CA1249110A - Tubes creux microporeux modifies par une charge - Google Patents

Tubes creux microporeux modifies par une charge

Info

Publication number: CA1249110A
Authority: CA; Canada
Prior art keywords: membrane; hollow fiber; modifying agent; charge modifying; charge
Prior art date: 1983-12-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000471039A

Other languages

English (en)

Inventor

Paul J. Marinaccio

Ronald V. Repetti

Joseph V. Fiore

Choakang Chu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

3M Purification Inc

Original Assignee

Cuno Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-12-29

Filing date

1984-12-27

Publication date

1989-01-24

1984-12-27 Application filed by Cuno Inc filed Critical Cuno Inc

1989-01-24 Application granted granted Critical

1989-01-24 Publication of CA1249110A publication Critical patent/CA1249110A/fr

Status Expired legal-status Critical Current

Links

239000012528 membrane Substances 0.000 claims abstract description 235
239000011148 porous material Substances 0.000 claims abstract description 38
239000007788 liquid Substances 0.000 claims abstract description 17
230000036619 pore blockages Effects 0.000 claims abstract description 9
238000005549 size reduction Methods 0.000 claims abstract description 5
239000003795 chemical substances by application Substances 0.000 claims description 80
125000000129 anionic group Chemical group 0.000 claims description 61
239000000835 fiber Substances 0.000 claims description 48
239000012510 hollow fiber Substances 0.000 claims description 43
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
125000002091 cationic group Chemical group 0.000 claims description 39
229920001778 nylon Polymers 0.000 claims description 36
239000004677 Nylon Substances 0.000 claims description 31
239000012982 microporous membrane Substances 0.000 claims description 27
239000003431 cross linking reagent Substances 0.000 claims description 21
-1 polyhexa-methylene Polymers 0.000 claims description 21
239000002253 acid Substances 0.000 claims description 15
239000000203 mixture Substances 0.000 claims description 14
229920000768 polyamine Polymers 0.000 claims description 14
229920000647 polyepoxide Polymers 0.000 claims description 14
239000007787 solid Substances 0.000 claims description 14
229920005989 resin Polymers 0.000 claims description 12
239000011347 resin Substances 0.000 claims description 12
150000002118 epoxides Chemical class 0.000 claims description 11
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 9
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 6
125000001931 aliphatic group Chemical group 0.000 claims description 6
125000004432 carbon atom Chemical group C* 0.000 claims description 6
125000000524 functional group Chemical group 0.000 claims description 6
150000003335 secondary amines Chemical class 0.000 claims description 6
FAGUFWYHJQFNRV-UHFFFAOYSA-N tetraethylenepentamine Chemical group NCCNCCNCCNCCN FAGUFWYHJQFNRV-UHFFFAOYSA-N 0.000 claims description 6
230000000274 adsorptive effect Effects 0.000 claims description 5
150000001412 amines Chemical group 0.000 claims description 5
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
229920000620 organic polymer Polymers 0.000 claims description 5
125000001424 substituent group Chemical group 0.000 claims description 5
BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims description 4
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
125000000217 alkyl group Chemical group 0.000 claims description 4
230000003247 decreasing effect Effects 0.000 claims description 3
150000002148 esters Chemical class 0.000 claims description 3
150000003141 primary amines Chemical class 0.000 claims description 3
GVNWZKBFMFUVNX-UHFFFAOYSA-N Adipamide Chemical compound NC(=O)CCCCC(N)=O GVNWZKBFMFUVNX-UHFFFAOYSA-N 0.000 claims description 2
229920002678 cellulose Polymers 0.000 claims description 2
239000001913 cellulose Substances 0.000 claims description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
239000000178 monomer Substances 0.000 claims description 2
125000001453 quaternary ammonium group Chemical group 0.000 claims description 2
229920003169 water-soluble polymer Polymers 0.000 claims 2
SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical group C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 claims 1
239000002033 PVDF binder Substances 0.000 claims 1
125000003700 epoxy group Chemical group 0.000 claims 1
229920002981 polyvinylidene fluoride Polymers 0.000 claims 1
150000003512 tertiary amines Chemical class 0.000 claims 1
238000001914 filtration Methods 0.000 abstract description 31
239000012530 fluid Substances 0.000 abstract description 18
239000012632 extractable Substances 0.000 abstract description 10
238000002616 plasmapheresis Methods 0.000 abstract description 8
238000009295 crossflow filtration Methods 0.000 abstract description 7
210000004379 membrane Anatomy 0.000 description 201
239000000243 solution Substances 0.000 description 53
238000000034 method Methods 0.000 description 35
239000002904 solvent Substances 0.000 description 32
238000012360 testing method Methods 0.000 description 32
210000004369 blood Anatomy 0.000 description 24
239000008280 blood Substances 0.000 description 24
238000010791 quenching Methods 0.000 description 22
210000002381 plasma Anatomy 0.000 description 20
229920000642 polymer Polymers 0.000 description 20
230000008569 process Effects 0.000 description 19
239000007864 aqueous solution Substances 0.000 description 18
