CA1261987A - Melanges de polymeres pouvant servir de surface de contact pour le sang dans un dispositif biomedical et methodes de preparation - Google Patents

Melanges de polymeres pouvant servir de surface de contact pour le sang dans un dispositif biomedical et methodes de preparation

Info

Publication number: CA1261987A
Authority: CA; Canada
Prior art keywords: polymer; polar; chain; segmented copolymer; glass transition
Prior art date: 1985-02-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000473993A

Other languages

English (en)

Inventor

Robert S. Ward, Jr.

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Thoratec LLC

Original Assignee

TH Goldschmidt AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-11

Filing date

1985-02-11

Publication date

1989-09-26

1985-02-11 Application filed by TH Goldschmidt AG filed Critical TH Goldschmidt AG

1985-02-11 Priority to CA000473993A priority Critical patent/CA1261987A/fr

1989-09-26 Application granted granted Critical

1989-09-26 Publication of CA1261987A publication Critical patent/CA1261987A/fr

Status Expired legal-status Critical Current

Links

229920000642 polymer Polymers 0.000 title claims abstract description 378
238000000034 method Methods 0.000 title claims description 63
239000000654 additive Substances 0.000 claims abstract description 182
229920005601 base polymer Polymers 0.000 claims abstract description 179
230000000996 additive effect Effects 0.000 claims abstract description 170
239000004814 polyurethane Substances 0.000 claims abstract description 63
229920002635 polyurethane Polymers 0.000 claims abstract description 57
239000008280 blood Substances 0.000 claims abstract description 55
210000004369 blood Anatomy 0.000 claims abstract description 55
229920001400 block copolymer Polymers 0.000 claims abstract description 40
229920001169 thermoplastic Polymers 0.000 claims abstract description 38
239000004416 thermosoftening plastic Substances 0.000 claims abstract description 34
239000004753 textile Substances 0.000 claims abstract description 10
229920006294 polydialkylsiloxane Polymers 0.000 claims abstract description 9
229920000233 poly(alkylene oxides) Polymers 0.000 claims abstract description 8
229920001577 copolymer Polymers 0.000 claims description 177
230000009477 glass transition Effects 0.000 claims description 117
238000002844 melting Methods 0.000 claims description 113
230000008018 melting Effects 0.000 claims description 113
239000007787 solid Substances 0.000 claims description 71
229920001519 homopolymer Polymers 0.000 claims description 66
-1 polydimethylsiloxane Polymers 0.000 claims description 50
229920000728 polyester Polymers 0.000 claims description 41
239000004952 Polyamide Substances 0.000 claims description 35
229920002647 polyamide Polymers 0.000 claims description 35
229920000570 polyether Polymers 0.000 claims description 24
229920002397 thermoplastic olefin Polymers 0.000 claims description 24
239000004721 Polyphenylene oxide Substances 0.000 claims description 23
239000004205 dimethyl polysiloxane Substances 0.000 claims description 22
229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 18
QLZJUIZVJLSNDD-UHFFFAOYSA-N 2-(2-methylidenebutanoyloxy)ethyl 2-methylidenebutanoate Chemical compound CCC(=C)C(=O)OCCOC(=O)C(=C)CC QLZJUIZVJLSNDD-UHFFFAOYSA-N 0.000 claims description 17
ROGIWVXWXZRRMZ-UHFFFAOYSA-N 2-methylbuta-1,3-diene;styrene Chemical compound CC(=C)C=C.C=CC1=CC=CC=C1 ROGIWVXWXZRRMZ-UHFFFAOYSA-N 0.000 claims description 17
150000001336 alkenes Chemical class 0.000 claims description 17
DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims description 17
239000005038 ethylene vinyl acetate Substances 0.000 claims description 17
229920006244 ethylene-ethyl acrylate Polymers 0.000 claims description 17
239000005042 ethylene-ethyl acrylate Substances 0.000 claims description 17
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 17
229920006395 saturated elastomer Polymers 0.000 claims description 17
239000012530 fluid Substances 0.000 claims description 16
239000004417 polycarbonate Substances 0.000 claims description 16
239000002904 solvent Substances 0.000 claims description 16
239000000463 material Substances 0.000 claims description 15
229920000515 polycarbonate Polymers 0.000 claims description 13
239000000203 mixture Chemical group 0.000 claims description 12
239000004014 plasticizer Substances 0.000 claims description 11
238000002156 mixing Methods 0.000 claims description 10
229920000098 polyolefin Polymers 0.000 claims description 10
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 9
239000004698 Polyethylene Substances 0.000 claims description 9
239000003795 chemical substances by application Substances 0.000 claims description 9
239000000835 fiber Substances 0.000 claims description 9
229920000573 polyethylene Polymers 0.000 claims description 9
102000004169 proteins and genes Human genes 0.000 claims description 9
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239000007795 chemical reaction product Substances 0.000 claims description 8
125000005442 diisocyanate group Chemical group 0.000 claims description 8
239000004800 polyvinyl chloride Substances 0.000 claims description 8
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239000001257 hydrogen Substances 0.000 claims description 7
229910052739 hydrogen Inorganic materials 0.000 claims description 7
150000001412 amines Chemical group 0.000 claims description 6
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
125000005376 alkyl siloxane group Chemical group 0.000 claims description 5
229920001281 polyalkylene Polymers 0.000 claims description 5
229920002959 polymer blend Polymers 0.000 claims description 4
239000011118 polyvinyl acetate Substances 0.000 claims description 4
229920002689 polyvinyl acetate Polymers 0.000 claims description 4
239000006185 dispersion Substances 0.000 claims description 3
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238000000137 annealing Methods 0.000 claims description 2
238000001816 cooling Methods 0.000 claims description 2
241001367053 Autographa gamma Species 0.000 claims 19
239000002174 Styrene-butadiene Substances 0.000 claims 16
MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 claims 16
JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 16
239000011115 styrene butadiene Substances 0.000 claims 16
229920003048 styrene butadiene rubber Polymers 0.000 claims 16
229920012753 Ethylene Ionomers Polymers 0.000 claims 12
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
229920000554 ionomer Polymers 0.000 claims 4
150000001993 dienes Chemical class 0.000 claims 3
VLCAYQIMSMPEBW-UHFFFAOYSA-N methyl 3-hydroxy-2-methylidenebutanoate Chemical compound COC(=O)C(=C)C(C)O VLCAYQIMSMPEBW-UHFFFAOYSA-N 0.000 claims 1
229920000578 graft copolymer Polymers 0.000 abstract description 4
239000000306 component Substances 0.000 description 39
235000013870 dimethyl polysiloxane Nutrition 0.000 description 19
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
229920001296 polysiloxane Polymers 0.000 description 9
239000000243 solution Substances 0.000 description 9
JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 8
208000007536 Thrombosis Diseases 0.000 description 8
238000005859 coupling reaction Methods 0.000 description 8
239000010408 film Substances 0.000 description 8
230000015572 biosynthetic process Effects 0.000 description 7
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
102000004506 Blood Proteins Human genes 0.000 description 5
108010017384 Blood Proteins Proteins 0.000 description 5
238000006243 chemical reaction Methods 0.000 description 5
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238000004519 manufacturing process Methods 0.000 description 5
238000005259 measurement Methods 0.000 description 5
230000000051 modifying effect Effects 0.000 description 5
230000000704 physical effect Effects 0.000 description 5
229920001897 terpolymer Polymers 0.000 description 5
CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 4
238000000576 coating method Methods 0.000 description 4
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
150000003673 urethanes Chemical class 0.000 description 4
UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 description 3
230000002411 adverse Effects 0.000 description 3
125000003118 aryl group Chemical group 0.000 description 3
230000036760 body temperature Effects 0.000 description 3
239000011248 coating agent Substances 0.000 description 3
230000002209 hydrophobic effect Effects 0.000 description 3
239000012948 isocyanate Substances 0.000 description 3
150000002513 isocyanates Chemical class 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
241000283986 Lepus Species 0.000 description 2
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
239000004793 Polystyrene Substances 0.000 description 2
230000002776 aggregation Effects 0.000 description 2
238000004220 aggregation Methods 0.000 description 2
125000001931 aliphatic group Chemical group 0.000 description 2
230000023555 blood coagulation Effects 0.000 description 2
WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
235000013877 carbamide Nutrition 0.000 description 2
125000003636 chemical group Chemical group 0.000 description 2
230000008878 coupling Effects 0.000 description 2
238000010168 coupling process Methods 0.000 description 2
150000004985 diamines Chemical class 0.000 description 2
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 2
238000011067 equilibration Methods 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
238000001125 extrusion Methods 0.000 description 2
238000001746 injection moulding Methods 0.000 description 2
239000010410 layer Substances 0.000 description 2
239000007788 liquid Substances 0.000 description 2
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
239000003921 oil Substances 0.000 description 2
229920000162 poly(ureaurethane) Polymers 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000000047 product Substances 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
230000009467 reduction Effects 0.000 description 2
238000006722 reduction reaction Methods 0.000 description 2
238000000935 solvent evaporation Methods 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
238000012360 testing method Methods 0.000 description 2
230000007306 turnover Effects 0.000 description 2
QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 description 1
WSSSPWUEQFSQQG-UHFFFAOYSA-N 4-methyl-1-pentene Chemical compound CC(C)CC=C WSSSPWUEQFSQQG-UHFFFAOYSA-N 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
241000283707 Capra Species 0.000 description 1
239000004970 Chain extender Substances 0.000 description 1
206010053567 Coagulopathies Diseases 0.000 description 1
229920004934 Dacron® Polymers 0.000 description 1
101100536354 Drosophila melanogaster tant gene Proteins 0.000 description 1
208000010496 Heart Arrest Diseases 0.000 description 1
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
208000009378 Low Cardiac Output Diseases 0.000 description 1
206010024899 Low cardiac output syndrome Diseases 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
239000006057 Non-nutritive feed additive Substances 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
206010030113 Oedema Diseases 0.000 description 1
229920012485 Plasticized Polyvinyl chloride Polymers 0.000 description 1
239000004962 Polyamide-imide Substances 0.000 description 1
239000005062 Polybutadiene Substances 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
239000004433 Thermoplastic polyurethane Substances 0.000 description 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
230000001464 adherent effect Effects 0.000 description 1
125000002947 alkylene group Chemical group 0.000 description 1
210000002376 aorta thoracic Anatomy 0.000 description 1
210000004204 blood vessel Anatomy 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
244000309466 calf Species 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
210000001715 carotid artery Anatomy 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
230000035602 clotting Effects 0.000 description 1
230000001112 coagulating effect Effects 0.000 description 1
229920000891 common polymer Polymers 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
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238000007598 dipping method Methods 0.000 description 1
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238000009826 distribution Methods 0.000 description 1
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239000012467 final product Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
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239000007943 implant Substances 0.000 description 1
238000002513 implantation Methods 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000007373 indentation Methods 0.000 description 1
239000011261 inert gas Substances 0.000 description 1
230000003993 interaction Effects 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
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238000012417 linear regression Methods 0.000 description 1
125000005647 linker group Chemical group 0.000 description 1
238000004811 liquid chromatography Methods 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
239000000178 monomer Substances 0.000 description 1
230000005405 multipole Effects 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920006112 polar polymer Polymers 0.000 description 1
229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
229920002492 poly(sulfone) Polymers 0.000 description 1
229920002312 polyamide-imide Polymers 0.000 description 1
229920002857 polybutadiene Polymers 0.000 description 1
229920000647 polyepoxide Polymers 0.000 description 1
239000005020 polyethylene terephthalate Substances 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
239000004926 polymethyl methacrylate Substances 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000036647 reaction Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
230000002787 reinforcement Effects 0.000 description 1
239000005060 rubber Substances 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
239000002356 single layer Substances 0.000 description 1
239000012265 solid product Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000012815 thermoplastic material Substances 0.000 description 1
229920002803 thermoplastic polyurethane Polymers 0.000 description 1
239000010409 thin film Substances 0.000 description 1
229910052719 titanium Inorganic materials 0.000 description 1
239000010936 titanium Substances 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000002792 vascular Effects 0.000 description 1
230000002861 ventricular Effects 0.000 description 1

