CA2058769A1 - Methodes pour le dosage des phospholipides et de leurs anticorps - Google Patents

Methodes pour le dosage des phospholipides et de leurs anticorps

Info

Publication number
CA2058769A1
CA2058769A1 CA2058769A CA2058769A CA2058769A1 CA 2058769 A1 CA2058769 A1 CA 2058769A1 CA 2058769 A CA2058769 A CA 2058769A CA 2058769 A CA2058769 A CA 2058769A CA 2058769 A1 CA2058769 A1 CA 2058769A1
Authority
CA
Canada
Prior art keywords
present
sample
antibodies
determining whether
autoimmune diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2058769A
Other languages
English (en)
Other versions
CA2058769C (fr
Inventor
Steven Anthony Krilis
Hugh Patrick Mcneill
Colin Nicholson Chesterman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2058769A1 publication Critical patent/CA2058769A1/fr
Application granted granted Critical
Publication of CA2058769C publication Critical patent/CA2058769C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Procédé permettant de déterminer si des anticorps antiphospholipides sont présents dans un échantillon. Le procédé consiste à mettre en conctact l'échantillon avec un phospholipide chargé négativement et avec beta-2-glycoprotéine-I ou un homologue ou un analogue de celle-ci et à déterminer si d'éventuels anticorps antiphospholipides se sont liés au phospholipide et à la beta-2-glycoprotéine-I mis en contact, la détection de la liaison d'anticoprs antiphospholipides au phospholipide et à la beta-2-glycoprotéine-I indiquant que des anticorps antiphospholipides sont présents dans l'échantillon. L'invention concerne également un procédé permettant de déterminer si un phospholipide chargé négativement est présent dans un échantillon, un kit destiné à être utilisé dans une analyse permettant de déterminer si des anticorps antiphospholipides sont présents dans un échantillon, un kit destiné à être utilisé dans une analyse permettant de déterminer si un phospholipide chargé négativement est présent dans un échantillon, un procédé permettant de déterminer si des anticorps antiphospholipides se trouvant dans un échantillon sont des anticorps contre une maladie autoimmune ou des anticorps contre une maladie infectieuse, ainsi qu'un procédé premettant de déterminer si des anticorps antiphospholipides contre une maladie autoimmune et des anticorps antiphospholipides contre une maladie infectieuse sont présents dans un échantillon.
CA002058769A 1990-04-06 1991-04-04 Methodes pour le dosage des phospholipides et de leurs anticorps Expired - Lifetime CA2058769C (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AUPJ9549 1990-04-06
AUPJ954990 1990-04-06
AUPK218690 1990-09-07
AUPK2186 1990-09-07

Publications (2)

Publication Number Publication Date
CA2058769A1 true CA2058769A1 (fr) 1991-10-07
CA2058769C CA2058769C (fr) 1999-03-02

Family

ID=25643843

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002058769A Expired - Lifetime CA2058769C (fr) 1990-04-06 1991-04-04 Methodes pour le dosage des phospholipides et de leurs anticorps

Country Status (8)