239000000706 filtrate Substances 0.000 description 16
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
239000000463 material Substances 0.000 description 12
238000005266 casting Methods 0.000 description 11
238000000576 coating method Methods 0.000 description 11
206010018910 Haemolysis Diseases 0.000 description 9
150000001875 compounds Chemical class 0.000 description 9
239000000356 contaminant Substances 0.000 description 9
230000008588 hemolysis Effects 0.000 description 9
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 9
230000004048 modification Effects 0.000 description 9
238000012986 modification Methods 0.000 description 9
229920006122 polyamide resin Polymers 0.000 description 9
238000011282 treatment Methods 0.000 description 9
229920002302 Nylon 6,6 Polymers 0.000 description 8
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 8
238000000926 separation method Methods 0.000 description 8
239000011248 coating agent Substances 0.000 description 7
239000010410 layer Substances 0.000 description 7
230000000171 quenching effect Effects 0.000 description 7
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
210000004027 cell Anatomy 0.000 description 6
CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 6
229960000907 methylthioninium chloride Drugs 0.000 description 6
239000002245 particle Substances 0.000 description 6
238000001179 sorption measurement Methods 0.000 description 6
238000002834 transmittance Methods 0.000 description 6
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 5
238000004132 cross linking Methods 0.000 description 5
238000001035 drying Methods 0.000 description 5
230000000694 effects Effects 0.000 description 5
150000002500 ions Chemical class 0.000 description 5
229920002492 poly(sulfone) Polymers 0.000 description 5
229920000867 polyelectrolyte Polymers 0.000 description 5
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 5
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
102000001554 Hemoglobins Human genes 0.000 description 4
108010054147 Hemoglobins Proteins 0.000 description 4
229920000877 Melamine resin Polymers 0.000 description 4
229920001448 anionic polyelectrolyte Polymers 0.000 description 4
230000001580 bacterial effect Effects 0.000 description 4
WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 4
239000003814 drug Substances 0.000 description 4
235000019253 formic acid Nutrition 0.000 description 4
230000007935 neutral effect Effects 0.000 description 4
229920002647 polyamide Polymers 0.000 description 4
239000004417 polycarbonate Substances 0.000 description 4
238000004382 potting Methods 0.000 description 4
238000001223 reverse osmosis Methods 0.000 description 4
150000003839 salts Chemical class 0.000 description 4
XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 3
239000004952 Polyamide Substances 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
150000007513 acids Chemical class 0.000 description 3
230000017531 blood circulation Effects 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
229920001577 copolymer Polymers 0.000 description 3
GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical class C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 description 3
239000000975 dye Substances 0.000 description 3
238000001125 extrusion Methods 0.000 description 3
230000014759 maintenance of location Effects 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
244000005700 microbiome Species 0.000 description 3
239000003607 modifier Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
238000007873 sieving Methods 0.000 description 3
238000011146 sterile filtration Methods 0.000 description 3
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
229920013683 Celanese Polymers 0.000 description 2
229920003270 Cymel® Polymers 0.000 description 2
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
239000000020 Nitrocellulose Substances 0.000 description 2
229920002292 Nylon 6 Polymers 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
229920002125 Sokalan® Polymers 0.000 description 2
229920006100 Vydyne® Polymers 0.000 description 2
FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 2
GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 2
125000003368 amide group Chemical group 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
230000008901 benefit Effects 0.000 description 2
239000001045 blue dye Substances 0.000 description 2
230000001413 cellular effect Effects 0.000 description 2
230000008859 change Effects 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000000306 component Substances 0.000 description 2
239000000470 constituent Substances 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
150000004985 diamines Chemical class 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
229940079593 drug Drugs 0.000 description 2
238000001962 electrophoresis Methods 0.000 description 2
230000002708 enhancing effect Effects 0.000 description 2
150000002170 ethers Chemical class 0.000 description 2
238000000605 extraction Methods 0.000 description 2
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
229960002897 heparin Drugs 0.000 description 2
229920000669 heparin Polymers 0.000 description 2
NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 2
229920001519 homopolymer Polymers 0.000 description 2
238000005259 measurement Methods 0.000 description 2
JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 description 2
TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 description 2
229920001220 nitrocellulos Polymers 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
239000008188 pellet Substances 0.000 description 2
239000003495 polar organic solvent Substances 0.000 description 2
229920000515 polycarbonate Polymers 0.000 description 2
229920005862 polyol Polymers 0.000 description 2
150000003077 polyols Chemical class 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
229920002635 polyurethane Polymers 0.000 description 2
239000004814 polyurethane Substances 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
238000011012 sanitization Methods 0.000 description 2
CMXPERZAMAQXSF-UHFFFAOYSA-M sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate;1,8-dihydroxyanthracene-9,10-dione Chemical compound [Na+].O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O.CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC CMXPERZAMAQXSF-UHFFFAOYSA-M 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000000758 substrate Substances 0.000 description 2
238000010998 test method Methods 0.000 description 2
230000000699 topical effect Effects 0.000 description 2
238000000108 ultra-filtration Methods 0.000 description 2
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
229920002554 vinyl polymer Polymers 0.000 description 2
238000005303 weighing Methods 0.000 description 2
238000004804 winding Methods 0.000 description 2
OPFTUNCRGUEPRZ-UHFFFAOYSA-N (+)-beta-Elemen Natural products CC(=C)C1CCC(C)(C=C)C(C(C)=C)C1 OPFTUNCRGUEPRZ-UHFFFAOYSA-N 0.000 description 1
DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
OPFTUNCRGUEPRZ-QLFBSQMISA-N (-)-beta-elemene Chemical compound CC(=C)[C@@H]1CC[C@@](C)(C=C)[C@H](C(C)=C)C1 OPFTUNCRGUEPRZ-QLFBSQMISA-N 0.000 description 1
OGNVQLDIPUXYDH-ZPKKHLQPSA-N (2R,3R,4S)-3-(2-methylpropanoylamino)-4-(4-phenyltriazol-1-yl)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid Chemical compound CC(C)C(=O)N[C@H]1[C@H]([C@H](O)[C@H](O)CO)OC(C(O)=O)=C[C@@H]1N1N=NC(C=2C=CC=CC=2)=C1 OGNVQLDIPUXYDH-ZPKKHLQPSA-N 0.000 description 1
KEQGZUUPPQEDPF-UHFFFAOYSA-N 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione Chemical compound CC1(C)N(Cl)C(=O)N(Cl)C1=O KEQGZUUPPQEDPF-UHFFFAOYSA-N 0.000 description 1
YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 1
229940035437 1,3-propanediol Drugs 0.000 description 1
UWFRVQVNYNPBEF-UHFFFAOYSA-N 1-(2,4-dimethylphenyl)propan-1-one Chemical compound CCC(=O)C1=CC=C(C)C=C1C UWFRVQVNYNPBEF-UHFFFAOYSA-N 0.000 description 1
VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 description 1
JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
BNCADMBVWNPPIZ-UHFFFAOYSA-N 2-n,2-n,4-n,4-n,6-n,6-n-hexakis(methoxymethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound COCN(COC)C1=NC(N(COC)COC)=NC(N(COC)COC)=N1 BNCADMBVWNPPIZ-UHFFFAOYSA-N 0.000 description 1
229910000619 316 stainless steel Inorganic materials 0.000 description 1
101001006370 Actinobacillus suis Hemolysin Proteins 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
244000144730 Amygdalus persica Species 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
108010017384 Blood Proteins Proteins 0.000 description 1
241000736839 Chara Species 0.000 description 1
241000254173 Coleoptera Species 0.000 description 1
241000518994 Conta Species 0.000 description 1
241000826056 Elioraea Species 0.000 description 1
JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
244000228957 Ferula foetida Species 0.000 description 1
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
239000004640 Melamine resin Substances 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
241000353097 Molva molva Species 0.000 description 1
101100345589 Mus musculus Mical1 gene Proteins 0.000 description 1
229920000305 Nylon 6,10 Polymers 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
235000006040 Prunus persica var persica Nutrition 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
229910000831 Steel Inorganic materials 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
150000001252 acrylic acid derivatives Chemical class 0.000 description 1
239000000654 additive Substances 0.000 description 1
238000013019 agitation Methods 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
150000008064 anhydrides Chemical class 0.000 description 1
230000002421 anti-septic effect Effects 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
229940064004 antiseptic throat preparations Drugs 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
239000010425 asbestos Substances 0.000 description 1
229920005601 base polymer Polymers 0.000 description 1
235000013405 beer Nutrition 0.000 description 1
235000013361 beverage Nutrition 0.000 description 1
239000013060 biological fluid Substances 0.000 description 1
239000010796 biological waste Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 description 1
239000012503 blood component Substances 0.000 description 1
238000009835 boiling Methods 0.000 description 1
235000013532 brandy Nutrition 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
235000019993 champagne Nutrition 0.000 description 1
239000013043 chemical agent Substances 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
XTHPWXDJESJLNJ-UHFFFAOYSA-N chlorosulfonic acid Substances OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
230000001427 coherent effect Effects 0.000 description 1
239000008119 colloidal silica Substances 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
235000009508 confectionery Nutrition 0.000 description 1
238000011109 contamination Methods 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
230000002939 deleterious effect Effects 0.000 description 1
230000008021 deposition Effects 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
238000007865 diluting Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000007598 dipping method Methods 0.000 description 1
238000009826 distribution Methods 0.000 description 1
229920001971 elastomer Polymers 0.000 description 1
238000000909 electrodialysis Methods 0.000 description 1
238000009713 electroplating Methods 0.000 description 1
239000003822 epoxy resin Substances 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
238000007380 fibre production Methods 0.000 description 1
239000002657 fibrous material Substances 0.000 description 1
238000011010 flushing procedure Methods 0.000 description 1
230000004907 flux Effects 0.000 description 1
239000006260 foam Substances 0.000 description 1
235000013305 food Nutrition 0.000 description 1
IVJISJACKSSFGE-UHFFFAOYSA-N formaldehyde;1,3,5-triazine-2,4,6-triamine Chemical compound O=C.NC1=NC(N)=NC(N)=N1 IVJISJACKSSFGE-UHFFFAOYSA-N 0.000 description 1
239000012634 fragment Substances 0.000 description 1
WOLATMHLPFJRGC-UHFFFAOYSA-N furan-2,5-dione;styrene Chemical compound O=C1OC(=O)C=C1.C=CC1=CC=CC=C1 WOLATMHLPFJRGC-UHFFFAOYSA-N 0.000 description 1
229960003692 gamma aminobutyric acid Drugs 0.000 description 1
239000011521 glass Substances 0.000 description 1
JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
238000005534 hematocrit Methods 0.000 description 1
125000000623 heterocyclic group Chemical group 0.000 description 1
239000012943 hotmelt Substances 0.000 description 1
238000007654 immersion Methods 0.000 description 1
239000012535 impurity Substances 0.000 description 1
239000002917 insecticide Substances 0.000 description 1
238000009434 installation Methods 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000002642 intravenous therapy Methods 0.000 description 1
239000000644 isotonic solution Substances 0.000 description 1
150000003951 lactams Chemical class 0.000 description 1
235000015250 liver sausages Nutrition 0.000 description 1
239000006210 lotion Substances 0.000 description 1
238000005461 lubrication Methods 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000008018 melting Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
229910000000 metal hydroxide Inorganic materials 0.000 description 1
150000004692 metal hydroxides Chemical class 0.000 description 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 description 1
LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
125000000896 monocarboxylic acid group Chemical group 0.000 description 1
230000036651 mood Effects 0.000 description 1
239000002324 mouth wash Substances 0.000 description 1
229940051866 mouthwash Drugs 0.000 description 1
KERBAAIBDHEFDD-UHFFFAOYSA-N n-ethylformamide Chemical compound CCNC=O KERBAAIBDHEFDD-UHFFFAOYSA-N 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
230000006911 nucleation Effects 0.000 description 1
238000010899 nucleation Methods 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
239000002304 perfume Substances 0.000 description 1
230000002572 peristaltic effect Effects 0.000 description 1
229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
229920000172 poly(styrenesulfonic acid) Polymers 0.000 description 1
239000004584 polyacrylic acid Substances 0.000 description 1
229920000151 polyglycol Polymers 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
229920000098 polyolefin Polymers 0.000 description 1
229940005642 polystyrene sulfonic acid Drugs 0.000 description 1
229920000166 polytrimethylene carbonate Polymers 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000005588 protonation Effects 0.000 description 1
238000005086 pumping Methods 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
229910052895 riebeckite Inorganic materials 0.000 description 1
238000005096 rolling process Methods 0.000 description 1
WTGQALLALWYDJH-WYHSTMEOSA-N scopolamine hydrobromide Chemical compound Br.C1([C@@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 WTGQALLALWYDJH-WYHSTMEOSA-N 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000002453 shampoo Substances 0.000 description 1
239000002356 single layer Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000000807 solvent casting Methods 0.000 description 1
241000894007 species Species 0.000 description 1
238000005507 spraying Methods 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000010959 steel Substances 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
229920001897 terpolymer Polymers 0.000 description 1
230000001256 tonic effect Effects 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
150000003672 ureas Chemical class 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000000052 vinegar Substances 0.000 description 1
235000021419 vinegar Nutrition 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
235000013522 vodka Nutrition 0.000 description 1
238000005406 washing Methods 0.000 description 1
235000015041 whisky Nutrition 0.000 description 1
235000014101 wine Nutrition 0.000 description 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0081—After-treatment of organic or inorganic membranes
- B01D67/0093—Chemical modification
- B01D67/00931—Chemical modification by introduction of specific groups after membrane formation, e.g. by grafting
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/08—Hollow fibre membranes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/30—Cross-linking

