CA2014457A1 - Derives de pyrimidine - Google Patents

Derives de pyrimidine

Info

Publication number: CA2014457A1
Authority: CA; Canada
Prior art keywords: alkyl; cycloalkyl; alkenyl; carbon atoms; group
Prior art date: 1989-04-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2014457A

Other languages

English (en)

Other versions

CA2014457C (fr

Inventor

Rodney Brian Hargreaves

Paul William Marshall

Bernard Joseph Mcloughlin

Stuart Dennett Mills

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Syngenta Ltd

Original Assignee

Imperial Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-21

Filing date

1990-04-12

Publication date

1990-10-21

1989-04-21 Priority claimed from GB898909054A external-priority patent/GB8909054D0/en

1989-05-08 Priority claimed from GB898910548A external-priority patent/GB8910548D0/en

1990-04-12 Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd

1990-10-21 Publication of CA2014457A1 publication Critical patent/CA2014457A1/fr

1999-09-28 Application granted granted Critical

1999-09-28 Publication of CA2014457C publication Critical patent/CA2014457C/fr

2010-04-12 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

CA002014457A 1989-04-21 1990-04-12 Derives de pyrimidine Expired - Fee Related CA2014457C (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB8909054.2		1989-04-21
GB898909054A GB8909054D0 (en)	1989-04-21	1989-04-21	Amino heterocycles
GB898910548A GB8910548D0 (en)	1989-05-08	1989-05-08	Heterocyclic compounds
GB8910548.0		1989-05-08

Publications (2)

Publication Number	Publication Date
CA2014457A1 true CA2014457A1 (fr)	1990-10-21
CA2014457C CA2014457C (fr)	1999-09-28

Family

ID=26295250

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002014457A Expired - Fee Related CA2014457C (fr)	1989-04-21	1990-04-12	Derives de pyrimidine

Country Status (29)

