CA1316111C - Compositions de cholestyramine et methode de preparation - Google Patents

Compositions de cholestyramine et methode de preparation

Info

Publication number: CA1316111C
Authority: CA; Canada
Prior art keywords: syrup; dough; paste; cholestyramine; powder
Prior art date: 1987-12-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA000554521A

Other languages

English (en)

Inventor

Moh. Samir Amer

Jack C. Gray

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Amer and Co

Original Assignee

Amer and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-16

Filing date

1987-12-16

Publication date

1993-04-13

1987-12-16 Application filed by Amer and Co filed Critical Amer and Co

1987-12-16 Priority to CA000554521A priority Critical patent/CA1316111C/fr

1993-04-13 Application granted granted Critical

1993-04-13 Publication of CA1316111C publication Critical patent/CA1316111C/fr

2010-04-13 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

229920001268 Cholestyramine Polymers 0.000 title claims abstract description 48
239000000203 mixture Substances 0.000 title claims abstract description 41
238000000034 method Methods 0.000 title claims description 19
238000002360 preparation method Methods 0.000 title description 4
239000006188 syrup Substances 0.000 claims abstract description 41
235000020357 syrup Nutrition 0.000 claims abstract description 41
239000000843 powder Substances 0.000 claims abstract description 27
DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims abstract description 24
150000001720 carbohydrates Chemical class 0.000 claims abstract description 21
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 13
239000000463 material Substances 0.000 claims abstract description 13
229920001100 Polydextrose Polymers 0.000 claims abstract description 12
239000001259 polydextrose Substances 0.000 claims abstract description 12
235000013856 polydextrose Nutrition 0.000 claims abstract description 12
229940035035 polydextrose Drugs 0.000 claims abstract description 12
235000013361 beverage Nutrition 0.000 claims abstract description 5
210000004369 blood Anatomy 0.000 claims abstract description 5
239000008280 blood Substances 0.000 claims abstract description 5
235000019534 high fructose corn syrup Nutrition 0.000 claims abstract description 3
235000014633 carbohydrates Nutrition 0.000 claims description 19
239000007787 solid Substances 0.000 claims description 17
238000002156 mixing Methods 0.000 claims description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
239000003613 bile acid Substances 0.000 claims description 7
230000009965 odorless effect Effects 0.000 claims description 6
229920000168 Microcrystalline cellulose Polymers 0.000 claims description 4
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 4
235000002017 Zea mays subsp mays Nutrition 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 4
235000005822 corn Nutrition 0.000 claims description 4
239000008108 microcrystalline cellulose Substances 0.000 claims description 4
235000019813 microcrystalline cellulose Nutrition 0.000 claims description 4
229940016286 microcrystalline cellulose Drugs 0.000 claims description 4
229920001285 xanthan gum Polymers 0.000 claims description 4
229960004903 invert sugar Drugs 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
229920000609 methyl cellulose Polymers 0.000 claims description 3
239000001923 methylcellulose Substances 0.000 claims description 3
235000010981 methylcellulose Nutrition 0.000 claims description 3
235000000346 sugar Nutrition 0.000 claims description 3
239000000230 xanthan gum Substances 0.000 claims description 3
235000010493 xanthan gum Nutrition 0.000 claims description 3
229940082509 xanthan gum Drugs 0.000 claims description 3
239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
150000004676 glycans Chemical class 0.000 claims description 2
235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
229920001282 polysaccharide Polymers 0.000 claims description 2
239000005017 polysaccharide Substances 0.000 claims description 2
235000020374 simple syrup Nutrition 0.000 claims description 2
229960004016 sucrose syrup Drugs 0.000 claims description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
241000209149 Zea Species 0.000 claims 1
235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
239000003638 chemical reducing agent Substances 0.000 claims 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
239000007788 liquid Substances 0.000 abstract description 18
239000003906 humectant Substances 0.000 abstract description 11
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 6
239000002781 deodorant agent Substances 0.000 abstract description 5
-1 alcohol polyol Chemical class 0.000 abstract description 4
229920005862 polyol Polymers 0.000 abstract description 4
235000011187 glycerol Nutrition 0.000 abstract description 3
235000012431 wafers Nutrition 0.000 description 14
235000019645 odor Nutrition 0.000 description 7
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 5
229960002737 fructose Drugs 0.000 description 5
235000011837 pasties Nutrition 0.000 description 5
229930091371 Fructose Natural products 0.000 description 4
239000005715 Fructose Substances 0.000 description 4
239000000654 additive Substances 0.000 description 4
230000001877 deodorizing effect Effects 0.000 description 4
239000000796 flavoring agent Substances 0.000 description 4
235000019634 flavors Nutrition 0.000 description 4
241000282461 Canis lupus Species 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
208000035150 Hypercholesterolemia Diseases 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
240000008042 Zea mays Species 0.000 description 3
230000001476 alcoholic effect Effects 0.000 description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
239000011248 coating agent Substances 0.000 description 3
238000000576 coating method Methods 0.000 description 3
235000019610 cohesiveness Nutrition 0.000 description 3
239000002285 corn oil Substances 0.000 description 3
235000005687 corn oil Nutrition 0.000 description 3
150000003077 polyols Chemical class 0.000 description 3
239000000243 solution Substances 0.000 description 3
