CA1341179C - Dispositif d'analyse pour le sang - Google Patents

Dispositif d'analyse pour le sang Download PDF

Info

Publication number: CA1341179C
Authority: CA; Canada
Prior art keywords: blood; conduit; pressure; reservoir; elongate
Prior art date: 1986-09-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA000595046A

Other languages

English (en)

Inventor

Iren Kovacs

Peter Gorog

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Xylum Corp

Original Assignee

Xylum Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-10

Filing date

1989-03-29

Publication date

2001-02-13

1986-09-10 Priority to GB868621757A priority Critical patent/GB8621757D0/en

1987-09-10 Priority to EP87905777A priority patent/EP0324749B1/fr

1987-09-10 Priority to PCT/GB1987/000633 priority patent/WO1988002116A1/fr

1987-09-10 Priority to JP62505188A priority patent/JPH07101219B2/ja

1987-09-10 Priority to AT87905777T priority patent/ATE82070T1/de

1987-09-10 Priority to AU79111/87A priority patent/AU609060B2/en

1987-09-10 Priority to US07/314,663 priority patent/US5665311A/en

1987-09-10 Priority to DE8787905777T priority patent/DE3782503T2/de

1989-03-29 Application filed by Xylum Corp filed Critical Xylum Corp

1989-03-29 Priority to CA000595046A priority patent/CA1341179C/fr

1996-11-04 Priority to US08/743,911 priority patent/US5925569A/en

2001-02-13 Application granted granted Critical

2001-02-13 Publication of CA1341179C publication Critical patent/CA1341179C/fr

2018-02-13 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000008280 blood Substances 0.000 title claims abstract description 171
210000004369 blood Anatomy 0.000 title claims abstract description 170
238000012360 testing method Methods 0.000 title claims description 15
238000000034 method Methods 0.000 claims abstract description 39
102000008186 Collagen Human genes 0.000 claims abstract description 38
108010035532 Collagen Proteins 0.000 claims abstract description 38
229920001436 collagen Polymers 0.000 claims abstract description 38
239000012530 fluid Substances 0.000 claims abstract description 38
239000002699 waste material Substances 0.000 claims abstract description 33
238000004080 punching Methods 0.000 claims abstract description 24
230000008569 process Effects 0.000 claims abstract description 20
238000011835 investigation Methods 0.000 claims abstract description 12
239000004033 plastic Substances 0.000 claims abstract description 5
229920003023 plastic Polymers 0.000 claims abstract description 5
238000003756 stirring Methods 0.000 claims abstract description 4
239000000126 substance Substances 0.000 claims description 29
230000023597 hemostasis Effects 0.000 claims description 26
238000005259 measurement Methods 0.000 claims description 21
230000002537 thrombolytic effect Effects 0.000 claims description 17
230000000977 initiatory effect Effects 0.000 claims description 14
229940030225 antihemorrhagics Drugs 0.000 claims description 12
230000000694 effects Effects 0.000 claims description 12
230000000025 haemostatic effect Effects 0.000 claims description 12
238000006073 displacement reaction Methods 0.000 claims description 11
239000003146 anticoagulant agent Substances 0.000 claims description 10
229940127219 anticoagulant drug Drugs 0.000 claims description 8
238000011144 upstream manufacturing Methods 0.000 claims description 7
230000017531 blood circulation Effects 0.000 claims description 5
230000015556 catabolic process Effects 0.000 claims description 4
230000007246 mechanism Effects 0.000 claims description 3
238000012544 monitoring process Methods 0.000 claims 13
230000000704 physical effect Effects 0.000 claims 1
208000007536 Thrombosis Diseases 0.000 abstract description 11
230000015572 biosynthetic process Effects 0.000 abstract description 11
230000023555 blood coagulation Effects 0.000 abstract description 4
206010053567 Coagulopathies Diseases 0.000 description 15
230000035602 clotting Effects 0.000 description 15
239000005662 Paraffin oil Substances 0.000 description 9
208000032843 Hemorrhage Diseases 0.000 description 7
230000000740 bleeding effect Effects 0.000 description 7
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
239000003814 drug Substances 0.000 description 4
238000010438 heat treatment Methods 0.000 description 4
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 3
239000004698 Polyethylene Substances 0.000 description 3
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
210000004204 blood vessel Anatomy 0.000 description 3
229940079593 drug Drugs 0.000 description 3
229960002897 heparin Drugs 0.000 description 3
229920000669 heparin Polymers 0.000 description 3
-1 polyethylene Polymers 0.000 description 3
229920000573 polyethylene Polymers 0.000 description 3
229910052710 silicon Inorganic materials 0.000 description 3
239000010703 silicon Substances 0.000 description 3
239000002729 catgut Substances 0.000 description 2
230000007423 decrease Effects 0.000 description 2
238000010586 diagram Methods 0.000 description 2
239000000835 fiber Substances 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
206010060964 Arterial haemorrhage Diseases 0.000 description 1
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
208000027276 Von Willebrand disease Diseases 0.000 description 1
229960001138 acetylsalicylic acid Drugs 0.000 description 1
229940127090 anticoagulant agent Drugs 0.000 description 1
230000008901 benefit Effects 0.000 description 1
239000000560 biocompatible material Substances 0.000 description 1
238000004159 blood analysis Methods 0.000 description 1
230000036770 blood supply Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000012631 diagnostic technique Methods 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000001435 haemodynamic effect Effects 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000010410 layer Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
230000037361 pathway Effects 0.000 description 1
239000010453 quartz Substances 0.000 description 1
238000011160 research Methods 0.000 description 1
238000004062 sedimentation Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
239000002356 single layer Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000012546 transfer Methods 0.000 description 1
208000012137 von Willebrand disease (hereditary or acquired) Diseases 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Ecology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Immunology (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Ultra Sonic Daignosis Equipment (AREA)

