CA2011008A1 - Variants du facteur de croissance epidermique et leur utilisation pharmacologique - Google Patents
Variants du facteur de croissance epidermique et leur utilisation pharmacologiqueInfo
- Publication number
- CA2011008A1 CA2011008A1 CA2011008A CA2011008A CA2011008A1 CA 2011008 A1 CA2011008 A1 CA 2011008A1 CA 2011008 A CA2011008 A CA 2011008A CA 2011008 A CA2011008 A CA 2011008A CA 2011008 A1 CA2011008 A1 CA 2011008A1
- Authority
- CA
- Canada
- Prior art keywords
- egf
- variants
- pharmaceutical use
- egf variants
- multimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000009024 Epidermal Growth Factor Human genes 0.000 abstract 3
- 101800003838 Epidermal growth factor Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940116977 epidermal growth factor Drugs 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US317,467 | 1989-03-01 | ||
| US07/317,467 US5218093A (en) | 1989-03-01 | 1989-03-01 | EGF variants and pharmaceutical use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2011008A1 true CA2011008A1 (fr) | 1990-09-01 |
| CA2011008C CA2011008C (fr) | 1997-09-16 |
Family
ID=23233788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002011008A Expired - Fee Related CA2011008C (fr) | 1989-03-01 | 1990-02-27 | Variants du facteur de croissance epidermique et leur utilisation pharmacologique |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US5218093A (fr) |
| CA (1) | CA2011008C (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT67319A (en) * | 1991-08-30 | 1995-03-28 | Life Medical Sciences Inc | Compositions for treating wounds |
| US5591709A (en) * | 1991-08-30 | 1997-01-07 | Life Medical Sciences, Inc. | Compositions and methods for treating wounds |
| AU5433701A (en) * | 1995-06-07 | 2001-09-20 | Ortho-Mcneil Pharmaceutical, Inc. | Agonist peptide dimers |
| US5859311A (en) * | 1995-11-27 | 1999-01-12 | University Of Kentucky Research Foundation | Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use |
| US6265204B1 (en) | 1997-01-17 | 2001-07-24 | Genencor International, Inc. | DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi |
| AU2001279073B2 (en) | 2000-07-28 | 2006-08-24 | Christopher J. Murphy | Transplant media |
| JP2006512891A (ja) * | 2002-04-18 | 2006-04-20 | ジェネンコー・インターナショナル・インク | 糸状菌における機能性抗体の生産 |
| CA2427190A1 (fr) * | 2002-04-30 | 2003-10-30 | Alberta Research Council Inc. | Production du facteur de croissance epidermique recombinant dans les plantes |
| US7084246B2 (en) * | 2003-04-17 | 2006-08-01 | Molecular Logix, Inc. | Epidermal growth factor agonists |
| US20070207209A1 (en) * | 2004-08-27 | 2007-09-06 | Murphy Christopher J | Trophic factor combinations for nervous system treatment |
| US9198952B2 (en) | 2008-09-22 | 2015-12-01 | The Brigham And Women's Hospital, Inc. | Compositions of and methods of using ligand dimers |
| US8207118B2 (en) | 2009-07-17 | 2012-06-26 | University Of Southern California | Skin wound healing compositions and methods of use thereof |
| WO2011119836A1 (fr) * | 2010-03-24 | 2011-09-29 | Massachusetts Institute Of Technology | Procédés et compositions pour la cardioprotection et la régénération cardiaque |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE38892B1 (en) * | 1973-03-28 | 1978-06-21 | Ici Ltd | Pharmaceutical compositions |
| NO158880C (no) * | 1977-11-08 | 1988-11-09 | Genentech Inc | Fremgangsmaate for fremstilling av et spesifikt pattedyrhormon. |
| US4764593A (en) * | 1983-04-25 | 1988-08-16 | Amgen Inc. | Manufacture and expression of genes for urogastrone and polypeptide analogs thereof |
| CA1213537A (fr) * | 1984-05-01 | 1986-11-04 | Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee | Methode d'expression de polypeptides |
| GB8507666D0 (en) * | 1985-03-25 | 1985-05-01 | Wellcome Found | Epidermal growth factor production |
| US4783524A (en) * | 1985-09-17 | 1988-11-08 | Monsanto Company | Growth factors |
-
1989
- 1989-03-01 US US07/317,467 patent/US5218093A/en not_active Expired - Fee Related
-
1990
- 1990-02-27 CA CA002011008A patent/CA2011008C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2011008C (fr) | 1997-09-16 |
| US5218093A (en) | 1993-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |