CA2013960A1 - Dibenzofuranes substitues et methodes d'utilisation - Google Patents

Dibenzofuranes substitues et methodes d'utilisation

Info

Publication number: CA2013960A1
Authority: CA; Canada
Prior art keywords: alkyl; substituted; compounds; methods; conh2
Prior art date: 1989-09-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2013960A

Other languages

English (en)

Other versions

CA2013960C (fr

Inventor

T. Scott Shoupe

Steven Coutts

David C. Baker

Elli S. Hand

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Euro Celtique SA

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-19

Filing date

1990-04-05

Publication date

1991-03-19

1990-04-05 Application filed by Individual filed Critical Individual

1991-03-19 Publication of CA2013960A1 publication Critical patent/CA2013960A1/fr

2000-06-27 Application granted granted Critical

2000-06-27 Publication of CA2013960C publication Critical patent/CA2013960C/fr

2010-04-05 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

150000004826 dibenzofurans Chemical class 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 7
150000001875 compounds Chemical class 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
BUUPQKDIAURBJP-UHFFFAOYSA-N sulfinic acid Chemical compound OS=O BUUPQKDIAURBJP-UHFFFAOYSA-N 0.000 abstract 1
229940124530 sulfonamide Drugs 0.000 abstract 1
150000003456 sulfonamides Chemical class 0.000 abstract 1
150000003463 sulfur Chemical class 0.000 abstract 1
150000003536 tetrazoles Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Furan Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CA002013960A 1989-09-19 1990-04-05 Dibenzofuranes substitues et methodes d'utilisation Expired - Fee Related CA2013960C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US409,630		1989-09-19
US07/409,630 US5019573A (en)	1989-09-19	1989-09-19	Substituted dibenzofurans and methods of using same

Publications (2)

Publication Number	Publication Date
CA2013960A1 true CA2013960A1 (fr)	1991-03-19
CA2013960C CA2013960C (fr)	2000-06-27

Family

ID=23621327

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002013960A Expired - Fee Related CA2013960C (fr)	1989-09-19	1990-04-05	Dibenzofuranes substitues et methodes d'utilisation

Country Status (22)

Country	Link
US (1)	US5019573A (fr)
EP (1)	EP0422329B1 (fr)
JP (1)	JPH03145484A (fr)
KR (1)	KR0155556B1 (fr)
CN (1)	CN1042030C (fr)
AR (1)	AR248405A1 (fr)
AT (1)	ATE125534T1 (fr)
AU (1)	AU632851B2 (fr)
CA (1)	CA2013960C (fr)
DE (1)	DE69021162T2 (fr)
DK (1)	DK0422329T3 (fr)
EG (1)	EG19729A (fr)
ES (1)	ES2076248T3 (fr)
FI (1)	FI904448A7 (fr)
GR (1)	GR3017784T3 (fr)
IE (1)	IE69050B1 (fr)
IL (1)	IL93856A (fr)
NO (1)	NO175780C (fr)
NZ (1)	NZ233058A (fr)
PH (1)	PH26748A (fr)
PT (1)	PT95362B (fr)
ZA (1)	ZA902345B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4980369A (en) *	1989-09-19	1990-12-25	Allergan, Inc.	Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl or thiochromanyl group having retinoid-like activity
US7850970B2 (en)	2003-08-26	2010-12-14	The Regents Of The University Of Colorado	Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
US8158362B2 (en)	2005-03-30	2012-04-17	Decode Genetics Ehf.	Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
CN1318411C (zh) *	2005-03-21	2007-05-30	中国海洋大学	氢化轮枝霉酮类化合物及其制备方法和用途
US20080124303A1 (en) *	2005-12-12	2008-05-29	Cavit Sciences, Inc	Methods and compositions for treatment of viral infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3867409A (en) *	1969-06-16	1975-02-18	Richardson Merrell Inc	Bis-basic esters of dibenzofuran
US3649651A (en) *	1969-07-02	1972-03-14	American Home Prod	Dibenzofuran derivatives and preparation thereof
US4022805A (en) *	1974-03-07	1977-05-10	Hoffmann-La Roche Inc.	8-Halo-dibenzofuran-3-acetic acids and certain esters thereof
US4769387A (en) *	1987-11-13	1988-09-06	Abbott Laboratories	Dibenzofuran lipoxygenase inhibiting compounds, compositions and use

1989
- 1989-09-19 US US07/409,630 patent/US5019573A/en not_active Expired - Lifetime
1990
- 1990-03-23 NZ NZ233058A patent/NZ233058A/en unknown
- 1990-03-23 IL IL9385690A patent/IL93856A/en active IP Right Grant
- 1990-03-27 ZA ZA902345A patent/ZA902345B/xx unknown
- 1990-04-03 PH PH40317A patent/PH26748A/en unknown
- 1990-04-05 CA CA002013960A patent/CA2013960C/fr not_active Expired - Fee Related
- 1990-04-27 AT AT90108031T patent/ATE125534T1/de not_active IP Right Cessation
- 1990-04-27 ES ES90108031T patent/ES2076248T3/es not_active Expired - Lifetime
- 1990-04-27 EP EP90108031A patent/EP0422329B1/fr not_active Expired - Lifetime
- 1990-04-27 DK DK90108031.7T patent/DK0422329T3/da active
- 1990-04-27 AR AR90316737A patent/AR248405A1/es active
- 1990-04-27 DE DE69021162T patent/DE69021162T2/de not_active Expired - Fee Related
- 1990-05-06 EG EG26890A patent/EG19729A/xx active
- 1990-05-22 CN CN90103815A patent/CN1042030C/zh not_active Expired - Fee Related
- 1990-08-07 IE IE283690A patent/IE69050B1/en not_active IP Right Cessation
- 1990-09-10 FI FI904448A patent/FI904448A7/fi not_active IP Right Cessation
- 1990-09-18 AU AU62651/90A patent/AU632851B2/en not_active Ceased
- 1990-09-18 NO NO904060A patent/NO175780C/no unknown
- 1990-09-19 JP JP2251662A patent/JPH03145484A/ja active Pending
- 1990-09-19 PT PT95362A patent/PT95362B/pt not_active IP Right Cessation
- 1990-09-19 KR KR1019900014836A patent/KR0155556B1/ko not_active Expired - Fee Related
1995
- 1995-10-18 GR GR950402886T patent/GR3017784T3/el unknown

Also Published As

Publication number	Publication date
AU6265190A (en)	1991-03-28
DE69021162D1 (de)	1995-08-31
GR3017784T3 (en)	1996-01-31
CN1042030C (zh)	1999-02-10
PT95362A (pt)	1991-06-25
DK0422329T3 (da)	1995-09-11
AU632851B2 (en)	1993-01-14
ZA902345B (en)	1990-12-28
NZ233058A (en)	1991-05-28
PH26748A (en)	1992-09-28
NO904060D0 (no)	1990-09-18
IE902836A1 (en)	1991-03-27
ATE125534T1 (de)	1995-08-15
FI904448A7 (fi)	1991-03-20
NO175780C (no)	1994-12-07
EG19729A (en)	1996-01-31
EP0422329B1 (fr)	1995-07-26
PT95362B (pt)	1997-06-30
DE69021162T2 (de)	1996-02-15
KR0155556B1 (ko)	1998-11-16
NO175780B (no)	1994-08-29
NO904060L (no)	1991-03-20
AR248405A1 (es)	1995-08-18
KR910006262A (ko)	1991-04-29
CN1050384A (zh)	1991-04-03
IE69050B1 (en)	1996-08-07
ES2076248T3 (es)	1995-11-01
JPH03145484A (ja)	1991-06-20
FI904448A0 (fi)	1990-09-10
CA2013960C (fr)	2000-06-27
IL93856A (en)	1996-08-04
US5019573A (en)	1991-05-28
EP0422329A1 (fr)	1991-04-17
IL93856A0 (en)	1990-12-23

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Legal Events

Date	Code	Title	Description
1996-09-23	EEER	Examination request
2007-04-05	MKLA	Lapsed