CA1338977C - Systemes d'administration vaginale - Google Patents

Systemes d'administration vaginale

Info

Publication number: CA1338977C
Authority: CA; Canada
Prior art keywords: vaginal; phase; systems; phases; delivery systems
Prior art date: 1985-10-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA000598759A

Other languages

English (en)

Inventor

Thomas Charles Riley Jr.

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kv Pharmaceutical Co

Original Assignee

Kv Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-31

Filing date

1989-05-04

Publication date

1997-03-11

1985-10-31 Priority claimed from PCT/US1985/002145 external-priority patent/WO1987002576A1/fr

1989-05-04 Application filed by Kv Pharmaceutical Co filed Critical Kv Pharmaceutical Co

1989-05-04 Priority to CA000598759A priority Critical patent/CA1338977C/fr

1997-03-11 Application granted granted Critical

1997-03-11 Publication of CA1338977C publication Critical patent/CA1338977C/fr

2014-03-11 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

208000034423 Delivery Diseases 0.000 title claims description 14
230000009677 vaginal delivery Effects 0.000 title claims description 14
239000013543 active substance Substances 0.000 claims abstract description 38
238000011282 treatment Methods 0.000 claims abstract description 15
229940121375 antifungal agent Drugs 0.000 claims abstract description 7
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims abstract 6
239000000839 emulsion Substances 0.000 claims description 18
238000010521 absorption reaction Methods 0.000 claims description 10
230000009471 action Effects 0.000 claims description 9
238000012377 drug delivery Methods 0.000 claims description 8
239000000203 mixture Substances 0.000 claims description 7
239000007788 liquid Substances 0.000 claims description 6
239000007787 solid Substances 0.000 claims description 6
239000004599 antimicrobial Substances 0.000 claims description 5
244000005700 microbiome Species 0.000 claims description 5
239000000725 suspension Substances 0.000 claims description 4
230000000843 anti-fungal effect Effects 0.000 claims description 3
230000000845 anti-microbial effect Effects 0.000 claims description 3
239000003242 anti bacterial agent Substances 0.000 claims description 2
239000006185 dispersion Substances 0.000 claims 1
238000002360 preparation method Methods 0.000 abstract description 5
238000000034 method Methods 0.000 abstract description 3
239000003429 antifungal agent Substances 0.000 abstract description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
230000009102 absorption Effects 0.000 description 9
239000003795 chemical substances by application Substances 0.000 description 8
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 8
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 8
239000003814 drug Substances 0.000 description 7
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
238000013270 controlled release Methods 0.000 description 6
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235000014113 dietary fatty acids Nutrition 0.000 description 5
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239000002480 mineral oil Substances 0.000 description 5
239000004615 ingredient Substances 0.000 description 4
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 4
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 4
229960002216 methylparaben Drugs 0.000 description 4
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239000000047 product Substances 0.000 description 4
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239000004405 propyl p-hydroxybenzoate Substances 0.000 description 4
229960003415 propylparaben Drugs 0.000 description 4
241000894006 Bacteria Species 0.000 description 3
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
241000233866 Fungi Species 0.000 description 3
240000004808 Saccharomyces cerevisiae Species 0.000 description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
229930006000 Sucrose Natural products 0.000 description 3
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239000008367 deionised water Substances 0.000 description 3
229910021641 deionized water Inorganic materials 0.000 description 3
201000010099 disease Diseases 0.000 description 3
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150000002148 esters Chemical class 0.000 description 3
150000004665 fatty acids Chemical class 0.000 description 3
239000000796 flavoring agent Substances 0.000 description 3
235000019634 flavors Nutrition 0.000 description 3
239000006260 foam Substances 0.000 description 3
235000011187 glycerol Nutrition 0.000 description 3
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239000003921 oil Substances 0.000 description 3
235000019198 oils Nutrition 0.000 description 3
230000003204 osmotic effect Effects 0.000 description 3
-1 phosphatides Substances 0.000 description 3
230000002265 prevention Effects 0.000 description 3
230000001568 sexual effect Effects 0.000 description 3
239000000600 sorbitol Substances 0.000 description 3
239000005720 sucrose Substances 0.000 description 3
239000000829 suppository Substances 0.000 description 3
210000001215 vagina Anatomy 0.000 description 3
ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
239000003086 colorant Substances 0.000 description 2
239000002537 cosmetic Substances 0.000 description 2
239000006071 cream Substances 0.000 description 2
239000003925 fat Substances 0.000 description 2
235000019197 fats Nutrition 0.000 description 2
239000012530 fluid Substances 0.000 description 2
239000003205 fragrance Substances 0.000 description 2
239000000499 gel Substances 0.000 description 2
150000002460 imidazoles Chemical class 0.000 description 2
238000003780 insertion Methods 0.000 description 2
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150000002500 ions Chemical class 0.000 description 2
239000012528 membrane Substances 0.000 description 2
230000000116 mitigating effect Effects 0.000 description 2
229960000988 nystatin Drugs 0.000 description 2
230000004044 response Effects 0.000 description 2
239000000344 soap Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
210000001635 urinary tract Anatomy 0.000 description 2
241001133760 Acoelorraphe Species 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
235000017060 Arachis glabrata Nutrition 0.000 description 1
244000105624 Arachis hypogaea Species 0.000 description 1
235000010777 Arachis hypogaea Nutrition 0.000 description 1
235000018262 Arachis monticola Nutrition 0.000 description 1
240000002791 Brassica napus Species 0.000 description 1
235000004977 Brassica sinapistrum Nutrition 0.000 description 1
241000222122 Candida albicans Species 0.000 description 1
244000020518 Carthamus tinctorius Species 0.000 description 1
235000003255 Carthamus tinctorius Nutrition 0.000 description 1
244000060011 Cocos nucifera Species 0.000 description 1
235000013162 Cocos nucifera Nutrition 0.000 description 1
239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
239000004606 Fillers/Extenders Substances 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
240000007817 Olea europaea Species 0.000 description 1
239000004264 Petrolatum Substances 0.000 description 1
244000000231 Sesamum indicum Species 0.000 description 1
235000003434 Sesamum indicum Nutrition 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000002535 acidifier Substances 0.000 description 1
229940095602 acidifiers Drugs 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000008272 agar Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
229940063655 aluminum stearate Drugs 0.000 description 1
238000010923 batch production Methods 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
229940095731 candida albicans Drugs 0.000 description 1
210000003756 cervix mucus Anatomy 0.000 description 1
210000003679 cervix uteri Anatomy 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
229940110456 cocoa butter Drugs 0.000 description 1
235000019868 cocoa butter Nutrition 0.000 description 1
229940075614 colloidal silicon dioxide Drugs 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000010924 continuous production Methods 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
230000006378 damage Effects 0.000 description 1
229940124447 delivery agent Drugs 0.000 description 1
239000002781 deodorant agent Substances 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
229940008099 dimethicone Drugs 0.000 description 1
239000004205 dimethyl polysiloxane Substances 0.000 description 1
235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
238000002651 drug therapy Methods 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
210000000981 epithelium Anatomy 0.000 description 1
210000004996 female reproductive system Anatomy 0.000 description 1
235000013305 food Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000000417 fungicide Substances 0.000 description 1
210000004907 gland Anatomy 0.000 description 1
229940074052 glyceryl isostearate Drugs 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000002175 menstrual effect Effects 0.000 description 1
230000005906 menstruation Effects 0.000 description 1
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
229960000282 metronidazole Drugs 0.000 description 1
239000004200 microcrystalline wax Substances 0.000 description 1
235000019808 microcrystalline wax Nutrition 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229940087419 nonoxynol-9 Drugs 0.000 description 1
229920004918 nonoxynol-9 Polymers 0.000 description 1
VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
230000001151 other effect Effects 0.000 description 1
235000020232 peanut Nutrition 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
229940056099 polyglyceryl-4 oleate Drugs 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
230000003252 repetitive effect Effects 0.000 description 1
230000001850 reproductive effect Effects 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
230000028327 secretion Effects 0.000 description 1
210000000582 semen Anatomy 0.000 description 1
230000020509 sex determination Effects 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000000934 spermatocidal agent Substances 0.000 description 1
238000005507 spraying Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
235000020238 sunflower seed Nutrition 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000003826 tablet Substances 0.000 description 1
FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
210000003708 urethra Anatomy 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Urology & Nephrology (AREA)
Bioinformatics & Cheminformatics (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Medicinal Preparation (AREA)
Infusion, Injection, And Reservoir Apparatuses (AREA)

