CA1327037C - Derives de la mitomycine a effet toxique reduit sur la moelle osseuse; methodes de preparation et d'utilisation - Google Patents
Derives de la mitomycine a effet toxique reduit sur la moelle osseuse; methodes de preparation et d'utilisationInfo
- Publication number
- CA1327037C CA1327037C CA000608960A CA608960A CA1327037C CA 1327037 C CA1327037 C CA 1327037C CA 000608960 A CA000608960 A CA 000608960A CA 608960 A CA608960 A CA 608960A CA 1327037 C CA1327037 C CA 1327037C
- Authority
- CA
- Canada
- Prior art keywords
- mitomycin
- saccharide
- pyranosyl
- derivative
- morpholinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- JKANAVGODYYCQF-UHFFFAOYSA-N prop-2-yn-1-amine Chemical compound NCC#C JKANAVGODYYCQF-UHFFFAOYSA-N 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- IOVGROKTTNBUGK-SJCJKPOMSA-N ritodrine Chemical compound N([C@@H](C)[C@H](O)C=1C=CC(O)=CC=1)CCC1=CC=C(O)C=C1 IOVGROKTTNBUGK-SJCJKPOMSA-N 0.000 description 1
- 206010039447 salmonellosis Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- JABYJIQOLGWMQW-UHFFFAOYSA-N undec-4-ene Chemical compound CCCCCCC=CCCC JABYJIQOLGWMQW-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23522488A | 1988-08-23 | 1988-08-23 | |
| US235,224 | 1988-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1327037C true CA1327037C (fr) | 1994-02-15 |
Family
ID=22884628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000608960A Expired - Fee Related CA1327037C (fr) | 1988-08-23 | 1989-08-22 | Derives de la mitomycine a effet toxique reduit sur la moelle osseuse; methodes de preparation et d'utilisation |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0431008A4 (fr) |
| JP (1) | JPH04500513A (fr) |
| KR (1) | KR900701269A (fr) |
| CN (1) | CN1040593A (fr) |
| AU (1) | AU628846B2 (fr) |
| CA (1) | CA1327037C (fr) |
| DK (1) | DK29691A (fr) |
| ES (1) | ES2018726A6 (fr) |
| GR (1) | GR1000785B (fr) |
| IE (1) | IE63036B1 (fr) |
| IL (1) | IL91332A0 (fr) |
| NO (1) | NO177673C (fr) |
| NZ (1) | NZ230343A (fr) |
| PT (1) | PT91499B (fr) |
| WO (1) | WO1990001931A1 (fr) |
| ZA (1) | ZA896025B (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091523A (en) * | 1990-04-25 | 1992-02-25 | Georgetown University | Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof |
| DE69127345D1 (de) * | 1990-11-13 | 1997-09-25 | Kyowa Hakko Kogyo Kk | Mitomycinderivate |
| GB2282384B8 (en) * | 1993-08-18 | 1997-09-04 | Europ Economic Community | Drug delivery agents incorporating mitomycin |
| CN104231045B (zh) * | 2014-08-22 | 2017-10-31 | 亚飞（上海）生物医药科技有限公司 | 一种靶向激活释放的丝裂霉素衍生物及其用途 |
| EP3184540A4 (fr) * | 2014-08-22 | 2018-03-21 | Yafei Shanghai Biolog Medicine Science& Technology | Corps de couplage à cible micromoléculaire activée de manière spécifique dans un micro-environnement tumoral et son utilisation |
| US9801909B2 (en) | 2015-04-06 | 2017-10-31 | The Penn State Research Foundation | Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US479130A (en) * | 1892-07-19 | Rudolf allert | ||
| US3226393A (en) * | 1962-06-07 | 1965-12-28 | American Cyanamid Co | N-substituted derivatives of mitomycin a and mitomycin c |
| DE1570029A1 (de) * | 1964-07-09 | 1970-04-09 | Kyowa Hakko Kogyo Kk | Verfahren zur Herstellung von Mitosanverbindungen |
