CA2025663A1 - Derives d'indole - Google Patents

Derives d'indole

Info

Publication number
CA2025663A1
CA2025663A1 CA2025663A CA2025663A CA2025663A1 CA 2025663 A1 CA2025663 A1 CA 2025663A1 CA 2025663 A CA2025663 A CA 2025663A CA 2025663 A CA2025663 A CA 2025663A CA 2025663 A1 CA2025663 A1 CA 2025663A1
Authority
CA
Canada
Prior art keywords
hydrogen
4alkyl
compounds
group
indole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2025663A
Other languages
English (en)
Other versions
CA2025663C (fr
Inventor
Eldiberto F. Alvarez
Carlos E. Recalde
Maria A. C. Villalobos
Antonio D. Diaz
Carlos B. Barrios
Maria Del Carmen Ochoa Estomba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2025663A1 publication Critical patent/CA2025663A1/fr
Application granted granted Critical
Publication of CA2025663C publication Critical patent/CA2025663C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne des composés ayant la structure (1), ainsi que des sels pharmaceutiquement acceptables, dans laquelle R représente hydrogène ou alcoyle C1-4, R' représente hydrogène, alcoyle C1-4, ou un groupe alcoyle C1-4 remplacé par un groupe alkyne ou allène, à condition que R' ne représente pas méthyle lorsque R et R'' représentent l'un et l'autre hydrogène, et R'' représente hydrogène ou un groupe alcoyle C1-4 remplacé par un groupe alkyne ou allène. Ces composés présentent une activité anti-dépressive. L'invention concerne également un procédé de préparation desdit composés, des compositions et des procédés pharmaceutiques.
CA002025663A 1989-02-08 1990-02-08 Derives d'indole Expired - Lifetime CA2025663C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES8900452 1989-02-08
ES8900452A ES2013391A6 (es) 1989-02-08 1989-02-08 Procedimiento para la preparacion de derivados acetilenicos y alenicos de 2-aminometil -5-metoxiindoles.
PCT/EP1990/000221 WO1990009375A1 (fr) 1989-02-08 1990-02-08 Derives d'indole

Publications (2)

Publication Number Publication Date
CA2025663A1 true CA2025663A1 (fr) 1990-08-09
CA2025663C CA2025663C (fr) 1999-07-27

Family

ID=8260310

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002025663A Expired - Lifetime CA2025663C (fr) 1989-02-08 1990-02-08 Derives d'indole

Country Status (14)

Country Link
US (1) US5130327A (fr)
EP (1) EP0382533B1 (fr)
JP (1) JP2994457B2 (fr)
KR (1) KR0171579B1 (fr)
AT (1) ATE85047T1 (fr)
AU (1) AU626640B2 (fr)
CA (1) CA2025663C (fr)
DE (1) DE69000806T2 (fr)
DK (1) DK0382533T3 (fr)
ES (2) ES2013391A6 (fr)
IE (1) IE64235B1 (fr)
NZ (1) NZ232426A (fr)
WO (1) WO1990009375A1 (fr)
ZA (1) ZA90936B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724171B1 (fr) * 1994-09-05 1997-01-03 Synthelabo Derives de 3,3a,4,5-tetrahydro-1h-oxazolo(3,4-a)quinolein-1-one, leur preparation et leur application en therapeutique
ES2137104B1 (es) * 1997-03-10 2000-08-16 Consejo Superior Investigacion Procedimiento para la preparacion de n-propargil-2-(5-benciloxi-indolil)-metilamina
WO2021118318A2 (fr) * 2019-12-13 2021-06-17 주식회사 메타센테라퓨틱스 Nouveau dérivé d'indole et son utilisation
WO2025162967A1 (fr) * 2024-01-30 2025-08-07 Institut National de la Santé et de la Recherche Médicale Ligands gpr50 destinés à être utilisés pour traiter des maladies médiées par gpr50

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB846560A (en) * 1957-02-06 1960-08-31 Smith & Nephew Improvements in indole derivatives

Also Published As

Publication number Publication date
DE69000806D1 (de) 1993-03-11
JPH03504979A (ja) 1991-10-31
DE69000806T2 (de) 1993-05-19
KR910700233A (ko) 1991-03-14
IE64235B1 (en) 1995-07-26
HK1002410A1 (en) 1998-08-21
AU5029990A (en) 1990-09-05
ZA90936B (en) 1990-12-28
ES2054234T3 (es) 1994-08-01
ES2013391A6 (es) 1990-05-01
WO1990009375A1 (fr) 1990-08-23
ATE85047T1 (de) 1993-02-15
US5130327A (en) 1992-07-14
EP0382533A1 (fr) 1990-08-16
EP0382533B1 (fr) 1993-01-27
JP2994457B2 (ja) 1999-12-27
DK0382533T3 (da) 1993-03-01
NZ232426A (en) 1992-05-26
IE900438L (en) 1990-08-08
CA2025663C (fr) 1999-07-27
AU626640B2 (en) 1992-08-06
KR0171579B1 (ko) 1999-02-01

Similar Documents

Publication Publication Date Title
CA2198917A1 (fr) Liberation prolongee de peptides depuis des compositions pharmaceutiques
AU7277987A (en) Pharmaceutically active tetrahydronaphthalene derivatives
CA2014545A1 (fr) Derives d'acide biliaire; methode de preparation desdits derives et compositions pharmaceutiques utilisant ces derives
CA2189603A1 (fr) Derive de la propiophenone et methodes de preparation
IE832436L (en) Novel chromans and chromenes
ES8802053A1 (es) Un procedimiento para la preparacion de nuevas piranopiridinas
CA2011329A1 (fr) Derives de xanthine
ZA909903B (en) New compounds
AU2577295A (en) Cyclosporin containing composition and process for the preparation thereof
AU582235B2 (en) Quinolylglycinamide derivatives,the process for preparation thereof and their therapeutic application as psychotropic drugs
EP0138344A3 (fr) Pyridazinones utiles comme beta-adrenorecepteurs antagonistes
CA2020474A1 (fr) Compose anti-inflammatoire ou antiallergique
CA2025663A1 (fr) Derives d'indole
KR950032183A (ko) 글루코피라노사이드 벤조티오펜
EP0347749A3 (fr) Dérivés de la pyrazoloacridone ayant une activité antitumorale
EP0218953A3 (fr) Dérivés de l'acide 19,20-bis-nor-prostanoique à activité anti-ulcéreuse et anorétique, leur procédé de préparation et compositions pharmaceutiques
IE873212L (en) Medicaments based on derivatives of 3,4-di-phenylpiperidine,¹the use of the derivatives as medicaments, and novel¹3,4-diphenylpiperidine derivatives and a process for the¹preparation therefor
CA2276719A1 (fr) Derives d'anilide et agents anti-arythmisants qui les contiennent
AU622521B2 (en) Pyrimidinetrione derivatives, processes for their preparation, agents containing them and their use as agents for combating pests
ES550781A0 (es) Un procedimiento para preparar un derivado de 1-benzhidril--4-cinamilpiperazina
IE830282L (en) Ergot alkaloids
ES515712A0 (es) "un procedimiento para la preparacion de nuevos derivados de tetrahidroquinolina".
IE43848L (en) Pharmaceutical compositions
GB1505518A (en) Pyrazole derivatives
JPS52144674A (en) Preparation of 5-bromo-3-(s-pyridyl)-indole-1-oxide derivatives

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry