CA1277274C - Expanseur de plasma a base d'amidon - Google Patents

Expanseur de plasma a base d'amidon

Info

Publication number: CA1277274C
Authority: CA; Canada
Prior art keywords: starch; process according; carried out; amylase; decomposition
Prior art date: 1985-01-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA000471870A

Other languages

English (en)

Inventor

Hubert Perter Ferber

Ernst Nitsch

Siegfried Muhlbock

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Laevosan GmbH and Co KG

Original Assignee

Laevosan GmbH and Co KG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-10

Filing date

1985-01-10

Publication date

1990-12-04

1985-01-10 Application filed by Laevosan GmbH and Co KG filed Critical Laevosan GmbH and Co KG

1985-01-10 Priority to CA000471870A priority Critical patent/CA1277274C/fr

1990-12-04 Application granted granted Critical

1990-12-04 Publication of CA1277274C publication Critical patent/CA1277274C/fr

2007-12-04 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

229920002472 Starch Polymers 0.000 title claims abstract description 35
235000019698 starch Nutrition 0.000 title claims abstract description 33
239000008107 starch Substances 0.000 title claims abstract description 30
239000003058 plasma substitute Substances 0.000 title claims abstract description 16
238000000354 decomposition reaction Methods 0.000 claims abstract description 34
238000000034 method Methods 0.000 claims abstract description 26
239000004382 Amylase Substances 0.000 claims abstract description 21
238000006266 etherification reaction Methods 0.000 claims abstract description 20
230000003301 hydrolyzing effect Effects 0.000 claims abstract description 18
238000006467 substitution reaction Methods 0.000 claims abstract description 16
230000007062 hydrolysis Effects 0.000 claims abstract description 14
238000006460 hydrolysis reaction Methods 0.000 claims abstract description 14
229920000945 Amylopectin Polymers 0.000 claims abstract description 11
238000002360 preparation method Methods 0.000 claims abstract description 9
108090000637 alpha-Amylases Proteins 0.000 claims abstract description 4
229920001612 Hydroxyethyl starch Polymers 0.000 claims description 15
229940050526 hydroxyethylstarch Drugs 0.000 claims description 15
DNZMDASEFMLYBU-RNBXVSKKSA-N hydroxyethyl starch Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O.OCCOC[C@H]1O[C@H](OCCO)[C@H](OCCO)[C@@H](OCCO)[C@@H]1OCCO DNZMDASEFMLYBU-RNBXVSKKSA-N 0.000 claims description 14
230000002255 enzymatic effect Effects 0.000 claims description 8
238000011026 diafiltration Methods 0.000 claims description 6
230000007717 exclusion Effects 0.000 claims description 5
239000002253 acid Substances 0.000 claims description 4
229920002261 Corn starch Polymers 0.000 claims description 3
235000019759 Maize starch Nutrition 0.000 claims description 3
240000006394 Sorghum bicolor Species 0.000 claims description 3
235000011684 Sorghum saccharatum Nutrition 0.000 claims description 3
238000000502 dialysis Methods 0.000 claims description 3
239000012528 membrane Substances 0.000 claims description 3
235000009430 Thespesia populnea Nutrition 0.000 claims description 2
229940100486 rice starch Drugs 0.000 claims description 2
TURGQPDWYFJEDY-UHFFFAOYSA-N 1-hydroperoxypropane Chemical compound CCCOO TURGQPDWYFJEDY-UHFFFAOYSA-N 0.000 claims 1
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
239000000047 product Substances 0.000 description 7
239000000243 solution Substances 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
229920002307 Dextran Polymers 0.000 description 5
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 5
238000006243 chemical reaction Methods 0.000 description 5
210000002381 plasma Anatomy 0.000 description 5
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
239000000706 filtrate Substances 0.000 description 4
238000001802 infusion Methods 0.000 description 4
210000002966 serum Anatomy 0.000 description 4
206010020751 Hypersensitivity Diseases 0.000 description 3
238000005903 acid hydrolysis reaction Methods 0.000 description 3
238000010171 animal model Methods 0.000 description 3
230000003247 decreasing effect Effects 0.000 description 3
210000000056 organ Anatomy 0.000 description 3
108010065511 Amylases Proteins 0.000 description 2
102000013142 Amylases Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
-1 alkylene chlorhydrin Chemical compound 0.000 description 2
125000002947 alkylene group Chemical group 0.000 description 2
235000019418 amylase Nutrition 0.000 description 2
229940025131 amylases Drugs 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical class OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
229940088598 enzyme Drugs 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
239000000835 fiber Substances 0.000 description 2
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 2
239000000843 powder Substances 0.000 description 2
230000035484 reaction time Effects 0.000 description 2
239000012465 retentate Substances 0.000 description 2
239000012266 salt solution Substances 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
239000007858 starting material Substances 0.000 description 2
238000001291 vacuum drying Methods 0.000 description 2
229920000856 Amylose Polymers 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
241001208007 Procas Species 0.000 description 1
GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
101710108253 Pullulanase A Proteins 0.000 description 1
239000003513 alkali Substances 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000011109 contamination Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000002036 drum drying Methods 0.000 description 1
230000007071 enzymatic hydrolysis Effects 0.000 description 1
238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
125000001033 ether group Chemical group 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
125000002768 hydroxyalkyl group Chemical group 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000000463 material Substances 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000011403 purification operation Methods 0.000 description 1
239000008279 sol Substances 0.000 description 1
238000013222 sprague-dawley male rat Methods 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
108010075550 termamyl Proteins 0.000 description 1
238000005406 washing Methods 0.000 description 1

Landscapes

Polysaccharides And Polysaccharide Derivatives (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

CA000471870A 1985-01-10 1985-01-10 Expanseur de plasma a base d'amidon Expired - Fee Related CA1277274C (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000471870A CA1277274C (fr)	1985-01-10	1985-01-10	Expanseur de plasma a base d'amidon

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000471870A CA1277274C (fr)	1985-01-10	1985-01-10	Expanseur de plasma a base d'amidon

Publications (1)

Publication Number	Publication Date
CA1277274C true CA1277274C (fr)	1990-12-04

Family

ID=4129553

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000471870A Expired - Fee Related CA1277274C (fr)	1985-01-10	1985-01-10	Expanseur de plasma a base d'amidon

Country Status (1)

Country	Link
CA (1)	CA1277274C (fr)

1985
- 1985-01-10 CA CA000471870A patent/CA1277274C/fr not_active Expired - Fee Related

Legal Events

Date	Code	Title	Description
2004-12-06	MKLA	Lapsed

Publication	Publication Date	Title
US4629698A (en)	1986-12-16	Plasma expander based on starch
US5218108A (en)	1993-06-08	Hydroxylethylstarch (hes) as plasma expander and process for preparing hes
CA1230186A (fr)	1987-12-08	Gels reticules d'acide hyaluronique et produits qui renferment ces gels
EP0688872B1 (fr)	1999-03-17	Procédé pour la préparation des produits contenants de l'amidon
US4963666A (en)	1990-10-16	Material of polysaccharides containing carboxyl groups, and a process for producing such polysaccharides
EP0372184B1 (fr)	1994-03-16	Amidons partiellement déramifiés et procédé enzymatique pour leur préparation
US2437518A (en)	1948-03-09	Manufacture of infusion and injection fluids
JP5340093B2 (ja)	2013-11-13	架橋ヒアルロン酸の製造方法
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CN101787083B (zh)	2012-05-02	非离子阳离子瓜尔胶及其制备方法
JPS59113889A (ja)	1984-06-30	固定化酵素もしくは固定化微生物菌体の製造方法
SK36994A3 (en)	1994-10-05	Method of producing starch decomposition products with a narrow molecular-weight distribution
US7550446B2 (en)	2009-06-23	Highly branched, unsubstituted or low-substituted starch products, dialysis solution and plasma expander containing the same, and the use thereof
CA1277274C (fr)	1990-12-04	Expanseur de plasma a base d'amidon
US7393841B2 (en)	2008-07-01	Hyperbranched amylopectin for use in methods for surgical or therapeutic treatment of mammals or in diagnostic methods, especially for use as a plasma volume expander
JP3002916B2 (ja)	2000-01-24	セルロース混合エーテルの製造法
US3725386A (en)	1973-04-03	Method for purifying crude, dry granular reacted cold water swelling hydroxypropyl starch derivatives
JP2000060590A (ja)	2000-02-29	シクロデキストリンの生成方法
US3804716A (en)	1974-04-16	Starch conversion products and processes for preparing same
US20070202577A1 (en)	2007-08-30	Method For The Production Of Hyperbranched Polysaccharide Fractions
TW200838552A (en)	2008-10-01	Methyl esters of hyaluronic acid
US3833555A (en)	1974-09-03	Polysaccharide cyclic carbamate containing compounds
US4167621A (en)	1979-09-11	Method for preparing starch ether derivatives
JP2005281654A (ja)	2005-10-13	温度応答性組成物およびそのヒドロゲル
EP0907662B1 (fr)	2003-06-04	Polysaccharides d'hydroxyalkyle galactosyles et leurs derives