CA000595046A 1986-09-10 1989-03-29 Dispositif d'analyse pour le sang Expired - Fee Related CA1341179C (fr)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
GB868621757A GB8621757D0 (en)	1986-09-10	1986-09-10	Blood testing device
JP62505188A JPH07101219B2 (ja)	1986-09-10	1987-09-10	血液検査装置
AT87905777T ATE82070T1 (de)	1986-09-10	1987-09-10	Geraet zur untersuchung von blut.
AU79111/87A AU609060B2 (en)	1986-09-10	1987-09-10	Blood testing device
EP87905777A EP0324749B1 (fr)	1986-09-10	1987-09-10	Dispositif d'analyse du sang
DE8787905777T DE3782503T2 (de)	1986-09-10	1987-09-10	Geraet zur untersuchung von blut.
PCT/GB1987/000633 WO1988002116A1 (fr)	1986-09-10	1987-09-10	Dispositif d'analyse du sang
US07/314,663 US5665311A (en)	1986-09-10	1987-09-10	Blood testing device
CA000595046A CA1341179C (fr)	1986-09-10	1989-03-29	Dispositif d'analyse pour le sang
US08/743,911 US5925569A (en)	1986-09-10	1996-11-04	Blood testing device and method

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB868621757A GB8621757D0 (en)	1986-09-10	1986-09-10	Blood testing device
CA000595046A CA1341179C (fr)	1986-09-10	1989-03-29	Dispositif d'analyse pour le sang

Publications (1)

Publication Number	Publication Date
CA1341179C true CA1341179C (fr)	2001-02-13

Family

ID=25672561

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000595046A Expired - Fee Related CA1341179C (fr)	1986-09-10	1989-03-29	Dispositif d'analyse pour le sang

Country Status (9)

Country	Link
US (2)	US5665311A (fr)
EP (1)	EP0324749B1 (fr)
JP (1)	JPH07101219B2 (fr)
AT (1)	ATE82070T1 (fr)
AU (1)	AU609060B2 (fr)
CA (1)	CA1341179C (fr)
DE (1)	DE3782503T2 (fr)
GB (1)	GB8621757D0 (fr)
WO (1)	WO1988002116A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8621757D0 (en) *	1986-09-10	1986-10-15	Gorog P	Blood testing device
US5047211A (en) *	1989-08-18	1991-09-10	Xylum Corporation	Disposable blood handling cassette device for measuring haemostasis
US5296379A (en) *	1990-03-23	1994-03-22	Peter Gorog	Apparatus and method for modeling arterial thrombus formations
GB2245061A (en) *	1990-03-23	1991-12-18	Peter Gorog	Modelling thrombosis formation
US5339830A (en) *	1992-01-21	1994-08-23	Blake Joseph W Iii	Blood coagulation test system
US5374396A (en) *	1992-05-05	1994-12-20	Tsi Incorporated	Syringe injection system for measuring non-volatile residue in solvents
NO925047L (no) *	1992-12-30	1994-07-01	Hafslund Nycomed As	Anordning og anvendelse av anordningen til måling av tendens til blodproppdannelse
US5351523A (en) *	1993-01-21	1994-10-04	Tsi Incorporated	Apparatus and process for determining filter efficiency in removing colloidal suspensions
US6004819A (en) *	1996-11-04	1999-12-21	Xylum Corporation	Blood testing device
WO1998028619A1 (fr) *	1996-12-20	1998-07-02	Xylum Corporation	Analyseur thrombotique et/ou d'etats thombolytiques
US6260407B1 (en) *	1998-04-03	2001-07-17	Symyx Technologies, Inc.	High-temperature characterization of polymers
DE10003093C2 (de) *	2000-01-25	2002-05-16	Goltz Volker Freiherr Von	Vorrichtung zur Untersuchung von Eigenschaften der globalen Hämostasefunktion in Vollblut oder plättchenreichem Plasma
US20040131500A1 (en) *	2002-01-18	2004-07-08	Chow Herbert S.	Device and method for evaluating platelets
JP2005538383A (ja) *	2002-09-10	2005-12-15	プラコア・インコーポレーテッド	血小板機能を監視する方法および装置
WO2004062570A2 (fr) *	2003-01-08	2004-07-29	Enrique Saldivar	Appareil et methode de mesure de la contractilite des plaquettes
US7422905B2 (en)	2004-02-27	2008-09-09	Medtronic, Inc.	Blood coagulation test cartridge, system, and method
US7439069B2 (en)	2004-02-27	2008-10-21	Nippoldt Douglas D	Blood coagulation test cartridge, system, and method
US7399637B2 (en)	2004-04-19	2008-07-15	Medtronic, Inc.	Blood coagulation test cartridge, system, and method
US7507337B2 (en) *	2004-09-03	2009-03-24	Symyx Technologies, Inc.	System and method for rapid chromatography with fluid temperature and mobile phase composition control
EP1875232A2 (fr) *	2005-04-25	2008-01-09	PlaCor, Inc.	Procede et dispositif pour surveiller la fonction plaquettaire
US20100099130A1 (en) *	2006-10-25	2010-04-22	Placor Inc.	Methods and devices for monitoring platelet function
US9256935B2 (en)	2013-12-03	2016-02-09	General Electric Company	Mapping transfer function for automated biological sample processing system
US10598580B2 (en) *	2014-12-19	2020-03-24	Health Onvector Inc	Viscometers and methods of measuring liquid viscosity

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1299363A (en) *	1968-09-27	1972-12-13	Amiram Ur	Monitoring of chemical, bio-chemical and biological reactions, particularly blood-clotting
US3720097A (en) *	1971-01-21	1973-03-13	Univ Pennsylvania	Apparatus and method for measuring mammalian blood viscosity
NL7303522A (fr) *	1973-03-13	1974-09-17
US4213456A (en) *	1978-01-07	1980-07-22	Bottger Paul E K	Medical multi-purpose instrument
DE2966583D1 (en) *	1978-10-02	1984-03-01	Wellcome Found	A method of and apparatus for monitoring platelet aggregation and test cell for use in such method and apparatus
JPS6026325B2 (ja) *	1979-06-15	1985-06-22	三菱電機株式会社	同期形論理回路
US4634679A (en) *	1982-11-10	1987-01-06	Becton Dickinson And Company	Method of determining adhesion of a liquid sample
DE3247815C2 (de) *	1982-12-23	1985-10-17	Gustav Viktor Rudolf Prof. London Born	Einrichtung zur Messung der Blutungszeit in vitro
GB8316332D0 (en) *	1983-06-15	1983-07-20	Gorog P	Measuring haemotasis
DE3541057A1 (de) *	1985-11-19	1987-05-21	Kratzer Michael	Verfahren und einrichtung zur messung der aggregation der blutplaettchen bzw. der koagulation des blutes
GB8621757D0 (en) *	1986-09-10	1986-10-15	Gorog P	Blood testing device
US5047211A (en) *	1989-08-18	1991-09-10	Xylum Corporation	Disposable blood handling cassette device for measuring haemostasis
US5296379A (en) *	1990-03-23	1994-03-22	Peter Gorog	Apparatus and method for modeling arterial thrombus formations