CA000598759A 1985-10-31 1989-05-04 Systemes d'administration vaginale Expired - Lifetime CA1338977C (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000598759A CA1338977C (fr)	1985-10-31	1989-05-04	Systemes d'administration vaginale

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1985/002145 WO1987002576A1 (fr)	1985-10-31	1985-10-31	Systemes de liberation d'agents actifs dans le vagin
CA000598759A CA1338977C (fr)	1985-10-31	1989-05-04	Systemes d'administration vaginale

Publications (1)

Publication Number	Publication Date
CA1338977C true CA1338977C (fr)	1997-03-11

Family

ID=25672681

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000598759A Expired - Lifetime CA1338977C (fr)	1985-10-31	1989-05-04	Systemes d'administration vaginale

Country Status (1)

Country	Link
CA (1)	CA1338977C (fr)

1989
- 1989-05-04 CA CA000598759A patent/CA1338977C/fr not_active Expired - Lifetime

Legal Events

Date	Code	Title	Description
2014-05-13	MKEX	Expiry	Effective date: 20140311

Publication	Publication Date	Title
US4551148A (en)	1985-11-05	Vaginal delivery systems and their methods of preparation and use
US5266329A (en)	1993-11-30	Vaginal delivery system
US9789057B2 (en)	2017-10-17	Pharmaceutical delivery system
EP0244405B1 (fr)	1991-10-23	Systemes de liberation d'agents actifs dans le vagin
US5055303A (en)	1991-10-08	Solid controlled release bioadherent emulsions
AU746019B2 (en)	2002-04-11	Topical non-steroidal anti-inflammatory drug composition
US5137718A (en)	1992-08-11	Infection fighting composition for topical application
US4361584A (en)	1982-11-30	Composition and method for the treatment of acne
US20230404959A1 (en)	2023-12-21	Topical formulation comprising omega-3 fatty acids, melatonin and vitamin d
EP1537857A1 (fr)	2005-06-08	Compositions à usage topique comprenant de la mupirocine, procédé de préparation et applications.
DE2201357A1 (de)	1972-09-07	Osmotische Wirkstoffabgabevorrichtung
CA1338977C (fr)	1997-03-11	Systemes d'administration vaginale
CZ15068U1 (cs)	2005-01-31	Dávkovací souprava
US20080161376A1 (en)	2008-07-03	Method of treating candida isolates
US8057433B2 (en)	2011-11-15	Delivery system
JP3106541U (ja)	2005-01-06	送達システム
KR200381664Y1 (ko)	2005-04-14	전달 장치
DE102024106817A1 (de)	2025-09-11	Zusammensetzung zur prophylaktischen und/oder therapeutischen Behandlung
MXPA06003131A (en)	2007-04-10	Pharmaceutical delivery system
CN2827419Y (zh)	2006-10-18	递送装置
Yadav et al.	0	Formulation and Ev Mathematical Treattm
GB2354439A (en)	2001-03-28	Skin care compositional
DE202004012450U1 (de)	2004-10-14	Abgabesystem