CA1318353C - Systeme a biocapteur pour le controle des caracteristiques d'un element choisi dans un milieu porteur - Google Patents
Systeme a biocapteur pour le controle des caracteristiques d'un element choisi dans un milieu porteurInfo
- Publication number
- CA1318353C CA1318353C CA000565850A CA565850A CA1318353C CA 1318353 C CA1318353 C CA 1318353C CA 000565850 A CA000565850 A CA 000565850A CA 565850 A CA565850 A CA 565850A CA 1318353 C CA1318353 C CA 1318353C
- Authority
- CA
- Canada
- Prior art keywords
- component
- binding
- sensor
- characteristic
- detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000004044 response Effects 0.000 claims abstract description 45
- 230000005669 field effect Effects 0.000 claims abstract description 6
- 238000001514 detection method Methods 0.000 claims description 39
- 238000012545 processing Methods 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 13
- 239000011230 binding agent Substances 0.000 claims description 7
- 238000012544 monitoring process Methods 0.000 claims description 6
- 239000013110 organic ligand Substances 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 abstract description 21
- 108090000623 proteins and genes Proteins 0.000 abstract description 21
- 102000014914 Carrier Proteins Human genes 0.000 abstract description 17
- 108091008324 binding proteins Proteins 0.000 abstract description 17
- 239000003446 ligand Substances 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 7
- 238000004458 analytical method Methods 0.000 abstract description 5
- 230000002441 reversible effect Effects 0.000 abstract description 4
- 239000000243 solution Substances 0.000 description 37
- 239000000463 material Substances 0.000 description 17
- 239000012212 insulator Substances 0.000 description 11
- 239000000758 substrate Substances 0.000 description 9
- 108091006146 Channels Proteins 0.000 description 8
- 230000000875 corresponding effect Effects 0.000 description 8
- 230000006870 function Effects 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
- 230000008859 change Effects 0.000 description 6
- 230000003750 conditioning effect Effects 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 238000010276 construction Methods 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 239000004065 semiconductor Substances 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 239000002800 charge carrier Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229910052681 coesite Inorganic materials 0.000 description 2
- 230000001143 conditioned effect Effects 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 229910052906 cristobalite Inorganic materials 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000011810 insulating material Substances 0.000 description 2
- 229910044991 metal oxide Inorganic materials 0.000 description 2
- 150000004706 metal oxides Chemical class 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000010865 sewage Substances 0.000 description 2
- 229910052682 stishovite Inorganic materials 0.000 description 2
- 229910052905 tridymite Inorganic materials 0.000 description 2
- 239000012808 vapor phase Substances 0.000 description 2
- KAVDAMFOTJIBCK-XSHPSBQMSA-N 5-[(e)-2-bromoethenyl]-1-[(1s,3r,4s)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidine-2,4-dione Chemical compound C1[C@@H](O)[C@H](CO)C[C@@H]1N1C(=O)NC(=O)C(\C=C\Br)=C1 KAVDAMFOTJIBCK-XSHPSBQMSA-N 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 229910001218 Gallium arsenide Inorganic materials 0.000 description 1
- 108010075750 P-Type Calcium Channels Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 108010092494 Periplasmic binding proteins Proteins 0.000 description 1
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 description 1
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 description 1
- 229910052581 Si3N4 Inorganic materials 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 101100286583 Xenopus laevis igf3 gene Proteins 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910052787 antimony Inorganic materials 0.000 description 1
- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 230000003196 chaotropic effect Effects 0.000 description 1
- 238000012993 chemical processing Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 229910052593 corundum Inorganic materials 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000010252 digital analysis Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000004889 fertilizer analysis Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- BPUBBGLMJRNUCC-UHFFFAOYSA-N oxygen(2-);tantalum(5+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ta+5].[Ta+5] BPUBBGLMJRNUCC-UHFFFAOYSA-N 0.000 description 1
- 210000001322 periplasm Anatomy 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- -1 plstinum Chemical compound 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000013139 quantization Methods 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 150000004756 silanes Chemical class 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000004856 soil analysis Methods 0.000 description 1