Landscapes

Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Transplantation (AREA)
Inorganic Chemistry (AREA)
Engineering & Computer Science (AREA)
Manufacturing & Machinery (AREA)
Separation Using Semi-Permeable Membranes (AREA)

CA000471039A 1983-12-29 1984-12-27 Tubes creux microporeux modifies par une charge Expired CA1249110A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US56676283A	1983-12-29	1983-12-29
US566,762		1983-12-29

Publications (1)

Publication Number	Publication Date
CA1249110A true CA1249110A (fr)	1989-01-24

Family

ID=24264272

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000471039A Expired CA1249110A (fr)	1983-12-29	1984-12-27	Tubes creux microporeux modifies par une charge

Country Status (4)

Country	Link
EP (1)	EP0167573A4 (fr)
JP (1)	JPS61500833A (fr)
CA (1)	CA1249110A (fr)
WO (1)	WO1985003012A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5587070A (en) *	1990-11-06	1996-12-24	Pall Corporation	System for processing biological fluid
US5601727A (en) *	1991-11-04	1997-02-11	Pall Corporation	Device and method for separating plasma from a biological fluid

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5531893A (en) *	1993-02-12	1996-07-02	Gelman Sciences Inc.	Inter-penetrating network charge modified microporous membrane
EP1473075B1 (fr) *	1999-02-25	2015-07-29	Pall Corporation	Membranes chargées négativement
US6783937B1 (en)	1999-02-25	2004-08-31	Pall Corporation	Negatively charged membrane
US20150190760A1 (en) *	2014-01-06	2015-07-09	Pall Corporation	Membrane with plurality of charges
EP3875168A1 (fr) *	2020-03-03	2021-09-08	Gambro Lundia AB	Dispositif de diffusion et/ou filtration