1986
- 1986-09-10 GB GB868621757A patent/GB8621757D0/en active Pending
1987
- 1987-09-10 JP JP62505188A patent/JPH07101219B2/ja not_active Expired - Lifetime
- 1987-09-10 US US07/314,663 patent/US5665311A/en not_active Expired - Fee Related
- 1987-09-10 AU AU79111/87A patent/AU609060B2/en not_active Ceased
- 1987-09-10 EP EP87905777A patent/EP0324749B1/fr not_active Expired
- 1987-09-10 WO PCT/GB1987/000633 patent/WO1988002116A1/fr not_active Ceased
- 1987-09-10 DE DE8787905777T patent/DE3782503T2/de not_active Expired - Fee Related
- 1987-09-10 AT AT87905777T patent/ATE82070T1/de not_active IP Right Cessation
1989
- 1989-03-29 CA CA000595046A patent/CA1341179C/fr not_active Expired - Fee Related
1996
- 1996-11-04 US US08/743,911 patent/US5925569A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1988002116A1 (fr)	1988-03-24
AU7911187A (en)	1988-04-07
DE3782503T2 (de)	1993-05-19
US5665311A (en)	1997-09-09
GB8621757D0 (en)	1986-10-15
EP0324749A1 (fr)	1989-07-26
EP0324749B1 (fr)	1992-11-04
ATE82070T1 (de)	1992-11-15
JPH07101219B2 (ja)	1995-11-01
JPH02500334A (ja)	1990-02-08
DE3782503D1 (de)	1992-12-10
US5925569A (en)	1999-07-20
AU609060B2 (en)	1991-04-26

Legal Events

Date	Code	Title	Description
2004-02-13	MKLA	Lapsed

Publication	Publication Date	Title
CA1341179C (fr)	2001-02-13	Dispositif d'analyse pour le sang
US5316730A (en)	1994-05-31	Disposable cartridge for investigating physical properties of blood
US5854423A (en)	1998-12-29	Apparatus and method for assessment of visco-elasticity and shear adherence strength properties of blood clots
JP2945473B2 (ja)	1999-09-06	鬱血測定のための使い捨て血液操作カセット装置
US3720097A (en)	1973-03-13	Apparatus and method for measuring mammalian blood viscosity
US3918908A (en)	1975-11-11	Method for prothrombin testing
US5339830A (en)	1994-08-23	Blood coagulation test system
US7223365B2 (en)	2007-05-29	Device and method for detecting the coagulation functions of global, especially primary hemostasis
EP0239690A2 (fr)	1987-10-07	Méthode et appareil de mesure du taux d'agglutination d'érythrocytes entiers
US3951606A (en)	1976-04-20	Apparatus for prothrombin testing
US4534939A (en)	1985-08-13	Gas flow cartridge with improved coagulation detection and expanded analytical test capability
US5296379A (en)	1994-03-22	Apparatus and method for modeling arterial thrombus formations
US6004819A (en)	1999-12-21	Blood testing device
US4884577A (en)	1989-12-05	Process and apparatus for measuring blood viscosity directly and rapidly
US5916813A (en)	1999-06-29	Thrombotic and/or thrombolytic status analyser
US4797369A (en)	1989-01-10	Method and apparatus for detecting a blood clot
JP3135574B2 (ja)	2001-02-19	血液の血栓溶解活性測定法
EP0129425B1 (fr)	1989-08-23	Méthode et appareil de mesure de la hémostase et de la thrombolyse
KR20230149730A (ko)	2023-10-27	혈전탄성도 테스트 장치 및 방법
EP0111551B1 (fr)	1987-05-06	Procede et dispositif permettant une mesure rapide et directe de la viscosite sanguine
GB2245061A (en)	1991-12-18	Modelling thrombosis formation
KR101865088B1 (ko)	2018-07-04	혈소판 기능 및 점도 검사 장치
JPH02151768A (ja)	1990-06-11	血餅を検出する装置及び方法