Landscapes

Compositions Of Macromolecular Compounds (AREA)

CA000473993A 1985-02-11 1985-02-11 Melanges de polymeres pouvant servir de surface de contact pour le sang dans un dispositif biomedical et methodes de preparation Expired CA1261987A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000473993A CA1261987A (fr)	1985-02-11	1985-02-11	Melanges de polymeres pouvant servir de surface de contact pour le sang dans un dispositif biomedical et methodes de preparation

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000473993A CA1261987A (fr)	1985-02-11	1985-02-11	Melanges de polymeres pouvant servir de surface de contact pour le sang dans un dispositif biomedical et methodes de preparation

Publications (1)

Publication Number	Publication Date
CA1261987A true CA1261987A (fr)	1989-09-26

Family

ID=4129804

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000473993A Expired CA1261987A (fr)	1985-02-11	1985-02-11	Melanges de polymeres pouvant servir de surface de contact pour le sang dans un dispositif biomedical et methodes de preparation

Country Status (1)

Country	Link
CA (1)	CA1261987A (fr)

1985
- 1985-02-11 CA CA000473993A patent/CA1261987A/fr not_active Expired

Legal Events

Date	Code	Title	Description
2006-09-26	MKEX	Expiry

Publication	Publication Date	Title
US4861830A (en)	1989-08-29	Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming
US4675361A (en)	1987-06-23	Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming
GB2073219A (en)	1981-10-14	Polymer surfaces for blood- contacting surfaces of a biomedical device, and methods for forming
US3562352A (en)	1971-02-09	Polysiloxane-polyurethane block copolymers
AU661183B2 (en)	1995-07-13	Thermoplastic polyurethane blends
CA1335317C (fr)	1995-04-18	Polyetherurethanes fluores et instruments medicaux fabriques avec ces materiaux
EP0758349B1 (fr)	2002-10-02	Groupes terminaux de modification de surface destines aux polymeres biomedicaux
AU2022203212B2 (en)	2023-10-05	Self-lubricating medical articles
US5059269A (en)	1991-10-22	Method of making an article having a hemocompatible surface
US5430121A (en)	1995-07-04	Thermoplastic polyurethanes modified by siloxane block copolymers
US4939007A (en)	1990-07-03	Article having a hemocompatible surface
US5516857A (en)	1996-05-14	Thermoplastic urethane elastomeric alloys
JP7411643B2 (ja)	2024-01-11	自己潤滑性医療用物品
WO1995026993A9 (fr)	1995-11-16	Groupes terminaux de modification de surface destines aux polymeres biomedicaux
JPH04210064A (ja)	1992-07-31	湿潤時に潤滑性のある医療用物品
WO1998055171A1 (fr)	1998-12-10	Copolymeres sequences de nylon reticules
JP2024507934A (ja)	2024-02-21	ポリウレタンベースの医療用品
JPH04252222A (ja)	1992-09-08	溶融加工性ポリウレタンウレア系コポリマーおよびそれらの製法
JP2024507576A (ja)	2024-02-20	ポリウレタンベースの医療用物品
GB2140437A (en)	1984-11-28	Polymer surfaces for blood-contacting surfaces of a biomedical device and methods for forming
KR20230148832A (ko)	2023-10-25	폴리우레탄에 기반하는 의료 용품
CA1261987A (fr)	1989-09-26	Melanges de polymeres pouvant servir de surface de contact pour le sang dans un dispositif biomedical et methodes de preparation
GB2140438A (en)	1984-11-28	Blood compatible polymer mixture
JP2023543013A (ja)	2023-10-12	潤滑性または低摩擦特性を有する表面
CA1211878A (fr)	1986-09-23	Surface de polymere pour les surfaces de dispositifs medicaux en contact avec le sang