CA2085342A1 - Suspension aqueuse stable de medicament - Google Patents

Suspension aqueuse stable de medicament

Info

Publication number: CA2085342A1
Authority: CA; Canada
Prior art keywords: drug; microspheres; coating; micrometers; matrix
Prior art date: 1990-06-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002085342A

Other languages

English (en)

Inventor

Milton R. Kaplan

Chel W. Lew

Catherine S. Lamb

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

KALMO ENTERPRISES Inc

Original Assignee

KALMO ENTERPRISES Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-14

Filing date

1991-06-13

Publication date

1991-12-15

1991-06-13 Application filed by KALMO ENTERPRISES Inc filed Critical KALMO ENTERPRISES Inc

1991-12-15 Publication of CA2085342A1 publication Critical patent/CA2085342A1/fr

Status Abandoned legal-status Critical Current

Links

239000003814 drug Substances 0.000 title claims abstract description 67
229940079593 drug Drugs 0.000 title claims abstract description 67
239000000725 suspension Substances 0.000 title claims description 9
239000004005 microsphere Substances 0.000 claims abstract description 60
239000002245 particle Substances 0.000 claims abstract description 44
239000003094 microcapsule Substances 0.000 claims abstract description 40
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
239000002702 enteric coating Substances 0.000 claims abstract description 16
238000009505 enteric coating Methods 0.000 claims abstract description 16
229920000642 polymer Polymers 0.000 claims abstract description 12
239000000227 bioadhesive Substances 0.000 claims abstract description 11
150000002632 lipids Chemical class 0.000 claims abstract description 9
238000000576 coating method Methods 0.000 claims description 34
239000011159 matrix material Substances 0.000 claims description 24
239000011248 coating agent Substances 0.000 claims description 23
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 21
239000002002 slurry Substances 0.000 claims description 15
238000000034 method Methods 0.000 claims description 14
229960003276 erythromycin Drugs 0.000 claims description 10
239000012530 fluid Substances 0.000 claims description 6
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 5
239000007787 solid Substances 0.000 claims description 5
230000007935 neutral effect Effects 0.000 claims description 4
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims description 3
NSYZCCDSJNWWJL-YXOIYICCSA-N erythromycin ethylsuccinate Chemical compound O1[C@H](C)C[C@H](N(C)C)[C@@H](OC(=O)CCC(=O)OCC)[C@@H]1O[C@H]1[C@@](O)(C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(OC)C2)[C@@H]1C NSYZCCDSJNWWJL-YXOIYICCSA-N 0.000 claims description 3
229960000741 erythromycin ethylsuccinate Drugs 0.000 claims description 3
150000004677 hydrates Chemical class 0.000 claims description 3
BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 claims description 3
235000020374 simple syrup Nutrition 0.000 claims description 3
229930182555 Penicillin Natural products 0.000 claims description 2
229930195708 Penicillin V Natural products 0.000 claims description 2
229960003022 amoxicillin Drugs 0.000 claims description 2
229960000723 ampicillin Drugs 0.000 claims description 2
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 2
229940056367 penicillin v Drugs 0.000 claims description 2
150000003839 salts Chemical class 0.000 claims description 2
239000007771 core particle Substances 0.000 claims 2
238000004519 manufacturing process Methods 0.000 claims 2
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
125000003473 lipid group Chemical group 0.000 claims 1
229940049954 penicillin Drugs 0.000 claims 1
239000007864 aqueous solution Substances 0.000 abstract description 7
239000008393 encapsulating agent Substances 0.000 description 22
239000000463 material Substances 0.000 description 13
239000000203 mixture Substances 0.000 description 12
210000002784 stomach Anatomy 0.000 description 11
239000002253 acid Substances 0.000 description 7
150000002148 esters Chemical class 0.000 description 7
239000010410 layer Substances 0.000 description 7
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
235000014113 dietary fatty acids Nutrition 0.000 description 6
238000009826 distribution Methods 0.000 description 6
239000000194 fatty acid Substances 0.000 description 6
229930195729 fatty acid Natural products 0.000 description 6
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 6
239000000243 solution Substances 0.000 description 6
239000011701 zinc Substances 0.000 description 6
-1 aliphatic fatty acids Chemical class 0.000 description 5
150000004665 fatty acids Chemical class 0.000 description 5
235000013305 food Nutrition 0.000 description 5
230000003111 delayed effect Effects 0.000 description 4
210000001035 gastrointestinal tract Anatomy 0.000 description 4
239000003760 tallow Substances 0.000 description 4
150000003626 triacylglycerols Chemical class 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
239000000654 additive Substances 0.000 description 3
229960004920 amoxicillin trihydrate Drugs 0.000 description 3
230000003115 biocidal effect Effects 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
239000003623 enhancer Substances 0.000 description 3