Country	Link
US (1)	US5223505A (fr)
EP (1)	EP0422178B1 (fr)
JP (1)	JP2528218B2 (fr)
KR (1)	KR920700203A (fr)
CN (1)	CN1024793C (fr)
AT (1)	ATE112561T1 (fr)
AU (1)	AU635260B2 (fr)
BG (1)	BG93508A (fr)
CA (1)	CA2014457C (fr)
DE (1)	DE69013112T2 (fr)
DK (1)	DK0422178T3 (fr)
ES (1)	ES2064727T3 (fr)
FI (1)	FI95377C (fr)
GB (1)	GB2230527B (fr)
GR (1)	GR1000371B (fr)
HR (1)	HRP930793A2 (fr)
HU (1)	HU209586B (fr)
IE (1)	IE63502B1 (fr)
IL (1)	IL94062A (fr)
MW (1)	MW9090A1 (fr)
MY (1)	MY105637A (fr)
NO (1)	NO177054C (fr)
NZ (1)	NZ233292A (fr)
PL (2)	PL165502B1 (fr)
PT (1)	PT93823B (fr)
RU (1)	RU2108329C1 (fr)
SI (1)	SI9010799A (fr)
WO (1)	WO1990012790A1 (fr)
YU (1)	YU79990A (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9012592D0 (en) *	1990-06-06	1990-07-25	Smithkline Beecham Intercredit	Compounds
GB9022644D0 (en) *	1990-10-18	1990-11-28	Ici Plc	Heterocyclic compounds
US5958934A (en) *	1996-05-23	1999-09-28	Syntex (U.S.A.) Inc.	Aryl pyrimidine derivatives and uses thereof
US5952331A (en) *	1996-05-23	1999-09-14	Syntex (Usa) Inc.	Aryl pyrimidine derivatives
TW440563B (en) *	1996-05-23	2001-06-16	Hoffmann La Roche	Aryl pyrimidine derivatives and a pharmaceutical composition thereof
EA200000840A1 (ru)	1998-02-17	2001-02-26	Туларик, Инк.	Антивирусные производные пиримидина
KR100643419B1 (ko)	1998-03-27	2006-11-10	얀센 파마슈티카 엔.브이.	Ｈｉｖ를 억제하는 피리미딘 유도체
DE19851421A1 (de) *	1998-11-07	2000-05-11	Boehringer Ingelheim Pharma	Neue Pyrimidine, deren Herstellung und Verwendung
TR200200763T2 (tr)	1999-09-24	2003-09-22	Janssen Pharmaceutica N.V.	Antiviral bileşimler
US6410726B1 (en)	2000-01-12	2002-06-25	Tularik Inc.	Arylsulfonic acid salts of pyrimidine-based antiviral
CN1527710A (zh) *	2001-05-14	2004-09-08	��˹�ж�-��˹˹��ҩƷ��˾	作为促肾上腺皮质激素释放因子配体的取代的吡嗪酮、吡啶和嘧啶
TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
HRP20050089B1 (hr)	2002-07-29	2015-06-19	Rigel Pharmaceuticals	Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti
CA2518465A1 (fr)	2003-03-25	2004-10-14	Takeda San Diego, Inc.	Inhibiteurs de dipeptidyle peptidase
US8309562B2 (en)	2003-07-03	2012-11-13	Myrexis, Inc.	Compounds and therapeutical use thereof
AU2004253967B2 (en) *	2003-07-03	2010-02-18	Cytovia, Inc.	4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
WO2006074147A2 (fr)	2005-01-03	2006-07-13	Myriad Genetics, Inc.	Composes et utilisation therapeutique associee
WO2005012294A1 (fr)	2003-07-30	2005-02-10	Rigel Pharmaceuticals, Inc.	Composes 2,4-pyrimidinediamine a utiliser dans le traitement ou la prevention de maladies auto-immunes
KR20060041309A (ko)	2003-08-13	2006-05-11	다케다 야쿠힌 고교 가부시키가이샤	４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도
EP1699777B1 (fr)	2003-09-08	2012-12-12	Takeda Pharmaceutical Company Limited	Inhibiteurs de la dipeptidylpeptidase
UA85871C2 (uk)	2004-03-15	2009-03-10	Такеда Фармасьютікал Компані Лімітед	Інгібітори дипептидилпептидази
SI1814878T1 (sl)	2004-11-24	2012-06-29	Rigel Pharmaceuticals Inc	Spojine spiro-2,4-pirimidindiamina in njihova uporaba
JP2008524331A (ja)	2004-12-21	2008-07-10	武田薬品工業株式会社	ジペプチジルペプチダーゼ阻害剤
US8258145B2 (en)	2005-01-03	2012-09-04	Myrexis, Inc.	Method of treating brain cancer
AU2006206458B2 (en)	2005-01-19	2012-10-25	Rigel Pharmaceuticals, Inc.	Prodrugs of 2,4-pyrimidinediamine compounds and their uses
EP1883302A4 (fr) *	2005-05-03	2009-05-20	Rigel Pharmaceuticals Inc	Inhibiteurs de kinase jak et utilisations de ceux-ci
MX2007014881A (es) *	2005-05-26	2008-02-15	Tibotec Pharm Ltd	Procedimiento para preparar 4-(1,6-dihidro-6-oxo-2-pirimidinil) amino benzonitrilo.
MY147393A (en)	2005-09-14	2012-11-30	Takeda Pharmaceutical	Administration of dipeptidyl peptidase inhibitors
CA2622642C (fr)	2005-09-16	2013-12-31	Takeda Pharmaceutical Company Limited	Inhibiteurs de dipeptidylpeptidase
US20090221610A1 (en) *	2006-01-31	2009-09-03	Yale University	Compositions and Methods for Treating Cognitive Disorders
US8324383B2 (en)	2006-09-13	2012-12-04	Takeda Pharmaceutical Company Limited	Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en)	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US20080217501A1 (en) *	2007-02-14	2008-09-11	Chad Jensen	Power a-frame
CL2008000467A1 (es) *	2007-02-14	2008-08-22	Janssen Pharmaceutica Nv	Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors
TWI401023B (zh) *	2008-02-06	2013-07-11	Du Pont	中離子農藥
US9616064B2 (en)	2011-03-30	2017-04-11	H. Lee Moffitt Cancer Center And Research Institute, Inc.	Rho kinase inhibitors and methods of use
US10172856B2 (en)	2017-04-06	2019-01-08	Janssen Pharmaceutica Nv	2,4-diaminopyrimidine derivatives as histamine H4 modulators
WO2019079369A1 (fr)	2017-10-19	2019-04-25	Effector Therapeutics, Inc.	Inhibiteurs de benzimidazole-indole de mnk1 et mnk2

