biological Studies	GnRH Agonists
US4530920A (en) *	1983-11-07	1985-07-23	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist

1982
- 1982-12-06 US US06/447,091 patent/US4410514A/en not_active Expired - Lifetime
1983
- 1983-12-05 WO PCT/US1983/001925 patent/WO1984002341A1/fr not_active Ceased
- 1983-12-05 JP JP59500297A patent/JPS60500057A/ja active Pending
- 1983-12-05 DE DE8484900248T patent/DE3381822D1/de not_active Expired - Lifetime
- 1983-12-05 EP EP84900248A patent/EP0131007B1/fr not_active Expired
- 1983-12-06 IL IL70388A patent/IL70388A/xx not_active IP Right Cessation
- 1983-12-06 CA CA000442638A patent/CA1248700A/fr not_active Expired
- 1983-12-06 PH PH29936A patent/PH19343A/en unknown

Also Published As

Publication number	Publication date
EP0131007B1 (fr)	1990-08-16
US4410514A (en)	1983-10-18
DE3381822D1 (de)	1990-09-20
IL70388A (en)	1987-01-30
PH19343A (en)	1986-04-02
EP0131007A4 (fr)	1987-02-03
IL70388A0 (en)	1984-03-30
JPS60500057A (ja)	1985-01-17
EP0131007A1 (fr)	1985-01-16
WO1984002341A1 (fr)	1984-06-21

Legal Events

Date	Code	Title	Description
2006-01-10	MKEX	Expiry

Publication	Publication Date	Title
CA1248700A (fr)	1989-01-10	Antagonistes de la gnrh
US4341767A (en)	1982-07-27	Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
CA1339623C (fr)	1998-01-06	Antagoniste de la luberine
US4667014A (en)	1987-05-19	Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4234571A (en)	1980-11-18	Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
CA1339043C (fr)	1997-04-01	Analogues nonapeptidiques et decapeptidiques de lhrh, utiles comme antagonistes de lhrh
EP0097031B1 (fr)	1988-09-21	Analogues nonapeptidiques et décapeptidiques de LHRH ayant une activité LHRH-antagoniste, leurs préparations et compositions les contenant
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