CA2022108A1 - Augmentation de la multiplication et de l'expression de proteines heterologues dans un hote recombinant contenant des mutations dans la bioxynthese de la paroi cellulaire et (ou) de la membrane plasmatique - Google Patents

Augmentation de la multiplication et de l'expression de proteines heterologues dans un hote recombinant contenant des mutations dans la bioxynthese de la paroi cellulaire et (ou) de la membrane plasmatique

Info

Publication number
CA2022108A1
CA2022108A1 CA002022108A CA2022108A CA2022108A1 CA 2022108 A1 CA2022108 A1 CA 2022108A1 CA 002022108 A CA002022108 A CA 002022108A CA 2022108 A CA2022108 A CA 2022108A CA 2022108 A1 CA2022108 A1 CA 2022108A1
Authority
CA
Canada
Prior art keywords
medium according
medium
yeast
mosm
osmolarity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002022108A
Other languages
English (en)
Inventor
Cheryl A. Schulman
Peter J. Kniskern
Robert Z. Maigetter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of CA2022108A1 publication Critical patent/CA2022108A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002022108A 1989-07-31 1990-07-27 Augmentation de la multiplication et de l'expression de proteines heterologues dans un hote recombinant contenant des mutations dans la bioxynthese de la paroi cellulaire et (ou) de la membrane plasmatique Abandoned CA2022108A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38768089A 1989-07-31 1989-07-31
US387,680 1989-07-31

Publications (1)

Publication Number Publication Date
CA2022108A1 true CA2022108A1 (fr) 1991-02-01

Family

ID=23530931

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002022108A Abandoned CA2022108A1 (fr) 1989-07-31 1990-07-27 Augmentation de la multiplication et de l'expression de proteines heterologues dans un hote recombinant contenant des mutations dans la bioxynthese de la paroi cellulaire et (ou) de la membrane plasmatique

Country Status (3)

Country Link
EP (1) EP0411896A3 (fr)
JP (1) JPH03175993A (fr)
CA (1) CA2022108A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9016031D0 (en) * 1990-07-20 1990-09-05 Univ Manchester Cell lysis
IL101651A0 (en) * 1991-04-29 1992-12-30 Merck & Co Inc Hepatitis b virus surface proteins with reduced host carbohydrate content
WO2010036826A1 (fr) * 2008-09-24 2010-04-01 Sanofi Pasteur Biologics Co. Procédés et compositions pour augmenter la production de toxines

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963483A (en) * 1987-10-13 1990-10-16 Merck & Co., Inc. Method for producing hepatitis B virus proteins in yeast
AU625392B2 (en) * 1987-10-29 1992-07-09 Zymogenetics Inc. Methods of regulating protein glycosylation
NZ229260A (en) * 1988-06-03 1994-02-25 Merck & Co Inc Hepatitis b virus, expression cassette for pre-s domain, host cells and
CA2022109A1 (fr) * 1989-07-31 1991-02-01 Cheryl A. Schulman Augmentation de l'expression de proteines heterologues dans des hotes recombinants dans un milieu qui n'est pas un milieu de culture

Also Published As

Publication number Publication date
EP0411896A3 (en) 1991-08-21
EP0411896A2 (fr) 1991-02-06
JPH03175993A (ja) 1991-07-31

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Legal Events

Date Code Title Description
FZDE Discontinued