CA2078004A1 - Methode de lyophilisation et de reconstitution de combinaisons de cellules nucleees non mammaliennes et de constituants sanguins - Google Patents

Methode de lyophilisation et de reconstitution de combinaisons de cellules nucleees non mammaliennes et de constituants sanguins

Info

Publication number: CA2078004A1
Authority: CA; Canada
Prior art keywords: cells; process according; polymers; range; nucleated
Prior art date: 1991-02-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002078004A

Other languages

English (en)

Inventor

Christine M. Williams

Goodrich Raymond P., Jr.

Roger W. Hackett

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

TRYOPHARM Corp

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-15

Filing date

1992-02-05

Publication date

1992-08-16

1992-02-05 Application filed by Individual filed Critical Individual

1992-08-16 Publication of CA2078004A1 publication Critical patent/CA2078004A1/fr

Status Abandoned legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 44
239000000203 mixture Substances 0.000 title claims abstract description 32
238000004108 freeze drying Methods 0.000 title claims abstract description 22
210000004369 blood Anatomy 0.000 title claims abstract description 15
239000008280 blood Substances 0.000 title claims abstract description 15
210000004962 mammalian cell Anatomy 0.000 title claims description 7
210000004027 cell Anatomy 0.000 claims abstract description 65
229920000642 polymer Polymers 0.000 claims abstract description 43
244000045947 parasite Species 0.000 claims abstract description 39
210000003743 erythrocyte Anatomy 0.000 claims abstract description 32
210000001772 blood platelet Anatomy 0.000 claims abstract description 7
210000000265 leukocyte Anatomy 0.000 claims abstract description 5
230000001413 cellular effect Effects 0.000 claims abstract 5
150000002972 pentoses Chemical class 0.000 claims abstract 2
239000000243 solution Substances 0.000 claims description 28
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 18
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 18
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 18
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims description 10
239000002953 phosphate buffered saline Substances 0.000 claims description 10
229920001612 Hydroxyethyl starch Polymers 0.000 claims description 9
229940050526 hydroxyethylstarch Drugs 0.000 claims description 9
229960005486 vaccine Drugs 0.000 claims description 9
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
230000002238 attenuated effect Effects 0.000 claims description 8
150000002772 monosaccharides Chemical class 0.000 claims description 8
241000606646 Anaplasma Species 0.000 claims description 7
239000008103 glucose Substances 0.000 claims description 7
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 6
239000011780 sodium chloride Substances 0.000 claims description 6
229920002307 Dextran Polymers 0.000 claims description 5
238000001035 drying Methods 0.000 claims description 5
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
238000005119 centrifugation Methods 0.000 claims description 4
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 3
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims description 3
229930091371 Fructose Natural products 0.000 claims description 3
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 3
239000005715 Fructose Substances 0.000 claims description 3
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims description 3
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims description 3
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 3
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 3
239000007853 buffer solution Substances 0.000 claims description 3
238000002156 mixing Methods 0.000 claims description 3
238000005406 washing Methods 0.000 claims description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
239000007864 aqueous solution Substances 0.000 claims description 2
150000002402 hexoses Chemical class 0.000 claims description 2
238000000859 sublimation Methods 0.000 claims description 2
230000008022 sublimation Effects 0.000 claims description 2
241000606665 Anaplasma marginale Species 0.000 claims 4
239000012634 fragment Substances 0.000 claims 4
210000000601 blood cell Anatomy 0.000 claims 3
239000008366 buffered solution Substances 0.000 claims 1
-1 monosaccharide hexoses Chemical class 0.000 abstract description 2
239000000872 buffer Substances 0.000 description 13
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
241000283690 Bos taurus Species 0.000 description 4
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
230000008901 benefit Effects 0.000 description 4
