CA2021658A1 - Systeme multiplex de dosage immunologique - Google Patents

Systeme multiplex de dosage immunologique

Info

Publication number
CA2021658A1
CA2021658A1 CA 2021658 CA2021658A CA2021658A1 CA 2021658 A1 CA2021658 A1 CA 2021658A1 CA 2021658 CA2021658 CA 2021658 CA 2021658 A CA2021658 A CA 2021658A CA 2021658 A1 CA2021658 A1 CA 2021658A1
Authority
CA
Canada
Prior art keywords
ligands
analyte
specific binding
sample
ligand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2021658
Other languages
English (en)
Other versions
CA2021658C (fr
Inventor
Myron J. Block
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Corp
Original Assignee
Ord Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ord Inc filed Critical Ord Inc
Publication of CA2021658A1 publication Critical patent/CA2021658A1/fr
Application granted granted Critical
Publication of CA2021658C publication Critical patent/CA2021658C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CA 2021658 1989-08-25 1990-07-20 Systeme multiplex de dosage immunologique Expired - Fee Related CA2021658C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39862189A 1989-08-25 1989-08-25
US398,621 1989-08-25

Publications (2)

Publication Number Publication Date
CA2021658A1 true CA2021658A1 (fr) 1991-02-26
CA2021658C CA2021658C (fr) 2001-10-09

Family

ID=23576097

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2021658 Expired - Fee Related CA2021658C (fr) 1989-08-25 1990-07-20 Systeme multiplex de dosage immunologique

Country Status (5)

Country Link
JP (1) JP2584530B2 (fr)
CA (1) CA2021658C (fr)
DE (1) DE4024350C2 (fr)
FR (1) FR2651327B1 (fr)
GB (1) GB2235292B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07505297A (ja) * 1992-04-06 1995-06-15 アボツト・ラボラトリーズ 内面全反射を使用して核酸または被分析物質を検出する方法及び装置
WO2002048690A1 (fr) * 2000-12-11 2002-06-20 Varian Australia Pty Ltd Procede et appareil destines a l'analyse d'echantillons multiplexes
JP3429282B2 (ja) 2001-02-02 2003-07-22 リサーチ・インターナショナル・インコーポレーテッド 自動化されたシステム、及びサンプルの分析方法
EP1735619A4 (fr) * 2004-04-01 2007-09-26 Rules Based Medicine Inc Analyse universelle multiple
US7496245B2 (en) 2004-08-20 2009-02-24 Research International, Inc. Misalignment compensating optical sensor and method
US7842465B2 (en) * 2006-01-17 2010-11-30 Palo Alto Research Center Incorporated Immunocytostaining methods for enhanced dye ratio discrimination in rare event detection
US7651869B2 (en) 2006-03-14 2010-01-26 Research International, Inc. Optical assay apparatus and methods
US7875433B2 (en) 2007-02-26 2011-01-25 Response Biomedical Corporation Comparative multiple analyte assay

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3604927A (en) * 1966-11-16 1971-09-14 Block Engineering Total reflection fluorescence spectroscopy
US3652761A (en) * 1969-09-04 1972-03-28 Corning Glass Works Immunochemical composites and antigen or antibody purification therewith
GB2057685B (en) * 1979-03-19 1983-12-21 Int Diagnostic Tech Double tagged immunoassay
JPS5745454A (en) * 1980-09-02 1982-03-15 Fuji Photo Film Co Ltd Immunochemical measuring method for various minor components
JPS585659A (ja) * 1981-06-24 1983-01-13 ハイブリテツク　インコ−ポレ−テツド 単クロ−ン性抗体を使用する免疫学的、抑制試験
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US4471058A (en) 1982-07-26 1984-09-11 Board Of Trustees Operating Michigan State University Method for the detection and/or determination of a polyvalent antigen using at least two different monoclonal antibodies
US4447546A (en) * 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
US4584277A (en) * 1983-04-05 1986-04-22 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
US4558014A (en) * 1983-06-13 1985-12-10 Myron J. Block Assay apparatus and methods
US4582791A (en) * 1983-10-07 1986-04-15 Syntex (U.S.A.) Inc. Reducing non-specific background in immunofluorescence techniques
US4595661A (en) * 1983-11-18 1986-06-17 Beckman Instruments, Inc. Immunoassays and kits for use therein which include low affinity antibodies for reducing the hook effect
JPH0789116B2 (ja) * 1985-06-14 1995-09-27 帝人株式会社 モノクローナル抗体を用いた免疫学的測定方法およびそのためのキット
JPS6238362A (ja) * 1985-08-12 1987-02-19 Chemo Sero Therapeut Res Inst Ｔｓｈの測定方法
WO1988001058A1 (fr) * 1986-08-06 1988-02-11 Roger Philip Ekins Determination de la concentration d'analyte a l'aide de deux substances de marquage
US4704891A (en) * 1986-08-29 1987-11-10 Becton, Dickinson And Company Method and materials for calibrating flow cytometers and other analysis instruments
GB8623494D0 (en) * 1986-09-30 1986-11-05 Mackay C D Assay technique
US4954435A (en) * 1987-01-12 1990-09-04 Becton, Dickinson And Company Indirect colorimetric detection of an analyte in a sample using ratio of light signals
JPH0827282B2 (ja) * 1987-07-01 1996-03-21 帝人株式会社 ヒト・プロテインｃの免疫学的測定法，測定試薬およびそのキット
GB2233450B (en) * 1989-06-24 1993-06-30 Univ Wales Medicine Detecting or quantifing multiple analytes with luminescent reagents

Also Published As

Publication number Publication date
FR2651327B1 (fr) 1994-03-11
JPH03272466A (ja) 1991-12-04
GB2235292A (en) 1991-02-27
GB2235292B (en) 1993-09-22
DE4024350A1 (de) 1991-02-28
DE4024350C2 (de) 2000-03-16
GB9016162D0 (en) 1990-09-05
FR2651327A1 (fr) 1991-03-01
CA2021658C (fr) 2001-10-09
JP2584530B2 (ja) 1997-02-26

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