CA1268780C - Groupes protecteurs n-hydroxyles et methode de preparation de 3-acylamino-1-hydroxy-2-azetidinones - Google Patents

Groupes protecteurs n-hydroxyles et methode de preparation de 3-acylamino-1-hydroxy-2-azetidinones

Info

Publication number
CA1268780C
CA1268780C CA 486940 CA486940A CA1268780C CA 1268780 C CA1268780 C CA 1268780C CA 486940 CA486940 CA 486940 CA 486940 A CA486940 A CA 486940A CA 1268780 C CA1268780 C CA 1268780C
Authority
CA
Canada
Prior art keywords
preparation
acylamino
azetidinones
hydroxy
protective groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA 486940
Other languages
English (en)
French (fr)
Other versions
CA1262357A (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to CA000595566A priority Critical patent/CA1268780A/en
Publication of CA1262357A publication Critical patent/CA1262357A/en
Application granted granted Critical
Publication of CA1268780C publication Critical patent/CA1268780C/xx
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
CA 486940 1984-08-03 1985-07-17 Groupes protecteurs n-hydroxyles et methode de preparation de 3-acylamino-1-hydroxy-2-azetidinones Expired - Lifetime CA1268780C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000595566A CA1268780A (en) 1984-08-03 1989-04-03 N-hydroxyl protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/637,260 US4581170A (en) 1984-08-03 1984-08-03 N-hydroxyl protecting groups and process and intermediates for the preparation of 3-acylamino-1-hydroxy-2-azetidinones

Publications (2)

Publication Number Publication Date
CA1262357A CA1262357A (en) 1989-10-17
CA1268780C true CA1268780C (fr) 1990-05-08

Family

ID=24555200

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 486940 Expired - Lifetime CA1268780C (fr) 1984-08-03 1985-07-17 Groupes protecteurs n-hydroxyles et methode de preparation de 3-acylamino-1-hydroxy-2-azetidinones

Country Status (12)

Country Link
US (1) US4581170A (de)
EP (2) EP0170280B1 (de)
JP (2) JPH06732B2 (de)
AT (1) ATE58896T1 (de)
AU (2) AU589567B2 (de)
CA (1) CA1268780C (de)
DE (1) DE3580803D1 (de)
DK (1) DK353385A (de)
FI (1) FI852974A7 (de)
IE (2) IE58758B1 (de)
NZ (1) NZ212750A (de)
ZA (1) ZA855492B (de)

Families Citing this family (65)

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US4670553A (en) * 1982-01-04 1987-06-02 E. R. Squibb & Sons, Inc. 2-oxo-1-(aminocarbonylaminosulfonyl-aminocarbonyl)azetidines
EP0233607B1 (de) * 1986-02-18 1991-03-13 E.R. Squibb & Sons, Inc. [(2,2,2-Trichloroethoxy)methoxy]amin
US5037974A (en) * 1988-05-23 1991-08-06 Merck & Co., Inc. Cyclization process for synthesis of a beta-lactam carbapenem intermediate
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6068993A (en) * 1997-07-02 2000-05-30 Biobras Sa Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
IL156488A0 (en) * 2001-01-26 2004-01-04 Schering Corp Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions
PT1355644E (pt) * 2001-01-26 2006-11-30 Schering Corp Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia
IL156585A0 (en) * 2001-01-26 2004-01-04 Schering Corp Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
ATE369851T1 (de) * 2001-01-26 2007-09-15 Schering Corp Kombinationen von gallensäuresequestriermitteln und hemmern der sterolabsorption zur behandlung von kardiovaskulären indikationen
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
EP1353695A2 (de) * 2001-01-26 2003-10-22 Schering Corporation Kombinationen von einem hemmer der sterol-absorption und nicotinsäure zur behandlung von kardiovaskulären indikationen
RS20100015A (sr) * 2001-01-26 2010-12-31 Schering Corporation Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije
DE60216275T2 (de) * 2001-05-25 2007-06-21 Schering Corp. Verwendung von mit azetidinon substituierten derivaten bei der behandlung der alzheimer-krankheit
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
EP1429756B1 (de) * 2001-09-21 2006-11-22 Schering Corporation Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
CN101785772A (zh) * 2001-09-21 2010-07-28 先灵公司 使用甾醇吸收抑制剂治疗或预防脉管炎的方法
JP2006508188A (ja) * 2002-11-06 2006-03-09 シェーリング　コーポレイション 脱髄の処置のためのコレステロール吸収インヒビター
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
DE602004016123D1 (de) 2003-03-07 2008-10-09 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
CN1756755A (zh) * 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
CN1756756A (zh) * 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
JP2007510659A (ja) * 2003-11-05 2007-04-26 シェーリング　コーポレイション 脂質調節剤および置換アゼチジノンの組み合わせならびに血管状態の処置
US9204798B2 (en) 2013-03-04 2015-12-08 Hello, Inc. System for monitoring health, wellness and fitness with feedback
US9530089B2 (en) 2013-03-04 2016-12-27 Hello Inc. Wearable device with overlapping ends coupled by magnets of a selected width, length and depth
US9406220B2 (en) 2013-03-04 2016-08-02 Hello Inc. Telemetry system with tracking receiver devices
US9553486B2 (en) 2013-03-04 2017-01-24 Hello Inc. Monitoring system and device with sensors that is remotely powered
US9149189B2 (en) 2013-03-04 2015-10-06 Hello, Inc. User or patient monitoring methods using one or more analysis tools
US20130290427A1 (en) 2013-03-04 2013-10-31 Hello Inc. Wearable device with unique user ID and telemetry system in communication with one or more social networks
US9361572B2 (en) 2013-03-04 2016-06-07 Hello Inc. Wearable device with magnets positioned at opposing ends and overlapped from one side to another
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US9445651B2 (en) 2013-03-04 2016-09-20 Hello Inc. Wearable device with overlapping ends coupled by magnets
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US9345404B2 (en) 2013-03-04 2016-05-24 Hello Inc. Mobile device that monitors an individuals activities, behaviors, habits or health parameters
US9848776B2 (en) 2013-03-04 2017-12-26 Hello Inc. Methods using activity manager for monitoring user activity
US9298882B2 (en) 2013-03-04 2016-03-29 Hello Inc. Methods using patient monitoring devices with unique patient IDs and a telemetry system
US9357922B2 (en) 2013-03-04 2016-06-07 Hello Inc. User or patient monitoring systems with one or more analysis tools
US9427160B2 (en) 2013-03-04 2016-08-30 Hello Inc. Wearable device with overlapping ends coupled by magnets positioned in the wearable device by an undercut
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US9526422B2 (en) 2013-03-04 2016-12-27 Hello Inc. System for monitoring individuals with a monitoring device, telemetry system, activity manager and a feedback system
US9737214B2 (en) 2013-03-04 2017-08-22 Hello Inc. Wireless monitoring of patient exercise and lifestyle
US9420856B2 (en) 2013-03-04 2016-08-23 Hello Inc. Wearable device with adjacent magnets magnetized in different directions
US9462856B2 (en) 2013-03-04 2016-10-11 Hello Inc. Wearable device with magnets sealed in a wearable device structure
US9662015B2 (en) 2013-03-04 2017-05-30 Hello Inc. System or device with wearable devices having one or more sensors with assignment of a wearable device user identifier to a wearable device user
US9424508B2 (en) 2013-03-04 2016-08-23 Hello Inc. Wearable device with magnets having first and second polarities
US9582748B2 (en) 2013-03-04 2017-02-28 Hello Inc. Base charging station for monitoring device
US9634921B2 (en) 2013-03-04 2017-04-25 Hello Inc. Wearable device coupled by magnets positioned in a frame in an interior of the wearable device with at least one electronic circuit
US9436903B2 (en) 2013-03-04 2016-09-06 Hello Inc. Wearable device with magnets with a defined distance between adjacent magnets
US9398854B2 (en) 2013-03-04 2016-07-26 Hello Inc. System with a monitoring device that monitors individual activities, behaviors or habit information and communicates with a database with corresponding individual base information for comparison
US9320434B2 (en) 2013-03-04 2016-04-26 Hello Inc. Patient monitoring systems and messages that send alerts to patients only when the patient is awake
US9432091B2 (en) 2013-03-04 2016-08-30 Hello Inc. Telemetry system with wireless power receiver and monitoring devices
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US9427189B2 (en) 2013-03-04 2016-08-30 Hello Inc. Monitoring system and device with sensors that are responsive to skin pigmentation
US9532716B2 (en) 2013-03-04 2017-01-03 Hello Inc. Systems using lifestyle database analysis to provide feedback
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US9159223B2 (en) 2013-03-04 2015-10-13 Hello, Inc. User monitoring device configured to be in communication with an emergency response system or team
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US9339188B2 (en) 2013-03-04 2016-05-17 James Proud Methods from monitoring health, wellness and fitness with feedback
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Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
FR2442240A1 (fr) * 1978-11-27 1980-06-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique comportant un groupement eliminable sur le radical amino, leur procede de preparation et leur application a la synthese de produits actifs comme medicaments
US4337197A (en) * 1980-10-31 1982-06-29 E. R. Squibb & Sons, Inc. O-sulfated β-lactam hydroxamic acids and intermediates
US4939253A (en) * 1982-08-04 1990-07-03 E. R. Squibb & Sons, Inc. 2-oxoazetidin-1-yloxy acetic acids and analogs
NZ205642A (en) * 1982-10-06 1986-08-08 Squibb & Sons Inc Beta-lactams and pharmaceutical compositions

Also Published As

Publication number Publication date
EP0371004A1 (de) 1990-05-30
JPH0662532B2 (ja) 1994-08-17
CA1262357A (en) 1989-10-17
JPH069528A (ja) 1994-01-18
DE3580803D1 (de) 1991-01-17
EP0170280B1 (de) 1990-12-05
IE58758B1 (en) 1993-11-03
DK353385D0 (da) 1985-08-02
DK353385A (da) 1986-02-04
JPS6147445A (ja) 1986-03-07
IE851917L (en) 1986-02-03
EP0170280A1 (de) 1986-02-05
AU589567B2 (en) 1989-10-19
ATE58896T1 (de) 1990-12-15
FI852974L (fi) 1986-02-04
FI852974A7 (fi) 1986-02-04
AU4083589A (en) 1990-02-08
AU4535685A (en) 1986-02-06
NZ212750A (en) 1989-04-26
AU614663B2 (en) 1991-09-05
IE58771B1 (en) 1993-11-03
US4581170A (en) 1986-04-08
FI852974A0 (fi) 1985-08-01
ZA855492B (en) 1986-03-26
JPH06732B2 (ja) 1994-01-05

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Legal Events

Date Code Title Description
MKLA Lapsed
MKLA Lapsed

Effective date: 19950417