- 238000010129 solution processing Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910001936 tantalum oxide Inorganic materials 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 230000036964 tight binding Effects 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000005353 urine analysis Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229910001845 yogo sapphire Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4708087A | 1987-05-05 | 1987-05-05 | |
| US047,080 | 1987-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1318353C true CA1318353C (fr) | 1993-05-25 |
Family
ID=21946965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000565850A Expired - Fee Related CA1318353C (fr) | 1987-05-05 | 1988-05-04 | Systeme a biocapteur pour le controle des caracteristiques d'un element choisi dans un milieu porteur |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0313629A1 (fr) |
| CA (1) | CA1318353C (fr) |
| WO (1) | WO1988008972A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5328847A (en) * | 1990-02-20 | 1994-07-12 | Case George D | Thin membrane sensor with biochemical switch |
| GB2287296B (en) * | 1994-03-08 | 1997-08-20 | Pektron Ltd | Flow sensing apparatus |
| US5719033A (en) * | 1995-06-28 | 1998-02-17 | Motorola, Inc. | Thin film transistor bio/chemical sensor |
| EP0894148A4 (fr) * | 1996-04-17 | 1999-06-16 | Motorola Inc | Detecteur moleculaire transistorise et procede correspondant |
| US5827482A (en) * | 1996-08-20 | 1998-10-27 | Motorola Corporation | Transistor-based apparatus and method for molecular detection and field enhancement |
| DE10247889A1 (de) * | 2002-10-14 | 2004-04-22 | Infineon Technologies Ag | Sensor-Anordnung und Verfahren zum Betreiben einer Sensor-Anordnung |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3831432A (en) * | 1972-09-05 | 1974-08-27 | Texas Instruments Inc | Environment monitoring device and system |
| US4020830A (en) * | 1975-03-12 | 1977-05-03 | The University Of Utah | Selective chemical sensitive FET transducers |
| US4238757A (en) * | 1976-03-19 | 1980-12-09 | General Electric Company | Field effect transistor for detection of biological reactions |
| US4334880A (en) * | 1980-10-20 | 1982-06-15 | Malmros Mark K | Analytical device having semiconductive polyacetylene element associated with analyte-binding substance |
| JPS59125054A (ja) * | 1983-01-05 | 1984-07-19 | Kuraray Co Ltd | イオン濃度測定装置 |
| NL8400916A (nl) * | 1984-03-22 | 1985-10-16 | Stichting Ct Voor Micro Elektr | Werkwijze voor het vervaardigen van een isfet en een aldus vervaardigde isfet. |
| DE3688489T2 (de) * | 1985-08-29 | 1993-09-16 | Matsushita Electric Ind Co Ltd | Einen feldeffekttransistor benutzender fuehler und dessen herstellungsverfahren. |
-
1988
- 1988-05-04 CA CA000565850A patent/CA1318353C/fr not_active Expired - Fee Related
- 1988-05-04 WO PCT/US1988/001494 patent/WO1988008972A1/fr not_active Ceased
- 1988-05-04 EP EP19880904377 patent/EP0313629A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1988008972A1 (fr) | 1988-11-17 |
| EP0313629A1 (fr) | 1989-05-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5074977A (en) | Digital biosensors and method of using same | |
| US4508613A (en) | Miniaturized potassium ion sensor | |
| US5309085A (en) | Measuring circuit with a biosensor utilizing ion sensitive field effect transistors | |
| US5387328A (en) | Bio-sensor using ion sensitive field effect transistor with platinum electrode | |
| EP2295957B1 (fr) | Circuit digitale de traitment de signeaux comprenant un transistor a effet de champ sensible aux ions et procede pour surveiller une propriete d'un fluide | |
| WO1993008464A1 (fr) | Procede et dispositif de detection biochimique | |
| Chen et al. | Portable urea biosensor based on the extended-gate field effect transistor | |
| KR0162623B1 (ko) | 습윤중 마이크로 제작 센서를 분석용으로 사용하기 위한 방법 | |
| US6482639B2 (en) | Microelectronic device and method for label-free detection and quantification of biological and chemical molecules | |
| JPS5626250A (en) | Composite chemical sensor | |
| JPH0418625B2 (fr) | ||
| CA1318353C (fr) | Systeme a biocapteur pour le controle des caracteristiques d'un element choisi dans un milieu porteur | |
| Wilhelm et al. | pH sensor based on differential measurements on one pH-FET chip | |
| EP0223597A2 (fr) | Compensation du tampon dans des appareils sensibles aux ions, modifiés enzymatiquement | |
| Kelly | Microelectronic approaches to solid state ion selective electrodes | |
| JPS6029658A (ja) | 尿素センサ | |
| Igarashi et al. | Multiple ion sensor array | |
| Wu et al. | A direct immunoassay for schistosoma japonium antibody (SjAb) in serum by piezoelectric body acoustic wave sensor | |
| Senillou et al. | A miniaturized ammonium sensor based on the integration of both ammonium and reference FETs in a single chip | |
| JPH0469338B2 (fr) | ||
| JPS63208753A (ja) | 免疫センサ及び免疫検出方法 | |
| US20090194427A1 (en) | Using polypyrrole as the contrast ph detector to fabricate a whole solid-state ph sensing device | |
| Kullick et al. | Pbs‐field‐effect‐transistor for heavy metal concentration monitoring | |
| Jamasb et al. | Correction of instability in ion-selective field effect transistors (ISFETs) for accurate continuous monitoring of pH | |
| US20050133367A1 (en) | Electrical urea biosensors and its manufacturing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |