CA1341108C - Polypeptides derives par la thrombine; compositions et procedes d'utilisation - Google Patents

Polypeptides derives par la thrombine; compositions et procedes d'utilisation

Info

Publication number
CA1341108C
CA1341108C CA 595965 CA595965A CA1341108C CA 1341108 C CA1341108 C CA 1341108C CA 595965 CA595965 CA 595965 CA 595965 A CA595965 A CA 595965A CA 1341108 C CA1341108 C CA 1341108C
Authority
CA
Canada
Prior art keywords
thrombin
gly
polypeptide
asp
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA 595965
Other languages
English (en)
Inventor
Darrell H. Carney
Kevin C. Glenn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Priority to CA 595965 priority Critical patent/CA1341108C/fr
Application granted granted Critical
Publication of CA1341108C publication Critical patent/CA1341108C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA 595965 1989-04-06 1989-04-06 Polypeptides derives par la thrombine; compositions et procedes d'utilisation Expired - Fee Related CA1341108C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 595965 CA1341108C (fr) 1989-04-06 1989-04-06 Polypeptides derives par la thrombine; compositions et procedes d'utilisation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 595965 CA1341108C (fr) 1989-04-06 1989-04-06 Polypeptides derives par la thrombine; compositions et procedes d'utilisation

Publications (1)

Publication Number Publication Date
CA1341108C true CA1341108C (fr) 2000-10-03

Family

ID=33315129

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 595965 Expired - Fee Related CA1341108C (fr) 1989-04-06 1989-04-06 Polypeptides derives par la thrombine; compositions et procedes d'utilisation

Country Status (1)

Country Link
CA (1) CA1341108C (fr)

Similar Documents

Publication Publication Date Title
EP0328552B1 (fr) Polypeptides derives de la thrombine, compositions les contenant et procedes d'utilisation
US6024936A (en) Antibody-based method of localizing activated thrombin receptors
Clauss et al. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration.
Odekon et al. Urokinase‐type plasminogen activator mediates basic fibroblast growth factor‐induced bovine endothelial cell migration independent of its proteolytic activity
LOSKUTOFF et al. Regulation of cell adhesion by PAI‐1
US5849701A (en) Peptide inhibitors of fibronectin and related collagen-binding proteins
Carmeliet et al. Molecules in focus Tissue factor
Adams et al. The angiogenins: an emerging family of ribonuclease related proteins with diverse cellular functions
WO1999022756A1 (fr) Inhibiteurs proteiques de la calpaine permeables aux cellules
Mitchell et al. The acute phase reactant serum amyloid A (SAA3) is a novel substrate for degradation by the metalloproteinases collagenase and stromelysin
EP0703923B1 (fr) Peptides derives du facteur vii
US5472945A (en) Modulation of blood pressure and inhibition of platelet activation with kininogen fragment
Swenson et al. α-Fibrinogenases
Thompson et al. Endothelial and serum factors which include apolipoprotein A1 tether elastin to smooth muscle cells inducing serine elastase activity via tyrosine kinase‐mediated transcription and translation
Kanthou et al. Thrombin receptor activating peptide (TRAP) stimulates mitogenesis, c-fos and PDGF-A gene expression in human vascular smooth muscle cells
SK84594A3 (en) Bifunctional variants of urokinase with improved fibrinolytic properties and with trombininhibiting effect
US6630572B1 (en) Thrombin derived polypeptides: compositions and methods for use
Bar-Shavit et al. Biologic activities of nonenzymatic thrombin: elucidation of a macrophage interactive domain
JPH0273022A (ja) 組織プラスミノーゲン活性化因子を用いた薬学的製剤
WO1992013887A1 (fr) Nouveaux peptides d'adhesion cellulaire
Rodell et al. Role of kinins in inflammatory responses: Prospects for drug therapy
De Caterina et al. Cellular effects of thrombin: pharmacology of the receptor (s) in various cell types and possible development of receptor antagonists
JPH0782172A (ja) 創傷治療剤
Shestenko et al. Angiogenin and its functions in angiogenesis
Springer et al. Cholecystokinin cleavage to cholecystokinin-octapeptide in vivo and in vitro: Accelerated cleavage in acute pancreatitis

Legal Events

Date Code Title Description
MKLA Lapsed

Effective date: 20141003