CA2012096A1 - Composes de cytosine et procede de production - Google Patents

Composes de cytosine et procede de production

Info

Publication number: CA2012096A1
Authority: CA; Canada
Prior art keywords: group; formula; compounds; compound; production
Prior art date: 1990-03-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA 2012096

Other languages

English (en)

Other versions

CA2012096C (fr

Inventor

Khashayar Karimian

Bruno Konrad Radatus

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Apotex Pharmachem Inc

Original Assignee

Acic Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-13

Filing date

1990-03-13

Publication date

1991-09-13

1990-03-13 Priority to CA 2012096 priority Critical patent/CA2012096C/fr

1990-03-13 Application filed by Acic Canada Inc filed Critical Acic Canada Inc

1991-03-13 Priority to HU9202905A priority patent/HUT61565A/hu

1991-03-13 Priority to PCT/CA1991/000078 priority patent/WO1991013901A1/fr

1991-03-13 Priority to US07/930,605 priority patent/US5399682A/en

1991-03-13 Priority to DE69111438T priority patent/DE69111438T2/de

1991-03-13 Priority to EP91906308A priority patent/EP0523080B1/fr

1991-03-13 Priority to AU74801/91A priority patent/AU7480191A/en

1991-03-13 Priority to AT91906308T priority patent/ATE125265T1/de

1991-03-13 Priority to BR919106157A priority patent/BR9106157A/pt

1991-09-13 Publication of CA2012096A1 publication Critical patent/CA2012096A1/fr

1994-02-02 Priority to US08/191,192 priority patent/US5527782A/en

1994-12-15 Priority to US08/356,498 priority patent/US5536824A/en

1995-06-06 Priority to US08/469,506 priority patent/US5596093A/en

1997-10-28 Application granted granted Critical

1997-10-28 Publication of CA2012096C publication Critical patent/CA2012096C/fr

2010-03-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
150000003839 salts Chemical class 0.000 abstract 3
-1 methoxytrityl Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
230000006820 DNA synthesis Effects 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000005257 alkyl acyl group Chemical group 0.000 abstract 1
125000005251 aryl acyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
235000021317 phosphate Nutrition 0.000 abstract 1
150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

CA 2012096 1990-03-13 1990-03-13 Composes de cytosine et procede de production Expired - Lifetime CA2012096C (fr)

Priority Applications (12)

Application Number	Priority Date	Filing Date	Title
CA 2012096 CA2012096C (fr)	1990-03-13	1990-03-13	Composes de cytosine et procede de production
BR919106157A BR9106157A (pt)	1990-03-13	1991-03-13	Compostos e processo 3'-o-tosil citidina e citosina e processo para producao dos mesmos
US07/930,605 US5399682A (en)	1990-03-13	1991-03-13	Process for preparing 2,3'-O-cyclocytidine
DE69111438T DE69111438T2 (de)	1990-03-13	1991-03-13	2,3'-o-cyclocytidine und verfahren zu deren herstellung.
EP91906308A EP0523080B1 (fr)	1990-03-13	1991-03-13	Composes de 2,3'-o-cyclocytidine, et leur procede de production
AU74801/91A AU7480191A (en)	1990-03-13	1991-03-13	3'-o-tosylcytidine and cytosine compounds, and process for production thereof
HU9202905A HUT61565A (en)	1990-03-13	1991-03-13	Process for producing 2,3'-0-cyclocytidine and 1-(beta-d-xylopento-furanosyl)-cytosine derivatives and their analogous compounds, as well as 3'-0-(p-toluenesulfonyl)-cytidine derivatives
PCT/CA1991/000078 WO1991013901A1 (fr)	1990-03-13	1991-03-13	Composes de tosylcytidine-3'-0 et de cytosine, et leur procede de production
AT91906308T ATE125265T1 (de)	1990-03-13	1991-03-13	2,3'-o-cyclocytidine und verfahren zu deren herstellung.
US08/191,192 US5527782A (en)	1990-03-13	1994-02-02	5-halo-2,3'-O-cyclocytidines
US08/356,498 US5536824A (en)	1990-03-13	1994-12-15	Organosulfonyl salts of 2,3'-O-cyclocytidine
US08/469,506 US5596093A (en)	1990-03-13	1995-06-06	Process for preparing halogenated 2,3-O-cyclocytidine derivatives

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA 2012096 CA2012096C (fr)	1990-03-13	1990-03-13	Composes de cytosine et procede de production

Publications (2)

Publication Number	Publication Date
CA2012096A1 true CA2012096A1 (fr)	1991-09-13
CA2012096C CA2012096C (fr)	1997-10-28

Family

ID=4144518

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA 2012096 Expired - Lifetime CA2012096C (fr)	1990-03-13	1990-03-13	Composes de cytosine et procede de production

Country Status (1)

Country	Link
CA (1)	CA2012096C (fr)

1990
- 1990-03-13 CA CA 2012096 patent/CA2012096C/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2012096C (fr)	1997-10-28

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Legal Events

Date	Code	Title	Description
1990-07-13	EEER	Examination request
2010-03-13	MKEX	Expiry