150000001720 carbohydrates Chemical class 0.000 description 4
235000014633 carbohydrates Nutrition 0.000 description 4
235000002639 sodium chloride Nutrition 0.000 description 4
ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 4
150000001447 alkali salts Chemical class 0.000 description 3
210000000170 cell membrane Anatomy 0.000 description 3
208000015181 infectious disease Diseases 0.000 description 3
239000012528 membrane Substances 0.000 description 3
229930024421 Adenine Natural products 0.000 description 2
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
108010054147 Hemoglobins Proteins 0.000 description 2
102000001554 Hemoglobins Human genes 0.000 description 2
241001494479 Pecora Species 0.000 description 2
229960000643 adenine Drugs 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
210000000805 cytoplasm Anatomy 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000007710 freezing Methods 0.000 description 2
230000008014 freezing Effects 0.000 description 2
239000000463 material Substances 0.000 description 2
230000003071 parasitic effect Effects 0.000 description 2
239000002245 particle Substances 0.000 description 2
239000012466 permeate Substances 0.000 description 2
229920001983 poloxamer Polymers 0.000 description 2
239000001103 potassium chloride Substances 0.000 description 2
235000011164 potassium chloride Nutrition 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000001488 sodium phosphate Substances 0.000 description 2
229910000162 sodium phosphate Inorganic materials 0.000 description 2
230000002194 synthesizing effect Effects 0.000 description 2
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
230000035899 viability Effects 0.000 description 2
230000003612 virological effect Effects 0.000 description 2
241001266092 Anaplasma ovis Species 0.000 description 1
241000282817 Bovidae Species 0.000 description 1
241000283707 Capra Species 0.000 description 1
241000282994 Cervidae Species 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
241000282324 Felis Species 0.000 description 1
229930010555 Inosine Natural products 0.000 description 1
UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
108010061951 Methemoglobin Proteins 0.000 description 1
108010064719 Oxyhemoglobins Proteins 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
229920003079 Povidone K 17 Polymers 0.000 description 1
LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
241000700605 Viruses Species 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
208000006730 anaplasmosis Diseases 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
230000019522 cellular metabolic process Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
210000004292 cytoskeleton Anatomy 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
238000003795 desorption Methods 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
235000019797 dipotassium phosphate Nutrition 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
229960005542 ethidium bromide Drugs 0.000 description 1
230000004992 fission Effects 0.000 description 1
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
238000009472 formulation Methods 0.000 description 1
238000005534 hematocrit Methods 0.000 description 1
108010083487 hemichrome Proteins 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
238000007654 immersion Methods 0.000 description 1
239000011261 inert gas Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
229960003786 inosine Drugs 0.000 description 1
244000000056 intracellular parasite Species 0.000 description 1
230000007774 longterm Effects 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
210000000948 non-nucleated cell Anatomy 0.000 description 1
244000000042 obligate parasite Species 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
244000052769 pathogen Species 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
229960002816 potassium chloride Drugs 0.000 description 1
LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
229940076788 pyruvate Drugs 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
229960002668 sodium chloride Drugs 0.000 description 1
CMXPERZAMAQXSF-UHFFFAOYSA-M sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate;1,8-dihydroxyanthracene-9,10-dione Chemical compound [Na+].O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O.CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC CMXPERZAMAQXSF-UHFFFAOYSA-M 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
210000003934 vacuole Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0233—Rickettsiales, e.g. Anaplasma
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Microbiology (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Immunology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

CA002078004A 1991-02-15 1992-02-05 Methode de lyophilisation et de reconstitution de combinaisons de cellules nucleees non mammaliennes et de constituants sanguins Abandoned CA2078004A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65655391A	1991-02-15	1991-02-15
US656,553		1991-02-15

Publications (1)

Publication Number	Publication Date
CA2078004A1 true CA2078004A1 (fr)	1992-08-16

Family

ID=24633537

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002078004A Abandoned CA2078004A1 (fr)	1991-02-15	1992-02-05	Methode de lyophilisation et de reconstitution de combinaisons de cellules nucleees non mammaliennes et de constituants sanguins

Country Status (5)

Country	Link
JP (1)	JPH05506457A (fr)
AU (1)	AU1415992A (fr)
CA (1)	CA2078004A1 (fr)
IL (1)	IL100954A0 (fr)
WO (1)	WO1992014360A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5213814A (en) *	1989-04-10	1993-05-25	Cryopharm Corporation	Lyophilized and reconstituted blood platelet compositions
IL90188A0 (en) *	1988-05-18	1989-12-15	Cryopharm Corp	Process and medium for the lyophilization of erythrocytes
US5045446A (en) *	1988-08-26	1991-09-03	Cryopharm Corporation	Lyophilization of cells
CA2062941A1 (fr) *	1990-05-25	1991-11-26	Raymond P. Goodrich, Jr.	Procede pour lyophiliser les cellules, matieres et plaquettes de type cellules dans un melange de polymeres amphipatiques biocompatibles
DE69534151T2 (de) *	1994-02-22	2006-01-12	Nippon Telegraph And Telephone Corp.	Gefriergetrocknete Blutzellen, Stammzellen und Plättchen und Verfahren zu deren Herstellung
US7112576B1 (en)	1999-12-10	2006-09-26	Regents Of The University Of Minnesota	Compositions and methods for cryopreservation of peripheral blood lymphocytes
KR20140014318A (ko)	2005-11-17	2014-02-05	니뽄젠야쿠코교 가부시키가이샤	세포 보존용 수용액
US8968992B2 (en)	2008-03-21	2015-03-03	Fenwal, Inc.	Red blood cell storage medium for extended storage
US8871434B2 (en)	2008-03-21	2014-10-28	Fenwal, Inc.	Red blood cell storage medium for extended storage
US11864553B2 (en)	2009-10-23	2024-01-09	Fenwal, Inc.	Methods and systems for providing red blood cell products with reduced plasma
BR112012020303A2 (pt)	2010-02-19	2019-09-24	Cadila Pharmaceuticals Ltd	"composição estável de células mortas com propriedades imunogênicas substancialmente retidas, e, processo e método de preparação da composição."
WO2012098358A1 (fr) *	2011-01-20	2012-07-26	Biopharma Technology Ltd	Procédé de lyophilisation
GB201101002D0 (en) *	2011-01-20	2011-03-09	Biopharma Technology Ltd	Freeze drying method
WO2015175672A1 (fr)	2014-05-14	2015-11-19	Merial, Inc.	Procédés de lyophilisation et de réhydratation de produits biologiques
JP7110360B2 (ja)	2017-10-09	2022-08-01	テルモビーシーティーバイオテクノロジーズ，エルエルシー	凍結乾燥方法
CN113614477B (zh)	2019-03-14	2023-04-28	泰尔茂比司特生物技术有限公司	冷冻干燥装载托盘组件及系统

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4874690A (en) *	1988-08-26	1989-10-17	Cryopharm Corporation	Lyophilization of red blood cells

1992
- 1992-02-05 CA CA002078004A patent/CA2078004A1/fr not_active Abandoned
- 1992-02-05 WO PCT/US1992/000650 patent/WO1992014360A1/fr not_active Ceased
- 1992-02-05 AU AU14159/92A patent/AU1415992A/en not_active Abandoned
- 1992-02-05 JP JP92506605A patent/JPH05506457A/ja active Pending
- 1992-02-14 IL IL100954A patent/IL100954A0/xx unknown

Also Published As

Publication number	Publication date
JPH05506457A (ja)	1993-09-22
AU1415992A (en)	1992-09-15
IL100954A0 (en)	1992-11-15
WO1992014360A1 (fr)	1992-09-03

Legal Events

Date	Code	Title	Description
1994-08-06	FZDE	Discontinued

Publication	Publication Date	Title
CA1327763C (fr)	1994-03-15	Lyophilisation de cellules
CA2064228C (fr)	1999-04-06	Compositions cellulaires lyophilisees et reconstituees
US5043261A (en)	1991-08-27	Lyophilized and reconstituted red blood cell and hemosome compositions
CA1313618C (fr)	1993-02-16	Lyophilisation des globules rouges
US5178884A (en)	1993-01-12	Lyophilized and reconstituted red blood cell compositions
US5242792A (en)	1993-09-07	Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides
CA2078004A1 (fr)	1992-08-16	Methode de lyophilisation et de reconstitution de combinaisons de cellules nucleees non mammaliennes et de constituants sanguins
Wolkers et al.	2002	From anhydrobiosis to freeze-drying of eukaryotic cells
EP0342879B1 (fr)	1993-05-12	Lyophilisation des érythrocytes et milieux utilisables à cet effet
US5690963A (en)	1997-11-25	Freeze dried red blood cells
US6884573B2 (en)	2005-04-26	Fixed dried red blood cells and method of use
US5153004A (en)	1992-10-06	Freezing and thawing of erythrocytes
CN1246778A (zh)	2000-03-08	用于制备干的、贮存稳定的血小板的方法和组合物
US5171661A (en)	1992-12-15	Medium for lyophilization of erythrocytes
US20070105220A1 (en)	2007-05-10	Erythrocytic cells and method for loading solutes
US5750330A (en)	1998-05-12	Method and composition for lyophilizing red blood cells
Yu et al.	2004	Freeze-drying of human red blood cells: influence of carbohydrates and their concentrations
EP0356258A2 (fr)	1990-02-28	Procédés de lyophilisation des globules rouges sanguins; support de lyophilisation à cet usage
Spargo	1995	Freeze Dried Red Blood Cells and Platelets.