CA2013809A1 - Agent for the Prophylaxis of Atopy and Methods for Preparing and Using Same - Google Patents
Agent for the Prophylaxis of Atopy and Methods for Preparing and Using SameInfo
- Publication number
- CA2013809A1 CA2013809A1 CA2013809A CA2013809A CA2013809A1 CA 2013809 A1 CA2013809 A1 CA 2013809A1 CA 2013809 A CA2013809 A CA 2013809A CA 2013809 A CA2013809 A CA 2013809A CA 2013809 A1 CA2013809 A1 CA 2013809A1
- Authority
- CA
- Canada
- Prior art keywords
- gamma
- linolenic acid
- atopy
- agent
- glycolipids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010003645 Atopy Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 abstract 3
- 229930186217 Glycolipid Natural products 0.000 abstract 3
- 229960000711 alprostadil Drugs 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 150000003904 phospholipids Chemical class 0.000 abstract 3
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 abstract 3
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 3
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 abstract 2
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 abstract 2
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 abstract 2
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 abstract 2
- 235000020664 gamma-linolenic acid Nutrition 0.000 abstract 2
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 abstract 2
- 229960002733 gamolenic acid Drugs 0.000 abstract 2
- 150000003165 prostaglandin E1 derivatives Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000724 thymus hormone Substances 0.000 abstract 2
- IUKXMNDGTWTNTP-RHDCIPCHSA-N 15-HETrE Chemical compound CCCCCC(O)\C=C\C=C/C\C=C/CCCCCCC(O)=O IUKXMNDGTWTNTP-RHDCIPCHSA-N 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 235000008452 baby food Nutrition 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
The subject invention provides an agent and a method for atopy prophylaxis. Supplying gamma-linolenic acid, dihomo-gamma-linolenic acid, the physiologically compatible salts, esters, amides, phospholipids, glycolipids thereof, and Prostaglandin E1 (PGE1), PGE1 derivatives, PGE1 analogs to babies can prevent a subsequent occurrence of manifest atopy forms. The agents according to the invention are preferably contained in a baby food and/or should be supplied to the baby together therewith.
In a further preferred embodiment the agent contains a thymus hormone, or thymus hormones provided in combination with the agent. Further provided for is the use of Prostaglandin E1, its derivatives and analogs and the physiologically compatible esters, amides, phospholipids and glycolipids thereof in a pharmacologically effective dosage form for the topical or inhalative treatment of acute manifest atopy in the dermal and mucosal areas. The substance used according to the invention are preferably used in combination with gamma-linolenic acid, 15-hydroxydihomo-gamma-linolenic acid and dihomo-gamma-linolenic acid, the physiologically compatible salts, esters, amides, phospholipids and glycolipids thereof.
In a further preferred embodiment the agent contains a thymus hormone, or thymus hormones provided in combination with the agent. Further provided for is the use of Prostaglandin E1, its derivatives and analogs and the physiologically compatible esters, amides, phospholipids and glycolipids thereof in a pharmacologically effective dosage form for the topical or inhalative treatment of acute manifest atopy in the dermal and mucosal areas. The substance used according to the invention are preferably used in combination with gamma-linolenic acid, 15-hydroxydihomo-gamma-linolenic acid and dihomo-gamma-linolenic acid, the physiologically compatible salts, esters, amides, phospholipids and glycolipids thereof.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3910761.2 | 1989-04-04 | ||
| DEP3910760.4 | 1989-04-04 | ||
| DE3910761A DE3910761A1 (en) | 1989-04-04 | 1989-04-04 | Composition for atopy prophylaxis |
| DE3910760A DE3910760A1 (en) | 1989-04-04 | 1989-04-04 | NEW USE OF KNOWN SUBSTANCES AND METHOD FOR THE PRODUCTION OF SUITABLE PREPARATIONS |
| DEP3930816.2 | 1989-09-14 | ||
| DE3930816 | 1989-09-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2013809A1 true CA2013809A1 (en) | 1990-10-04 |
| CA2013809C CA2013809C (en) | 1996-12-17 |
Family
ID=27199345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002013809A Expired - Fee Related CA2013809C (en) | 1989-04-04 | 1990-04-04 | Agent for the prophylaxis of atopy and methods for preparing and using same |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2013809C (en) |
-
1990
- 1990-04-04 CA CA002013809A patent/CA2013809C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2013809C (en) | 1996-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |