CA1270842C - Derives de substitution 5,6-epoxy-7-oxabicycloheptane d'analogues de la prostaglandine - Google Patents
Derives de substitution 5,6-epoxy-7-oxabicycloheptane d'analogues de la prostaglandineInfo
- Publication number
- CA1270842C CA1270842C CA 507060 CA507060A CA1270842C CA 1270842 C CA1270842 C CA 1270842C CA 507060 CA507060 CA 507060 CA 507060 A CA507060 A CA 507060A CA 1270842 C CA1270842 C CA 1270842C
- Authority
- CA
- Canada
- Prior art keywords
- epoxy
- prostaglandin analogs
- lower alkyl
- substituted prostaglandin
- oxabicycloheptane substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- FEDCCDFKBRMHAC-UHFFFAOYSA-N 3-(8-oxabicyclo[5.1.0]octan-3-yl)-2,8-dioxabicyclo[5.1.0]octane Chemical group C1(CCCC2C(O1)O2)C1CCCC2C(C1)O2 FEDCCDFKBRMHAC-UHFFFAOYSA-N 0.000 title abstract 2
- 150000003180 prostaglandins Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA595286A CA1271198C (fr) | 1985-05-21 | 1986-04-18 | Derives de substitution 5,6-epoxy-7-oxabicycloptane d'analogues de la prostaglandine |
| CA000595287A CA1270842A (fr) | 1985-05-21 | 1989-03-30 | Derives de substitution 5,6-epoxy-7-oxabicycloheptane d'analogues de la prostaglandine |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US736,628 | 1985-05-21 | ||
| US06/736,628 US4611005A (en) | 1985-05-21 | 1985-05-21 | 5,6-epoxy-7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA595286A Division CA1271198C (fr) | 1985-05-21 | 1986-04-18 | Derives de substitution 5,6-epoxy-7-oxabicycloptane d'analogues de la prostaglandine |
| CA000595287A Division CA1270842A (fr) | 1985-05-21 | 1989-03-30 | Derives de substitution 5,6-epoxy-7-oxabicycloheptane d'analogues de la prostaglandine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA1262737A CA1262737A (fr) | 1989-11-07 |
| CA1270842C true CA1270842C (fr) | 1990-06-26 |
Family
ID=24960622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 507060 Expired - Lifetime CA1270842C (fr) | 1985-05-21 | 1986-04-18 | Derives de substitution 5,6-epoxy-7-oxabicycloheptane d'analogues de la prostaglandine |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4611005A (fr) |
| EP (1) | EP0205857A3 (fr) |
| JP (1) | JPS61271290A (fr) |
| CA (1) | CA1270842C (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4734426A (en) * | 1986-09-24 | 1988-03-29 | E. R. Squibb & Sons, Inc. | 5,6-epoxy-7-oxabicycloheptane substituted diamide prostaglandin analogs |
| CA2450073C (fr) | 2001-07-25 | 2017-08-29 | Biomarin Pharmaceutical Inc. | Compositions et procedes de modulation du transport a travers la barriere hematho-encephalique |
| EP2671508B1 (fr) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Système pharma-informatique |
| JP2010503710A (ja) | 2006-09-18 | 2010-02-04 | ラプトール ファーマシューティカル インコーポレイテッド | 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置 |
| ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| KR20180114970A (ko) | 2009-05-06 | 2018-10-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4143054A (en) * | 1977-11-04 | 1979-03-06 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane- and 7-oxabicycloheptene compounds |
| US4187236A (en) * | 1977-11-04 | 1980-02-05 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane compounds |
| US4220594A (en) * | 1977-11-04 | 1980-09-02 | E. R. Squibb & Sons, Inc. | Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol |
| US4254044A (en) * | 1977-11-04 | 1981-03-03 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds |
| GB2039909B (en) * | 1979-01-05 | 1983-06-15 | Wilson N | Prostaglandins |
| US4228180A (en) * | 1979-11-01 | 1980-10-14 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs |
| ZA829068B (en) * | 1980-07-01 | 1983-02-23 | Nat Res Dev | Prostaglandins |
| US4609671A (en) * | 1985-06-27 | 1986-09-02 | E. R. Squibb & Sons, Inc. | 5,6-epoxy-7-oxabicycloheptane substituted amino prostaglandin analogs useful in the treatment of thrombotic disease |
| US4611006A (en) * | 1985-06-28 | 1986-09-09 | E. R. Squibb & Sons, Inc. | 5,6-epoxy-7-oxabicycloheptane substituted ethers useful in the treatment of thrombotic disease |
-
1985
- 1985-05-21 US US06/736,628 patent/US4611005A/en not_active Expired - Fee Related
-
1986
- 1986-04-18 CA CA 507060 patent/CA1270842C/fr not_active Expired - Lifetime
- 1986-05-09 EP EP86106308A patent/EP0205857A3/fr not_active Ceased
- 1986-05-20 JP JP61117118A patent/JPS61271290A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0205857A3 (fr) | 1987-10-28 |
| EP0205857A2 (fr) | 1986-12-30 |
| US4611005A (en) | 1986-09-09 |
| CA1262737A (fr) | 1989-11-07 |
| JPS61271290A (ja) | 1986-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU564842B2 (en) | Pyranyl (or cyclohexyl) methane sulfamates and their use as anticonvulsants | |
| DE69033069D1 (de) | Prostaglandinanaloge | |
| CA1262138C (fr) | Analogues de prostaglandine tetrahydrothienyl substitue | |
| EP0198686A3 (fr) | Dioxolanes méthanesulfamates comme anticonvulsifs | |
| EP0164987A3 (fr) | Analogues de prostaglandines 7-oxabicycloheptanes substitués | |
| EP0210664A3 (fr) | Analogues de prostaglandine diamides de diacides 7-oxabicycloheptane substitués | |
| SE8401398D0 (sv) | 7-oxabicykloheptansubstituerade prostaglandinanaloger | |
| GB2196338B (en) | 7-oxabicycloheptane substituted hydroxamic acid prostaglandin analogs | |
| CA1262140C (fr) | Alcools de 7-oxabicycloheptane prostaglandine substitues | |
| EP0205857A3 (fr) | Analogues de prostaglandine 5,6-époxy-7-oxabicycloheptanes substitués | |
| IL90267A (en) | Enantiomeric glutaramide diuretic agents, process for their preparation and compositions containing them | |
| EP0183238A3 (fr) | Analogues de prostaglandine 7-oxabicycloheptane substitué | |
| SE8100846L (sv) | Antirinovirusmedel | |
| CA1267150C (fr) | Derives de substitution par le thiabicycloheptane d'analogues d'amino-prostaglandines | |
| GB2177091B (en) | 5,6-epoxy-7-oxabicycloheptane substituted amino prostaglandin analogs useful in the treatment of thrombotic disease | |
| CA1262912C (fr) | Derives de substitution tetrahydrofuranyliques d'analogues de la prostaglandine | |
| CA1268468C (fr) | Analogues des prostaglandines avec groupement thiabicycloheptane substitue | |
| CA1271198C (fr) | Derives de substitution 5,6-epoxy-7-oxabicycloptane d'analogues de la prostaglandine | |
| CA1267906C (fr) | Analogues de prostaglandine avec groupement 7-oxabicycloheptane substitue | |
| EP0319254A3 (fr) | Intermédiaires pour la production des pyridobenzocycloheptènes | |
| IT8648672A0 (it) | Procedimento per la preparazione dell'estere etilico dell'acido apovincaminico | |
| PH18003A (en) | Fluorinated diamino-heptene and heptyne derivatives | |
| IT1173549B (it) | Estere dell'acido teofillin-7-acetico con il d,l-trans-sobrerolo avente attivita' mucosecretolitica-fluidificante e antibroncospastica, procedimento per la sua preparazione e sue composizioni farmaceutiche | |
| IT1181812B (it) | Procedimento per la preparazione dell'acido gamma-dimetilammino l-beta-idrossibutirrico | |
| IT1149845B (it) | Procedimento per la preparazione di acilidrazoni dell'estere dell'acido formilacetico |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed | ||
| MKLA | Lapsed |
Effective date: 19920509 |