CA2012137A1 - Acides hydroxamiques et hydroxyurees dibenzoheterocycliques comme inhibiteurs de la 5-lipoxygenase - Google Patents

Acides hydroxamiques et hydroxyurees dibenzoheterocycliques comme inhibiteurs de la 5-lipoxygenase

Info

Publication number: CA2012137A1
Authority: CA; Canada
Prior art keywords: inhibitors; lipoxygenase; dibenzoheterocyclic; hydroxamic acids; hydroxy ureas
Prior art date: 1990-03-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2012137A

Other languages

English (en)

Other versions

CA2012137C (fr

Inventor

Yves Girard

Pierre Hamel

Daniel Delorme

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Frosst Canada and Co

Original Assignee

Merck Frosst Canada and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-14

Filing date

1990-03-14

Publication date

1991-09-14

1990-03-14 Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co

1990-03-14 Priority to CA002012137A priority Critical patent/CA2012137C/fr

1990-03-14 Priority claimed from US07/493,527 external-priority patent/US5036067A/en

1991-09-14 Publication of CA2012137A1 publication Critical patent/CA2012137A1/fr

2000-08-08 Application granted granted Critical

2000-08-08 Publication of CA2012137C publication Critical patent/CA2012137C/fr

2010-03-14 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 title abstract 2
108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
235000013877 carbamide Nutrition 0.000 title 1
-1 hydroxy ureas Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
206010000234 Abortion spontaneous Diseases 0.000 abstract 1
206010002383 Angina Pectoris Diseases 0.000 abstract 1
206010012735 Diarrhoea Diseases 0.000 abstract 1
208000005171 Dysmenorrhea Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
206010036600 Premature labour Diseases 0.000 abstract 1
208000005392 Spasm Diseases 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000001088 anti-asthma Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000001120 cytoprotective effect Effects 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
208000026440 premature labor Diseases 0.000 abstract 1
208000000995 spontaneous abortion Diseases 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA002012137A 1990-03-14 1990-03-14 Acides hydroxamiques et hydroxyurees dibenzoheterocycliques comme inhibiteurs de la 5-lipoxygenase Expired - Fee Related CA2012137C (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA002012137A CA2012137C (fr)	1990-03-14	1990-03-14	Acides hydroxamiques et hydroxyurees dibenzoheterocycliques comme inhibiteurs de la 5-lipoxygenase

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CA002012137A CA2012137C (fr)	1990-03-14	1990-03-14	Acides hydroxamiques et hydroxyurees dibenzoheterocycliques comme inhibiteurs de la 5-lipoxygenase
US07/493,527 US5036067A (en)	1990-03-14	1990-03-14	Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase

Publications (2)

Publication Number	Publication Date
CA2012137A1 true CA2012137A1 (fr)	1991-09-14
CA2012137C CA2012137C (fr)	2000-08-08

Family

ID=25674010

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002012137A Expired - Fee Related CA2012137C (fr)	1990-03-14	1990-03-14	Acides hydroxamiques et hydroxyurees dibenzoheterocycliques comme inhibiteurs de la 5-lipoxygenase

Country Status (1)

Country	Link
CA (1)	CA2012137C (fr)

1990
- 1990-03-14 CA CA002012137A patent/CA2012137C/fr not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2012137C (fr)	2000-08-08

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Legal Events

Date	Code	Title	Description
1997-03-10	EEER	Examination request
2005-03-14	MKLA	Lapsed