CA1265964A - Pompe electrophoretique implantable pour la dispensation de medicaments ioniques et methodes d'utilisation - Google Patents

Pompe electrophoretique implantable pour la dispensation de medicaments ioniques et methodes d'utilisation

Info

Publication number: CA1265964A
Authority: CA; Canada
Prior art keywords: reservoir; membrane; pump; implantable; electrodes
Prior art date: 1985-04-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000479337A

Other languages

English (en)

Inventor

Nabil I. Rizk

Charles L. Stevens

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-17

Filing date

1985-04-17

Publication date

1990-02-20

1985-04-17 Application filed by Individual filed Critical Individual

1985-04-17 Priority to CA000479337A priority Critical patent/CA1265964A/fr

1990-02-20 Application granted granted Critical

1990-02-20 Publication of CA1265964A publication Critical patent/CA1265964A/fr

Status Expired legal-status Critical Current

Links

239000003814 drug Substances 0.000 title claims abstract description 58
229940079593 drug Drugs 0.000 title claims abstract description 56
238000000034 method Methods 0.000 title abstract description 11
239000012528 membrane Substances 0.000 claims abstract description 89
238000009792 diffusion process Methods 0.000 claims abstract description 52
239000000945 filler Substances 0.000 claims abstract description 29
239000000463 material Substances 0.000 claims description 24
238000001962 electrophoresis Methods 0.000 claims description 11
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 9
229910052799 carbon Inorganic materials 0.000 claims description 8
238000004891 communication Methods 0.000 claims description 8
239000003990 capacitor Substances 0.000 claims description 7
238000007789 sealing Methods 0.000 claims description 7
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 6
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239000011248 coating agent Substances 0.000 claims description 3
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239000003014 ion exchange membrane Substances 0.000 claims description 3
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229910052697 platinum Inorganic materials 0.000 claims description 3
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 2
229910021607 Silver chloride Inorganic materials 0.000 claims description 2
239000003456 ion exchange resin Substances 0.000 claims description 2
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NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract description 54
102000004877 Insulin Human genes 0.000 abstract description 27
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239000003242 anti bacterial agent Substances 0.000 abstract 1
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239000000835 fiber Substances 0.000 description 6
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HSZCZNFXUDYRKD-UHFFFAOYSA-M lithium iodide Chemical compound [Li+].[I-] HSZCZNFXUDYRKD-UHFFFAOYSA-M 0.000 description 6
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 5
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239000008103 glucose Substances 0.000 description 3
235000012054 meals Nutrition 0.000 description 3
239000002002 slurry Substances 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
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WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
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239000000020 Nitrocellulose Substances 0.000 description 1
FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
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229910002804 graphite Inorganic materials 0.000 description 1
239000010439 graphite Substances 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
201000001421 hyperglycemia Diseases 0.000 description 1
230000001506 immunosuppresive effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
230000037427 ion transport Effects 0.000 description 1
125000003010 ionic group Chemical group 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
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238000012544 monitoring process Methods 0.000 description 1
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239000002674 ointment Substances 0.000 description 1
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239000000813 peptide hormone Substances 0.000 description 1
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210000004303 peritoneum Anatomy 0.000 description 1
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238000001556 precipitation Methods 0.000 description 1
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150000003839 salts Chemical class 0.000 description 1
229920000260 silastic Polymers 0.000 description 1
235000002639 sodium chloride Nutrition 0.000 description 1
239000000126 substance Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
210000001835 viscera Anatomy 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Landscapes

Infusion, Injection, And Reservoir Apparatuses (AREA)

CA000479337A 1985-04-17 1985-04-17 Pompe electrophoretique implantable pour la dispensation de medicaments ioniques et methodes d'utilisation Expired CA1265964A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000479337A CA1265964A (fr)	1985-04-17	1985-04-17	Pompe electrophoretique implantable pour la dispensation de medicaments ioniques et methodes d'utilisation

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000479337A CA1265964A (fr)	1985-04-17	1985-04-17	Pompe electrophoretique implantable pour la dispensation de medicaments ioniques et methodes d'utilisation

Publications (1)

Publication Number	Publication Date
CA1265964A true CA1265964A (fr)	1990-02-20

Family

ID=4130291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000479337A Expired CA1265964A (fr)	1985-04-17	1985-04-17	Pompe electrophoretique implantable pour la dispensation de medicaments ioniques et methodes d'utilisation

Country Status (1)

Country	Link
CA (1)	CA1265964A (fr)

1985
- 1985-04-17 CA CA000479337A patent/CA1265964A/fr not_active Expired

Legal Events

Date	Code	Title	Description
2003-02-20	MKLA	Lapsed

Publication	Publication Date	Title
US4639244A (en)	1987-01-27	Implantable electrophoretic pump for ionic drugs and associated methods
US6409698B1 (en)	2002-06-25	Perforate electrodiffusion pump
US5312325A (en)	1994-05-17	Pulsating transdermal drug delivery system
US5591123A (en)	1997-01-07	Programmable control mounting system for transdermal drug applicator
US5865786A (en)	1999-02-02	Programmable control and mounting system for transdermal drug applicator
EP0225872B1 (fr)	1992-09-02	Commande programmable et systeme de montage d'un applicateur de medicaments transdermiques
US5224928A (en)	1993-07-06	Mounting system for transdermal drug applicator
US5135479A (en)	1992-08-04	Programmable control and mounting system for transdermal drug applicator
US5013293A (en)	1991-05-07	Pulsating transdermal drug delivery system
US4886514A (en)	1989-12-12	Electrochemically driven drug dispenser
US5746711A (en)	1998-05-05	Programmable control and mounting system for transdermal drug applicator
US4708716A (en)	1987-11-24	Transdermal drug applicator
US4505710A (en)	1985-03-19	Implantable fluid dispensing system
KR930005050B1 (ko)	1993-06-15	전기영동을 이용한 경피식 약제 투약장치
US4077405A (en)	1978-03-07	Apparatus for infusing liquids into human or animal bodies
US3894538A (en)	1975-07-15	Device for supplying medicines
JP2939550B2 (ja)	1999-08-25	イオントフォレーゼ電極
US6009344A (en)	1999-12-28	Iontophoretic drug delivery system
DE2626348B2 (de)	1979-05-31	Implantierbare Dosiereinrichtung
CA1308323C (fr)	1992-10-06	Chambre de formulation avec un dispositif exterieur d'administration par transport electrique
CA1299457C (fr)	1992-04-28	Dispositif pulsatoire d'administration transdermique de medicaments
WO1991005582A1 (fr)	1991-05-02	Dispositif et procede d'iontophorese utilisant une membrane regulatrice du debit
CA1265964A (fr)	1990-02-20	Pompe electrophoretique implantable pour la dispensation de medicaments ioniques et methodes d'utilisation
AU614987B2 (en)	1991-09-19	Implantable electrophoretic pump for ionic drugs and associated methods
JP2818999B2 (ja)	1998-10-30	経皮薬剤アプリケータ