CA1337265C - Anticorps administres par voie orale pour le traitement de patients immunodeprimes et composition utilisee a cet effet - Google Patents
Anticorps administres par voie orale pour le traitement de patients immunodeprimes et composition utilisee a cet effetInfo
- Publication number
- CA1337265C CA1337265C CA 607656 CA607656A CA1337265C CA 1337265 C CA1337265 C CA 1337265C CA 607656 CA607656 CA 607656 CA 607656 A CA607656 A CA 607656A CA 1337265 C CA1337265 C CA 1337265C
- Authority
- CA
- Canada
- Prior art keywords
- composition
- milk
- enteric
- immunogens
- hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 23
- 230000028993 immune response Effects 0.000 title claims abstract description 14
- 238000009175 antibody therapy Methods 0.000 title description 2
- 235000013336 milk Nutrition 0.000 claims abstract description 32
- 210000004080 milk Anatomy 0.000 claims abstract description 32
- 239000008267 milk Substances 0.000 claims abstract description 32
- 206010022678 Intestinal infections Diseases 0.000 claims abstract description 21
- 241001465754 Metazoa Species 0.000 claims abstract description 20
- 206010061217 Infestation Diseases 0.000 claims abstract description 18
- 238000011282 treatment Methods 0.000 claims abstract description 12
- 208000030507 AIDS Diseases 0.000 claims abstract description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
- 238000011321 prophylaxis Methods 0.000 claims abstract description 6
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 27
- 208000015181 infectious disease Diseases 0.000 claims description 17
- 230000000890 antigenic effect Effects 0.000 claims description 11
- 230000002163 immunogen Effects 0.000 claims description 7
- 241000223935 Cryptosporidium Species 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 6
- 241000283707 Capra Species 0.000 claims description 5
- 244000005700 microbiome Species 0.000 claims description 5
- 241000132028 Bellis Species 0.000 claims description 4
- 241000589877 Campylobacter coli Species 0.000 claims description 4
- 241000589875 Campylobacter jejuni Species 0.000 claims description 4
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 4
- 241000193163 Clostridioides difficile Species 0.000 claims description 4
- 241000224432 Entamoeba histolytica Species 0.000 claims description 4
- 241000607142 Salmonella Species 0.000 claims description 4
- 241000223997 Toxoplasma gondii Species 0.000 claims description 4
- 241000607447 Yersinia enterocolitica Species 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 4
- 229940007078 entamoeba histolytica Drugs 0.000 claims description 4
- 244000000021 enteric pathogen Species 0.000 claims description 4
- 241001529453 unidentified herpesvirus Species 0.000 claims description 4
- 229940098232 yersinia enterocolitica Drugs 0.000 claims description 4
- 241000607534 Aeromonas Species 0.000 claims description 3
- 241000726107 Blastocystis hominis Species 0.000 claims description 3
- 241000701022 Cytomegalovirus Species 0.000 claims description 3
- 241000588724 Escherichia coli Species 0.000 claims description 3
- 241000224466 Giardia Species 0.000 claims description 3
- 241000545499 Mycobacterium avium-intracellulare Species 0.000 claims description 3
- 241000702670 Rotavirus Species 0.000 claims description 3
- 229940011597 blastocystis hominis Drugs 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 235000008476 powdered milk Nutrition 0.000 claims 3
- 238000009109 curative therapy Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 10
- 230000001010 compromised effect Effects 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 description 7
- 241000283690 Bos taurus Species 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 206010069691 HIV enteropathy Diseases 0.000 description 5
- 210000003022 colostrum Anatomy 0.000 description 5
- 235000021277 colostrum Nutrition 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 206010025476 Malabsorption Diseases 0.000 description 4
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 4
- 108010074605 gamma-Globulins Proteins 0.000 description 4
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- 208000016261 weight loss Diseases 0.000 description 4
- 230000004580 weight loss Effects 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 208000003322 Coinfection Diseases 0.000 description 2
- 230000005875 antibody response Effects 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000112 colonic effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 235000015243 ice cream Nutrition 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- ACTOXUHEUCPTEW-BWHGAVFKSA-N 2-[(4r,5s,6s,7r,9r,10r,11e,13e,16r)-6-[(2s,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2s,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-o Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)[C@@H]1CC[C@H](N(C)C)[C@@H](C)O1 ACTOXUHEUCPTEW-BWHGAVFKSA-N 0.000 description 1
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
- 208000012124 AIDS-related disease Diseases 0.000 description 1
- 210000004366 CD4-positive T-lymphocyte Anatomy 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 241000820057 Ithone Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 239000004187 Spiramycin Substances 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 230000036436 anti-hiv Effects 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229960001596 famotidine Drugs 0.000 description 1
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 244000000074 intestinal pathogen Species 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000020166 milkshake Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229960000381 omeprazole Drugs 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229960001294 spiramycin Drugs 0.000 description 1
- 229930191512 spiramycin Natural products 0.000 description 1
- 235000019372 spiramycin Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000008939 whole milk Nutrition 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPI967488 | 1988-08-04 | ||
| AUPI9674 | 1988-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1337265C true CA1337265C (fr) | 1995-10-10 |
Family
ID=3773261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 607656 Expired - Fee Related CA1337265C (fr) | 1988-08-04 | 1989-08-04 | Anticorps administres par voie orale pour le traitement de patients immunodeprimes et composition utilisee a cet effet |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA1337265C (fr) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9433651B2 (en) | 2013-06-05 | 2016-09-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9463208B2 (en) | 2010-02-01 | 2016-10-11 | Rebiotix, Inc. | Bacteriotherapy for clostridium difficile colitis |
| US9511100B2 (en) | 2013-06-05 | 2016-12-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9511099B2 (en) | 2013-06-05 | 2016-12-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9694039B2 (en) | 2013-06-05 | 2017-07-04 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9782445B2 (en) | 2013-06-05 | 2017-10-10 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10226431B2 (en) | 2015-06-09 | 2019-03-12 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| US10383901B2 (en) | 2013-06-05 | 2019-08-20 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10799539B2 (en) | 2015-06-09 | 2020-10-13 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| US10828340B2 (en) | 2015-06-09 | 2020-11-10 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| US10905726B2 (en) | 2015-06-09 | 2021-02-02 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
-
1989
- 1989-08-04 CA CA 607656 patent/CA1337265C/fr not_active Expired - Fee Related
Cited By (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11986500B2 (en) | 2010-02-01 | 2024-05-21 | Rebiotix Inc | Bacteriotherapy for clostridium difficile colitis |
| US9463208B2 (en) | 2010-02-01 | 2016-10-11 | Rebiotix, Inc. | Bacteriotherapy for clostridium difficile colitis |
| US12303537B2 (en) | 2010-02-01 | 2025-05-20 | Ferring Microbiome Inc. | Bacteriotherapy for clostridium difficile colitis |
| US12102655B2 (en) | 2010-02-01 | 2024-10-01 | Rebiotix Inc. | Bacteriotherapy for clostridium difficile colitis |
| US9629881B2 (en) | 2010-02-01 | 2017-04-25 | Rebiotix, Inc. | Bacteriotherapy for clostridium difficile colitis |
| US10471107B2 (en) | 2013-06-05 | 2019-11-12 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10434125B2 (en) | 2013-06-05 | 2019-10-08 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9694039B2 (en) | 2013-06-05 | 2017-07-04 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9782445B2 (en) | 2013-06-05 | 2017-10-10 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9511100B2 (en) | 2013-06-05 | 2016-12-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10383901B2 (en) | 2013-06-05 | 2019-08-20 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10391129B2 (en) | 2013-06-05 | 2019-08-27 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9675648B2 (en) | 2013-06-05 | 2017-06-13 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10434126B2 (en) | 2013-06-05 | 2019-10-08 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US11554143B2 (en) | 2013-06-05 | 2023-01-17 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10434124B2 (en) | 2013-06-05 | 2019-10-08 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9433651B2 (en) | 2013-06-05 | 2016-09-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10493111B2 (en) | 2013-06-05 | 2019-12-03 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10603341B2 (en) | 2013-06-05 | 2020-03-31 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10610547B2 (en) | 2013-06-05 | 2020-04-07 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10624932B2 (en) | 2013-06-05 | 2020-04-21 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10688137B2 (en) | 2013-06-05 | 2020-06-23 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9511099B2 (en) | 2013-06-05 | 2016-12-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9642880B2 (en) | 2013-06-05 | 2017-05-09 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10391064B2 (en) | 2015-06-09 | 2019-08-27 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| US10905726B2 (en) | 2015-06-09 | 2021-02-02 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| US11642381B2 (en) | 2015-06-09 | 2023-05-09 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| US11654164B2 (en) | 2015-06-09 | 2023-05-23 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| US10828340B2 (en) | 2015-06-09 | 2020-11-10 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| US12036250B2 (en) | 2015-06-09 | 2024-07-16 | Rebiotix Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| US10799539B2 (en) | 2015-06-09 | 2020-10-13 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| US10226431B2 (en) | 2015-06-09 | 2019-03-12 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |