CA1335725C - Methode de detection de caillots sanguins a l'aide de proteines se liant a la fibrine - Google Patents

Methode de detection de caillots sanguins a l'aide de proteines se liant a la fibrine

Info

Publication number
CA1335725C
CA1335725C CA 578453 CA578453A CA1335725C CA 1335725 C CA1335725 C CA 1335725C CA 578453 CA578453 CA 578453 CA 578453 A CA578453 A CA 578453A CA 1335725 C CA1335725 C CA 1335725C
Authority
CA
Canada
Prior art keywords
protein
fibrin
linker
compound
thrombolytic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA 578453
Other languages
English (en)
Inventor
Stephen W. Hadley
Marjorie A. Mohler
John M. Reno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Poniard Pharmaceuticals Inc
Original Assignee
Genentech Inc
Poniard Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Poniard Pharmaceuticals Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of CA1335725C publication Critical patent/CA1335725C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA 578453 1987-09-25 1988-09-26 Methode de detection de caillots sanguins a l'aide de proteines se liant a la fibrine Expired - Fee Related CA1335725C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10132987A 1987-09-25 1987-09-25
US07/101,329 1987-09-25

Publications (1)

Publication Number Publication Date
CA1335725C true CA1335725C (fr) 1995-05-30

Family

ID=22284078

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 578453 Expired - Fee Related CA1335725C (fr) 1987-09-25 1988-09-26 Methode de detection de caillots sanguins a l'aide de proteines se liant a la fibrine

Country Status (2)

Country Link
CA (1) CA1335725C (fr)
WO (1) WO1989002752A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012072819A1 (fr) * 2010-12-03 2012-06-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Agents pour l'imagerie moléculaire de sérine protéases dans des pathologies humaines

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059541A (en) * 1988-04-29 1991-10-22 Neorx Corporation Minimal derivatization of proteins
DE69018226T2 (de) * 1989-07-20 1995-09-21 Sandoz-Patent-Gmbh, 79539 Loerrach Markierte polypeptidderivate.
ATE188387T1 (de) * 1991-02-08 2000-01-15 Diatide Inc Technetium-99m markierte polypeptide zur bildformung
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
DE69334033D1 (de) * 1992-05-21 2006-07-27 Diatide Inc Technetium-99M markierte Peptide zur Bilderzeugung von Thrombus
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
ZA942439B (en) * 1993-04-08 1996-01-08 Diatech Inc Radiolabeled compounds for thrombus imaging
US6866837B2 (en) 1998-06-05 2005-03-15 Mallinckrodt Inc. Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors
WO2003059877A2 (fr) * 2001-12-21 2003-07-24 Immunochemistry Technologies, Llc Nouveaux marqueurs d'affinite

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416865A (en) * 1973-02-20 1983-11-22 Research Corporation Radiopharmaceuticals for localization of thromboembolic disease
JPS56125317A (en) * 1980-03-08 1981-10-01 Nippon Mejifuijitsukusu Kk Stable radioactive diagnosticum with radioactive metallic mark
US4418052A (en) * 1980-08-12 1983-11-29 Wong Dennis W Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012072819A1 (fr) * 2010-12-03 2012-06-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Agents pour l'imagerie moléculaire de sérine protéases dans des pathologies humaines
US9272054B2 (en) 2010-12-03 2016-03-01 Institut National De La Sante Et De La Recherche Medicale (Inserm) Agents for the molecular imaging of serine-protease in human pathologies

Also Published As

Publication number Publication date
WO1989002752A1 (fr) 1989-04-06

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Legal Events

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