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3524546A (en) *	1967-10-11	1970-08-18	Du Pont	Permeation separation with acidgrafted nylon membranes
US3808305A (en) *	1971-07-27	1974-04-30	H Gregor	Crosslinked,interpolymer fixed-charge membranes
US4045352A (en) *	1973-05-23	1977-08-30	California Institute Of Technology	Ion-exchange hollow fibers
DE2522821A1 (de) *	1975-05-23	1976-11-25	Battelle Institut E V	Permselektive membran fuer kuenstliche nieren
US4250029A (en) *	1977-04-25	1981-02-10	Rohm And Haas Company	Coated membranes
US4214020A (en) *	1977-11-17	1980-07-22	Monsanto Company	Processes for coating bundles of hollow fiber membranes
US4473474A (en) *	1980-10-27	1984-09-25	Amf Inc.	Charge modified microporous membrane, process for charge modifying said membrane and process for filtration of fluid
JPS6332093B2 (fr) *	1980-10-27	1988-06-28	Kyuno Inc
US4473475A (en) *	1981-05-29	1984-09-25	Amf Inc.	Charge modified microporous membrane, process for charge modifying said membrane, and process for filtration of fluids
DE3271691D1 (en) *	1981-12-21	1986-07-17	Aligena Ag	Semipermeable membranes of modified polystyrene, process for their manufacture and their use

1984
- 1984-12-21 EP EP19850900441 patent/EP0167573A4/fr not_active Withdrawn
- 1984-12-21 JP JP60500218A patent/JPS61500833A/ja active Pending
- 1984-12-21 WO PCT/US1984/002103 patent/WO1985003012A1/fr not_active Ceased
- 1984-12-27 CA CA000471039A patent/CA1249110A/fr not_active Expired

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5587070A (en) *	1990-11-06	1996-12-24	Pall Corporation	System for processing biological fluid
US5616254A (en) *	1990-11-06	1997-04-01	Pall Corporation	System and method for processing biological fluid
US5601727A (en) *	1991-11-04	1997-02-11	Pall Corporation	Device and method for separating plasma from a biological fluid

Also Published As

Publication number	Publication date
JPS61500833A (ja)	1986-05-01
EP0167573A4 (fr)	1988-05-02
EP0167573A1 (fr)	1986-01-15
WO1985003012A1 (fr)	1985-07-18

Legal Events

Date	Code	Title	Description
2006-01-24	MKEX	Expiry

Publication	Publication Date	Title
US4888115A (en)	1989-12-19	Cross-flow filtration
CA1253305A (fr)	1989-05-02	Membrane microporeuse polymerique modifiee par une charge anionique en solution
US4915839A (en)	1990-04-10	Process for surface modifying a microporous membrane
US4673504A (en)	1987-06-16	Charge modified microporous membrane
US4708803A (en)	1987-11-24	Liquid filtration using hydrophilic cationic isotropic microporous nylon membrane
US4711793A (en)	1987-12-08	Process for charge modifying a microphorous membrane
US4473474A (en)	1984-09-25	Charge modified microporous membrane, process for charge modifying said membrane and process for filtration of fluid
AU652912B2 (en)	1994-09-08	Novel high flux hollow fiber membrane
KR100432463B1 (ko)	2004-08-06	폴리술폰 중공사 반투막
US4720343A (en)	1988-01-19	Macroporous asymmetrical hydrophilic membrane made of a synthetic polymer
US5114585A (en)	1992-05-19	Charged porous filter
CA1156410A (fr)	1983-11-08	Membrane microporeuse modifiee par une charge; methode pour modifier ladite membrane a l'aide de cette charge; methode de filtration du fluide
CA2095423A1 (fr)	1993-11-06	Methode hautement efficiente d'extraction du ldl-cholesterol du sang
JP2003532746A (ja)	2003-11-05	負電荷を持つ膜
US4980067A (en)	1990-12-25	Polyionene-transformed microporous membrane
CA1249110A (fr)	1989-01-24	Tubes creux microporeux modifies par une charge
US6632361B2 (en)	2003-10-14	Shaped objects for pyrogen retention and processes for their manufacture
CA1107467A (fr)	1981-08-25	Membranes de polycarbonates utilisees en hemodialyse
US6214382B1 (en)	2001-04-10	Hydrophilic film and process for producing the same
US4921654A (en)	1990-05-01	Low protein binding membrane
EP0476875A2 (fr)	1992-03-25	Procédé pour la purification et la concentration de produits biologiques actifs
CA1282565C (fr)	1991-04-09	Methode pour modifier la surface d'une membrane microporeuse
CA1313734C (fr)	1993-02-23	Coussinet feutre a base de fibres de cellulose et d'une membrane organique microporeuse
JP3489372B2 (ja)	2004-01-19	選択透過性分離膜
WO2024247796A1 (fr)	2024-12-05	Membrane poreuse à fibres creuses et module de purification du sang