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB815833A (en) *	1956-09-26	1959-07-01	Boots Pure Drug Co Ltd	Phenanthridine compounds
BE492034A (fr) *	1948-11-05
US2784124A (en) *	1953-07-01	1957-03-05	Howard R Moore	Method of coating ferrous metal surface and composition therefor
US2748124A (en) *	1954-05-06	1956-05-29	Searle & Co	1-(4-anilino-2-pyrimidino)-3-alkylureas
US2845425A (en) *	1956-10-04	1958-07-29	Lilly Co Eli	Substituted aminopyrimidines
DE1241832B (de) *	1963-02-23	1967-06-08	Hoechst Ag	Verfahren zur Herstellung von Pyrimidiniumverbindungen
DE1445740A1 (de) *	1963-09-04	1968-11-28	Bayer Ag	Verfahren zur Herstellung von Bispyrimidinium-Verbindungen
GB1229413A (fr) *	1967-06-14	1971-04-21
IN142539B (fr) *	1974-05-10	1977-07-23	Ciba Geigy India Ltd
US4339453A (en) *	1979-07-23	1982-07-13	Merck & Co., Inc.	Antimicrobial aminopyrimidinium salts
GR80171B (en) *	1983-08-29	1985-01-02	Ciba Geigy Ag	N-(2-nitrophenyl)-4-aminopyrimidine derivatives process for the preparation thereof and use
US4725600A (en) *	1984-07-13	1988-02-16	Fujisawa Pharmaceutical Co., Ltd.	Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
DE3717480A1 (de) *	1987-05-23	1988-12-01	Shell Agrar Gmbh & Co Kg	Neue herbizid und mikrobizid wirksame 2,6-diaminopyrimidine
IL88507A (en) *	1987-12-03	1993-02-21	Smithkline Beckman Intercredit	2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them

1990
- 1990-04-06 IE IE125890A patent/IE63502B1/en not_active IP Right Cessation
- 1990-04-09 GB GB9007964A patent/GB2230527B/en not_active Expired - Fee Related
- 1990-04-11 IL IL9406290A patent/IL94062A/en not_active IP Right Cessation
- 1990-04-11 NZ NZ233292A patent/NZ233292A/en unknown
- 1990-04-12 CA CA002014457A patent/CA2014457C/fr not_active Expired - Fee Related
- 1990-04-19 JP JP2506034A patent/JP2528218B2/ja not_active Expired - Lifetime
- 1990-04-19 AU AU54354/90A patent/AU635260B2/en not_active Ceased
- 1990-04-19 DK DK90906289.5T patent/DK0422178T3/da active
- 1990-04-19 YU YU00799/90A patent/YU79990A/xx unknown
- 1990-04-19 ES ES90906289T patent/ES2064727T3/es not_active Expired - Lifetime
- 1990-04-19 AT AT90906289T patent/ATE112561T1/de not_active IP Right Cessation
- 1990-04-19 RU SU4894489A patent/RU2108329C1/ru active
- 1990-04-19 EP EP90906289A patent/EP0422178B1/fr not_active Expired - Lifetime
- 1990-04-19 WO PCT/GB1990/000595 patent/WO1990012790A1/fr not_active Ceased
- 1990-04-19 HU HU903555A patent/HU209586B/hu not_active IP Right Cessation
- 1990-04-19 DE DE69013112T patent/DE69013112T2/de not_active Expired - Fee Related
- 1990-04-19 KR KR1019900702652A patent/KR920700203A/ko not_active Ceased
- 1990-04-20 SI SI9010799A patent/SI9010799A/sl unknown
- 1990-04-20 PL PL90284871A patent/PL165502B1/pl unknown
- 1990-04-20 PL PL90301231A patent/PL165917B1/pl unknown
- 1990-04-20 US US07/513,304 patent/US5223505A/en not_active Expired - Fee Related
- 1990-04-20 PT PT93823A patent/PT93823B/pt not_active IP Right Cessation
- 1990-04-21 CN CN90103931A patent/CN1024793C/zh not_active Expired - Fee Related
- 1990-04-21 MY MYPI90000670A patent/MY105637A/en unknown
- 1990-04-23 GR GR900100304A patent/GR1000371B/el not_active IP Right Cessation
- 1990-12-06 MW MW90/90A patent/MW9090A1/xx unknown
- 1990-12-20 NO NO905519A patent/NO177054C/no not_active IP Right Cessation
- 1990-12-20 FI FI906307A patent/FI95377C/fi not_active IP Right Cessation
- 1990-12-21 BG BG093508A patent/BG93508A/bg unknown
1993
- 1993-04-06 HR HRP-799/90A patent/HRP930793A2/hr not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2014457C (fr)	1999-09-28
EP0422178A1 (fr)	1991-04-17
HRP930793A2 (en)	1996-08-31
DE69013112D1 (de)	1994-11-10
DE69013112T2 (de)	1995-01-26
AU635260B2 (en)	1993-03-18
JP2528218B2 (ja)	1996-08-28
DK0422178T3 (da)	1994-12-19
KR920700203A (ko)	1992-02-19
PL165502B1 (pl)	1994-12-30
WO1990012790A1 (fr)	1990-11-01
YU79990A (en)	1991-10-31
NZ233292A (en)	1992-05-26
MW9090A1 (en)	1991-11-13
FI95377B (fi)	1995-10-13
NO905519L (no)	1991-02-20
RU2108329C1 (ru)	1998-04-10
CN1024793C (zh)	1994-06-01
IL94062A (en)	1995-11-27
EP0422178B1 (fr)	1994-10-05
ATE112561T1 (de)	1994-10-15
HUT56080A (en)	1991-07-29
BG93508A (bg)	1993-12-24
IE63502B1 (en)	1995-05-03
GB9007964D0 (en)	1990-06-06
HU209586B (en)	1994-08-29
HU903555D0 (en)	1991-05-28
GR1000371B (el)	1992-06-30
FI95377C (fi)	1996-01-25
IE901258L (en)	1990-10-21
JPH03505741A (ja)	1991-12-12
GB2230527B (en)	1993-05-05
GR900100304A (en)	1991-09-27
PT93823A (pt)	1990-11-20
SI9010799A (en)	1995-08-31
NO905519D0 (no)	1990-12-20
PL165917B1 (pl)	1995-03-31
NO177054B (no)	1995-04-03
IL94062A0 (en)	1991-01-31
GB2230527A (en)	1990-10-24
ES2064727T3 (es)	1995-02-01
FI906307A0 (fi)	1990-12-20
US5223505A (en)	1993-06-29
AU5435490A (en)	1990-11-16
PT93823B (pt)	1996-09-30
CN1047080A (zh)	1990-11-21
NO177054C (no)	1995-07-12
MY105637A (en)	1994-11-30

Legal Events

Date	Code	Title	Description
1996-11-27	EEER	Examination request
2004-04-13	MKLA	Lapsed

Publication	Publication Date	Title
CA2014457A1 (fr)	1990-10-21	Derives de pyrimidine
IE871944L (en)	1988-01-18	N-phosphonomethoxyalkyl derivatives of purine and pyrimidine¹bases
EP0398720A3 (fr)	1991-07-03	Dérivés de pipérazine
EP0321968A3 (en)	1990-10-31	Compounds active on the cardiovascular system
AU642482B2 (en)	1993-10-21	4-aminopyridinium derivatives
IL64647A (en)	1985-10-31	2,8-disubstituted-4-thiomorpholino-pyrimido(5,4-d)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
MY106091A (en)	1995-03-31	Heterocyclic compounds.
ATE48994T1 (de)	1990-01-15	Benzimidazol-derivat, verfahren zu seiner herstellung und pharmazeutische zusammensetzung.
JO1631B1 (en)	1991-11-27	Derivatives of permidine
ATE131480T1 (de)	1995-12-15	Pyrimidoindolderivate und verfahren zu ihrer herstellung
ATE19083T1 (de)	1986-04-15	Weitere neue amidine, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische praeparate und ihre verwendung.
IE881752L (en)	1988-12-12	New aminoacylates of glycerol acetal