CA2078054A1 - Procedes de fermentation a rendement eleve - Google Patents

Procedes de fermentation a rendement eleve

Info

Publication number: CA2078054A1
Authority: CA; Canada
Prior art keywords: culture medium; vaccine antigen; culture; divalent; fermentation
Prior art date: 1991-09-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA 2078054

Other languages

English (en)

Inventor

Sun Yukun

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-13

Filing date

1992-09-11

Publication date

1993-03-14

1992-09-11 Application filed by Individual filed Critical Individual

1993-03-14 Publication of CA2078054A1 publication Critical patent/CA2078054A1/fr

Status Abandoned legal-status Critical Current

Links

238000000855 fermentation Methods 0.000 title claims description 25
230000004151 fermentation Effects 0.000 title claims description 25
238000000034 method Methods 0.000 claims abstract description 29
239000001963 growth medium Substances 0.000 claims abstract description 24
229960005486 vaccine Drugs 0.000 claims abstract description 22
239000000427 antigen Substances 0.000 claims abstract description 21
102000036639 antigens Human genes 0.000 claims abstract description 21
108091007433 antigens Proteins 0.000 claims abstract description 21
206010012735 Diarrhoea Diseases 0.000 claims abstract description 20
235000015097 nutrients Nutrition 0.000 claims abstract description 10
229910052943 magnesium sulfate Inorganic materials 0.000 claims abstract description 8
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims abstract 14
235000019341 magnesium sulphate Nutrition 0.000 claims abstract 7
241000588724 Escherichia coli Species 0.000 claims abstract 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
239000002054 inoculum Substances 0.000 claims description 14
150000001875 compounds Chemical class 0.000 claims description 9
150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 5
239000002518 antifoaming agent Substances 0.000 claims description 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
229910052760 oxygen Inorganic materials 0.000 claims description 4
239000001301 oxygen Substances 0.000 claims description 4
229940041514 candida albicans extract Drugs 0.000 claims description 3
239000012138 yeast extract Substances 0.000 claims description 3
210000004027 cell Anatomy 0.000 claims 12
239000000463 material Substances 0.000 claims 6
230000001954 sterilising effect Effects 0.000 claims 4
238000012258 culturing Methods 0.000 claims 3
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
210000004748 cultured cell Anatomy 0.000 claims 2
238000000354 decomposition reaction Methods 0.000 claims 2
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims 1
229910000396 dipotassium phosphate Inorganic materials 0.000 claims 1
235000019797 dipotassium phosphate Nutrition 0.000 claims 1
238000010438 heat treatment Methods 0.000 claims 1
XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 claims 1
230000000415 inactivating effect Effects 0.000 claims 1
238000002156 mixing Methods 0.000 claims 1
235000019799 monosodium phosphate Nutrition 0.000 claims 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 1
229910000162 sodium phosphate Inorganic materials 0.000 claims 1
238000003208 gene overexpression Methods 0.000 abstract 1
125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 abstract 1
150000002500 ions Chemical class 0.000 description 13
241000501458 Cultus Species 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
239000002609 medium Substances 0.000 description 4
241000042812 Divales Species 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
244000052769 pathogen Species 0.000 description 2
230000001717 pathogenic effect Effects 0.000 description 2
239000013612 plasmid Substances 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
229910001868 water Inorganic materials 0.000 description 2
VVVDGSCGBGBGFN-UHFFFAOYSA-O 2-[decoxy(hydroxy)phosphoryl]oxyethyl-trimethylazanium Chemical compound CCCCCCCCCCOP(O)(=O)OCC[N+](C)(C)C VVVDGSCGBGBGFN-UHFFFAOYSA-O 0.000 description 1
BSFODEXXVBBYOC-UHFFFAOYSA-N 8-[4-(dimethylamino)butan-2-ylamino]quinolin-6-ol Chemical compound C1=CN=C2C(NC(CCN(C)C)C)=CC(O)=CC2=C1 BSFODEXXVBBYOC-UHFFFAOYSA-N 0.000 description 1
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
241001527902 Aratus Species 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
101100123850 Caenorhabditis elegans her-1 gene Proteins 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
241000905957 Channa melasoma Species 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
241001366015 Desis Species 0.000 description 1
101100536354 Drosophila melanogaster tant gene Proteins 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 1
102000004856 Lectins Human genes 0.000 description 1
108090001090 Lectins Proteins 0.000 description 1
241000336847 Luda Species 0.000 description 1
101100490488 Mus musculus Add3 gene Proteins 0.000 description 1
229910017974 NH40H Inorganic materials 0.000 description 1
101150014691 PPARA gene Proteins 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
101150104938 Pigl gene Proteins 0.000 description 1
208000037062 Polyps Diseases 0.000 description 1
229940037003 alum Drugs 0.000 description 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
229960000723 ampicillin Drugs 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
244000309466 calf Species 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
239000000284 extract Substances 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
230000007775 late Effects 0.000 description 1
239000002523 lectin Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229910052754 neon Inorganic materials 0.000 description 1
GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 1
OIPPWFOQEKKFEE-UHFFFAOYSA-N orcinol Chemical compound CC1=CC(O)=CC(O)=C1 OIPPWFOQEKKFEE-UHFFFAOYSA-N 0.000 description 1
IZRPKIZLIFYYKR-UHFFFAOYSA-N phenyltoloxamine Chemical compound CN(C)CCOC1=CC=CC=C1CC1=CC=CC=C1 IZRPKIZLIFYYKR-UHFFFAOYSA-N 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CA 2078054 1991-09-13 1992-09-11 Procedes de fermentation a rendement eleve Abandoned CA2078054A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US75943291A	1991-09-13	1991-09-13
US07/759,432		1991-09-13

Publications (1)

Publication Number	Publication Date
CA2078054A1 true CA2078054A1 (fr)	1993-03-14

Family

ID=25055628

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA 2078054 Abandoned CA2078054A1 (fr)	1991-09-13	1992-09-11	Procedes de fermentation a rendement eleve

Country Status (1)

Country	Link
CA (1)	CA2078054A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7118884B1 (en)	1994-04-28	2006-10-10	Amgen Inc.	Method for controlling metallophosphate precipitation in high cell density fermentations

1992
- 1992-09-11 CA CA 2078054 patent/CA2078054A1/fr not_active Abandoned

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7118884B1 (en)	1994-04-28	2006-10-10	Amgen Inc.	Method for controlling metallophosphate precipitation in high cell density fermentations
US7381545B2 (en)	1994-04-28	2008-06-03	Amgen Inc.	Method for controlling metallophosphate precipitation in high cell density fermentations

Legal Events

Date	Code	Title	Description
1995-03-11	FZDE	Dead

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