108010011485 Aspartame Proteins 0.000 description 2
235000005979 Citrus limon Nutrition 0.000 description 2
244000131522 Citrus pyriformis Species 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
108010068370 Glutens Proteins 0.000 description 2
102000007330 LDL Lipoproteins Human genes 0.000 description 2
108010007622 LDL Lipoproteins Proteins 0.000 description 2
241000700159 Rattus Species 0.000 description 2
239000000605 aspartame Substances 0.000 description 2
235000010357 aspartame Nutrition 0.000 description 2
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
229960003438 aspartame Drugs 0.000 description 2
239000011230 binding agent Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
235000019219 chocolate Nutrition 0.000 description 2
235000012000 cholesterol Nutrition 0.000 description 2
235000020971 citrus fruits Nutrition 0.000 description 2
235000014510 cooky Nutrition 0.000 description 2
239000008121 dextrose Substances 0.000 description 2
235000005911 diet Nutrition 0.000 description 2
230000037213 diet Effects 0.000 description 2
235000021312 gluten Nutrition 0.000 description 2
210000000936 intestine Anatomy 0.000 description 2
229960002900 methylcellulose Drugs 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
235000010356 sorbitol Nutrition 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
102000011632 Caseins Human genes 0.000 description 1
108010076119 Caseins Proteins 0.000 description 1
241000207199 Citrus Species 0.000 description 1
235000008733 Citrus aurantifolia Nutrition 0.000 description 1
206010010774 Constipation Diseases 0.000 description 1
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
240000001238 Gaultheria procumbens Species 0.000 description 1
235000007297 Gaultheria procumbens Nutrition 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
235000006679 Mentha X verticillata Nutrition 0.000 description 1
235000014749 Mentha crispa Nutrition 0.000 description 1
244000024873 Mentha crispa Species 0.000 description 1
244000246386 Mentha pulegium Species 0.000 description 1
235000016257 Mentha pulegium Nutrition 0.000 description 1
235000002899 Mentha suaveolens Nutrition 0.000 description 1
235000004357 Mentha x piperita Nutrition 0.000 description 1
235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
229920000881 Modified starch Polymers 0.000 description 1
108010058846 Ovalbumin Proteins 0.000 description 1
241001516739 Platonia insignis Species 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
235000019485 Safflower oil Nutrition 0.000 description 1
241000245026 Scoliopus bigelovii Species 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
235000016639 Syzygium aromaticum Nutrition 0.000 description 1
244000223014 Syzygium aromaticum Species 0.000 description 1
101150007148 THI5 gene Proteins 0.000 description 1
235000011941 Tilia x europaea Nutrition 0.000 description 1
241000209140 Triticum Species 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
238000013019 agitation Methods 0.000 description 1
239000003957 anion exchange resin Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000008122 artificial sweetener Substances 0.000 description 1
235000021311 artificial sweeteners Nutrition 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
235000012467 brownies Nutrition 0.000 description 1
229940077731 carbohydrate nutrients Drugs 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
229940107170 cholestyramine resin Drugs 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
235000009508 confectionery Nutrition 0.000 description 1
208000029078 coronary artery disease Diseases 0.000 description 1
239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
230000029087 digestion Effects 0.000 description 1
238000007598 dipping method Methods 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000010235 enterohepatic circulation Effects 0.000 description 1
235000019197 fats Nutrition 0.000 description 1
238000011049 filling Methods 0.000 description 1
235000013312 flour Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000001727 glucose Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
208000019622 heart disease Diseases 0.000 description 1
235000021083 high saturated fats Nutrition 0.000 description 1
235000012907 honey Nutrition 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000004571 lime Substances 0.000 description 1
XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
239000008297 liquid dosage form Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
239000011707 mineral Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
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235000013379 molasses Nutrition 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
239000007968 orange flavor Substances 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
235000014594 pastries Nutrition 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
230000036470 plasma concentration Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
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239000002243 precursor Substances 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
125000001453 quaternary ammonium group Chemical group 0.000 description 1
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239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000005096 rolling process Methods 0.000 description 1
239000003813 safflower oil Substances 0.000 description 1
235000005713 safflower oil Nutrition 0.000 description 1
235000021003 saturated fats Nutrition 0.000 description 1
235000020183 skimmed milk Nutrition 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229940080237 sodium caseinate Drugs 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
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150000005846 sugar alcohols Polymers 0.000 description 1
239000008399 tap water Substances 0.000 description 1
235000020679 tap water Nutrition 0.000 description 1
235000019587 texture Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
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235000013343 vitamin Nutrition 0.000 description 1
229940095676 wafer product Drugs 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

Landscapes

Medicinal Preparation (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

CA000554521A 1987-12-16 1987-12-16 Compositions de cholestyramine et methode de preparation Expired - Fee Related CA1316111C (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000554521A CA1316111C (fr)	1987-12-16	1987-12-16	Compositions de cholestyramine et methode de preparation

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000554521A CA1316111C (fr)	1987-12-16	1987-12-16	Compositions de cholestyramine et methode de preparation

Publications (1)

Publication Number	Publication Date
CA1316111C true CA1316111C (fr)	1993-04-13

Family

ID=4137088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000554521A Expired - Fee Related CA1316111C (fr)	1987-12-16	1987-12-16	Compositions de cholestyramine et methode de preparation

Country Status (1)

Country	Link
CA (1)	CA1316111C (fr)

1987
- 1987-12-16 CA CA000554521A patent/CA1316111C/fr not_active Expired - Fee Related

Legal Events

Date	Code	Title	Description
1995-10-15	MKLA	Lapsed

Publication	Publication Date	Title
US4895723A (en)	1990-01-23	Cholestyramine compositions and method for preparation thereof
US5281584A (en)	1994-01-25	Effect of particle-size distribution of cellulose ethers on palatability of compositions
EP0336894B1 (fr)	1991-12-04	Système de livraison de pectine sans sucre
US4778676A (en)	1988-10-18	Confectionery delivery system for actives
US4882152A (en)	1989-11-21	Confectionery delivery system for laxatives, vitamins and antacids
US4882160A (en)	1989-11-21	Confectionery delivery system for dictary fiber
DE2542158A1 (de)	1976-04-01	Pharmazeutisches mittel fuer die verabreichung in der mundhoehle und verfahren zu seiner herstellung
US4882154A (en)	1989-11-21	Confectionery delivery system for mineral supplements
US5686107A (en)	1997-11-11	Chewable pharmaceutical tablets
EP0306469B1 (fr)	1992-03-04	Composition de garniture contenant du psyllium
US4882157A (en)	1989-11-21	Confectionery delivery system for anti-cholesterolemics
GB1590507A (en)	1981-06-03	Method of controlling fecal output and compositions therefor
US4882153A (en)	1989-11-21	Confectionery delivery system for antitussives
US4882159A (en)	1989-11-21	Confectionery delivery system for appetite suppressants
US4837255A (en)	1989-06-06	Palatable hypocholesterolaemic gel formulation containing a pharmaceutically acceptable non-digestible anion exchange resin
JP3065351B2 (ja)	2000-07-17	オオバコ含有組成物
EP0320519B1 (fr)	1992-10-14	Compositions de cholestyramine et leur méthode de préparation
US4476121A (en)	1984-10-09	Bowel evacuant and method of treating constipation
US4882156A (en)	1989-11-21	Confectionery delivery system for expectorants
JPH01172324A (ja)	1989-07-07	コレスチラミン組成物及びその製造法
CA2021544A1 (fr)	1991-01-21	Formule mastiquable pour la dispensation d'ingredients actifs
CA1316111C (fr)	1993-04-13	Compositions de cholestyramine et methode de preparation
US4882155A (en)	1989-11-21	Confectionery delivery system for antiarrhythmics
US4882158A (en)	1989-11-21	Confectionery delivery system for decongestants
EP0652757B1 (fr)	2002-03-13	Compositions d'ether cellulosique melangees a sec et sans sucre en tant que laxatifs a effet de masse