150000002170 ethers Chemical class 0.000 description 3
238000001125 extrusion Methods 0.000 description 3
125000005456 glyceride group Chemical group 0.000 description 3
210000000936 intestine Anatomy 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000003960 organic solvent Substances 0.000 description 3
239000011257 shell material Substances 0.000 description 3
229910052725 zinc Inorganic materials 0.000 description 3
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 3
KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
DKMROQRQHGEIOW-UHFFFAOYSA-N Diethyl succinate Chemical compound CCOC(=O)CCC(=O)OCC DKMROQRQHGEIOW-UHFFFAOYSA-N 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
235000021355 Stearic acid Nutrition 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 2
229940063655 aluminum stearate Drugs 0.000 description 2
229940124350 antibacterial drug Drugs 0.000 description 2
235000014633 carbohydrates Nutrition 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000003086 colorant Substances 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
230000002496 gastric effect Effects 0.000 description 2
239000012943 hotmelt Substances 0.000 description 2
239000008172 hydrogenated vegetable oil Substances 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
239000002184 metal Substances 0.000 description 2
125000005397 methacrylic acid ester group Chemical group 0.000 description 2
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
238000005192 partition Methods 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
229920006395 saturated elastomer Polymers 0.000 description 2
210000000813 small intestine Anatomy 0.000 description 2
239000002904 solvent Substances 0.000 description 2
239000011877 solvent mixture Substances 0.000 description 2
239000008117 stearic acid Substances 0.000 description 2
235000020357 syrup Nutrition 0.000 description 2
239000006188 syrup Substances 0.000 description 2
FQWUNUXAOHTLLG-ASDGIDEWSA-N 6-[(3s,6s,9s,12r)-3,6-dibenzyl-2,5,8,11-tetraoxo-1,4,7,10-tetrazabicyclo[10.3.0]pentadecan-9-yl]-n-hydroxyhexanamide Chemical group C([C@H]1C(=O)N2CCC[C@@H]2C(=O)N[C@H](C(N[C@@H](CC=2C=CC=CC=2)C(=O)N1)=O)CCCCCC(=O)NO)C1=CC=CC=C1 FQWUNUXAOHTLLG-ASDGIDEWSA-N 0.000 description 1
229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
229920001661 Chitosan Polymers 0.000 description 1
QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 1
229920003134 Eudragit® polymer Polymers 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
229920000148 Polycarbophil calcium Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920001800 Shellac Polymers 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
229920002494 Zein Polymers 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
150000007933 aliphatic carboxylic acids Chemical class 0.000 description 1
125000003342 alkenyl group Chemical group 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
125000000304 alkynyl group Chemical group 0.000 description 1
229960003311 ampicillin trihydrate Drugs 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
238000003556 assay Methods 0.000 description 1
239000003782 beta lactam antibiotic agent Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
239000000969 carrier Substances 0.000 description 1
229920002301 cellulose acetate Polymers 0.000 description 1
229940081734 cellulose acetate phthalate Drugs 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
238000013270 controlled release Methods 0.000 description 1
239000004148 curcumin Substances 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000000975 dye Substances 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
239000003925 fat Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
230000005484 gravity Effects 0.000 description 1
230000036571 hydration Effects 0.000 description 1
238000006703 hydration reaction Methods 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
230000000873 masking effect Effects 0.000 description 1
238000005259 measurement Methods 0.000 description 1
229940063559 methacrylic acid Drugs 0.000 description 1
239000003607 modifier Substances 0.000 description 1
229940102013 moisturel Drugs 0.000 description 1
150000004712 monophosphates Chemical group 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
229940090663 penicillin v potassium Drugs 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
238000005191 phase separation Methods 0.000 description 1
229950005134 polycarbophil Drugs 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
238000005086 pumping Methods 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
239000004208 shellac Substances 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
239000002356 single layer Substances 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
239000012798 spherical particle Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
125000003107 substituted aryl group Chemical group 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000004448 titration Methods 0.000 description 1
125000005591 trimellitate group Chemical group 0.000 description 1
UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000005019 zein Substances 0.000 description 1
229940093612 zein Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)