Country Link
US (1) US5344758A (fr)
EP (1) EP0474849B1 (fr)
JP (1) JPH0688823A (fr)
AT (1) ATE127925T1 (fr)
CA (1) CA2058769C (fr)
DE (1) DE69112966T2 (fr)
ES (1) ES2079653T3 (fr)
WO (1) WO1991015772A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006006A1 (fr) * 1989-10-19 1991-05-02 Yamasa Shoyu Kabushiki Kaisha Excipient de liaison d'anticorps antiphospholipides, immuno-analyse utilisant cet excipient et kit associe
AU666352B2 (en) * 1992-02-05 1996-02-08 Takao Koike Solid-phase reagent and assay method for measuring antibodies specific to antiphospholipid syndrome
CA2072548A1 (fr) * 1992-06-26 1993-12-27 Michael W. Stewart Methodes de dosage des anticorps antiphospholipidiques
WO1995009363A1 (fr) 1993-09-29 1995-04-06 Yamasa Corporation Procede de titrage de lipoproteine oxydee et applications de ce procede
CA2176007A1 (fr) * 1993-11-16 1995-05-26 Eiji Matsuura Procede pour le dosage d'anticorps antiphospholipides et kit associe
JP3370786B2 (ja) * 1994-07-25 2003-01-27 鐘淵化学工業株式会社 自己抗体の免疫学的測定法
WO1996004559A1 (fr) * 1994-08-01 1996-02-15 Institut Français De Recherches Scientifiques Pour Le Developpement En Cooperation - Orstom Procede de separation et/ou de detection et/ou de quantification de compose(s) infectieux et support pour la mise en ×uvre du procede
US6410775B1 (en) * 1995-06-07 2002-06-25 La Jolla Pharmaceutical Company APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies
US5874409A (en) * 1995-06-07 1999-02-23 La Jolla Pharmaceutical Company APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies
US6017721A (en) * 1995-10-18 2000-01-25 The United States Of America As Represented By The Department Of Health And Human Services Chromatographic method and device for preparing blood serum for compatibility testing
US5776487A (en) * 1996-04-19 1998-07-07 Pasteur Sanofi Diagnostics Liposome reagents for immunoassays
US5780319A (en) * 1996-04-19 1998-07-14 Pasteur Sanofi Diagnostics Immunoassays to detect antiphospholipid antibodies
KR20000016414A (ko) * 1996-06-06 2000-03-25 와이즈먼 앤드루 Apl 면역반응성 펩티드, 그것의 콘주게이트 및 apl항체-매개병변의 치료방법
US6177282B1 (en) * 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
US6858210B1 (en) 1998-06-09 2005-02-22 La Jolla Pharmaceutical Co. Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
US6818213B1 (en) 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
CA2333147C (fr) 1998-07-13 2012-02-07 Board Of Regents, The University Of Texas System Procedes de traitement du cancer reposant sur l'utilisation d'anticorps vis-a-vis des aminophospholipides
US6406693B1 (en) 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
US7067109B1 (en) 1998-07-13 2006-06-27 Board Of Regents, The University Of Texas System Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids
IL126447A (en) * 1998-10-04 2004-09-27 Vascular Biogenics Ltd An immune preparation that confers tolerance in oral administration and its use in the prevention and / or treatment of atherosclerosis
US20050197283A1 (en) * 1998-10-04 2005-09-08 Vascular Biogenics Ltd. Compositions containing beta 2-glycoprotein I for the prevention and/or treatment of vascular disease
US7361481B2 (en) * 1999-04-09 2008-04-22 Women's And Children's Hospital Diagnosis of lysosomal storage disorders using saposins and other markers
JP2001207584A (ja) 2000-01-31 2001-08-03 Nichiha Corp 着色建築板及びその製造方法
DE10018954B4 (de) * 2000-04-17 2007-07-19 Orgentec Diagnostika Gmbh Verwendung einer beschichteten Kunststoff-Festphase in einem Verfahren zur Bestimmung eines Analyten
US6777193B1 (en) * 2000-08-04 2004-08-17 Escuela Nacional De Ciencias Biologicas, Del Instituto Politecnico Nacional Methods for diagnostic and/or treatment of antiphospholipids antibodies-related diseases, and devices
GB0104057D0 (en) * 2001-02-20 2001-04-04 Babraham Inst Antiphospholipid antibody syndrome
KR100445939B1 (ko) * 2002-03-23 2004-08-25 강철훈 알루미늄 이온을 포함하는 단백질 염색용 처리용액 및 이를 이용한 단백질 염색방법
AU2003237870A1 (en) * 2002-06-07 2003-12-22 The Brigham & Women's Hospital, Inc. Method and composition for inhibing or slowing blood coagulation
US7771956B2 (en) * 2003-06-30 2010-08-10 Brigham & Women's Hospital, Inc. Method for detecting the presence of a phospholipid
CN101146826A (zh) * 2005-01-24 2008-03-19 得克萨斯大学体系董事会 与磷脂酰丝氨酸结合的fc融合构建体及其治疗用途
EP1874334A4 (fr) * 2005-04-15 2011-03-30 Vascular Biogenics Ltd Compositions contenant des peptides derives de la glycoproteine i beta 2 pour la prevention et le traitement de maladie cardiovasculaire
EP1872132B1 (fr) * 2005-04-18 2013-09-18 Bio-Rad Laboratories, Inc. Immobilisation en phase solide de phospholipides et de proteines cofacteur via liaison covalente
FR2927171B1 (fr) * 2008-02-01 2010-03-19 Apoh Technollgies Sa Procede de detection et/ou de quantification et/ou d'identification in vitro de bacteries dans un materiau biologique
WO2013007570A1 (fr) * 2011-07-12 2013-01-17 Centre National De La Recherche Scientifique Procédé de criblage grande vitesse de l'activité lipase et/ou d'inhibiteurs de lipase dans des échantillons biologiques et des milieux de culture
CN116068172B (zh) * 2023-03-06 2023-06-20 苏州惠中生物科技有限公司 一种用于抗心磷脂抗体定量检测的磁微粒化学发光试剂及试剂盒

