CA2082811A1 - Utilisation du 5,10-methylene-tetrahydrofolate comme modulateur d'un agent chimiotherapeutique - Google Patents

Utilisation du 5,10-methylene-tetrahydrofolate comme modulateur d'un agent chimiotherapeutique

Info

Publication number: CA2082811A1
Authority: CA; Canada
Prior art keywords: tetrahydrofolate; methylene; modulator; chemotherapeutic agent; ch2fh4
Prior art date: 1990-05-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA002082811A

Other languages

English (en)

Other versions

CA2082811C (fr

Inventor

Colin P. Spears

Bengt G. Gustavsson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Southern California USC

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-11

Filing date

1991-05-13

Publication date

1991-11-12

1991-05-13 Application filed by Individual filed Critical Individual

1991-11-12 Publication of CA2082811A1 publication Critical patent/CA2082811A1/fr

2004-11-16 Application granted granted Critical

2004-11-16 Publication of CA2082811C publication Critical patent/CA2082811C/fr

2011-05-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

QYNUQALWYRSVHF-OLZOCXBDSA-N (6R)-5,10-methylenetetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1C1)N)N1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QYNUQALWYRSVHF-OLZOCXBDSA-N 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 title 1
229940127089 cytotoxic agent Drugs 0.000 title 1
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
-1 compound 5,10-methylene-tetrahydrofolate Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229960002949 fluorouracil Drugs 0.000 abstract 1
230000005917 in vivo anti-tumor Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA002082811A 1990-05-11 1991-05-13 Utilisation du 5,10-methylene-tetrahydrofolate comme modulateur d'un agent chimiotherapeutique Expired - Lifetime CA2082811C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US52171290A	1990-05-11	1990-05-11
US521,712		1990-05-11
PCT/US1991/003186 WO1991017660A1 (fr)	1990-05-11	1991-05-13	5,10-methylene-tetrahydrofolate comme modulateur d'un agent chimiotherapeutique

Publications (2)

Publication Number	Publication Date
CA2082811A1 true CA2082811A1 (fr)	1991-11-12
CA2082811C CA2082811C (fr)	2004-11-16

Family

ID=24077829

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002082811A Expired - Lifetime CA2082811C (fr)	1990-05-11	1991-05-13	Utilisation du 5,10-methylene-tetrahydrofolate comme modulateur d'un agent chimiotherapeutique

Country Status (3)

Country	Link
AU (1)	AU7953291A (fr)
CA (1)	CA2082811C (fr)
WO (1)	WO1991017660A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH684644A5 (de)	1992-07-13	1994-11-15	Eprova Ag	5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
US5719132A (en) *	1996-06-27	1998-02-17	Bristol-Myers Squibb Company	Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
CH693255A5 (de) *	1997-06-13	2003-05-15	Eprova Ag	Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels.
SE0303526D0 (sv) *	2003-12-22	2003-12-22	Biofol Ab	Chemotherapeutic agents
EP2617421A1 (fr) *	2012-01-20	2013-07-24	Isofol Medical AB	Tétrahydrofolates en combinaison avec les inhibiteurs EGFR dans l'utilisation pour le traitement du cancer

1991
- 1991-05-13 CA CA002082811A patent/CA2082811C/fr not_active Expired - Lifetime
- 1991-05-13 AU AU79532/91A patent/AU7953291A/en not_active Abandoned
- 1991-05-13 WO PCT/US1991/003186 patent/WO1991017660A1/fr not_active Ceased

Also Published As

Publication number	Publication date
WO1991017660A1 (fr)	1991-11-28
CA2082811C (fr)	2004-11-16
AU7953291A (en)	1991-12-10

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Legal Events

Date	Code	Title	Description
1998-05-13	EEER	Examination request
2011-05-13	MKEX	Expiry