CA002085342A 1990-06-14 1991-06-13 Suspension aqueuse stable de medicament Abandoned CA2085342A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53818390A	1990-06-14	1990-06-14
US538,183		1990-06-14

Publications (1)

Publication Number	Publication Date
CA2085342A1 true CA2085342A1 (fr)	1991-12-15

Family

ID=24145861

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002085342A Abandoned CA2085342A1 (fr)	1990-06-14	1991-06-13	Suspension aqueuse stable de medicament

Country Status (4)

Country	Link
AU (1)	AU8219191A (fr)
CA (1)	CA2085342A1 (fr)
IL (1)	IL98508A0 (fr)
WO (1)	WO1991019486A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5160742A (en) *	1991-12-31	1992-11-03	Abbott Laboratories	System for delivering an active substance for sustained release
SE9201930D0 (sv) *	1992-06-24	1992-06-24	Astra Ab	Gastric antibacterial treatment
AT403988B (de) *	1994-05-18	1998-07-27	Lannacher Heilmittel	Festes orales retardpräparat
AU719137B2 (en) *	1996-05-07	2000-05-04	Mayne Pharma International Pty Ltd	Taste masked liquid suspensions
AUPN969796A0 (en)	1996-05-07	1996-05-30	F.H. Faulding & Co. Limited	Taste masked liquid suspensions
DE19648576C2 (de)	1996-11-23	1999-08-12	Lohmann Therapie Syst Lts	Lutschtablette zur modifizierten Freisetzung von Wirkstoffen im Gastrointestinaltrakt
DE19706979A1 (de) *	1997-02-21	1998-08-27	Lindopharm Gmbh	Kombinationspräparat für oral applizierbare Erythromycine
US6197331B1 (en)	1997-07-24	2001-03-06	Perio Products Ltd.	Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity
DE19741114C2 (de) *	1997-09-12	2002-10-24	Riemser Arzneimittel Ag	Feuchtigkeitsstabile und magensaftresistente Arzneiform für Fische
EE200000693A (et)	1998-05-20	2002-04-15	The Liposome Company, Inc.	Uudsed makroosakeste formulatsioonid
SI20244A (sl) *	1999-05-19	2000-12-31	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Granulacija v talini
EP1333807A4 (fr) *	2000-10-13	2005-06-29	Advancis Pharmaceuticals	Derives d'erythromycine a liberation prolongee
EP1390024A4 (fr) *	2001-05-11	2010-02-17	Merrion Res Iii Ltd	Sels d'acide isostearique utilises comme accelerateurs de permeation
US20030124196A1 (en)	2001-08-22	2003-07-03	Susan Weinbach	Pulsatile release compositions and methods for enhanced intestinal drug absorption
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1991
- 1991-06-13 AU AU82191/91A patent/AU8219191A/en not_active Abandoned
- 1991-06-13 CA CA002085342A patent/CA2085342A1/fr not_active Abandoned
- 1991-06-13 WO PCT/US1991/004198 patent/WO1991019486A1/fr not_active Ceased
- 1991-06-14 IL IL98508A patent/IL98508A0/xx unknown

Also Published As

Publication number	Publication date
WO1991019486A1 (fr)	1991-12-26
AU8219191A (en)	1992-01-07
IL98508A0 (en)	1992-07-15

Legal Events

Date	Code	Title	Description
1993-12-13	FZDE	Discontinued

Publication	Publication Date	Title
US5614222A (en)	1997-03-25	Stable aqueous drug suspensions and methods for preparation thereof
WO1991019486A1 (fr)	1991-12-26	Suspensions de medicaments aqueuses stables
US3119742A (en)	1964-01-28	Method of preparing sustained release pharmaceutical pellets and product thereof
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