Also Published As

Publication number Publication date
EP0474849A4 (fr) 1994-03-30
ATE127925T1 (de) 1995-09-15
US5344758A (en) 1994-09-06
DE69112966T2 (de) 1996-02-15
JPH0688823A (ja) 1994-03-29
DE69112966D1 (de) 1995-10-19
WO1991015772A1 (fr) 1991-10-17
ES2079653T3 (es) 1996-01-16
CA2058769C (fr) 1999-03-02
EP0474849B1 (fr) 1995-09-13
EP0474849A1 (fr) 1992-03-18

Similar Documents

Publication Publication Date Title
CA2058769A1 (fr) Methodes pour le dosage des phospholipides et de leurs anticorps
AU2460988A (en) Simultaneous immunoassay for the determination of antigens and antibodies
AU5665696A (en) Novel methods for the assay of troponin i and t and complexe s of troponin i and t and selection of antibodies for use in immunoassays
EP0154884A3 (fr) Produit conjugué d'acide nucléique et protéine
ZA882998B (en) Simultaneous enzyme immunoassay for detecting antigen and/or antibody in humans
GR80199B (en) Assay kit for detection of antibodies in human serum and method of producing same
AU1748988A (en) Method and test device for separating labeled reagent in an immunometric binding assay
FI886000L (fi) Immunologisia määritysmenetelmiä ja niissä käytettävä reagenssi
AU629121B2 (en) Test method and device to assay for total protein
AU584542B2 (en) Method for magnetically seperating labeled reagent in an immunometric binding assay
AU1728883A (en) Antigen assay method and kit
FI884472L (fi) Määrityskitti ja -menetelmä kokonaisten solujen immunologiseen määritykseen
EP0296796A3 (en) Analytical method and element for protein assay
EP0307149A3 (en) Solid phase immunoassay for an antibody and biological constructions for use therein
DE3069618D1 (en) Support-ligand analog-fluorescer conjugate and serum assay method involving such conjugate
CA2175478A1 (fr) Lignees cellulaires transfectees exprimant des autoantigenes et leur utilisation dans des dosages immunologiques destines a la detection de maladies autoimmunes
GR900300168T1 (en) Serum proteins related to autoimmune disease
AU2541488A (en) Reagents and probes for distinguishing and isolating different gtp-binding proteins
AU2353188A (en) A diagnostic agent and a method for the determination of apolipoprotein b
AU8944291A (en) Immunoassay for the determination of anti-hiv antibodies in human samples
ES539223A0 (es) Mejoras intruducidas en un ensayo para determinar un antigeno bacteriano en una muestra de ensayo
AU5186890A (en) Method and diagnostic test kit for detection of autoimmune antibody
AU6189486A (en) Monoclonal antibodies to prosomal proteins
GB9211902D0 (en) Method of determining the allergenic response of a sample of mammalian blood to an antigen
ES8606500A1 (es) Un metodo para determinar la presencia de ige especifica en sueros humanos

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry