CA1340580C - Proteine alveolaire tensioactive recombinante - Google Patents

Proteine alveolaire tensioactive recombinante

Info

Publication number: CA1340580C
Authority: CA; Canada
Prior art keywords: asp; dna; protein; canine; encoding
Prior art date: 1985-12-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA 497418

Other languages

English (en)

Inventor

James W. Schilling Jr.

Robert T. White

Barbara Cordell

Bradley J. Benson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Takeda GmbH

Original Assignee

Byk Gulden Lomberg Chemische Fabrik GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-11

Filing date

1985-12-11

Publication date

1999-06-08

1985-12-11 Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH

1985-12-11 Priority to CA 497418 priority Critical patent/CA1340580C/fr

1999-06-08 Application granted granted Critical

1999-06-08 Publication of CA1340580C publication Critical patent/CA1340580C/fr

2016-06-08 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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201000000260 interstitial emphysema Diseases 0.000 description 1
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PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 1
238000012332 laboratory investigation Methods 0.000 description 1
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230000004060 metabolic process Effects 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
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150000007522 mineralic acids Chemical class 0.000 description 1
238000002703 mutagenesis Methods 0.000 description 1
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WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
238000002663 nebulization Methods 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
201000002652 newborn respiratory distress syndrome Diseases 0.000 description 1
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230000003000 nontoxic effect Effects 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
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150000007530 organic bases Chemical class 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
239000006179 pH buffering agent Substances 0.000 description 1
238000005192 partition Methods 0.000 description 1
229950009506 penicillinase Drugs 0.000 description 1
238000000819 phase cycle Methods 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
150000008105 phosphatidylcholines Chemical class 0.000 description 1
YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 description 1
230000026731 phosphorylation Effects 0.000 description 1
238000006366 phosphorylation reaction Methods 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
230000007505 plaque formation Effects 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
201000003144 pneumothorax Diseases 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
235000011118 potassium hydroxide Nutrition 0.000 description 1
HJRIWDYVYNNCFY-UHFFFAOYSA-M potassium;dimethylarsinate Chemical compound [K+].C[As](C)([O-])=O HJRIWDYVYNNCFY-UHFFFAOYSA-M 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
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230000037452 priming Effects 0.000 description 1
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235000013930 proline Nutrition 0.000 description 1
235000004252 protein component Nutrition 0.000 description 1
239000012460 protein solution Substances 0.000 description 1
210000003456 pulmonary alveoli Anatomy 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
229940048084 pyrophosphate Drugs 0.000 description 1
230000008439 repair process Effects 0.000 description 1
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239000012723 sample buffer Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
239000013049 sediment Substances 0.000 description 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
239000012679 serum free medium Substances 0.000 description 1
238000004513 sizing Methods 0.000 description 1
238000002791 soaking Methods 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000007787 solid Substances 0.000 description 1
229940063673 spermidine Drugs 0.000 description 1
ANLMVXSIPASBFL-FAEUDGQSSA-N streptamine Chemical compound N[C@H]1[C@H](O)[C@@H](N)[C@H](O)[C@@H](O)[C@@H]1O ANLMVXSIPASBFL-FAEUDGQSSA-N 0.000 description 1
239000000126 substance Substances 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
239000013589 supplement Substances 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
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238000013518 transcription Methods 0.000 description 1
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230000001131 transforming effect Effects 0.000 description 1
239000013638 trimer Substances 0.000 description 1
239000001226 triphosphate Substances 0.000 description 1
235000011178 triphosphate Nutrition 0.000 description 1
125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
238000005199 ultracentrifugation Methods 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1
238000009423 ventilation Methods 0.000 description 1
239000011800 void material Substances 0.000 description 1
229940056904 zinc ascorbate Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pulmonology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA 497418 1985-12-11 1985-12-11 Proteine alveolaire tensioactive recombinante Expired - Lifetime CA1340580C (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA 497418 CA1340580C (fr)	1985-12-11	1985-12-11	Proteine alveolaire tensioactive recombinante

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA 497418 CA1340580C (fr)	1985-12-11	1985-12-11	Proteine alveolaire tensioactive recombinante

Publications (1)

Publication Number	Publication Date
CA1340580C true CA1340580C (fr)	1999-06-08

Family

ID=33315094

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA 497418 Expired - Lifetime CA1340580C (fr)	1985-12-11	1985-12-11	Proteine alveolaire tensioactive recombinante

Country Status (1)

Country	Link
CA (1)	CA1340580C (fr)

1985
- 1985-12-11 CA CA 497418 patent/CA1340580C/fr not_active Expired - Lifetime

Legal Events

Date	Code	Title	Description
2016-08-10	MKEX	Expiry	Effective date: 20160608

Publication	Publication Date	Title
EP0210189B1 (fr)	1994-12-07	Proteine tensio-active alveolaire recombinante
US4912038A (en)	1990-03-27	Recombinant DNA sequence encoding alveolar surfactant protein
US4933280A (en)	1990-06-12	Recombinant DNA sequence encoding Alveolar Surfactant Protein
CA1340461C (fr)	1999-03-23	Proteines tensioactives alveolaires
EP0290516A1 (fr)	1988-11-17	Proteines associees a des agents tensioactifs hydrophobes pulmonaires
JP2757987B2 (ja)	1998-05-25	ヒト抗‐炎症ホスホリパーゼ阻害蛋白
US5840527A (en)	1998-11-24	Recombinant alveolar surfactant protein
JP2005053929A (ja)	2005-03-03	肺胞界面活性タンパク質
EP0307513A2 (fr)	1989-03-22	Protéines hydrophobes pulmonaires à tensioactivité associée
HK1005883B (en)	1999-01-29	Recombinant alveolar surfactant protein
US5430020A (en)	1995-07-04	Recombinant alveolar surfactant protein
WO1988005820A1 (fr)	1988-08-11	Proteine tensio-active alveolaire recombinante
HK1005887B (en)	1999-01-29	Recombinant alveolar surfactant protein
JPH09500017A (ja)	1997-01-07	血小板糖蛋白ｖ遺伝子と使用
Steinmann et al.	1991	Substitution of cysteine for glycine-α1-691 in the proα1 (I) chain of type I procollagen in a proband with lethal osteogenesis imperfecta destabilizes the triple helix at a site C-terminal to the substitution
NO875477L (no)	1988-02-26	Rekombinant alveolaert overflateaktivt protein.
JPH0242986A (ja)	1990-02-13	新規なヒト生理活性ポリペプチドをコードするｄｎａ
HK1008744A1 (en)	1999-05-14	Alveolar surfactant proteins
HK1008744B (en)	1999-05-14	Alveolar surfactant proteins