| US3367945A (en) * | 1965-05-18 | 1968-02-06 | Kyowa Hakko Kogyo Kk | Thiourea derivatives of mitomycin |
| JPS5240B2 (fr) * | 1973-12-17 | 1977-01-05 | ||
| JPS5630978A (en) * | 1979-08-24 | 1981-03-28 | Kyowa Hakko Kogyo Co Ltd | Novel mitomycin and its preparation |
| US4268676A (en) * | 1979-12-05 | 1981-05-19 | University Patents, Inc. | Mitomycin analogs |
| US4746746A (en) * | 1983-02-07 | 1988-05-24 | University Patents, Inc. | Mitomycin analogs |
| JPS601197A (ja) * | 1983-06-17 | 1985-01-07 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体 |
| US4814445A (en) * | 1984-09-04 | 1989-03-21 | Bristol-Myers Company | Process for preparing mitomycin analogs |
| DE3674043D1 (de) * | 1985-04-10 | 1990-10-18 | Kyowa Hakko Kogyo Kk | Pharmakologisch aktive mitomycinderivate. |
| US4720543A (en) * | 1985-06-06 | 1988-01-19 | Georgetown University | 1a-7-substituted derivatives of mitomycin and uses thereof |
| JPS6354380A (ja) * | 1986-08-26 | 1988-03-08 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体 |
| JPS63246336A (ja) * | 1986-11-10 | 1988-10-13 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン−抗体複合体含有組成物 |
| JPH06335575A (ja) * | 1993-05-28 | 1994-12-06 | Tokyo Electric Co Ltd | 電気かみそり |
-
1989
- 1989-07-25 WO PCT/US1989/003180 patent/WO1990001931A1/fr not_active Ceased
- 1989-07-25 KR KR1019900700816A patent/KR900701269A/ko not_active Ceased
- 1989-07-25 AU AU40650/89A patent/AU628846B2/en not_active Ceased
- 1989-07-25 EP EP19890909473 patent/EP0431008A4/en not_active Withdrawn
- 1989-07-25 JP JP1508792A patent/JPH04500513A/ja active Pending
- 1989-08-08 ZA ZA896025A patent/ZA896025B/xx unknown
- 1989-08-16 IL IL91332A patent/IL91332A0/xx unknown
- 1989-08-17 NZ NZ230343A patent/NZ230343A/en unknown
- 1989-08-18 GR GR890100514A patent/GR1000785B/el unknown
- 1989-08-21 PT PT91499A patent/PT91499B/pt not_active IP Right Cessation
- 1989-08-22 ES ES8902910A patent/ES2018726A6/es not_active Expired - Lifetime
- 1989-08-22 IE IE269189A patent/IE63036B1/en not_active IP Right Cessation
- 1989-08-22 CN CN89106432A patent/CN1040593A/zh active Pending
- 1989-08-22 CA CA000608960A patent/CA1327037C/fr not_active Expired - Fee Related
-
1991
- 1991-02-19 NO NO910662A patent/NO177673C/no unknown
- 1991-02-20 DK DK029691A patent/DK29691A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1990001931A1 (fr) | 1990-03-08 |
| IE892691L (en) | 1990-02-23 |
| CN1040593A (zh) | 1990-03-21 |
| ES2018726A6 (es) | 1991-05-01 |
| AU4065089A (en) | 1990-03-23 |
| NO177673B (no) | 1995-07-24 |
| JPH04500513A (ja) | 1992-01-30 |
| NO177673C (no) | 1995-11-01 |
| NO910662D0 (no) | 1991-02-19 |
| PT91499A (pt) | 1990-03-08 |
| ZA896025B (en) | 1990-05-30 |
| KR900701269A (ko) | 1990-12-01 |
| NZ230343A (en) | 1992-01-29 |
| AU628846B2 (en) | 1992-09-24 |
| DK29691D0 (da) | 1991-02-20 |
| IL91332A0 (en) | 1990-03-19 |
| NO910662L (no) | 1991-03-21 |
| IE63036B1 (en) | 1995-03-22 |
| EP0431008A4 (en) | 1992-03-11 |
| GR1000785B (el) | 1992-12-30 |
| DK29691A (da) | 1991-04-23 |
| GR890100514A (en) | 1991-12-30 |
| EP0431008A1 (fr) | 1991-06-12 |
| PT91499B (pt) | 1995-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |